Gene Symbol: Lpxn
Alias: 4933402K05Rik, A530083L21Rik, AV278559, LDPL, leupaxin
Gupta A, Lee B, Khadeer M, Tang Z, Chellaiah M, Abu Amer Y, et al
. Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast. J Bone Miner Res. 2003;18:669-85 pubmed publisher
b>Leupaxin is a cytoskeleton adaptor protein that was first identified in human macrophages and was found to share homology with the focal adhesion protein, paxillin...
Watanabe N, Amano N, Ishizuka H, Mashima K. Leupaxin binds to PEST domain tyrosine phosphatase PEP. Mol Cell Biochem. 2005;269:13-7 pubmed
..Here, we show the binding capability of PEP for leupaxin, which is preferentially expressed in hematopoietic cells and a comparatively new member of the paxillin family ..
Yogo K, Mizutamari M, Mishima K, Takenouchi H, Ishida Kitagawa N, Sasaki T, et al
. Src homology 2 (SH2)-containing 5'-inositol phosphatase localizes to podosomes, and the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts. Endocrinology. 2006;147:3307-17 pubmed
..These results demonstrate that c-Src enhances the translocation of SHIP to podosomes and regulates its function there through the SH2 domain, leading to an attenuation of bone resorption. ..
Sahu S, Khadeer M, Robertson B, Núñez S, Bai G, Gupta A. Association of leupaxin with Src in osteoclasts. Am J Physiol Cell Physiol. 2007;292:C581-90 pubmed
b>Leupaxin (LPXN), which belongs to the paxillin extended family of adaptor proteins, was previously identified as a component of the sealing zone in osteoclasts...
Tanaka T, Moriwaki K, Murata S, Miyasaka M. LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin. Cancer Sci. 2010;101:363-8 pubmed publisher
..A Lin-11 Isl-1 Mec-3 (LIM) domain-containing adaptor protein, leupaxin, a member of the paxillin family, is expressed in leukocytes as well as in certain cancer cells, and shares ..
Chew V, Lam K. Leupaxin negatively regulates B cell receptor signaling. J Biol Chem. 2007;282:27181-91 pubmed
..We show here that leupaxin (LPXN), a member of this family, was tyrosine-phosphorylated and recruited to the plasma membrane of human BJAB ..
Sundberg Smith L, DiMichele L, Sayers R, Mack C, Taylor J. The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription. Circ Res. 2008;102:1502-11 pubmed publisher
b>Leupaxin is a LIM domain-containing adapter protein belonging to the paxillin family that has been previously reported to be preferentially expressed in hematopoietic cells...
Rashid M, Belmont J, Carpenter D, Turner C, Olson E. Neural-specific deletion of the focal adhesion adaptor protein paxillin slows migration speed and delays cortical layer formation. Development. 2017;144:4002-4014 pubmed publisher