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Genomes and Genes
| Lpar3SummaryGene Symbol: Lpar3 Description: lysophosphatidic acid receptor 3 Alias: Edg7, lpA3, LPA receptor 3, LPA-3, endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7, lysophosphatidic acid receptor Edg-7 Species: mouse Top Publications
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Publications
A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sproutingAnja U Bräuer
Institute of Anatomy, Department of Cell Biology and Neurobiology, Philippstr 12, Humboldt University Medical School Charité, D 10115 Berlin, Germany
Nat Neurosci 6:572-8. 2003..Thus, we propose a novel mechanism by which axons are able to control phospholipid-mediated signaling and overcome the growth-inhibiting, phospholipid-rich environment of the extracellular space...
Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behaviorJ J Contos
Department of Pharmacology, Neuroscience Graduate Program, Biomedical Sciences Program, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0636, USA
Proc Natl Acad Sci U S A 97:13384-9. 2000..Our results provide evidence that endogenous lysophospholipid signaling requires an lp receptor gene and indicate that LPA signaling through the LP(A1) receptor is required for normal development of an inborn, neonatal behavior...- Embryo spacing and implantation timing are differentially regulated by LPA3-mediated lysophosphatidic acid signaling in miceKotaro Hama
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
Biol Reprod 77:954-9. 2007..the establishment of early pregnancy by affecting embryo spacing and subsequent implantation through its receptor, LPA3. Targeted deletion of Lpa3 in mice resulted in delayed implantation and embryo crowding, which is associated with a .. - Age-dependent loss of sperm production in mice via impaired lysophosphatidic acid signalingXiaoqin Ye
Department of Molecular Biology, The Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, California 92037, USA
Biol Reprod 79:328-36. 2008..Germ cell apoptosis led to a reduction in germ cell proliferation. These data demonstrate a novel in vivo function for LPA signaling as a germ cell survival factor during spermatogenesis... 
Expression patterns of the lysophospholipid receptor genes during mouse early developmentHideyo Ohuchi
Department of Life Systems, Institute of Technology and Science, University of Tokushima, Tokushima, Japan
Dev Dyn 237:3280-94. 2008..genes, which belong to the G protein-coupled receptor (GPCR) family: EDG1 to EDG8 (S1P1 to S1P5 and LPA1 to LPA3), LPA4 (GPR23/P2Y9), and LPA5 (GPR92)...- Lysophosphatidic acid receptors LPA1 and LPA3 promote CXCL12-mediated smooth muscle progenitor cell recruitment in neointima formationPallavi Subramanian
Institute for Molecular Cardiovascular Research, RWTH Aachen University, Pauwelsstr 30 52074 Aachen, Germany
Circ Res 107:96-105. 2010..Lysophosphatidic acid (LPA) induces CXCL12 and neointimal accumulation of smooth muscle cells (SMCs) in uninjured arteries. Thus, we hypothesize that LPA may regulate CXCL12-mediated vascular remodelling... - Stimulatory actions of lysophosphatidic acid on mouse ATDC5 chondroprogenitor cellsRyota Itoh
Department of Cellular Differentiation, Institute for Frontier Medical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
J Bone Miner Metab 28:659-71. 2010..These results indicate that LPA plays an important role in the activation of chondroprogenitor cells... - LPA receptor expression in the central nervous system in health and following injuryYona Goldshmit
Centre for Neuroscience, The University of Melbourne, Melbourne, Victoria, Australia
Cell Tissue Res 341:23-32. 2010..LPA release following CNS injury may have different consequences for each cell type because of this differential expression in the adult nervous system... - Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesisAdrienne E Dubin
Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Neurosci 30:7300-9. 2010..Compared with other known factors, lysophospholipids represent the major activator of calcium signaling identified within NPCs at this early stage in corticogenesis... - Altered spatiotemporal expression of collagen types I, III, IV, and VI in Lpar3-deficient peri-implantation mouse uterusHonglu Diao
Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
Biol Reprod 84:255-65. 2011b>Lpar3 is upregulated in the preimplantation uterus, and deletion of Lpar3 leads to delayed uterine receptivity in mice. Microarray analysis revealed that there was higher expression of Col3a1 and Col6a3 in the Preimplantation Day 3... - Unique uterine localization and regulation may differentiate LPA3 from other lysophospholipid receptors for its role in embryo implantationXiaoqin Ye
Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
Fertil Steril 95:2107-13, 2113.e1-4. 2011To determine factors differentiating LPA3 from other lysophospholipid (LP) receptors for its role in embryo implantation. - LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA)Liana C Chan
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
J Leukoc Biol 82:1193-200. 2007..In summary, our results indicate that immature mouse DCs migrate preferentially in response to unsaturated LPA and that LPA(3) is important in this response... - P2X7 nucleotide receptors mediate blebbing in osteoblasts through a pathway involving lysophosphatidic acidNattapon Panupinthu
Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, The University of Western Ontario, London, Canada
J Biol Chem 282:3403-12. 2007..This pathway may contribute to P2X7-stimulated osteogenesis during skeletal development and mechanotransduction... - The mouse lp(A3)/Edg7 lysophosphatidic acid receptor gene: genomic structure, chromosomal localization, and expression patternJ J Contos
Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
Gene 267:243-53. 2001..To understand the evolution and function of LPA receptor genes, we characterized lp(A3)/Edg7 in mouse and human and compared the expression pattern with the other two known LPA receptor genes (lp(A1)/Edg2 and .. - Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p(1) in neurogenesis and s1p(1-3) in angiogenesisChristine McGiffert
Neurosciences Graduate Program, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
FEBS Lett 531:103-8. 2002..The punctate pattern colocalized with vascular endothelial markers. Together, these results suggest that s1p(1) influences neurogenesis and s1p(1-3) influence angiogenesis in the developing brain... - Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) miceFederica Di Palma
Section on Neurogenetics, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA
Proc Natl Acad Sci U S A 99:14994-9. 2002..Hence, we identify a molecular link between hair cell physiology and melanocyte function. Last, MCOLN2 and MCOLN3 are candidate genes for hereditary and/or sporadic forms of neurosensory disorders in humans... - Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs)Takeshi Yamada
School of Allied Health Sciences, Faculty of Medicine, Osaka University, Yamadaoka, Suita Shi, Osaka 565 0871, Japan
J Biol Chem 280:19358-63. 2005..responses in various cells via heterotrimeric G protein-coupled receptors (GPCRs) including LPA1, LPA2, and LPA3. LPA-induced cytoskeletal changes are mediated by Rho family small GTPases, such as RhoA, Rac1, and Cdc42... - LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacingXiaoqin Ye
Department of Molecular Biology, Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Nature 435:104-8. 2005..we report a newly discovered molecular influence on implantation through the lysophosphatidic acid (LPA) receptor LPA3 (refs 2-4)... - Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificitySusanna Wang
Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
PLoS Genet 2:e15. 2006..These data have implications on the potential effects of sex on the genetic regulation of other complex traits... - Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during developmentLaurens A van Meeteren
Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Mol Cell Biol 26:5015-22. 2006.... - Lysophosphatidic receptor, LPA3, is positively and negatively regulated by progesterone and estrogen in the mouse uterusKotaro Hama
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Life Sci 79:1736-40. 2006..These results show that progesterone and estrogen cooperatively regulate LPA(3) expression, thereby contributing to the receptivity of uteri during early pregnancy... - Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acidMasayuki Tanaka
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
J Biol Chem 281:25822-30. 2006..The present study revealed a previously unassigned role of ATX in stabilizing vessels through novel LPA signaling pathways... - TNF-alpha promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokinesChenqi Zhao
Rheumatology and Immunology Research Center, CHUQ CHUL Research Center and Faculty of Medicine, Laval University, Quebec City, Quebec, Canada
J Lipid Res 52:1307-18. 2011..We suggest that LPA, via LPA(1) and LPA(3) receptors, may play a significant role in inducing and/or sustaining the massive infiltration of leukocytes during inflammation...