Gene Symbol: Loxl3
Description: lysyl oxidase-like 3
Alias: Lor2, Loxl2, lysyl oxidase homolog 3, lysyl oxidase-like 2, lysyl oxidase-like protein 3, lysyl oxidase-related protein 2
Jang W, Hua A, Spilson S, Miller W, Roe B, Meisler M. Comparative sequence of human and mouse BAC clones from the mnd2 region of chromosome 2p13. Genome Res. 1999;9:53-61 pubmed
..with the indicated sizes and intergenic distances were identified: D6Mm5e (>/=81 kb)-787 bp-DOK (2 kb)-845 bp-LOR2 (>/=6 kb)...
Pischon N, Mäki J, Weisshaupt P, Heng N, Palamakumbura A, N Guessan P, et al
. Lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype. Calcif Tissue Int. 2009;85:119-26 pubmed publisher
..However, mineral nodule formation and osteoblastic differentiation were markedly decreased, as revealed by significant downregulation of osteoblastic markers, type I collagen, bone sialoprotein, and Runx2/Cbfa1. ..
Zhang J, Yang R, Liu Z, Hou C, Zong W, Zhang A, et al
. Loss of lysyl oxidase-like 3 causes cleft palate and spinal deformity in mice. Hum Mol Genet. 2015;24:6174-85 pubmed publisher
..In this study, we investigated the essential role of lysyl oxidase-like 3 (LOXL3), a member of the LOX family, in embryonic development...
Kraft Sheleg O, Zaffryar Eilot S, Genin O, Yaseen W, Soueid Baumgarten S, Kessler O, et al
. Localized LoxL3-Dependent Fibronectin Oxidation Regulates Myofiber Stretch and Integrin-Mediated Adhesion. Dev Cell. 2016;36:550-61 pubmed publisher
..We show that lysyl oxidase-like 3 (LoxL3) is a key regulator of integrin signaling that ensures localized control of the cascade...
Zhang J, Liu Z, Zhang T, Lin Z, Li Z, Zhang A, et al
. Loss of Lysyl Oxidase-like 3 Attenuates Embryonic Lung Development in Mice. Sci Rep. 2016;6:33856 pubmed publisher
Lysyl oxidase-like 3 (LOXL3), a human disease gene candidate, is a member of the lysyl oxidase (LOX) family and is indispensable for mouse palatogenesis and vertebral column development...
Ma L, Huang C, Wang X, Xin D, Wang L, Zou Q, et al
. Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation. Mol Cell. 2017;65:296-309 pubmed publisher
..LOX-like 3 (Loxl3) associates with Stat3 in the nucleus to deacetylate and deacetyliminate Stat3 on multiple acetyl-lysine sites...