Lnpk

Summary

Gene Symbol: Lnpk
Description: lunapark, ER junction formation factor
Alias: 2310011O18Rik, 4921514L11Rik, 9530051D01Rik, AI666268, Lnp, Lnpk1, ulnaless, endoplasmic reticulum junction formation protein lunapark, protein lunapark, ER junction formation factor 1, ER junction formation factor lunapark, limb and neural patterns, protein ulnaless
Species: mouse
Products:     Lnpk

Top Publications

  1. Davisson M, Cattanach B. The mouse mutation ulnaless on chromosome 2. J Hered. 1990;81:151-3 pubmed
    The dominant skeletal mutation ulnaless (Ul) in the mouse causes extreme reduction of the radius and ulna and deformities of the tibia and fibula...
  2. Peichel C, Abbott C, Vogt T. Genetic and physical mapping of the mouse Ulnaless locus. Genetics. 1996;144:1757-67 pubmed
    The mouse Ulnaless locus is a semidominant mutation which displays defects in patterning along the proximal-distal and anterior-posterior axes of all four limbs...
  3. Herault Y, Fraudeau N, Zakany J, Duboule D. Ulnaless (Ul), a regulatory mutation inducing both loss-of-function and gain-of-function of posterior Hoxd genes. Development. 1997;124:3493-500 pubmed
    b>Ulnaless (Ul), an X-ray-induced dominant mutation in mice, severely disrupts development of forearms and forelegs...
  4. Spitz F, Gonzalez F, Duboule D. A global control region defines a chromosomal regulatory landscape containing the HoxD cluster. Cell. 2003;113:405-17 pubmed
    ..These domains were interrupted in the Ulnaless mutation, a balanced inversion that modified the topography of the locus...
  5. Peichel C, Prabhakaran B, Vogt T. The mouse Ulnaless mutation deregulates posterior HoxD gene expression and alters appendicular patterning. Development. 1997;124:3481-92 pubmed
    The semi-dominant mouse mutation Ulnaless alters patterning of the appendicular but not the axial skeleton. Ulnaless forelimbs and hindlimbs have severe reductions of the proximal limb and less severe reductions of the distal limb...
  6. Rusiniak M, O Brien E, Novak E, Barone S, McGarry M, Reddington M, et al. Molecular markers near the mouse brachymorphic (bm) gene, which affects connective tissues and bleeding time. Mamm Genome. 1996;7:98-102 pubmed
    ..Accordingly, three mouse mutants (brachymorphic [bm], hemimelic extra toes [Hx], and ulnaless [Ul]), with inherited skeletal abnormalities, were analyzed for hemorrhagic tendencies...
  7. Ruf S, Symmons O, Uslu V, Dolle D, Hot C, Ettwiller L, et al. Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor. Nat Genet. 2011;43:379-86 pubmed publisher
  8. Schorderet P, Duboule D. Structural and functional differences in the long non-coding RNA hotair in mouse and human. PLoS Genet. 2011;7:e1002071 pubmed publisher
    ..Alternatively, redundant or compensatory mechanisms may mask its function when studied under physiological conditions. ..
  9. Gross S, Krause Y, Wuelling M, Vortkamp A. Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice. PLoS ONE. 2012;7:e43553 pubmed publisher
    ..We analyzed forelimbs of Hoxa11(-/-);d11(-/-) and Ulnaless mice, which are characterized by specifically shortened zeugopods...

More Information

Publications12

  1. Montavon T, Thevenet L, Duboule D. Impact of copy number variations (CNVs) on long-range gene regulation at the HoxD locus. Proc Natl Acad Sci U S A. 2012;109:20204-11 pubmed publisher
    ..These results illustrate the detrimental consequences of interrupting highly conserved regulatory landscapes and reveal a mechanism where genomic duplications lead to partial loss of function of nearby located genes. ..
  2. Montavon T, Le Garrec J, Kerszberg M, Duboule D. Modeling Hox gene regulation in digits: reverse collinearity and the molecular origin of thumbness. Genes Dev. 2008;22:346-59 pubmed publisher
    ..We also show that the same model applies to the collinear regulation of Hox genes during the emergence of external genitalia, though with some differences likely illustrating the distinct functionalities of these structures in adults. ..
  3. Delpretti S, Montavon T, Leleu M, Joye E, Tzika A, Milinkovitch M, et al. Multiple enhancers regulate Hoxd genes and the Hotdog LncRNA during cecum budding. Cell Rep. 2013;5:137-50 pubmed publisher
    ..In this context, we discuss the implementation of a common "budding toolkit" between the cecum and the limbs. ..