Genomes and Genes
Gene Symbol: Lpar4
Description: lysophosphatidic acid receptor 4
Alias: 5730485F04Rik, Gpr23, LPA4, p2y9, lysophosphatidic acid receptor 4, G protein-coupled receptor 23, LPA receptor 4, LPA-4, P2Y purinoceptor 9, purinergic receptor 9
- Igarashi H, Akahoshi N, Ohto Nakanishi T, Yasuda D, Ishii S. The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells. Sci Rep. 2015;5:11410 pubmed publisher..Here, we show a novel regulatory role for LPA4 in hematopoiesis. Lpar4â€‰mRNA was predominantly expressed in mouse bone marrow (BM) PDGFRÎ±(+) stromal cells, known as the ..
- Hata E, Sasaki N, Takeda A, Tohya K, Umemoto E, Akahoshi N, et al. Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes. Int Immunol. 2016;28:283-92 pubmed publisher..Here, we show that two LPA receptors, LPA4 and LPA6, are selectively expressed on HEV endothelial cells (ECs) and that LPA4 plays a major role in the ..
- Takara K, Eino D, Ando K, Yasuda D, Naito H, Tsukada Y, et al. Lysophosphatidic Acid Receptor 4 Activation Augments Drug Delivery in Tumors by Tightening Endothelial Cell-Cell Contact. Cell Rep. 2017;20:2072-2086 pubmed publisher..In studies using mutant mice, we found that LPA4 is involved in vascular network formation...
- Ohuchi H, Hamada A, Matsuda H, Takagi A, Tanaka M, Aoki J, et al. Expression patterns of the lysophospholipid receptor genes during mouse early development. Dev Dyn. 2008;237:3280-94 pubmed publisher..which belong to the G protein-coupled receptor (GPCR) family: EDG1 to EDG8 (S1P1 to S1P5 and LPA1 to LPA3), LPA4 (GPR23/P2Y9), and LPA5 (GPR92)...