Lrp2

Summary

Gene Symbol: Lrp2
Description: low density lipoprotein receptor-related protein 2
Alias: AI315343, AW536255, D230004K18Rik, Gp330, Megalin, LRP-2, glycoprotein 330, low-density lipoprotein receptor-related protein 2
Species: mouse

Top Publications

  1. pmc APC-dependent suppression of colon carcinogenesis by PPARgamma
    Geoffrey D Girnun
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, One Jimmy Fund Way, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:13771-6. 2002
  2. ncbi Expression and role of cubilin in the internalization of nutrients during the peri-implantation development of the rodent embryo
    Emeline Assemat
    INSERM, UMR 538, Faculte de Medecine Saint Antoine, Paris, France
    Biol Reprod 72:1079-86. 2005
  3. ncbi Low-density lipoprotein receptor-related protein (LRP)-2/megalin is transiently expressed in a subpopulation of neural progenitors in the embryonic mouse spinal cord
    Grzegorz Wicher
    Department of Neuroscience, Biomedical Center, Uppsala University, Sweden
    J Comp Neurol 492:123-31. 2005
  4. doi Transthyretin internalization by sensory neurons is megalin mediated and necessary for its neuritogenic activity
    Carolina E Fleming
    Instituto de Biologia Molecular e Celular IBMC, Nerve Regeneration Group and Molecular Neurobiology Group, 4150 180 Porto, Portugal
    J Neurosci 29:3220-32. 2009
  5. pmc Megalin/LRP2 expression is induced by peroxisome proliferator-activated receptor -alpha and -gamma: implications for PPARs' roles in renal function
    Felipe Cabezas
    Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    PLoS ONE 6:e16794. 2011
  6. ncbi Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I
    Eva Carro
    Laboratory of Neuroendocrinology, Cajal Institute, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    J Neurosci 25:10884-93. 2005
  7. ncbi Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins
    S M Hammad
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425 2204, USA
    J Biol Chem 275:12003-8. 2000
  8. ncbi Syntaxin 3 and Munc-18-2 in epithelial cells during kidney development
    S Lehtonen
    Haartman Institute and Department of Pathology, University of Helsinki, Finland
    Kidney Int 56:815-26. 1999
  9. ncbi Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect
    Jörg R Leheste
    Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    FASEB J 17:247-9. 2003
  10. ncbi LRP2/megalin is required for patterning of the ventral telencephalon
    Robert Spoelgen
    Max Delbrueck Center for Molecular Medicine, Berlin, 13092, Germany
    Development 132:405-14. 2005

Research Grants

  1. SPERM FUNCTION IN FERTILIZATION EVENTS
    Gary Olson; Fiscal Year: 2001
  2. ETHANOL, RETINOIDS, AND CONGENITAL HEART MALFORMATIONS
    Janee Gelineau van Waes; Fiscal Year: 2003
  3. SPERM FUNCTION IN FERTILIZATION EVENTS
    Gary Olson; Fiscal Year: 2006
  4. Role of Selenoprotein P in Male Fertility
    Gary Olson; Fiscal Year: 2007
  5. SPERM FUNCTION IN FERTILIZATION EVENTS
    Gary Olson; Fiscal Year: 1992
  6. SPERM FUNCTION IN FERTILIZATION EVENTS
    Gary Olson; Fiscal Year: 1993

Scientific Experts

  • Tetsuya Ishida
  • Brian T Smith
  • Erik Vegt
  • H Birn
  • Grzegorz Wicher
  • L C Schulz
  • Jörg Strotmann
  • Ursula Pieper-Fürst
  • Gary Olson
  • Janee Gelineau-van Waes
  • Jakub Gburek
  • Hongwei Yu
  • Erik Ilsø Christensen
  • S Bachmann
  • S K Moestrup
  • Thomas E Willnow
  • Janee Gelineau van Waes
  • Olivier Devuyst
  • Annette Hammes
  • T E Willnow
  • Annabel Christ
  • Dong Hua Yang
  • Rikke Nielsen
  • Simonetta Lisi
  • Franziska Theilig
  • Eva Carro
  • Tina Storm
  • Robert Spoelgen
  • Jens Raila
  • María Cristina Ortega
  • Felipe Cabezas
  • Eileen Pernot
  • Sara Terryn
  • Ximena Alvira-Botero
  • Kirsten A Wunderlich
  • Anders Nykjaer
  • Marcus Pohl
  • Chandresh R Gajera
  • Kleber S Parreira
  • Carolina E Fleming
  • Shigeyki Nada
  • R Spoelgen
  • Renata Kozyraki
  • Jan Hilpert
  • P Gailly
  • Heng Zhang
  • Yaeko Motoyoshi
  • Ovidiu König
  • François Gerbe
  • Akihiko Saito
  • Carlos Spuch
  • Norbert Hubner
  • Huguette Debaix
  • Shingo Kurumada
  • Veronique Dubreuil
  • Andrew S Peterson
  • Ryohei Kaseda
  • Kirsten Faber
  • Bin Zheng
  • Pierre J Courtoy
  • Romer Gonzalez-Villalobos
  • Masayo Yamagata
  • Emeline Assemat
  • J Nagai
  • Meghan E Maurer
  • Florian J Schweigert
  • Christian Jacobsen
  • Francois Jouret
  • Elizabeth R Smith
  • Isabelle H Roland
  • Xiang Xi Xu
  • Michele Marino
  • Aldo Pinchera
  • Robert T McCluskey
  • Konstantinos Zarbalis
  • Sharon Strope
  • Peter Marschang
  • Claudio Marcocci
  • Christopher J Drake
  • C Jacobsen
  • A Nykjaer
  • Helle Heibroch Petersen
  • Jörg R Leheste
  • Desa Bacic
  • Uwe Schlichting
  • J Herz
  • A J Lusis
  • Maren Wellner
  • J Hilpert
  • Geoffrey D Girnun

Detail Information

Publications85

  1. pmc APC-dependent suppression of colon carcinogenesis by PPARgamma
    Geoffrey D Girnun
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, One Jimmy Fund Way, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:13771-6. 2002
    ..This finding suggests a potentially important use for PPARgamma ligands as chemopreventative agents in colon cancer...
  2. ncbi Expression and role of cubilin in the internalization of nutrients during the peri-implantation development of the rodent embryo
    Emeline Assemat
    INSERM, UMR 538, Faculte de Medecine Saint Antoine, Paris, France
    Biol Reprod 72:1079-86. 2005
    ..to the maternal environment or to the amniotic and neural tube cavities, and had a very similar distribution to megalin, a member of the LDLR gene family and a coreceptor for cubilin in adult tissues...
  3. ncbi Low-density lipoprotein receptor-related protein (LRP)-2/megalin is transiently expressed in a subpopulation of neural progenitors in the embryonic mouse spinal cord
    Grzegorz Wicher
    Department of Neuroscience, Biomedical Center, Uppsala University, Sweden
    J Comp Neurol 492:123-31. 2005
    The lipoprotein receptor LRP2/megalin is expressed by absorptive epithelia and involved in receptor-mediated endocytosis of a wide range of ligands...
  4. doi Transthyretin internalization by sensory neurons is megalin mediated and necessary for its neuritogenic activity
    Carolina E Fleming
    Instituto de Biologia Molecular e Celular IBMC, Nerve Regeneration Group and Molecular Neurobiology Group, 4150 180 Porto, Portugal
    J Neurosci 29:3220-32. 2009
    ..Moreover, we show that in vitro, in dorsal root ganglia neurons, clathrin-dependent megalin-mediated TTR internalization is needed for TTR neuritogenic activity...
  5. pmc Megalin/LRP2 expression is induced by peroxisome proliferator-activated receptor -alpha and -gamma: implications for PPARs' roles in renal function
    Felipe Cabezas
    Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    PLoS ONE 6:e16794. 2011
    b>Megalin is a large endocytic receptor with relevant functions during development and adult life...
  6. ncbi Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I
    Eva Carro
    Laboratory of Neuroendocrinology, Cajal Institute, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    J Neurosci 25:10884-93. 2005
    ..We found that physical exercise increases the levels of the choroid plexus endocytic receptor megalin/low-density lipoprotein receptor-related protein-2 (LRP2), a multicargo transporter known to participate in brain ..
  7. ncbi Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins
    S M Hammad
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425 2204, USA
    J Biol Chem 275:12003-8. 2000
    ..Since cubilin has been reported to bind the endocytic receptor megalin, we explored the possibility that megalin acts in conjunction with cubilin to mediate HDL endocytosis...
  8. ncbi Syntaxin 3 and Munc-18-2 in epithelial cells during kidney development
    S Lehtonen
    Haartman Institute and Department of Pathology, University of Helsinki, Finland
    Kidney Int 56:815-26. 1999
    ..We have analyzed the expression patterns of vesicle-docking proteins of the syntaxin family in mouse kidney, focusing on syntaxin 3 and its interaction partner, the Sec1-related Munc-18-2...
  9. ncbi Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect
    Jörg R Leheste
    Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    FASEB J 17:247-9. 2003
    b>Megalin is an endocytic receptor highly expressed in the proximal tubules of the kidney...
  10. ncbi LRP2/megalin is required for patterning of the ventral telencephalon
    Robert Spoelgen
    Max Delbrueck Center for Molecular Medicine, Berlin, 13092, Germany
    Development 132:405-14. 2005
    b>Megalin is a low-density lipoprotein receptor-related protein (LRP2) expressed in the neuroepithelium and the yolk sac of the early embryo...
  11. pmc Megalin binds and internalizes angiotensin-(1-7)
    Romer Gonzalez-Villalobos
    Dept of Medicine Section of Nephrology SL 45, Tulane Univ Health Sciences Ctr, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 290:F1270-5. 2006
    b>Megalin is a multiligand receptor heavily involved in protein endocytosis. We recently demonstrated that megalin binds and mediates internalization of ANG II...
  12. pmc Defective forebrain development in mice lacking gp330/megalin
    T E Willnow
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Proc Natl Acad Sci U S A 93:8460-4. 1996
    gp330/megalin, a member of the low density lipoprotein (LDL) receptor gene family, is expressed on the apical surfaces of epithelial tissues, including the neuroepithelium, where it mediates the endocytic uptake of diverse macromolecules,..
  13. ncbi Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B(12)
    Henrik Birn
    Department of Cell Biology, Institute of Anatomy, University of Aarhus, DK 8000 Aarhus C, Germany
    Am J Physiol Renal Physiol 282:F408-16. 2002
    b>Megalin has previously been shown to bind and mediate endocytosis of transcobalamin (TC)-B(12)...
  14. pmc Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria
    Yaeko Motoyoshi
    Department of Bioethics, Tokai University School of Medicine, Isehara City, Kanagawa, Japan
    Kidney Int 74:1262-9. 2008
    b>Megalin, a member of the LDL receptor family, is expressed on the apical membrane of proximal tubules and serves as an endocytic scavenger of filtered proteins and hence might contribute to the tubule injury as a consequence of ..
  15. pmc Megalin knockout mice as an animal model of low molecular weight proteinuria
    J R Leheste
    Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    Am J Pathol 155:1361-70. 1999
    b>Megalin is an endocytic receptor expressed on the luminal surface of the renal proximal tubules. The receptor is believed to play an important role in the tubular uptake of macromolecules filtered through the glomerulus...
  16. pmc Targeted disruption of cubilin reveals essential developmental roles in the structure and function of endoderm and in somite formation
    Brian T Smith
    Department of Cell Biology and Anatomy Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    BMC Dev Biol 6:30. 2006
    Cubilin is a peripheral membrane protein that interacts with the integral membrane proteins megalin and amnionless to mediate ligand endocytosis by absorptive epithelia such as the extraembryonic visceral endoderm (VE).
  17. ncbi Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis
    Dong Hua Yang
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Dev Biol 251:27-44. 2002
    ..We suggest that Dab2 functions in a signal pathway to regulate endodermal cell organization using endocytosis of ligands from the blastocoel cavity as a positioning cue...
  18. ncbi Mutually dependent localization of megalin and Dab2 in the renal proximal tubule
    J Nagai
    Cell Biology, Institute of Anatomy, Univ of Aarhus, University Park, Bldg 234, DK 8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 289:F569-76. 2005
    ..Dab2) is a cytoplasmic adaptor protein that binds to the cytoplasmic tail of the multiligand endocytic receptor megalin, abundantly expressed in renal proximal tubules...
  19. ncbi Endocytosis of megalin by visceral endoderm cells requires the Dab2 adaptor protein
    Meghan E Maurer
    Division of Basic Sciences and Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    J Cell Sci 118:5345-55. 2005
    ..The lipoprotein receptor megalin is expressed in the visceral endoderm (VE), a polarized epithelium that supplies maternal nutrients to the early ..
  20. ncbi Differential distribution of cubilin and megalin expression in the mouse embryo
    Christopher J Drake
    Medical University of South Carolina, Department of Cell Biology, Charleston, South Carolina, USA
    Anat Rec A Discov Mol Cell Evol Biol 277:163-70. 2004
    Cubilin and megalin are cell surface proteins that work cooperatively in many absorptive epithelia to mediate endocytosis of lipoproteins, vitamin carriers, and other proteins...
  21. ncbi Mouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules
    Sharon Strope
    Molecular Biology Graduate Program, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA
    Development 131:4787-95. 2004
    ....
  22. pmc Dynamic changes in leptin distribution in the progression from ovum to blastocyst of the pre-implantation mouse embryo
    Laura C Schulz
    Department of Obstetrics, Gynecology and Women s Health, N625A Health Sciences Center, 1 Hospital Drive, Columbia, Missouri 65212, USA
    Reproduction 141:767-77. 2011
    ..Throughout development, leptin co-localized with LRP2, a multi-ligand transport protein, and its patterning resembled that noted for the maternal-effect proteins OOEP, ..
  23. doi Internalization of odorant-binding proteins into the mouse olfactory epithelium
    Jörg Strotmann
    Institute of Physiology, University of Hohenheim, Stuttgart, Germany
    Histochem Cell Biol 136:357-69. 2011
    ..that could mediate such an uptake process led to the identification of the low density lipoprotein receptor Lrp2/Megalin. In the olfactory epithelium, megalin was found to be specifically expressed in sustentacular cells and the ..
  24. doi The soluble intracellular domain of megalin does not affect renal proximal tubular function in vivo
    Annabel Christ
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, Berlin, Germany
    Kidney Int 78:473-7. 2010
    b>Megalin-mediated endocytic uptake constitutes the main pathway for clearance of plasma proteins from the glomerular filtrate in proximal tubules...
  25. ncbi An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3
    A Nykjaer
    Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    Cell 96:507-15. 1999
    ..protein, is filtered through the glomerulus and reabsorbed in the proximal tubules by the endocytic receptor megalin. Endocytosis is required to preserve 25-(OH) vitamin D3 and to deliver to the cells the precursor for generation ..
  26. doi Expression of the megalin C-terminal fragment by macrophages during liver fibrogenesis in mice
    Ursula Pieper-Fürst
    Department of Internal Medicine I, University Hospital Bonn, Germany
    Biochim Biophys Acta 1812:1640-8. 2011
    The low-density-lipoprotein receptor megalin (LRP2, gp330) is strongly expressed in the kidney, where it is responsible for the resorption of metabolites from primary urine...
  27. doi Megalin mediates the influence of sonic hedgehog on oligodendrocyte precursor cell migration and proliferation during development
    María Cristina Ortega
    Grupo de Neurobiología del Desarrollo GNDe, Unidad de Neurologia Experimental, Hospital Nacional de Paraplejicos, Finca La Peraleda s n, Toledo, Spain
    Glia 60:851-66. 2012
    ..However, the multiligand receptor megalin (or LRP-2) is also involved in Shh-induced OPC proliferation and migration, and thus, we have evaluated the ..
  28. doi Renal phenotypic investigations of megalin-deficient patients: novel insights into tubular proteinuria and albumin filtration
    Tina Storm
    Department of Biomedicine, Universityof Aarhus, Aarhus, Denmark
    Nephrol Dial Transplant 28:585-91. 2013
    ..Studies of megalin-deficient mice suggest that the large multi-ligand endocytic receptor megalin plays an essential role in this ..
  29. pmc Renal uptake of different radiolabelled peptides is mediated by megalin: SPECT and biodistribution studies in megalin-deficient mice
    Erik Vegt
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Nucl Med Mol Imaging 38:623-32. 2011
    ..The mechanisms of kidney reabsorption of these peptides are incompletely understood, but the scavenger receptor megalin has been shown to play a role in the reabsorption of (111)In-octreotide...
  30. pmc The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes
    Shigeyki Nada
    Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    EMBO J 28:477-89. 2009
    ..These results indicate that the lipid raft adaptor p18 is essential for anchoring the MEK-ERK pathway to late endosomes, and shed new light on a role of endosomal MEK-ERK pathway in controlling endosome dynamics...
  31. doi The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system
    Eileen Pernot
    Institut de Recherches Interdisciplinaires en Biologie Humaine et Moléculaire, Brussels, Belgium
    Pflugers Arch 462:871-83. 2011
    ..Altogether, our results indicate that Inpp5k 5-phosphatase is important for the control of the arginine vasopressin/aquaporin-2 signalling pathway and water transport in kidney collecting ducts...
  32. pmc Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics
    Bin Zheng
    Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093 0651, USA
    Proc Natl Acad Sci U S A 103:16776-81. 2006
    ..compartments, abundant autophagic vacuoles, and abnormal localization of several endocytic markers, including megalin, a receptor for nutrients and proteins; ARH, a coat protein that binds megalin; LAMP2; and LC3...
  33. ncbi Soluble megalin is accumulated in the lumen of the rat endolymphatic sac
    Tetsuya Ishida
    Department of Histology and Cell Biology, School of Medicine, Kagawa University, Miki, Kagawa 761 0793, Japan
    Cell Struct Funct 31:77-85. 2006
    ..b>Megalin is a 600-kDa multiligand endocytic receptor expressed in certain types of absorptive epithelia including kidney ..
  34. ncbi Disabled-2 is an epithelial surface positioning gene
    Dong Hua Yang
    Ovarian Cancer and Tumor Cell Biology Programs, Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 282:13114-22. 2007
    ..show here that Dab2 mediates directional trafficking and polarized distribution of cell surface proteins such as megalin and E-cadherin and propose that loss of polarity is the underlying mechanism for the loss of epithelial cell ..
  35. pmc Endocytosis provides a major alternative pathway for lysosomal biogenesis in kidney proximal tubular cells
    Rikke Nielsen
    Cell Biology, Institute of Anatomy, University of Aarhus, 8000 Aarhus, Denmark
    Proc Natl Acad Sci U S A 104:5407-12. 2007
    ..Here we provide evidence for an alternative, efficient secretion-recapture pathway mediated by megalin and exemplified by cathepsin B in kidney proximal convoluted tubules (PCT)...
  36. ncbi Stage-specific association of apolipoprotein A-I and E in developing mouse retina
    Shingo Kurumada
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Invest Ophthalmol Vis Sci 48:1815-23. 2007
    ..To characterize the intercellular lipid transport systems in differentiating retina...
  37. pmc Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11
    R Spoelgen
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MA 02129, USA
    Neuroscience 158:1460-8. 2009
    ....
  38. pmc Expression patterns of the aquaporin gene family during renal development: influence of genetic variability
    Kleber S Parreira
    Division of Nephrology, Université Catholique de Louvain Medical School, 10 Avenue Hippocrate, 1200, Brussels, Belgium
    Pflugers Arch 458:745-59. 2009
    ..5) and progressive increase to adult levels, similar to the mRNA pattern observed for proximal tubule markers (Megalin, NaPi-IIa, OAT1) and reflecting the continuous increase in renal cortical structures during development...
  39. doi Altered expression of metallothionein-I and -II and their receptor megalin in inherited photoreceptor degeneration
    Kirsten A Wunderlich
    Department of Ophthalmology, Clinical Sciences Lund, Lund University, Lund, Sweden
    Invest Ophthalmol Vis Sci 51:4809-20. 2010
    To examine in rodent models of retinitis pigmentosa (RP) the expression of the neuroprotectants metallothionein-I and -II and of megalin, an endocytic receptor that mediates their transport into neurons.
  40. doi LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche
    Chandresh R Gajera
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, D 13125 Berlin, Germany
    J Cell Sci 123:1922-30. 2010
    ..We demonstrate that LRP2, a clearance receptor for BMP4 is specifically expressed in ependymal cells of the lateral ventricles in the adult ..
  41. pmc Intrarenal renin angiotensin system revisited: role of megalin-dependent endocytosis along the proximal nephron
    Marcus Pohl
    Institute of Anatomy, Charite Universitatsmedizin, 10115 Berlin, Germany
    J Biol Chem 285:41935-46. 2010
    ..AGT was identified as a ligand of the multiple ligand-binding repeats of megalin. AGT biosynthesis was restricted to the proximal straight tubule, revealing substantial AGT mRNA expression...
  42. doi A novel renal carbonic anhydrase type III plays a role in proximal tubule dysfunction
    P Gailly
    Division of Cell Physiology, Christian de Duve Institute of Cellular Pathology, Universite Catholique de Louvain, Brussels, Belgium
    Kidney Int 74:52-61. 2008
    ..carbonic anhydrase type III (CAIII) upregulation was confirmed in other mice lacking the multiligand receptor megalin and in a patient with Dent's disease due to an inactivating CLCN5 mutation...
  43. doi Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells
    Gary E Olson
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 283:6854-60. 2008
    ..Ligand blotting assays of kidney membrane preparations fractionated by SDS-PAGE revealed that Sepp1 binds megalin, a lipoprotein receptor localized to the proximal tubule epithelium...
  44. ncbi Core 2 GlcNAc modification and megalin ligand-binding activity
    Heng Zhang
    Sphingolipid Expression Laboratory, RIKEN Frontier Research System, Wako, Saitama, Japan
    Biochim Biophys Acta 1780:479-85. 2008
    b>Megalin, a receptor-like transporter glycoprotein, is expressed on kidney proximal tubular cells and reabsorbs small-molecular-weight proteins from the glomerular filtrate...
  45. ncbi Megalin-mediated endocytosis of cystatin C in proximal tubule cells
    Ryohei Kaseda
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Biochem Biophys Res Commun 357:1130-4. 2007
    ..Using quartz-crystal microbalance analyses, we demonstrate that cystatin C binds directly to megalin, an endocytic receptor in PTC, in a Ca(+)-dependent manner...
  46. ncbi Abrogation of protein uptake through megalin-deficient proximal tubules does not safeguard against tubulointerstitial injury
    Franziska Theilig
    Institut für Vegetative Anatomie, Charite Universitatsmedizin Berlin, Philippstrasse 12, 10115 Berlin
    J Am Soc Nephrol 18:1824-34. 2007
    ..This concept was tested in a transgenic mouse model with megalin deficiency...
  47. pmc Midbody and primary cilium of neural progenitors release extracellular membrane particles enriched in the stem cell marker prominin-1
    Veronique Dubreuil
    Max Planck Institute of Molecular Cell Biology and Genetics, D 01307 Dresden, Germany
    J Cell Biol 176:483-95. 2007
    ....
  48. ncbi Megalin-mediated reuptake of retinol in the kidneys of mice is essential for vitamin A homeostasis
    Jens Raila
    Institute of Nutritional Science, University of Potsdam, D 14558 Nuthetal Bergholz Rehbruecke, Germany
    J Nutr 135:2512-6. 2005
    ..reuptake of retinol (ROH) and retinol-binding protein (RBP) in the kidneys is mediated by the endocytic receptor megalin, suggesting an important role for this receptor in vitamin A (VA) metabolism...
  49. pmc Cubilin is an albumin binding protein important for renal tubular albumin reabsorption
    H Birn
    Department of Cell Biology, University of Aarhus, Aarhus, Denmark
    J Clin Invest 105:1353-61. 2000
    ..In addition, we find that mice lacking the endocytic receptor megalin show altered urinary excretion, and reduced tubular reabsorption, of albumin...
  50. ncbi Receptor-associated protein is important for normal processing of megalin in kidney proximal tubules
    H Birn
    Department of Cell Biology, Institute of Anatomy, University of Aarhus, Denmark
    J Am Soc Nephrol 11:191-202. 2000
    ..RAP also binds to the related 600-kD multiligand endocytic receptor megalin expressed in many absorptive epithelia including renal proximal tubule...
  51. ncbi High-resolution maps of the murine Chromosome 2 region containing the cholesterol gallstone locus, Lith1
    G Bouchard
    The Jackson Laboratory, 600 Main St, Bar Harbor, Maine 04609, USA
    Mamm Genome 10:1070-4. 1999
    ..pump (Bsep) also known as sister of P-glycoprotein (Spgp) and the low-density-lipoprotein-receptor-related gene megalin (Gp330). Both genetic maps were in agreement and ordered the microsatellite markers into a 10.4 +/- 1.5 cM region...
  52. doi Megalin interacts with APP and the intracellular adapter protein FE65 in neurons
    Ximena Alvira-Botero
    Laboratory of Neuroscience, Research Center, Hospital 12 de Octubre, 28041 Madrid, Spain
    Mol Cell Neurosci 45:306-15. 2010
    Increasing evidence has implicated megalin, a low-density lipoprotein receptor-related protein, in the pathogenesis of Alzheimer's disease (AD)...
  53. pmc Tubular up-regulation of clusterin mRNA in murine lupus-like nephritis
    S Moll
    Department of Internal Medicine, University of Geneva Medical School, Switzerland
    Am J Pathol 152:953-62. 1998
    ....
  54. ncbi Mapping of three members of the mouse protein disulfide isomerase family
    V Briquet-Laugier
    Lipid Research Laboratory, West Los Angeles Veterans Administration Medical Center, Los Angeles, California 90073, USA
    Mamm Genome 9:176-7. 1998
  55. ncbi A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland
    Y Jiang
    Department of Medicine, Howard Hughes Medical Institute, La Jolla, California, USA
    J Biol Chem 271:10723-30. 1996
    ..Identification of a second mouse gene highly homologous to NZF-1, encoded by a distinct genomic locus, reveals a dispersed gene family encoding proteins containing Cys-Cys, His-Cys motifs...
  56. ncbi Mapping of the glycoprotein 330 (Gp330) gene to mouse chromosome 2
    Y R Xia
    Department of Medicine, University of California, Los Angeles 90024
    Genomics 17:780-1. 1993
    b>Glycoprotein 330 (Gp330) is a member of the low-density lipoprotein receptor gene family that is expressed in the kidney. We have mapped the Gp330 gene to mouse chromosome 2, 4...
  57. ncbi Gp330 is specifically expressed in outer cells during epithelial differentiation in the preimplantation mouse embryo
    C Gueth-Hallonet
    Departement de Biologie du Developpement, Institut Jacques Monod, CNRS Université Paris VII, France
    Development 120:3289-99. 1994
    ..In this work, we have investigated the expression of gp330, a 330 x 10(3) M(r) glycoprotein found in clathrin-coated areas of the plasma membrane of some epithelial cells ..
  58. ncbi In situ hybridization mapping of a 500-kDa calcium-sensing protein gene (LRP2) to human chromosome region 2q31-->q32.1 and porcine chromosome region 15q22-->q24
    B P Chowdhary
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala
    Cytogenet Cell Genet 71:120-3. 1995
    Recently, a 500-kDa protein, with homology to the rat Gp330 glycoprotein, was found to be expressed on the surface of human parathyroid, placental cytotrophoblast, and renal proximal tubule cells...
  59. ncbi Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule
    Helle Heibroch Petersen
    Max Delbrueck Center for Molecular Medicine and Medical Faculty of the Free University of Berlin, Germany
    J Cell Sci 116:453-61. 2003
    b>Megalin is a member of the LDL receptor gene family that plays an important role in forebrain development and in cellular vitamin D metabolism through endocytic uptake of vitamin D metabolites...
  60. ncbi Impaired PTH-induced endocytotic down-regulation of the renal type IIa Na+/Pi-cotransporter in RAP-deficient mice with reduced megalin expression
    Desa Bacic
    Institute of Physiology, University of Zurich, 8057 Zurich, Switzerland
    Pflugers Arch 446:475-84. 2003
    ..b>Megalin is involved in receptor-mediated endocytosis of proteins from the urine in the renal proximal tubule...
  61. pmc Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1
    Peter Marschang
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Cell Biol 24:3782-93. 2004
    ..Analysis of LRP1b knockout mice may provide further insights into the role of LRP1b as a tumor suppressor and into the mechanisms of cancer development...
  62. ncbi Kidney-specific inactivation of the megalin gene impairs trafficking of renal inorganic sodium phosphate cotransporter (NaPi-IIa)
    Sebastian Bachmann
    Department of Anatomy, Charite, University Medical School of Berlin, Campus Mitte, Philippstrasse 12, D 10098 Berlin, Germany
    J Am Soc Nephrol 15:892-900. 2004
    ..The key elements triggering this process are not clear to date. Megalin serves as a receptor for the endocytosis of multiple ligands and is coexpressed with NaPi-IIa in the proximal ..
  63. pmc Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome
    Hongwei Yu
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, STR 541, 114 Doughty Street, Charleston, SC 29403, USA
    BMC Dev Biol 4:1. 2004
    ..Although they have a number of biochemical and structural abnormalities, one cause of death is from apparent respiratory failure due to developmental pulmonary abnormalities...
  64. pmc Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: a control mechanism for thyroid hormone release
    Simonetta Lisi
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Proc Natl Acad Sci U S A 100:14858-63. 2003
    ..However, some Tg internalized by megalin bypasses lysosomes and is transcytosed across cells and released into the bloodstream...
  65. pmc A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development
    Konstantinos Zarbalis
    Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, USA
    PLoS Biol 2:E219. 2004
    ..Our results also highlight the utility of focused screens in the mouse, in addition to the large-scale and broadly targeted screens that are being carried out at mutagenesis centers...
  66. ncbi Intraperitoneal administration of recombinant receptor-associated protein causes phosphaturia via an alteration in subcellular distribution of the renal sodium phosphate co-transporter
    Masayo Yamagata
    Department of Environmental Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo cho, Izumi, Osaka 594 1101, Japan
    J Am Soc Nephrol 16:2338-45. 2005
    b>Megalin is a multifunctional endocytic receptor that is expressed in renal proximal tubules and plays critical roles in the renal uptake of various proteins...
  67. ncbi Megalin is a receptor for apolipoprotein M, and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein M
    Kirsten Faber
    Department of Clinical Biochemistry, Univeristy of Lund, University Hospital, Malmo, Sweden
    Mol Endocrinol 20:212-8. 2006
    ..In this study, we show that the multiligand receptor megalin, which is expressed in kidney proximal tubule cells, is a receptor for apoM and mediates its uptake in the kidney...
  68. ncbi Role of endocytosis in cellular uptake of sex steroids
    Annette Hammes
    Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
    Cell 122:751-62. 2005
    ..Contrary to the free hormone hypothesis, we demonstrate that megalin, an endocytic receptor in reproductive tissues, acts as a pathway for cellular uptake of biologically active ..
  69. ncbi Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesis
    Francois Jouret
    Division of Nephrology, Universite Catholique de Louvain, 10 Avenue Hippocrate, Brussels, Belgium B 1200
    J Am Soc Nephrol 16:3235-46. 2005
    ..They provide new insights into the complex regulation of V-ATPase subunits, the maturation of IC along the nephron, and the pathophysiology of hereditary dRTA...
  70. ncbi Thyroid dysfunction in megalin deficient mice
    Simonetta Lisi
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Mol Cell Endocrinol 236:43-7. 2005
    b>Megalin mediates transcytosis of thyroglobulin (Tg), the thyroid hormone precursor, resulting in its passage into the bloodstream...
  71. pmc Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model
    M Mehrabian
    Department of Medicine, University of California, Los Angeles, California 90095, USA
    J Clin Invest 101:2485-96. 1998
    ..Finally, they support the existence of specific genetic interactions between body fat, insulin metabolism, and lipoprotein metabolism...
  72. pmc beta2-glycoprotein-I (apolipoprotein H) and beta2-glycoprotein-I-phospholipid complex harbor a recognition site for the endocytic receptor megalin
    S K Moestrup
    Department of Medical Biochemistry, University of Aarhus, 8000 Aarhus C
    J Clin Invest 102:902-9. 1998
    ..beta2-glycoprotein-I/apolipoprotein H as a plasma component binding to the renal epithelial endocytic receptor megalin. A calcium-dependent megalin-mediated beta2-glycoprotein-I endocytosis was subsequently demonstrated by ligand ..
  73. ncbi Dynamic expression of Lrp2 pathway members reveals progressive epithelial differentiation of primitive endoderm in mouse blastocyst
    François Gerbe
    INSERM, UMR384, Faculte de Medecine, 28 place H Dunant BP38, Clermont Ferrand 63001, Universite d Auvergne, Clermont Fd, France
    Dev Biol 313:594-602. 2008
    ..In this work, we isolated Lrp2 as a novel PrE precursor (pre-PrE) marker by using a microarray strategy that combines a transcriptome analysis of ..
  74. ncbi Expression of the type IV collagenase system during mouse kidney development and tubule segmentation
    B Legallicier
    INSERM U489, Tenon Hospital and St Antoine Medical Faculty, Paris 6 University, Paris, France
    J Am Soc Nephrol 12:2358-69. 2001
    ..kidneys; and a two-step immunoperoxidase labeling procedure using specific markers of proximal tubule (megalin), ascending limb of Henle's loop (Tamm Horsfall protein), and collecting duct (Dolichos biflorus agglutinin ..
  75. ncbi Evidence for an essential role of megalin in transepithelial transport of retinol
    E I Christensen
    Department of Cell Biology, Institute of Anatomy, University of Aarhus, Denmark
    J Am Soc Nephrol 10:685-95. 1999
    ..Analysis of mice with target disruption of the gene for the major endocytic receptor of proximal tubules, megalin, revealed no RBP in proximal tubules of these mice...
  76. ncbi Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin
    Jakub Gburek
    Dept of Cell Biology, Institute of Anatomy, Aarhus University, Denmark
    Am J Physiol Renal Physiol 285:F451-8. 2003
    ..Here, we report that the endocytic receptors megalin and cubilin are involved in renal reabsorption of myoglobin...
  77. pmc Microarray analysis of E9.5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex
    Janee Gelineau-van Waes
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198 5455, USA
    BMC Genomics 9:156. 2008
    ..The identification of alterations in gene expression and signaling pathways involved in the observed dysmorphology following inactivation of RFC1-mediated folate transport are the focus of this investigation...
  78. pmc Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules
    Erik I Christensen
    Institute of Anatomy, Department of Cell Biology, University of Aarhus, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 100:8472-7. 2003
    ..whether this endocytic failure could primarily reflect a loss of reabsorption by the multiligand receptors, megalin, and cubilin, caused by a trafficking defect...
  79. ncbi Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney
    A N van Hoek
    Program in Membrane Biology Renal Unit and Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Physiol Renal Physiol 278:F310-6. 2000
    ..The functional significance of the apparent species-dependent expression of AQP4 in proximal tubules is unknown, but may relate to physiological differences between rats and mice...
  80. ncbi Identification of megalin/gp330 as a receptor for lipoprotein(a) in vitro
    A Niemeier
    Medical Clinic, University Hospital Eppendorf, Hamburg, Germany
    Arterioscler Thromb Vasc Biol 19:552-61. 1999
    ..In this report, we show that the low density lipoprotein receptor (LDLR) gene family member megalin/glycoprotein (gp) 330 is capable of binding and mediating the cellular uptake and degradation of Lp(a) in vitro...
  81. ncbi Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction
    M Gotthardt
    Department of Molecular Genetics and Pathology, University of Texas Southwestern Medical Center, Dallas 75390 9046, USA
    J Biol Chem 275:25616-24. 2000
    ..They form the basis for the elucidation of the molecular pathways by which cells respond to the diversity of ligands that bind to these multifunctional receptors on the cell surface...
  82. ncbi Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D3 metabolism
    Jan Hilpert
    Max Delbrueck Center for Molecular Medicine and Medical Faculty of the Free University of Berlin, Berlin, Germany
    Kidney Int 62:1672-81. 2002
    The endocytic receptor megalin constitutes the major pathway for clearance of low-molecular weight plasma proteins from the glomerular filtrate into the renal proximal tubules...
  83. ncbi Estrogen and the inner ear: megalin knockout mice suffer progressive hearing loss
    Ovidiu König
    Universitäts HNO Klinik, Elfriede Aulhorn Strasse 5, D 72076 Tubingen, Germany
    FASEB J 22:410-7. 2008
    b>Megalin, the largest member of the low-density lipoprotein receptor-related protein family, functions as an endocytic receptor for a variety of essential lipophilic metabolites, including the steroid hormone estrogen...
  84. doi Megalin deficiency induces critical changes in mouse spinal cord development
    Grzegorz Wicher
    Department of Neuroscience, Neuroanatomy, Biomedical Center, Uppsala University, Uppsala, Sweden
    Neuroreport 19:559-63. 2008
    Low density lipoprotein receptor-related protein, megalin, is a multifunctional lipoproptein receptor expressed by absorptive epithelia for endocytosis of numerous ligands...

Research Grants30

  1. SPERM FUNCTION IN FERTILIZATION EVENTS
    Gary Olson; Fiscal Year: 2001
    ....
  2. ETHANOL, RETINOIDS, AND CONGENITAL HEART MALFORMATIONS
    Janee Gelineau van Waes; Fiscal Year: 2003
    ..abstract_text> ..
  3. SPERM FUNCTION IN FERTILIZATION EVENTS
    Gary Olson; Fiscal Year: 2006
    ..3: To determine if eFGL binding to specific sperm ligands promotes sperm death and/or death cocoon polymerization.4: To define the function of eFGL by targeted disruption of the fgl2 gene in mice. ..
  4. Role of Selenoprotein P in Male Fertility
    Gary Olson; Fiscal Year: 2007
    ..Aim 3: To identify and localize Se-P-binding proteins in the testis and epididymis. Aim 4: To determine the molecular basis for sperm defects in Se-P null mice. ..
  5. SPERM FUNCTION IN FERTILIZATION EVENTS
    Gary Olson; Fiscal Year: 1992
    ..Completion of these specific aims will provide new data on the mechanisms underlying the mosaic construction of the sperm plasma membrane and provide needed data on the molecular basis of specific fertilization events...
  6. SPERM FUNCTION IN FERTILIZATION EVENTS
    Gary Olson; Fiscal Year: 1993
    ....