Gene Symbol: Loxl4
Description: lysyl oxidase-like 4
Alias: 4833426I20Rik, Loxc, lysyl oxidase homolog 4, lysyl oxidase-like protein 4, lysyl oxidase-related protein C
Species: mouse
Products:     Loxl4

Top Publications

  1. Ito H, Akiyama H, Iguchi H, Iyama K, Miyamoto M, Ohsawa K, et al. Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage. J Biol Chem. 2001;276:24023-9 pubmed
    We cloned a cDNA encoding a novel lysyl oxidase-related protein, named LOXC, by suppression subtractive hybridization between differentiated and calcified ATDC5 cells, a clonal mouse chondrogenic EC cell line...
  2. Pischon N, Mäki J, Weisshaupt P, Heng N, Palamakumbura A, N Guessan P, et al. Lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype. Calcif Tissue Int. 2009;85:119-26 pubmed publisher
    ..However, mineral nodule formation and osteoblastic differentiation were markedly decreased, as revealed by significant downregulation of osteoblastic markers, type I collagen, bone sialoprotein, and Runx2/Cbfa1. ..
  3. Zhang J, Liu Z, Zhang T, Lin Z, Li Z, Zhang A, et al. Loss of Lysyl Oxidase-like 3 Attenuates Embryonic Lung Development in Mice. Sci Rep. 2016;6:33856 pubmed publisher
    ..Excess elastic fibres were detected in LOXL3-deficient lungs, which might be related to the increased LOXL4 expression...
  4. Choi S, Kim H, Jin T, Moon W. LOXL4 knockdown enhances tumor growth and lung metastasis through collagen-dependent extracellular matrix changes in triple-negative breast cancer. Oncotarget. 2017;8:11977-11989 pubmed publisher
    ..To determine the effects of lysyl oxidase-like 4 (LOXL4) expression on breast tumor formation and metastasis, we evaluated primary tumor growth and lung metastasis in ..