Lrp2

Summary

Gene Symbol: Lrp2
Description: low density lipoprotein receptor-related protein 2
Alias: AI315343, AW536255, D230004K18Rik, Gp330, Megalin, b2b1625.2Clo, low-density lipoprotein receptor-related protein 2, glycoprotein 330
Species: mouse
Products:     Lrp2

Top Publications

  1. Girnun G, Smith W, Drori S, Sarraf P, Mueller E, Eng C, et al. APC-dependent suppression of colon carcinogenesis by PPARgamma. Proc Natl Acad Sci U S A. 2002;99:13771-6 pubmed
    ..This finding suggests a potentially important use for PPARgamma ligands as chemopreventative agents in colon cancer. ..
  2. Assemat E, Vinot S, Gofflot F, Linsel Nitschke P, Illien F, Châtelet F, et al. Expression and role of cubilin in the internalization of nutrients during the peri-implantation development of the rodent embryo. Biol Reprod. 2005;72:1079-86 pubmed
    ..to the maternal environment or to the amniotic and neural tube cavities, and had a very similar distribution to megalin, a member of the LDLR gene family and a coreceptor for cubilin in adult tissues...
  3. Fleming C, Mar F, Franquinho F, Saraiva M, Sousa M. Transthyretin internalization by sensory neurons is megalin mediated and necessary for its neuritogenic activity. J Neurosci. 2009;29:3220-32 pubmed publisher
    ..Moreover, we show that in vitro, in dorsal root ganglia neurons, clathrin-dependent megalin-mediated TTR internalization is needed for TTR neuritogenic activity...
  4. Drake C, Fleming P, LaRue A, Barth J, Chintalapudi M, Argraves W. Differential distribution of cubilin and megalin expression in the mouse embryo. Anat Rec A Discov Mol Cell Evol Biol. 2004;277:163-70 pubmed
    Cubilin and megalin are cell surface proteins that work cooperatively in many absorptive epithelia to mediate endocytosis of lipoproteins, vitamin carriers, and other proteins...
  5. Leheste J, Melsen F, Wellner M, Jansen P, Schlichting U, Renner Müller I, et al. Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect. FASEB J. 2003;17:247-9 pubmed
    b>Megalin is an endocytic receptor highly expressed in the proximal tubules of the kidney...
  6. Yang D, Smith E, Roland I, Sheng Z, He J, Martin W, et al. Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis. Dev Biol. 2002;251:27-44 pubmed
    ..We suggest that Dab2 functions in a signal pathway to regulate endodermal cell organization using endocytosis of ligands from the blastocoel cavity as a positioning cue. ..
  7. Motoyoshi Y, Matsusaka T, Saito A, Pastan I, Willnow T, Mizutani S, et al. Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria. Kidney Int. 2008;74:1262-9 pubmed publisher
    b>Megalin, a member of the LDL receptor family, is expressed on the apical membrane of proximal tubules and serves as an endocytic scavenger of filtered proteins and hence might contribute to the tubule injury as a consequence of ..
  8. Smith B, Mussell J, Fleming P, Barth J, Spyropoulos D, Cooley M, et al. Targeted disruption of cubilin reveals essential developmental roles in the structure and function of endoderm and in somite formation. BMC Dev Biol. 2006;6:30 pubmed
    Cubilin is a peripheral membrane protein that interacts with the integral membrane proteins megalin and amnionless to mediate ligand endocytosis by absorptive epithelia such as the extraembryonic visceral endoderm (VE).
  9. Gonzalez Villalobos R, Klassen R, Allen P, Johanson K, Baker C, Kobori H, et al. Megalin binds and internalizes angiotensin-(1-7). Am J Physiol Renal Physiol. 2006;290:F1270-5 pubmed
    b>Megalin is a multiligand receptor heavily involved in protein endocytosis. We recently demonstrated that megalin binds and mediates internalization of ANG II...

More Information

Publications62

  1. Carro E, Spuch C, Trejo J, Antequera D, Torres Aleman I. Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I. J Neurosci. 2005;25:10884-93 pubmed
    ..We found that physical exercise increases the levels of the choroid plexus endocytic receptor megalin/low-density lipoprotein receptor-related protein-2 (LRP2), a multicargo transporter known to participate in brain ..
  2. Alvira Botero X, Pérez González R, Spuch C, Vargas T, Antequera D, Garzón M, et al. Megalin interacts with APP and the intracellular adapter protein FE65 in neurons. Mol Cell Neurosci. 2010;45:306-15 pubmed publisher
    Increasing evidence has implicated megalin, a low-density lipoprotein receptor-related protein, in the pathogenesis of Alzheimer's disease (AD)...
  3. Birn H, Willnow T, Nielsen R, Norden A, Bönsch C, Moestrup S, et al. Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B(12). Am J Physiol Renal Physiol. 2002;282:F408-16 pubmed
    b>Megalin has previously been shown to bind and mediate endocytosis of transcobalamin (TC)-B(12)...
  4. Hammad S, Barth J, Knaak C, Argraves W. Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins. J Biol Chem. 2000;275:12003-8 pubmed
    ..Since cubilin has been reported to bind the endocytic receptor megalin, we explored the possibility that megalin acts in conjunction with cubilin to mediate HDL endocytosis...
  5. Willnow T, Hilpert J, Armstrong S, Rohlmann A, Hammer R, Burns D, et al. Defective forebrain development in mice lacking gp330/megalin. Proc Natl Acad Sci U S A. 1996;93:8460-4 pubmed
    gp330/megalin, a member of the low density lipoprotein (LDL) receptor gene family, is expressed on the apical surfaces of epithelial tissues, including the neuroepithelium, where it mediates the endocytic uptake of diverse macromolecules,..
  6. Leheste J, Rolinski B, Vorum H, Hilpert J, Nykjaer A, Jacobsen C, et al. Megalin knockout mice as an animal model of low molecular weight proteinuria. Am J Pathol. 1999;155:1361-70 pubmed
    b>Megalin is an endocytic receptor expressed on the luminal surface of the renal proximal tubules. The receptor is believed to play an important role in the tubular uptake of macromolecules filtered through the glomerulus...
  7. Spoelgen R, Hammes A, Anzenberger U, Zechner D, Andersen O, Jerchow B, et al. LRP2/megalin is required for patterning of the ventral telencephalon. Development. 2005;132:405-14 pubmed
    b>Megalin is a low-density lipoprotein receptor-related protein (LRP2) expressed in the neuroepithelium and the yolk sac of the early embryo...
  8. Nada S, Hondo A, Kasai A, Koike M, Saito K, Uchiyama Y, et al. The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes. EMBO J. 2009;28:477-89 pubmed publisher
    ..These results indicate that the lipid raft adaptor p18 is essential for anchoring the MEK-ERK pathway to late endosomes, and shed new light on a role of endosomal MEK-ERK pathway in controlling endosome dynamics. ..
  9. Nykjaer A, Dragun D, Walther D, Vorum H, Jacobsen C, Herz J, et al. An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell. 1999;96:507-15 pubmed
    ..protein, is filtered through the glomerulus and reabsorbed in the proximal tubules by the endocytic receptor megalin. Endocytosis is required to preserve 25-(OH) vitamin D3 and to deliver to the cells the precursor for generation ..
  10. Nagai J, Christensen E, Morris S, Willnow T, Cooper J, Nielsen R. Mutually dependent localization of megalin and Dab2 in the renal proximal tubule. Am J Physiol Renal Physiol. 2005;289:F569-76 pubmed
    ..Dab2) is a cytoplasmic adaptor protein that binds to the cytoplasmic tail of the multiligand endocytic receptor megalin, abundantly expressed in renal proximal tubules...
  11. Strope S, Rivi R, Metzger T, Manova K, Lacy E. Mouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules. Development. 2004;131:4787-95 pubmed
  12. Amsellem S, Gburek J, Hamard G, Nielsen R, Willnow T, Devuyst O, et al. Cubilin is essential for albumin reabsorption in the renal proximal tubule. J Am Soc Nephrol. 2010;21:1859-67 pubmed publisher
    ..This process involves two interacting receptors, megalin and cubilin, which form a complex with amnionless...
  13. Lighthouse J, Zhang L, Hsieh J, Rosenquist T, Holdener B. MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm. Dev Dyn. 2011;240:577-88 pubmed publisher
    ..Moreover, we demonstrated that MESD was essential for the apical localization of the related LRP2 (Megalin/MEG) in the visceral endoderm, resulting in impaired endocytic function...
  14. Maurer M, Cooper J. Endocytosis of megalin by visceral endoderm cells requires the Dab2 adaptor protein. J Cell Sci. 2005;118:5345-55 pubmed
    ..The lipoprotein receptor megalin is expressed in the visceral endoderm (VE), a polarized epithelium that supplies maternal nutrients to the early ..
  15. Oh S, Kim T, Lim J, Jeong J. Progesterone induces expression of Lrp2 in the murine uterus. Biochem Biophys Res Commun. 2013;441:175-9 pubmed publisher
    ..using high density DNA microarray analysis, we identified low density lipoprotein receptor-related protein 2 (Lrp2) is one of the genes upregulated by P4 and PR...
  16. Hirano M, Totani K, Fukuda T, Gu J, Suzuki A. N-Glycoform-dependent interactions of megalin with its ligands. Biochim Biophys Acta Gen Subj. 2017;1861:3106-3118 pubmed publisher
    b>Megalin is a 600-kDa single-spanning transmembrane glycoprotein and functions as an endocytic receptor, distributed not only in the kidney but also in other tissues...
  17. Pieper Fürst U, Hall R, Huss S, Hochrath K, Fischer H, Tacke F, et al. Expression of the megalin C-terminal fragment by macrophages during liver fibrogenesis in mice. Biochim Biophys Acta. 2011;1812:1640-8 pubmed publisher
    The low-density-lipoprotein receptor megalin (LRP2, gp330) is strongly expressed in the kidney, where it is responsible for the resorption of metabolites from primary urine...
  18. Arora K, Sequeira J, Quadros E. Maternofetal transport of vitamin B12: role of TCblR/CD320 and megalin. FASEB J. 2017;31:3098-3106 pubmed publisher
    ..To understand this mechanism, we evaluated the role of TC, TCblR/CD320, and megalin in maternofetal transport of B12 in a TCblR/CD320-knockout (KO) mouse...
  19. Vegt E, Melis M, Eek A, de Visser M, Brom M, Oyen W, et al. Renal uptake of different radiolabelled peptides is mediated by megalin: SPECT and biodistribution studies in megalin-deficient mice. Eur J Nucl Med Mol Imaging. 2011;38:623-32 pubmed publisher
    ..The mechanisms of kidney reabsorption of these peptides are incompletely understood, but the scavenger receptor megalin has been shown to play a role in the reabsorption of (111)In-octreotide...
  20. Vohwinkel C, Buchäckert Y, Al tamari H, Mazzocchi L, Eltzschig H, Mayer K, et al. Restoration of Megalin-Mediated Clearance of Alveolar Protein as a Novel Therapeutic Approach for Acute Lung Injury. Am J Respir Cell Mol Biol. 2017;57:589-602 pubmed publisher
    ..Here, we describe a transforming growth factor (TGF)-β-triggered mechanism, in which megalin, the primary mediator of alveolar protein transport, is negatively regulated by glycogen synthase kinase (GSK) 3β..
  21. Christensen E, Moskaug J, Vorum H, Jacobsen C, Gundersen T, Nykjaer A, et al. Evidence for an essential role of megalin in transepithelial transport of retinol. J Am Soc Nephrol. 1999;10:685-95 pubmed
    ..Analysis of mice with target disruption of the gene for the major endocytic receptor of proximal tubules, megalin, revealed no RBP in proximal tubules of these mice...
  22. van Hoek A, Ma T, Yang B, Verkman A, Brown D. Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney. Am J Physiol Renal Physiol. 2000;278:F310-6 pubmed
    ..The functional significance of the apparent species-dependent expression of AQP4 in proximal tubules is unknown, but may relate to physiological differences between rats and mice...
  23. Anderson L, Cotterchio M, Knight J, Borgida A, Gallinger S, Cleary S. Genetic variants in vitamin d pathway genes and risk of pancreas cancer; results from a population-based case-control study in ontario, Canada. PLoS ONE. 2013;8:e66768 pubmed publisher
    ..CYP2R1, calcium sensing receptor (CASR), vitamin D binding protein (GC), retinoid X receptor-alpha (RXRA) and megalin (LRP2) genes were significantly associated with pancreas cancer risk...
  24. Xia Y, Bachinsky D, Smith J, McCluskey R, Warden C, Lusis A. Mapping of the glycoprotein 330 (Gp330) gene to mouse chromosome 2. Genomics. 1993;17:780-1 pubmed
    b>Glycoprotein 330 (Gp330) is a member of the low-density lipoprotein receptor gene family that is expressed in the kidney. We have mapped the Gp330 gene to mouse chromosome 2, 4...
  25. Cases O, Joseph A, Obry A, Santin M, Ben Yacoub S, Pâques M, et al. Foxg1-Cre Mediated Lrp2 Inactivation in the Developing Mouse Neural Retina, Ciliary and Retinal Pigment Epithelia Models Congenital High Myopia. PLoS ONE. 2015;10:e0129518 pubmed publisher
    ..Mutations in the endocytic receptor LRP2 gene result in Donnai-Barrow (DBS) and Stickler syndromes, both characterized by HM...
  26. Marschang P, Brich J, Weeber E, Sweatt J, Shelton J, Richardson J, et al. Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Mol Cell Biol. 2004;24:3782-93 pubmed
    ..Analysis of LRP1b knockout mice may provide further insights into the role of LRP1b as a tumor suppressor and into the mechanisms of cancer development. ..
  27. Christ A, Terryn S, Schmidt V, Christensen E, Huska M, Andrade Navarro M, et al. The soluble intracellular domain of megalin does not affect renal proximal tubular function in vivo. Kidney Int. 2010;78:473-7 pubmed publisher
    b>Megalin-mediated endocytic uptake constitutes the main pathway for clearance of plasma proteins from the glomerular filtrate in proximal tubules...
  28. Olson G, Winfrey V, Hill K, Burk R. Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells. J Biol Chem. 2008;283:6854-60 pubmed publisher
    ..Ligand blotting assays of kidney membrane preparations fractionated by SDS-PAGE revealed that Sepp1 binds megalin, a lipoprotein receptor localized to the proximal tubule epithelium...
  29. Follit J, San Agustin J, Jonassen J, Huang T, Rivera Perez J, Tremblay K, et al. Arf4 is required for Mammalian development but dispensable for ciliary assembly. PLoS Genet. 2014;10:e1004170 pubmed publisher
    ..This work suggests that while Arf4 is not required for ciliary assembly, it is important for the efficient transport of fibrocystin to cilia, and also plays critical roles in non-ciliary processes. ..
  30. Jiang Y, Yu V, Buchholz F, O Connell S, Rhodes S, Candeloro C, et al. A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland. J Biol Chem. 1996;271:10723-30 pubmed
    ..Identification of a second mouse gene highly homologous to NZF-1, encoded by a distinct genomic locus, reveals a dispersed gene family encoding proteins containing Cys-Cys, His-Cys motifs. ..
  31. Tomaz R, Harman J, Karimlou D, Weavers L, Fritsch L, Bou Kheir T, et al. Jmjd2c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation. Development. 2017;144:567-579 pubmed publisher
    ..These findings unveil Jmjd2c and G9a as novel enhancer-associated factors, and implicate Jmjd2c as a molecular scaffold for the assembly of essential enhancer-protein complexes with an impact on timely gene activation. ..
  32. Moll S, Menoud P, French L, Sappino A, Pastore Y, Schifferli J, et al. Tubular up-regulation of clusterin mRNA in murine lupus-like nephritis. Am J Pathol. 1998;152:953-62 pubmed
  33. Aroor A, Zuberek M, Duta C, Meuth A, Sowers J, Whaley Connell A, et al. Angiotensin II Stimulation of DPP4 Activity Regulates Megalin in the Proximal Tubules. Int J Mol Sci. 2016;17: pubmed publisher
    ..Previously, we demonstrated that megalin, a receptor endocytotic protein in the proximal tubule, is downregulated in obese mice, which was prevented by ..
  34. Kurokawa S, Eriksson S, Rose K, Wu S, Motley A, Hill S, et al. Sepp1(UF) forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1. Free Radic Biol Med. 2014;69:67-76 pubmed publisher
    ..form of Sepp1 is filtered in the glomerulus and taken up by renal proximal convoluted tubule (PCT) cells via megalin-mediated endocytosis...
  35. Chou S, Hsu K, Otsu W, Hsu Y, Luo Y, Yeh C, et al. CLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking. Nat Commun. 2016;7:10412 pubmed publisher
    ..CLIC4 selectively modulates retromer-mediated apical transport by negatively regulating the formation of branched actin on early endosomes. ..
  36. Wunderlich K, Leveillard T, Penkowa M, Zrenner E, Perez M. Altered expression of metallothionein-I and -II and their receptor megalin in inherited photoreceptor degeneration. Invest Ophthalmol Vis Sci. 2010;51:4809-20 pubmed publisher
    ..models of retinitis pigmentosa (RP) the expression of the neuroprotectants metallothionein-I and -II and of megalin, an endocytic receptor that mediates their transport into neurons...
  37. Parreira K, Debaix H, Cnops Y, Geffers L, Devuyst O. Expression patterns of the aquaporin gene family during renal development: influence of genetic variability. Pflugers Arch. 2009;458:745-59 pubmed publisher
    ..5) and progressive increase to adult levels, similar to the mRNA pattern observed for proximal tubule markers (Megalin, NaPi-IIa, OAT1) and reflecting the continuous increase in renal cortical structures during development...
  38. Bachmann S, Schlichting U, Geist B, Mutig K, Petsch T, Bacic D, et al. Kidney-specific inactivation of the megalin gene impairs trafficking of renal inorganic sodium phosphate cotransporter (NaPi-IIa). J Am Soc Nephrol. 2004;15:892-900 pubmed
    ..The key elements triggering this process are not clear to date. Megalin serves as a receptor for the endocytosis of multiple ligands and is coexpressed with NaPi-IIa in the proximal ..
  39. Petersen H, Hilpert J, Militz D, Zandler V, Jacobsen C, Roebroek A, et al. Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. J Cell Sci. 2003;116:453-61 pubmed
    b>Megalin is a member of the LDL receptor gene family that plays an important role in forebrain development and in cellular vitamin D metabolism through endocytic uptake of vitamin D metabolites...
  40. Faber K, Hvidberg V, Moestrup S, Dahlback B, Nielsen L. Megalin is a receptor for apolipoprotein M, and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein M. Mol Endocrinol. 2006;20:212-8 pubmed
    ..In this study, we show that the multiligand receptor megalin, which is expressed in kidney proximal tubule cells, is a receptor for apoM and mediates its uptake in the kidney...
  41. Yang D, Cai K, Roland I, Smith E, Xu X. Disabled-2 is an epithelial surface positioning gene. J Biol Chem. 2007;282:13114-22 pubmed
    ..show here that Dab2 mediates directional trafficking and polarized distribution of cell surface proteins such as megalin and E-cadherin and propose that loss of polarity is the underlying mechanism for the loss of epithelial cell ..
  42. Gerbe F, Cox B, Rossant J, Chazaud C. Dynamic expression of Lrp2 pathway members reveals progressive epithelial differentiation of primitive endoderm in mouse blastocyst. Dev Biol. 2008;313:594-602 pubmed
    ..In this work, we isolated Lrp2 as a novel PrE precursor (pre-PrE) marker by using a microarray strategy that combines a transcriptome analysis of ..
  43. Ortega M, Cases O, Merchan P, Kozyraki R, Clemente D, De Castro F. Megalin mediates the influence of sonic hedgehog on oligodendrocyte precursor cell migration and proliferation during development. Glia. 2012;60:851-66 pubmed publisher
    ..However, the multiligand receptor megalin (or LRP-2) is also involved in Shh-induced OPC proliferation and migration, and thus, we have evaluated the ..
  44. Li X, Zhuo J. Mechanisms of AT1a receptor-mediated uptake of angiotensin II by proximal tubule cells: a novel role of the multiligand endocytic receptor megalin. Am J Physiol Renal Physiol. 2014;307:F222-33 pubmed publisher
    The present study tested the hypothesis that the multiligand endocytic receptor megalin is partially involved in the uptake of ANG II and downstream signaling responses in mouse proximal tubule cells (mPCT) by interacting with AT1a ..
  45. Causeret F, Sumia I, Pierani A. Kremen1 and Dickkopf1 control cell survival in a Wnt-independent manner. Cell Death Differ. 2016;23:323-32 pubmed publisher
    ..Our findings thus reveal a new Wnt-independent function for Kremen1 and Dickkopf1 in the regulation of cell survival with potential implications in cancer therapies. ..
  46. Barasch J, Hollmén M, Deng R, Hod E, Rupert P, Abergel R, et al. Disposal of iron by a mutant form of lipocalin 2. Nat Commun. 2016;7:12973 pubmed publisher
    ..that a mutant form (K3Cys) of endogenous lipocalin 2 (LCN2) is filtered by the kidney but can bypass sites of megalin-dependent recapture, resulting in urinary excretion...
  47. Kurumada S, Onishi A, Imai H, Ishii K, Kobayashi T, Sato S. Stage-specific association of apolipoprotein A-I and E in developing mouse retina. Invest Ophthalmol Vis Sci. 2007;48:1815-23 pubmed
    ..The present results document several new aspects of apoA-I and apoE in the developing retina. The switchover of the lipoprotein systems runs a parallel course with the differentiation. ..
  48. Gajera C, Emich H, Lioubinski O, Christ A, Beckervordersandforth Bonk R, Yoshikawa K, et al. LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche. J Cell Sci. 2010;123:1922-30 pubmed publisher
    ..We demonstrate that LRP2, a clearance receptor for BMP4 is specifically expressed in ependymal cells of the lateral ventricles in the adult ..
  49. Strotmann J, Breer H. Internalization of odorant-binding proteins into the mouse olfactory epithelium. Histochem Cell Biol. 2011;136:357-69 pubmed publisher
    ..that could mediate such an uptake process led to the identification of the low density lipoprotein receptor Lrp2/Megalin. In the olfactory epithelium, megalin was found to be specifically expressed in sustentacular cells and the ..
  50. Gomes J, Nogueira R, Vieira M, Santos S, Ferraz Nogueira J, Relvas J, et al. Transthyretin provides trophic support via megalin by promoting neurite outgrowth and neuroprotection in cerebral ischemia. Cell Death Differ. 2016;23:1749-1764 pubmed publisher
    ..This TTR neuritogenic activity is mediated by the megalin receptor and is lost in megalin-deficient neurons...
  51. Pósfai E, Petropoulos S, de Barros F, Schell J, Jurisica I, Sandberg R, et al. Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo. elife. 2017;6: pubmed publisher
    ..Plasticity of both lineages is coincident with their window of sensitivity to Hippo signaling. ..
  52. De S, Kuwahara S, Hosojima M, Ishikawa T, Kaseda R, Sarkar P, et al. Exocytosis-Mediated Urinary Full-Length Megalin Excretion Is Linked With the Pathogenesis of Diabetic Nephropathy. Diabetes. 2017;66:1391-1404 pubmed publisher
    ..Using ELISA, we found previously that urinary levels of full-length megalin (C-megalin), a multiligand endocytic receptor in proximal tubules, was positively correlated with DN progression ..
  53. Gil S, Youn B, Byun K, Huang H, Namkoong C, Jang P, et al. Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathway. Nat Commun. 2013;4:1862 pubmed publisher
    ..Our study identifies the hypothalamic clusterin-low-density lipoprotein receptor-related protein-2 axis as a novel anorexigenic signalling pathway that is tightly coupled with long-form leptin receptor-mediated signalling. ..