Gene Symbol: Lpcat3
Description: lysophosphatidylcholine acyltransferase 3
Alias: C3f, Grcc3f, Lpcat, Lpeat, Lplat5, Lpsat, Mboat5, Moact5, Oact5, PTG, lysophospholipid acyltransferase 5, 1-acylglycerophosphoserine O-acyltransferase, LPC acyltransferase 3, O-acyltransferase domain-containing protein 5, lyso-PC acyltransferase 3, lyso-PE acyltransferase, lyso-PS acyltransferase, lysophosphatidylethanolamine acyltransferase, lysophosphatidylserine acyltransferase
Species: mouse
Products:     Lpcat3

Top Publications

  1. Hishikawa D, Shindou H, Kobayashi S, Nakanishi H, Taguchi R, Shimizu T. Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. Proc Natl Acad Sci U S A. 2008;105:2830-5 pubmed publisher
    ..Our findings constitute a critical milestone for our understanding about how membrane diversity and asymmetry are established and their biological significance. ..
  2. Ansari Lari M, Oeltjen J, Schwartz S, Zhang Z, Muzny D, Lu J, et al. Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Genome Res. 1998;8:29-40 pubmed
  3. Hashidate Yoshida T, Harayama T, Hishikawa D, Morimoto R, Hamano F, Tokuoka S, et al. Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport. elife. 2015;4: pubmed publisher
    ..Here, we show that the lack of lysophosphatidylcholine acyltransferase 3 (LPCAT3) leads to drastic reductions in membrane arachidonate levels, and that LPCAT3-deficient mice are neonatally lethal ..
  4. Li Z, Jiang H, Ding T, Lou C, Bui H, Kuo M, et al. Deficiency in lysophosphatidylcholine acyltransferase 3 reduces plasma levels of lipids by reducing lipid absorption in mice. Gastroenterology. 2015;149:1519-29 pubmed publisher
    ..b>LPCAT3 is the most abundant isoform of LPCAT in the small intestine and liver, which are important sites of plasma ..
  5. Kabir I, Li Z, Bui H, Kuo M, Gao G, Jiang X. Small Intestine but Not Liver Lysophosphatidylcholine Acyltransferase 3 (Lpcat3) Deficiency Has a Dominant Effect on Plasma Lipid Metabolism. J Biol Chem. 2016;291:7651-60 pubmed publisher
    Lysophosphatidylcholine acyltransferase 3 (Lpcat3) is involved in phosphatidylcholine remodeling in the small intestine and liver...
  6. Tanaka H, Zaima N, Sasaki T, Yamamoto N, Inuzuka K, Yata T, et al. Lysophosphatidylcholine Acyltransferase-3 Expression Is Associated with Atherosclerosis Progression. J Vasc Res. 2017;54:200-208 pubmed publisher
    ..Recent studies have shown that lysophosphatidylcholine acyltransferase-3 (LPCAT3) converts lysophosphatidylcholine (LPC) and free AA into phosphatidylcholine (PC)-containing AA (arachidonyl-PC) ..
  7. Li Z, Ding T, Pan X, Li Y, Li R, Sanders P, et al. Lysophosphatidylcholine acyltransferase 3 knockdown-mediated liver lysophosphatidylcholine accumulation promotes very low density lipoprotein production by enhancing microsomal triglyceride transfer protein expression. J Biol Chem. 2012;287:20122-31 pubmed publisher
    ..Four isoforms of LPCAT have been identified. In this study we found that LPCAT3 is the major hepatic isoform, and its knockdown significantly reduces hepatic LPCAT activity...
  8. Chen S, Lu W, Yueh M, Rettenmeier E, Liu M, Paszek M, et al. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A. 2017;114:E1432-E1440 pubmed publisher
    ..These findings provide a mechanism of NCoR1 in intestinal homeostasis during development and provide a key link to those events that control developmental repression of UGT1A1 and hyperbilirubinemia. ..
  9. Eto M, Shindou H, Koeberle A, Harayama T, Yanagida K, Shimizu T. Lysophosphatidylcholine acyltransferase 3 is the key enzyme for incorporating arachidonic acid into glycerophospholipids during adipocyte differentiation. Int J Mol Sci. 2012;13:16267-80 pubmed publisher
    ..Lysophosphatidylcholine acyltransferase (LPCAT), lysophosphatidylethanolamine acyltransferase (LPEAT) and lysophosphatidylserine acyltransferase (LPSAT) activities were enhanced, especially ..

More Information


  1. Xu B, Hsu P, Stark K, Karayiorgou M, Gogos J. Derepression of a neuronal inhibitor due to miRNA dysregulation in a schizophrenia-related microdeletion. Cell. 2013;152:262-75 pubmed publisher
    ..Reduction of miR-185 also has milder age- and region-specific effects on the expression of some Golgi-related genes. Our findings illuminate the contribution of microRNAs in psychiatric disorders and cognitive dysfunction. ..
  2. Ishibashi M, Varin A, Filomenko R, Lopez T, Athias A, Gambert P, et al. Liver x receptor regulates arachidonic acid distribution and eicosanoid release in human macrophages: a key role for lysophosphatidylcholine acyltransferase 3. Arterioscler Thromb Vasc Biol. 2013;33:1171-9 pubmed publisher
    ..Among putative LXR target genes, lysophosphatidylcholine acyltransferase 3 (LPCAT3) involved in the Lands cycle controls the fatty acid composition at the sn-2 position of glycerophospholipids and, ..
  3. Singh A, Liu J. Identification of Hepatic Lysophosphatidylcholine Acyltransferase 3 as a Novel Target Gene Regulated by Peroxisome Proliferator-activated Receptor ?. J Biol Chem. 2017;292:884-897 pubmed publisher
    ..Hepatic lysophosphatidylcholine acyltransferase 3 (LPCAT3) has critical functions in triglycerides transport and endoplasmic reticulum stress response due to its unique ..
  4. Rong X, Wang B, Dunham M, Hedde P, Wong J, Gratton E, et al. Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion. elife. 2015;4: pubmed publisher
    ..Here we show that the phospholipid remodeling enzyme lysophosphatidylcholine acyltransferase 3 (Lpcat3) is a critical determinant of triglyceride (TG) secretion due to its unique ability to catalyze the incorporation ..
  5. Wang B, Rong X, Duerr M, Hermanson D, Hedde P, Wong J, et al. Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet. Cell Metab. 2016;23:492-504 pubmed publisher
    ..Here we demonstrate that the LXR-responsive phospholipid-remodeling enzyme Lpcat3 modulates intestinal fatty acid and cholesterol absorption and is required for survival on a high-fat diet...