Gene Symbol: LOC102642252
Description: uncharacterized LOC102642252
Alias: IgH, IgVH, immunoglobulin heavy chain V-region, immunoglobulin heavy chain variable region
Species: mouse

Top Publications

  1. Roy B, Shukla S, Łyszkiewicz M, Krey M, Viegas N, Düber S, et al. Somatic hypermutation in peritoneal B1b cells. Mol Immunol. 2009;46:1613-9 pubmed publisher
    ..This finding is consistent with the idea of a layered immune system in which peritoneal B1a and splenic follicular B2 cells appear at the two extremes and peritoneal B1b and B2 cells represent intermediates. ..
  2. Roy B, Agarwal S, Brennecke A, Krey M, Pabst O, Düber S, et al. B-1-cell subpopulations contribute differently to gut immunity. Eur J Immunol. 2013;43:2023-32 pubmed publisher
    ..This suggests that the contribution of natural unmutated IgA by B-1a cells to intestinal immunity is negligible. ..
  3. Imboden M, Riggs M, Schaefer D, Homan E, Bremel R. Antibodies fused to innate immune molecules reduce initiation of Cryptosporidium parvum infection in mice. Antimicrob Agents Chemother. 2010;54:1385-92 pubmed publisher
    ..The results lay the groundwork for the development of a new class of antimicrobials effective against Cryptosporidium. ..
  4. Queen C, Schneider W, Selick H, Payne P, Landolfi N, Duncan J, et al. A humanized antibody that binds to the interleukin 2 receptor. Proc Natl Acad Sci U S A. 1989;86:10029-33 pubmed
    ..These mouse amino acids were also retained in the humanized antibody. The humanized anti-Tac antibody has an affinity for p55 of 3 x 10(9) M-1, about 1/3 that of murine anti-Tac. ..
  5. van Der Keyl H, Hsu C, Tolat A, Kansil S, Dalesandro M, Dorer D, et al. Gene family use and somatic mutation in primary and secondary fluorescein-specific IgM antibody responses. Immunol Cell Biol. 1996;74:245-54 pubmed
    ..It appears that fusion of secondary cells, 3-6 days after immunization, is able to 'capture' the IgM-producing population of B cells at a stage in their development following mutation but prior to antigenic selection. ..
  6. Sorouri M, Fitzsimmons S, Aydanian A, Bennett S, Shapiro M. Diversity of the antibody response to tetanus toxoid: comparison of hybridoma library to phage display library. PLoS ONE. 2014;9:e106699 pubmed publisher
    ..Finally, the phage-derived tetanus-specific clones had a lower binding affinity than the hybridomas, a phenomenon thought to be the result of random pairing of the V-genes. ..
  7. Seidl K, Wilshire J, MacKenzie J, Kantor A, Herzenberg L. Predominant VH genes expressed in innate antibodies are associated with distinctive antigen-binding sites. Proc Natl Acad Sci U S A. 1999;96:2262-7 pubmed
    ..g., C57BL/6) have shown that anti-PtC antibodies are mainly encoded by the VH11 and VH12 immunoglobulin heavy chain variable region gene families...
  8. Reddy S, Ge X, Miklos A, Hughes R, Kang S, Hoi K, et al. Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells. Nat Biotechnol. 2010;28:965-9 pubmed publisher
    ..Antibodies generated in this manner from six mice, each immunized with one of three antigens were overwhelmingly antigen specific (21/27 or 78%). Those generated from a mouse with high serum titers had nanomolar binding affinities...
  9. Kretschmer K, Jungebloud A, Stopkowicz J, Kleinke T, Hoffmann R, Weiss S. The selection of marginal zone B cells differs from that of B-1a cells. J Immunol. 2003;171:6495-501 pubmed
    ..e., B-1 and marginal zone (MZ) B cells. The strongly oligoclonal IgH chain repertoire of Tg B-1a cells in such mice was attributed to strong positive selection by autoantigens...

More Information


  1. Kretschmer K, Engel H, Weiss S. Strong antigenic selection shaping the immunoglobulin heavy chain repertoire of B-1a lymphocytes in lambda 2(315) transgenic mice. Eur J Immunol. 2002;32:2317-27 pubmed
    ..study positive selection processes, we show that restriction to a single L chain results in a strongly oligoclonal IgH chain repertoire in fetal and neonatal liver-derived B cells, as well as in peritoneal CD5(+) B-1 lymphocytes from ..
  2. Prado C, Rodriguez M, Cortegano I, Ruiz C, Alía M, de Andres B, et al. Postnatal and adult immunoglobulin repertoires of innate-like CD19(+)CD45R(lo) B Cells. J Innate Immun. 2014;6:499-514 pubmed publisher
    ..Moreover, statistical models suggest that a proportion of the switched sequences in adult 19(+)45R(lo) cells had experienced antigen selection, unlike other innate-like B cell compartments. ..
  3. Rogosch T, Kerzel S, Sikula L, Gentil K, Liebetruth M, Schlingmann K, et al. Plasma cells and nonplasma B cells express differing IgE repertoires in allergic sensitization. J Immunol. 2010;184:4947-54 pubmed publisher
  4. Roy B, Brennecke A, Agarwal S, Krey M, Düber S, Weiss S. An intrinsic propensity of murine peritoneal B1b cells to switch to IgA in presence of TGF-? and retinoic acid. PLoS ONE. 2013;8:e82121 pubmed publisher
    ..Our study extends our knowledge about the existing differences among B cell subpopulations with regards to IgA production and indicates towards their differential contribution to gut associated humoral immunity. ..
  5. Xia Y, Wen W, Huang W, Huang B. Development of a phage displayed disulfide-stabilized Fv fragment vaccine against Vibrio anguillarum. Vaccine. 2005;23:3174-80 pubmed
    ..Thus, this phage-displayed dsFv may be used as vaccine against V. anguillarum in fishery. ..
  6. Trad A, Tanasa R, Lange H, Zemlin M, Schroeder H, Lemke H. Clonal Progression during the T Cell-Dependent B Cell Antibody Response Depends on the Immunoglobulin DH Gene Segment Repertoire. Front Immunol. 2014;5:385 pubmed publisher
    The diversity of the third complementarity determining region of the IgH chain is constrained by natural selection of immunoglobulin diversity (DH) sequence...
  7. Tas J, Mesin L, Pasqual G, Targ S, Jacobsen J, Mano Y, et al. Visualizing antibody affinity maturation in germinal centers. Science. 2016;351:1048-54 pubmed publisher
    ..Our findings have implications for development of vaccines in which antibodies with nonimmunodominant specificities must be elicited, as is the case for HIV-1 and influenza. ..
  8. Holodick N, Vizconde T, Hopkins T, Rothstein T. Age-Related Decline in Natural IgM Function: Diversification and Selection of the B-1a Cell Pool with Age. J Immunol. 2016;196:4348-57 pubmed publisher
    ..These results strongly suggest selection-induced skewing alters B-1a cell-derived natural Ab, which may in turn be responsible for the loss of natural IgM-mediated protection against pneumococcal infection. ..
  9. Rohatgi S, Dutta D, Tahir S, Sehgal D. Molecular dissection of antibody responses against pneumococcal surface protein A: evidence for diverse DH-less heavy chain gene usage and avidity maturation. J Immunol. 2009;182:5570-85 pubmed publisher
    ..ELISA additivity assay indicated that members within a group recognized topographically related epitopes. This study provides molecular insights into the biology of D(H)-less Abs. ..
  10. Lange H, Zemlin M, Tanasa R, Trad A, Weiss T, Menning H, et al. Thymus-independent type 2 antigen induces a long-term IgG-related network memory. Mol Immunol. 2008;45:2847-60 pubmed publisher
  11. Clarke S, Staudt L, Kavaler J, Schwartz D, Gerhard W, Weigert M. V region gene usage and somatic mutation in the primary and secondary responses to influenza virus hemagglutinin. J Immunol. 1990;144:2795-801 pubmed
    ..Secondary C4 antibodies are also encoded by the same Vk8-Jk5 gene segment and by diverse VH genes. Additional heterogeneity in the secondary response is caused by somatic mutation. ..
  12. Kretschmer K, Jungebloud A, Stopkowicz J, Stoermann B, Hoffmann R, Weiss S. Antibody repertoire and gene expression profile: implications for different developmental and functional traits of splenic and peritoneal B-1 lymphocytes. J Immunol. 2003;171:1192-201 pubmed
    ..Thus, splenic and peritoneal B-1a cells differ not only in their developmental program but also in functional properties. ..
  13. Haines B, Angeles C, Parmelee A, McLean P, Brodeur P. Germline diversity of the expressed BALB/c VhJ558 gene family. Mol Immunol. 2001;38:9-18 pubmed
    Although the mouse immunoglobulin heavy chain (Igh) locus contains 15 heavy chain V (Vh) gene families, at least half of the Vh gene segments are members of the VhJ558 family...
  14. Mihara M, Tan I, Chuzhin Y, Reddy B, Budhai L, Holzer A, et al. CTLA4Ig inhibits T cell-dependent B-cell maturation in murine systemic lupus erythematosus. J Clin Invest. 2000;106:91-101 pubmed
    ..High-dose CTLA4Ig did not induce permanent tolerance in this autoimmune disease model. Furthermore, although the mice survived in a conventional housing facility, treatment with Ad-CTLA4Ig was immunosuppressive. ..
  15. Lange H, Kobarg J, Yazynin S, Solterbeck M, Henningsen M, Hansen H, et al. Genetic analysis of the maternally induced affinity enhancement in the non-Ox1 idiotypic antibody repertoire of the primary immune response to 2-phenyloxazolone. Scand J Immunol. 1999;49:55-66 pubmed
  16. Shimoda M, Inoue Y, Ametani A, Fujiwara J, Tsuji N, Kurisaki J, et al. Anti-DNA IgA autoantibodies are spontaneously generated in mouse Peyer's patches. Immunology. 1998;95:200-7 pubmed
    ..Our findings suggest that even in normal healthy animals, anti-DNA antibodies of IgA isotype can be produced in certain peripheral environments such as in PP by spontaneous antigenic stimulation. ..
  17. Krishnan M, Jou N, Marion T. Correlation between the amino acid position of arginine in VH-CDR3 and specificity for native DNA among autoimmune antibodies. J Immunol. 1996;157:2430-9 pubmed
  18. Kavaler J, Caton A, Staudt L, Schwartz D, Gerhard W. A set of closely related antibodies dominates the primary antibody response to the antigenic site CB of the A/PR/8/34 influenza virus hemagglutinin. J Immunol. 1990;145:2312-21 pubmed
    ..The preferential participation of B cells expressing this VH/VK combination is largely responsible for the dominance of anti-Cb site antibodies in the primary anti-hemagglutinin response. ..