Lpar3

Summary

Gene Symbol: Lpar3
Description: lysophosphatidic acid receptor 3
Alias: Edg7, lpA3, LPA receptor 3, LPA-3, endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7, lysophosphatidic acid receptor Edg-7
Species: mouse

Top Publications

  1. pmc LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing
    Xiaoqin Ye
    Department of Molecular Biology, Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 435:104-8. 2005
  2. ncbi A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting
    Anja U Bräuer
    Institute of Anatomy, Department of Cell Biology and Neurobiology, Philippstr 12, Humboldt University Medical School Charité, D 10115 Berlin, Germany
    Nat Neurosci 6:572-8. 2003
  3. pmc Distinct spatiotemporal expression of serine proteases Prss23 and Prss35 in periimplantation mouse uterus and dispensable function of Prss35 in fertility
    Honglu Diao
    Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, Georgia, United States of America
    PLoS ONE 8:e56757. 2013
  4. pmc 11-deoxy prostaglandin F(2α), a thromboxane A2 receptor agonist, partially alleviates embryo crowding in Lpar3((-/-)) females
    Xiaoqin Ye
    Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, Georgia 30602, USA
    Fertil Steril 97:757-63. 2012
  5. doi Lysophosphatidic acid induces neurite branch formation through LPA3
    Daisuke Furuta
    Division of Molecular Neurobiology, Department of Life Science, Kinki University, Higashiosaka, Japan
    Mol Cell Neurosci 50:21-34. 2012
  6. doi Expression patterns of the lysophospholipid receptor genes during mouse early development
    Hideyo Ohuchi
    Department of Life Systems, Institute of Technology and Science, University of Tokushima, Tokushima, Japan
    Dev Dyn 237:3280-94. 2008
  7. doi Lysophosphatidic acid receptors LPA1 and LPA3 promote CXCL12-mediated smooth muscle progenitor cell recruitment in neointima formation
    Pallavi Subramanian
    Institute for Molecular Cardiovascular Research, RWTH Aachen University, Pauwelsstr 30 52074 Aachen, Germany
    Circ Res 107:96-105. 2010
  8. doi Stimulatory actions of lysophosphatidic acid on mouse ATDC5 chondroprogenitor cells
    Ryota Itoh
    Department of Cellular Differentiation, Institute for Frontier Medical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    J Bone Miner Metab 28:659-71. 2010
  9. doi LPA receptor expression in the central nervous system in health and following injury
    Yona Goldshmit
    Centre for Neuroscience, The University of Melbourne, Melbourne, Victoria, Australia
    Cell Tissue Res 341:23-32. 2010
  10. pmc Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis
    Adrienne E Dubin
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 30:7300-9. 2010

Scientific Experts

  • Xiaoqin Ye
  • H Ohuchi
  • Jerold Chun
  • Honglu Diao
  • Kotaro Hama
  • Hiroyuki Arai
  • Junken Aoki
  • Daisuke Furuta
  • Shuo Xiao
  • Chenqi Zhao
  • J J Contos
  • Pallavi Subramanian
  • Ryota Itoh
  • Adrienne E Dubin
  • Yona Goldshmit
  • Nattapon Panupinthu
  • Liana C Chan
  • Asuka Inoue
  • Tomokazu Amano
  • Hiroshi Suzuki
  • Tomoko Endo
  • Masayuki Tanaka
  • Laurens A van Meeteren
  • Susanna Wang
  • Takeshi Yamada
  • Anja U Bräuer
  • Federica Di Palma
  • Christine McGiffert
  • Fei Zhao
  • Rong Li
  • Masayuki Yamane
  • Ryutaro Moriyama
  • Toshifumi Tsujiuchi
  • Nobuyuki Fukushima
  • J Chun
  • Maria J Fernandes
  • Zuguo Li
  • Shiyou Chen
  • Anne Sardella
  • John D Aplin
  • Sylvain G Bourgoin
  • Patrice E Poubelle
  • Yuji Hiraki
  • Marc van Zandvoort
  • Shamima Akhtar
  • Zhe Zhou
  • Uwe Schumann
  • Aki Takimoto
  • Alice Pebay
  • Patricia Reinhard
  • Remco T A Megens
  • Ann M Turnley
  • Kathryn Munro
  • Deron R Herr
  • Andreas Schober
  • Christian Weber
  • Shunya Kondo
  • Hiroko Sano
  • Shigenori Miura
  • Xiaofeng Li
  • Soo Yuen Leong
  • Christian Ludin
  • Ela Karshovska
  • Masakatsu Shibasaki
  • Robert V Farese
  • Motomu Kanai
  • Rie Motoki
  • Fred Possmayer
  • Wendy Peters
  • Stephen M Sims
  • Hua Z Ke
  • Norio Matsuki
  • Lin Zhao
  • Yan Xu
  • Sylvaine Cases
  • S Jeffrey Dixon
  • Ryunosuke Ohkawa
  • Paula Ruurs
  • Masato Ota
  • Aldons J Lusis
  • Wouter H Moolenaar
  • Nadir Yehya
  • Shinichi Okudaira
  • Jean Philippe Pradere
  • Hui Wang
  • Jos Jonkers
  • Yasuhiro Kishi
  • Christine L Mummery
  • Sumihare Noji
  • Trevor R Pettit

Detail Information

Publications26

  1. pmc LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing
    Xiaoqin Ye
    Department of Molecular Biology, Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 435:104-8. 2005
    ..we report a newly discovered molecular influence on implantation through the lysophosphatidic acid (LPA) receptor LPA3 (refs 2-4)...
  2. ncbi A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting
    Anja U Bräuer
    Institute of Anatomy, Department of Cell Biology and Neurobiology, Philippstr 12, Humboldt University Medical School Charité, D 10115 Berlin, Germany
    Nat Neurosci 6:572-8. 2003
    ..Thus, we propose a novel mechanism by which axons are able to control phospholipid-mediated signaling and overcome the growth-inhibiting, phospholipid-rich environment of the extracellular space...
  3. pmc Distinct spatiotemporal expression of serine proteases Prss23 and Prss35 in periimplantation mouse uterus and dispensable function of Prss35 in fertility
    Honglu Diao
    Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, Georgia, United States of America
    PLoS ONE 8:e56757. 2013
    ..This study demonstrates the distinct expression of Prss23 and Prss35 in the periimplantation uterus and the dispensable role of Prss35 in fertility and embryo development...
  4. pmc 11-deoxy prostaglandin F(2α), a thromboxane A2 receptor agonist, partially alleviates embryo crowding in Lpar3((-/-)) females
    Xiaoqin Ye
    Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, Georgia 30602, USA
    Fertil Steril 97:757-63. 2012
    To determine cyclooxygenase-derived prostanoid signaling in alleviating embryo crowding in the Lpar3((-/-)) females.
  5. doi Lysophosphatidic acid induces neurite branch formation through LPA3
    Daisuke Furuta
    Division of Molecular Neurobiology, Department of Life Science, Kinki University, Higashiosaka, Japan
    Mol Cell Neurosci 50:21-34. 2012
    ..These findings suggest that the novel signaling pathway involving LPA(3), G(q), and Rnd2 may play an important role in neuronal network formation...
  6. doi Expression patterns of the lysophospholipid receptor genes during mouse early development
    Hideyo Ohuchi
    Department of Life Systems, Institute of Technology and Science, University of Tokushima, Tokushima, Japan
    Dev Dyn 237:3280-94. 2008
    ..genes, which belong to the G protein-coupled receptor (GPCR) family: EDG1 to EDG8 (S1P1 to S1P5 and LPA1 to LPA3), LPA4 (GPR23/P2Y9), and LPA5 (GPR92)...
  7. doi Lysophosphatidic acid receptors LPA1 and LPA3 promote CXCL12-mediated smooth muscle progenitor cell recruitment in neointima formation
    Pallavi Subramanian
    Institute for Molecular Cardiovascular Research, RWTH Aachen University, Pauwelsstr 30 52074 Aachen, Germany
    Circ Res 107:96-105. 2010
    ..Lysophosphatidic acid (LPA) induces CXCL12 and neointimal accumulation of smooth muscle cells (SMCs) in uninjured arteries. Thus, we hypothesize that LPA may regulate CXCL12-mediated vascular remodelling...
  8. doi Stimulatory actions of lysophosphatidic acid on mouse ATDC5 chondroprogenitor cells
    Ryota Itoh
    Department of Cellular Differentiation, Institute for Frontier Medical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    J Bone Miner Metab 28:659-71. 2010
    ..These results indicate that LPA plays an important role in the activation of chondroprogenitor cells...
  9. doi LPA receptor expression in the central nervous system in health and following injury
    Yona Goldshmit
    Centre for Neuroscience, The University of Melbourne, Melbourne, Victoria, Australia
    Cell Tissue Res 341:23-32. 2010
    ..LPA release following CNS injury may have different consequences for each cell type because of this differential expression in the adult nervous system...
  10. pmc Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis
    Adrienne E Dubin
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 30:7300-9. 2010
    ..Compared with other known factors, lysophospholipids represent the major activator of calcium signaling identified within NPCs at this early stage in corticogenesis...
  11. pmc Altered spatiotemporal expression of collagen types I, III, IV, and VI in Lpar3-deficient peri-implantation mouse uterus
    Honglu Diao
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    Biol Reprod 84:255-65. 2011
    b>Lpar3 is upregulated in the preimplantation uterus, and deletion of Lpar3 leads to delayed uterine receptivity in mice. Microarray analysis revealed that there was higher expression of Col3a1 and Col6a3 in the Preimplantation Day 3...
  12. pmc Unique uterine localization and regulation may differentiate LPA3 from other lysophospholipid receptors for its role in embryo implantation
    Xiaoqin Ye
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    Fertil Steril 95:2107-13, 2113.e1-4. 2011
    To determine factors differentiating LPA3 from other lysophospholipid (LP) receptors for its role in embryo implantation.
  13. pmc TNF-alpha promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines
    Chenqi Zhao
    Rheumatology and Immunology Research Center, CHUQ CHUL Research Center and Faculty of Medicine, Laval University, Quebec City, Quebec, Canada
    J Lipid Res 52:1307-18. 2011
    ..We suggest that LPA, via LPA(1) and LPA(3) receptors, may play a significant role in inducing and/or sustaining the massive infiltration of leukocytes during inflammation...
  14. pmc Age-dependent loss of sperm production in mice via impaired lysophosphatidic acid signaling
    Xiaoqin Ye
    Department of Molecular Biology, The Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Reprod 79:328-36. 2008
    ..Germ cell apoptosis led to a reduction in germ cell proliferation. These data demonstrate a novel in vivo function for LPA signaling as a germ cell survival factor during spermatogenesis...
  15. ncbi Embryo spacing and implantation timing are differentially regulated by LPA3-mediated lysophosphatidic acid signaling in mice
    Kotaro Hama
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    Biol Reprod 77:954-9. 2007
    ..the establishment of early pregnancy by affecting embryo spacing and subsequent implantation through its receptor, LPA3. Targeted deletion of Lpa3 in mice resulted in delayed implantation and embryo crowding, which is associated with a ..
  16. ncbi The mouse lp(A3)/Edg7 lysophosphatidic acid receptor gene: genomic structure, chromosomal localization, and expression pattern
    J J Contos
    Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Gene 267:243-53. 2001
    ..To understand the evolution and function of LPA receptor genes, we characterized lp(A3)/Edg7 in mouse and human and compared the expression pattern with the other two known LPA receptor genes (lp(A1)/Edg2 and ..
  17. ncbi Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p(1) in neurogenesis and s1p(1-3) in angiogenesis
    Christine McGiffert
    Neurosciences Graduate Program, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    FEBS Lett 531:103-8. 2002
    ..The punctate pattern colocalized with vascular endothelial markers. Together, these results suggest that s1p(1) influences neurogenesis and s1p(1-3) influence angiogenesis in the developing brain...
  18. pmc Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice
    Federica Di Palma
    Section on Neurogenetics, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 99:14994-9. 2002
    ..Hence, we identify a molecular link between hair cell physiology and melanocyte function. Last, MCOLN2 and MCOLN3 are candidate genes for hereditary and/or sporadic forms of neurosensory disorders in humans...
  19. ncbi Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs)
    Takeshi Yamada
    School of Allied Health Sciences, Faculty of Medicine, Osaka University, Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    J Biol Chem 280:19358-63. 2005
    ..responses in various cells via heterotrimeric G protein-coupled receptors (GPCRs) including LPA1, LPA2, and LPA3. LPA-induced cytoskeletal changes are mediated by Rho family small GTPases, such as RhoA, Rac1, and Cdc42...
  20. pmc Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity
    Susanna Wang
    Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    PLoS Genet 2:e15. 2006
    ..These data have implications on the potential effects of sex on the genetic regulation of other complex traits...
  21. pmc Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development
    Laurens A van Meeteren
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Mol Cell Biol 26:5015-22. 2006
    ....
  22. ncbi Lysophosphatidic receptor, LPA3, is positively and negatively regulated by progesterone and estrogen in the mouse uterus
    Kotaro Hama
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Life Sci 79:1736-40. 2006
    ..These results show that progesterone and estrogen cooperatively regulate LPA(3) expression, thereby contributing to the receptivity of uteri during early pregnancy...
  23. ncbi Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid
    Masayuki Tanaka
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 281:25822-30. 2006
    ..The present study revealed a previously unassigned role of ATX in stabilizing vessels through novel LPA signaling pathways...
  24. ncbi P2X7 nucleotide receptors mediate blebbing in osteoblasts through a pathway involving lysophosphatidic acid
    Nattapon Panupinthu
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, The University of Western Ontario, London, Canada
    J Biol Chem 282:3403-12. 2007
    ..This pathway may contribute to P2X7-stimulated osteogenesis during skeletal development and mechanotransduction...
  25. ncbi LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA)
    Liana C Chan
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    J Leukoc Biol 82:1193-200. 2007
    ..In summary, our results indicate that immature mouse DCs migrate preferentially in response to unsaturated LPA and that LPA(3) is important in this response...
  26. pmc Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior
    J J Contos
    Department of Pharmacology, Neuroscience Graduate Program, Biomedical Sciences Program, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0636, USA
    Proc Natl Acad Sci U S A 97:13384-9. 2000
    ..Our results provide evidence that endogenous lysophospholipid signaling requires an lp receptor gene and indicate that LPA signaling through the LP(A1) receptor is required for normal development of an inborn, neonatal behavior...