Gene Symbol: Lpar4
Description: lysophosphatidic acid receptor 4
Alias: 5730485F04Rik, Gpr23, LPA4, p2y9, lysophosphatidic acid receptor 4, G protein-coupled receptor 23, LPA receptor 4, LPA-4, P2Y purinoceptor 9, purinergic receptor 9
Species: mouse
Products:     Lpar4

Top Publications

  1. Taghavi P, Verhoeven E, Jacobs J, Lambooij J, Stortelers C, Tanger E, et al. In vitro genetic screen identifies a cooperative role for LPA signaling and c-Myc in cell transformation. Oncogene. 2008;27:6806-16 pubmed publisher
    ..We find that LPA1 and LPA4, but not LPA3, can reproduce the transforming effect of LPA2...
  2. Lee Z, Cheng C, Zhang H, Subler M, Wu J, Mukherjee A, et al. Role of LPA4/p2y9/GPR23 in negative regulation of cell motility. Mol Biol Cell. 2008;19:5435-45 pubmed publisher
    ..The LPA(1-3) receptors are members of the endothelial cell differentiation gene (Edg) family. LPA(4)/p2y9/GPR23, a member of the purinergic receptor family, and recently identified LPA(5)/GPR92 and p2y5 are structurally ..
  3. Dubin A, Herr D, Chun J. Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis. J Neurosci. 2010;30:7300-9 pubmed publisher
    ..Compared with other known factors, lysophospholipids represent the major activator of calcium signaling identified within NPCs at this early stage in corticogenesis. ..
  4. Sumida H, Noguchi K, Kihara Y, Abe M, Yanagida K, Hamano F, et al. LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis. Blood. 2010;116:5060-70 pubmed publisher
    ..In situ hybridization detected Lpa4 mRNA in the endothelium of some vasculatures. Similarly, the lymphatic vessels of edematous embryos were dilated...
  5. Furuta D, Yamane M, Tsujiuchi T, Moriyama R, Fukushima N. Lysophosphatidic acid induces neurite branch formation through LPA3. Mol Cell Neurosci. 2012;50:21-34 pubmed publisher
    ..These findings suggest that the novel signaling pathway involving LPA(3), G(q), and Rnd2 may play an important role in neuronal network formation. ..
  6. van Meeteren L, Ruurs P, Stortelers C, Bouwman P, van Rooijen M, Pradere J, et al. Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development. Mol Cell Biol. 2006;26:5015-22 pubmed
  7. Tanaka M, Okudaira S, Kishi Y, Ohkawa R, Iseki S, Ota M, et al. Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid. J Biol Chem. 2006;281:25822-30 pubmed
    ..The present study revealed a previously unassigned role of ATX in stabilizing vessels through novel LPA signaling pathways. ..
  8. Lee C, Rivera R, Dubin A, Chun J. LPA(4)/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing G(s)-, G(q)/G(i)-mediated calcium signaling and G(12/13)-mediated Rho activation. J Biol Chem. 2007;282:4310-7 pubmed
    ..A recently reported fourth receptor, LPA(4)/GPR23, was notable for its low homology to the previously identified receptors LPA(1-3) and for its ability to increase ..
  9. Teplyuk N, Galindo M, Teplyuk V, Pratap J, Young D, Lapointe D, et al. Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors. J Biol Chem. 2008;283:27585-97 pubmed publisher
    ..g. Rgs2, Rgs4, Rgs5, Rgs16, Gpr23, Gpr30, Gpr54, Gpr64, and Gna13)...

More Information


  1. Igarashi H, Akahoshi N, Ohto Nakanishi T, Yasuda D, Ishii S. The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells. Sci Rep. 2015;5:11410 pubmed publisher
    ..Here, we show a novel regulatory role for LPA4 in hematopoiesis. Lpar4 mRNA was predominantly expressed in mouse bone marrow (BM) PDGFRα(+) stromal cells, known as the ..
  2. Hata E, Sasaki N, Takeda A, Tohya K, Umemoto E, Akahoshi N, et al. Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes. Int Immunol. 2016;28:283-92 pubmed publisher
    ..Here, we show that two LPA receptors, LPA4 and LPA6, are selectively expressed on HEV endothelial cells (ECs) and that LPA4 plays a major role in the ..
  3. Takara K, Eino D, Ando K, Yasuda D, Naito H, Tsukada Y, et al. Lysophosphatidic Acid Receptor 4 Activation Augments Drug Delivery in Tumors by Tightening Endothelial Cell-Cell Contact. Cell Rep. 2017;20:2072-2086 pubmed publisher
    ..In studies using mutant mice, we found that LPA4 is involved in vascular network formation...
  4. Ohuchi H, Hamada A, Matsuda H, Takagi A, Tanaka M, Aoki J, et al. Expression patterns of the lysophospholipid receptor genes during mouse early development. Dev Dyn. 2008;237:3280-94 pubmed publisher
    ..which belong to the G protein-coupled receptor (GPCR) family: EDG1 to EDG8 (S1P1 to S1P5 and LPA1 to LPA3), LPA4 (GPR23/P2Y9), and LPA5 (GPR92)...