Lpcat1

Summary

Gene Symbol: Lpcat1
Description: lysophosphatidylcholine acyltransferase 1
Alias: 2900035H07Rik, Aytl2, BB137372, BC005662, C87117, LPCAT, rd11, lysophosphatidylcholine acyltransferase 1, 1-acylglycerophosphocholine O-acyltransferase, 1-alkylglycerophosphocholine O-acetyltransferase, LPC acyltransferase 1, LPCAT-1, acetyl-CoA:lyso-PAF acetyltransferase, acetyl-CoA:lyso-platelet-activating factor acetyltransferase, acyltransferase-like 2, lyso-PAF acetyltransferase, lysoPAFAT, lysoPC acyltransferase 1, mLPCAT1
Species: mouse
Products:     Lpcat1

Top Publications

  1. Chen X, Hyatt B, Mucenski M, Mason R, Shannon J. Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells. Proc Natl Acad Sci U S A. 2006;103:11724-9 pubmed
    ..We have cloned full-length rat and mouse cDNAs coding for a lysoPC acyltransferase (LPCAT)...
  2. Zou C, Ellis B, Smith R, Chen B, Zhao Y, Mallampalli R. Acyl-CoA:lysophosphatidylcholine acyltransferase I (Lpcat1) catalyzes histone protein O-palmitoylation to regulate mRNA synthesis. J Biol Chem. 2011;286:28019-25 pubmed publisher
    The enzyme acyl-CoA:lysophosphatidylcholine acyltransferase (Lpcat1) is a critical cytosolic enzyme needed for lung surfactant synthesis that catalyzes an acyltransferase reaction by adding a palmitate to the sn-2 position of ..
  3. Zou C, Butler P, Coon T, Smith R, Hammen G, Zhao Y, et al. LPS impairs phospholipid synthesis by triggering beta-transducin repeat-containing protein (beta-TrCP)-mediated polyubiquitination and degradation of the surfactant enzyme acyl-CoA:lysophosphatidylcholine acyltransferase I (LPCAT1). J Biol Chem. 2011;286:2719-27 pubmed publisher
    Acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a relatively newly described and yet indispensable enzyme needed for generation of the bioactive surfactant phospholipid, dipalmitoylphosphatidylcholine (DPPtdCho)...
  4. Bridges J, Ikegami M, Brilli L, Chen X, Mason R, Shannon J. LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice. J Clin Invest. 2010;120:1736-48 pubmed publisher
    ..and partially characterized a mouse enzyme with characteristics of a lung lysophosphatidylcholine acyltransferase (LPCAT1) that we predicted would be involved in surfactant synthesis...
  5. Friedman J, Chang B, Krauth D, Lopez I, Waseem N, Hurd R, et al. Loss of lysophosphatidylcholine acyltransferase 1 leads to photoreceptor degeneration in rd11 mice. Proc Natl Acad Sci U S A. 2010;107:15523-8 pubmed publisher
    ..We then identified a one-nucleotide insertion (c.420-421insG) in exon 3 of the Lpcat1 gene. Subsequent screening of this gene in the B6-JR2845 strain revealed a seven-nucleotide deletion (c...
  6. Nakanishi H, Shindou H, Hishikawa D, Harayama T, Ogasawara R, Suwabe A, et al. Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production. J Biol Chem. 2006;281:20140-7 pubmed
    ..Here, we present the cloning and characterization of a cDNA for mouse lung-type LPCAT (LPCAT1). The cDNA encodes an enzyme of 60 kDa, with three putative transmembrane domains...
  7. Cheng L, Han X, Shi Y. A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice. Am J Physiol Endocrinol Metab. 2009;297:E1276-82 pubmed publisher
    ..However, the molecular mechanisms underlying such defects remain elusive. LPCAT1 is a newly reported lysophospholipid acyltransferase implicated in the anti-inflammatory response by its role in ..
  8. Harayama T, Shindou H, Ogasawara R, Suwabe A, Shimizu T. Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor. J Biol Chem. 2008;283:11097-106 pubmed publisher
    ..We partially purified a Ca(2+)-independent lyso-PAF AT from mouse lung. Immunoreactivity for lysophosphatidylcholine acyltransferase 1 (LPCAT1) was detected in the active fraction...
  9. Soupene E, Fyrst H, Kuypers F. Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes. Proc Natl Acad Sci U S A. 2008;105:88-93 pubmed
    ..These proteins are three members of a LPCAT family, of which all three genes are expressed in an erythroleukemic cell line...

More Information

Publications20

  1. Butler P, Mallampalli R. Cross-talk between remodeling and de novo pathways maintains phospholipid balance through ubiquitination. J Biol Chem. 2010;285:6246-58 pubmed publisher
    ..Overexpression of the remodeling enzyme, LPCAT1 (acyl-CoA:lysophosphatidylcholine acyltransferase) in epithelia decreased de novo PtdCho synthesis without ..
  2. Kihara Y, Yanagida K, Masago K, Kita Y, Hishikawa D, Shindou H, et al. Platelet-activating factor production in the spinal cord of experimental allergic encephalomyelitis mice via the group IVA cytosolic phospholipase A2-lyso-PAFAT axis. J Immunol. 2008;181:5008-14 pubmed
    ..we demonstrate that the activities of phospholipase A(2) (PLA(2)) and acetyl-CoA:lyso-PAF acetyltransferase (LysoPAFAT) are elevated in the SC of EAE mice on a C57BL/6 genetic background compared with those of naive mice and ..
  3. Gao L, Rabbitt E, Condon J, Renthal N, Johnston J, Mitsche M, et al. Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition. J Clin Invest. 2015;125:2808-24 pubmed publisher
    ..SP-A, as well as the enzyme lysophosphatidylcholine acyltransferase-1 (LPCAT1), required for synthesis of surfactant dipalmitoylphosphatidylcholine, and the proinflammatory glycerophospholipid ..
  4. Akagi S, Kono N, Ariyama H, Shindou H, Shimizu T, Arai H. Lysophosphatidylcholine acyltransferase 1 protects against cytotoxicity induced by polyunsaturated fatty acids. FASEB J. 2016;30:2027-39 pubmed publisher
    ..An RNA interference screen of lipid-metabolizing enzymes revealed that lysophosphatidylcholine acyltransferase 1 (LPCAT1) was involved in the DPPC production...
  5. Soupene E, Kuypers F. Phosphatidylcholine formation by LPCAT1 is regulated by Ca(2+) and the redox status of the cell. BMC Biochem. 2012;13:8 pubmed publisher
    ..De-acylated lipids are then re-acylated by lysophospholipid acyltransferase enzymes such as LPCAT1 which catalyses the formation of phosphatidylcholine (PC) from lysoPC and long-chain acyl-CoA...
  6. Huang Y, Kapere Ochieng J, Kempen M, Munck A, Swagemakers S, van Ijcken W, et al. Hypoxia inducible factor 3? plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development. PLoS ONE. 2013;8:e57695 pubmed publisher
    ..Moreover, Hif3? affected the expression of genes not typically involved in the hypoxia response, providing evidence for a novel function of Hif3? beyond the hypoxia response. ..
  7. Dai X, Han J, Qi Y, Zhang H, Xiang L, Lv J, et al. AAV-mediated lysophosphatidylcholine acyltransferase 1 (Lpcat1) gene replacement therapy rescues retinal degeneration in rd11 mice. Invest Ophthalmol Vis Sci. 2014;55:1724-34 pubmed publisher
    ..The rd11 mice carry a spontaneous mutation in the lysophosphatidylcholine acyltransferase 1 (Lpcat1) gene...
  8. Dai X, Zhang H, Han J, He Y, Zhang Y, Qi Y, et al. Effects of Subretinal Gene Transfer at Different Time Points in a Mouse Model of Retinal Degeneration. PLoS ONE. 2016;11:e0156542 pubmed publisher
    b>Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is necessary for photoreceptors to generate an important lipid component of their membranes. The absence of LPCAT1 results in early and rapid rod and cone degeneration...
  9. Laresgoiti U, Nikolić M, Rao C, Brady J, Richardson R, Batchen E, et al. Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate. Development. 2016;143:3686-3699 pubmed
    ..Further elucidation of these pathways might provide therapeutic opportunities for restoring alveolar capacity. ..
  10. Harayama T, Eto M, Shindou H, Kita Y, Otsubo E, Hishikawa D, et al. Lysophospholipid acyltransferases mediate phosphatidylcholine diversification to achieve the physical properties required in vivo. Cell Metab. 2014;20:295-305 pubmed publisher
    ..We propose a model of harmonized processes for phospholipid diversification to satisfy in vivo requirements, with an example of its biological relevance. ..
  11. Lin S, Ikegami M, Moon C, Naren A, Shannon J. Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Specifically Interacts with Phospholipid Transfer Protein StarD10 to Facilitate Surfactant Phospholipid Trafficking in Alveolar Type II Cells. J Biol Chem. 2015;290:18559-74 pubmed publisher
    ..both de novo and by the remodeling of unsaturated phosphatidylcholine (PC) by lyso-PC acyltransferase 1 (LPCAT1)...