Gene Symbol: Lpar5
Description: lysophosphatidic acid receptor 5
Alias: GPR93, Gm1072, Gpr92, LPA5, lysophosphatidic acid receptor 5, G protein-coupled receptor 92, LPA receptor 5, LPA-5
Species: mouse
Products:     Lpar5

Top Publications

  1. Choi S, Lee M, Shiu A, Yo S, Hallden G, Aponte G. GPR93 activation by protein hydrolysate induces CCK transcription and secretion in STC-1 cells. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1366-75 pubmed
    ..Our recent discovery that a G protein-coupled receptor, GPR93, is activated by dietary protein hydrolysate causing induced intracellular calcium-mediated signaling events in ..
  2. Lin S, Yeruva S, He P, Singh A, Zhang H, Chen M, et al. Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2. Gastroenterology. 2010;138:649-58 pubmed publisher
    ..LPA is a potent stimulant of NHE3 and fluid absorption in the intestine, signaling through LPA(5). Regulation by LPA(5) depends on its interaction with NHERF2. LPA might be useful in the treatment of certain diarrheal diseases. ..
  3. Furuta D, Yamane M, Tsujiuchi T, Moriyama R, Fukushima N. Lysophosphatidic acid induces neurite branch formation through LPA3. Mol Cell Neurosci. 2012;50:21-34 pubmed publisher
    ..These findings suggest that the novel signaling pathway involving LPA(3), G(q), and Rnd2 may play an important role in neuronal network formation. ..
  4. Callaerts Vegh Z, Leo S, Vermaercke B, Meert T, D Hooge R. LPA5 receptor plays a role in pain sensitivity, emotional exploration and reversal learning. Genes Brain Behav. 2012;11:1009-19 pubmed publisher
    ..In this study, we examined mice lacking the LPA5 receptor using an extensive battery of behavioral tests...
  5. Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, et al. Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility. elife. 2016;5:e10561 pubmed publisher
    ..These results strongly suggest that FRC-derived LPA serves as a cell-extrinsic factor that optimizes T-cell movement through the densely packed LN reticular network. ..
  6. Lee C, Rivera R, Gardell S, Dubin A, Chun J. GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5. J Biol Chem. 2006;281:23589-97 pubmed
    ..result of one screen to identify receptors that produced LPA-dependent changes in cell shape: the orphan receptor GPR92 has properties of a new LPA receptor...
  7. Ohuchi H, Hamada A, Matsuda H, Takagi A, Tanaka M, Aoki J, et al. Expression patterns of the lysophospholipid receptor genes during mouse early development. Dev Dyn. 2008;237:3280-94 pubmed publisher
    ..protein-coupled receptor (GPCR) family: EDG1 to EDG8 (S1P1 to S1P5 and LPA1 to LPA3), LPA4 (GPR23/P2Y9), and LPA5 (GPR92)...
  8. Dubin A, Herr D, Chun J. Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis. J Neurosci. 2010;30:7300-9 pubmed publisher
    ..Compared with other known factors, lysophospholipids represent the major activator of calcium signaling identified within NPCs at this early stage in corticogenesis. ..
  9. Dong Y, Hirane M, Araki M, Fukushima N, Tsujiuchi T. Lysophosphatidic acid receptor-5 negatively regulates cellular responses in mouse fibroblast 3T3 cells. Biochem Biophys Res Commun. 2014;446:585-9 pubmed publisher
    ..In the present study, to evaluate a role of LPA5 in cellular responses, Lpar5 knockdown (3T3-L5) cells were generated from 3T3 cells...

More Information


  1. Hu J, Oda S, Shotts K, Donovan E, Strauch P, Pujanauski L, et al. Lysophosphatidic acid receptor 5 inhibits B cell antigen receptor signaling and antibody response. J Immunol. 2014;193:85-95 pubmed publisher
    ..we demonstrate that BCR signal transduction by mature murine B cells is inhibited upon LPA engagement of the LPA5 (GPR92) receptor via a G?12/13-Arhgef1 pathway...
  2. Lee S, Fujiwara Y, Liu J, Yue J, Shimizu Y, Norman D, et al. Autotaxin and LPA1 and LPA5 receptors exert disparate functions in tumor cells versus the host tissue microenvironment in melanoma invasion and metastasis. Mol Cancer Res. 2015;13:174-85 pubmed publisher
    ..B16F10 melanoma cells predominantly express LPA5 and LPA2 receptors but lack LPA1. LPA dose dependently inhibited invasion of cells across a Matrigel layer...
  3. Tsukahara R, Yamamoto S, Yoshikawa K, Gotoh M, Tsukahara T, Neyama H, et al. LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model. J Pharmacol Sci. 2018;136:93-96 pubmed publisher
    ..In the present study, we revealed that the LPA5 receptor expression in corpus callosum elevated after the initiation of demyelination, and the hyperalgesia through ..
  4. Kotarsky K, Boketoft A, Bristulf J, Nilsson N, Norberg A, Hansson S, et al. Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes. J Pharmacol Exp Ther. 2006;318:619-28 pubmed
    Here, the ligand binding, activation, and tissue distribution of the orphan G protein-coupled receptor (GPCR) GPR92 were studied. GPR92 binds and is activated by compounds based on the lysophosphatidic acid (LPA) backbone...
  5. Lin M, Rivera R, Chun J. Targeted deletion of LPA5 identifies novel roles for lysophosphatidic acid signaling in development of neuropathic pain. J Biol Chem. 2012;287:17608-17 pubmed publisher
    ..We therefore generated an Lpar5 null mutant by targeted deletion followed by PSNL challenge...