Gene Symbol: Lmo2
Description: LIM domain only 2
Alias: Rbtn-2, Rbtn2, Rhom-2, Ttg2, rhombotin-2, LIM domain only protein 2, LIM only 2, LMO-2, T-cell translocation protein 2, cysteine-rich protein TTG-2
Species: mouse
Products:     Lmo2

Top Publications

  1. Manaia A, Lemarchandel V, Klaine M, Max Audit I, Romeo P, Dieterlen Lievre F, et al. Lmo2 and GATA-3 associated expression in intraembryonic hemogenic sites. Development. 2000;127:643-53 pubmed
    ..of definitive hemopoietic stem cells, we analysed the expression of the hemopoietic-related transcription factors Lmo2 and GATA-3 during the early steps of mouse development (7-12 dpc), with a particular emphasis on intraembryonic ..
  2. Cai Y, Xu Z, Xie J, Ham A, Koury M, Hiebert S, et al. Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine erythroid progenitors. Biochem Biophys Res Commun. 2009;390:295-301 pubmed publisher
    ..These results identify Eto2 and Mtgr1 as authentic interaction partners of Tal1 and suggest they act as heteromeric corepressors of this bHLH transcription factor during erythroid differentiation. ..
  3. Silver L, Palis J. Initiation of murine embryonic erythropoiesis: a spatial analysis. Blood. 1997;89:1154-64 pubmed
    ..erythropoiesis is decreased or abrogated by targeted disruption of the hematopoietic transcription factors tal-1, rbtn2, GATA-1, and GATA-2...
  4. Landry J, Kinston S, Knezevic K, Donaldson I, Green A, Gottgens B. Fli1, Elf1, and Ets1 regulate the proximal promoter of the LMO2 gene in endothelial cells. Blood. 2005;106:2680-7 pubmed
    ..We have used a comparative genomics approach to identify transcriptional regulatory elements of the LMO2 gene, a transcriptional cofactor originally identified through its involvement in T-cell leukemia and subsequently ..
  5. Forster A, Pannell R, Drynan L, McCormack M, Collins E, Daser A, et al. Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer. Cancer Cell. 2003;3:449-58 pubmed
    ..This de novo strategy is a direct recapitulation of naturally occurring human cancer-associated translocations. ..
  6. Foroni L, Boehm T, White L, Forster A, Sherrington P, Liao X, et al. The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development. J Mol Biol. 1992;226:747-61 pubmed
    ..identified at a chromosome translocation in a T-cell acute leukaemia and later used to isolate two related genes (RBTN2 or Ttg-2 and RBTN3)...
  7. DAVE U, Akagi K, Tripathi R, Cleveland S, THOMPSON M, Yi M, et al. Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy. PLoS Genet. 2009;5:e1000491 pubmed publisher
    ..an IL2RG-containing retrovirus subsequently developed T-cell leukemia and four contained insertional mutations at LMO2. Genetic evidence also suggests a role for IL2RG in tumor formation, although this remains controversial...
  8. Treanor L, Volanakis E, Zhou S, Lu T, Sherr C, Sorrentino B. Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies. Blood. 2011;117:5453-62 pubmed publisher
    b>LMO2 is a target of chromosomal translocations in T-cell tumors and was activated by retroviral vector insertions in T-cell tumors from X-SCID patients in gene therapy trials...
  9. Warren A, Colledge W, Carlton M, Evans M, Smith A, Rabbitts T. The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development. Cell. 1994;78:45-57 pubmed
    The LIM domain protein rbtn2 is associated with T cell acute leukemias...

More Information


  1. McCormack M, Young L, Vasudevan S, de Graaf C, Codrington R, Rabbitts T, et al. The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal. Science. 2010;327:879-83 pubmed publisher
    The LMO2 oncogene causes a subset of human T cell acute lymphoblastic leukemias (T-ALL), including four cases that arose as adverse events in gene therapy trials...
  2. Larson R, Fisch P, Larson T, Lavenir I, Langford T, King G, et al. T cell tumours of disparate phenotype in mice transgenic for Rbtn-2. Oncogene. 1994;9:3675-81 pubmed
    b>RBTN2 is a LIM domain protein which can be activated by the translocation t(11;14)(p13;q11) in childhood T cell acute leukaemia. Transgenic mice were examined in which rbtn2 protein is expressed in the T cell lineage...
  3. Drynan L, Hamilton T, Rabbitts T. T cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity. Oncogene. 2001;20:4412-5 pubmed
    The LMO2 gene is involved in T-cell acute leukaemia (T-ALL) in children with chromosomal translocations t(11;14)(p13;q11) or (7;11)(q35;p13)...
  4. Yamada Y, Pannell R, Forster A, Rabbitts T. The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis but not vasculogenesis in mice. Proc Natl Acad Sci U S A. 2000;97:320-4 pubmed
    The LMO2 gene is activated by chromosomal translocations in human T cell acute leukemias, but in mouse embryogenesis, Lmo2 is essential for initiation of yolk sac and definitive hematopoiesis...
  5. Yamada Y, Warren A, Dobson C, Forster A, Pannell R, Rabbitts T. The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis. Proc Natl Acad Sci U S A. 1998;95:3890-5 pubmed
    The LIM-finger protein Lmo2, which is activated in T cell leukemias by chromosomal translocations, is required for yolk sac erythropoiesis...
  6. Tatarek J, Cullion K, Ashworth T, Gerstein R, Aster J, Kelliher M. Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL. Blood. 2011;118:1579-90 pubmed publisher
    ..Thymic expression of the Tal1 and Lmo2 oncogenes in mice results in rapid development of T-ALL; and similar to T-ALL patients, more than half the leukemic ..
  7. Landry J, Bonadies N, Kinston S, Knezevic K, Wilson N, Oram S, et al. Expression of the leukemia oncogene Lmo2 is controlled by an array of tissue-specific elements dispersed over 100 kb and bound by Tal1/Lmo2, Ets, and Gata factors. Blood. 2009;113:5783-92 pubmed publisher
    The Lmo2 gene encodes a transcriptional cofactor critical for the development of hematopoietic stem cells...
  8. Tripic T, Deng W, Cheng Y, Zhang Y, Vakoc C, Gregory G, et al. SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood. 2009;113:2191-201 pubmed publisher
    ..in a conditional erythroid rescue system as well as through the use of tiling arrays we detected the SCL/TAL1, LMO2, Ldb1, E2A complex at all positively acting GATA-1-bound elements examined...
  9. Osada H, Grutz G, Axelson H, Forster A, Rabbitts T. Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. Proc Natl Acad Sci U S A. 1995;92:9585-9 pubmed
    The RBTN2 LIM-domain protein, originally identified as an oncogenic protein in human T-cell leukemia, is essential for erythropoiesis. A possible role for RBTN2 in transcription during erythropoiesis has been investigated...
  10. Ono Y, Fukuhara N, Yoshie O. TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3. Mol Cell Biol. 1998;18:6939-50 pubmed
    ..In this case, TAL1 and LMO act as cofactors for GATA3 to activate the transcription of RALDH2. ..
  11. Boehm T, Foroni L, Kaneko Y, Perutz M, Rabbitts T. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc Natl Acad Sci U S A. 1991;88:4367-71 pubmed
    ..The results define the rhombotin gene family as a class of T-cell oncogenes with duplicated cysteine-rich LIM domains. ..
  12. McCormack M, Forster A, Drynan L, Pannell R, Rabbitts T. The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development. Mol Cell Biol. 2003;23:9003-13 pubmed
    The LMO2 gene encodes a LIM-only protein and is a target of chromosomal translocations in human T-cell leukemia...
  13. Joshi K, Lee S, Lee B, Lee J, Lee S. LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons. Neuron. 2009;61:839-51 pubmed publisher
    ..Thus, LMO4 plays essential roles in directing a balanced generation of inhibitory and excitatory neurons in the ventral spinal cord. ..
  14. Triplett T, Cardenas K, Lancaster J, Hu Z, Selden H, Jasso G, et al. Endogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation. Proc Natl Acad Sci U S A. 2016;113:E1016-25 pubmed publisher
    ..Collectively, these studies provide the first evidence that endogenous tumor-associated DCs supply signals driving T-ALL growth, and implicate tumor-associated DCs and their mitogenic signals as auspicious therapeutic targets. ..
  15. Sum E, Peng B, Yu X, Chen J, Byrne J, Lindeman G, et al. The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity. J Biol Chem. 2002;277:7849-56 pubmed
    ..These findings reveal a novel complex between BRCA1, LMO4, and CtIP and indicate a role for LMO4 as a repressor of BRCA1 activity in breast tissue. ..
  16. Bhattacharya A, Chen C, Ho S, Mitchell J. Upstream distal regulatory elements contact the Lmo2 promoter in mouse erythroid cells. PLoS ONE. 2012;7:e52880 pubmed publisher
    The Lim domain only 2 (Lmo2) gene encodes a transcriptional cofactor critical for the development of hematopoietic stem cells...
  17. Tanaka A, Itoh F, Nishiyama K, Takezawa T, Kurihara H, Itoh S, et al. Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis. Blood. 2010;115:4138-47 pubmed publisher
    ..We also demonstrated that E2-2 can perturb VEGFR2 expression via inhibition of VEGFR2 promoter activity. This study suggests that E2-2 can maintain EC quiescence and that Id1 can counter this effect. ..
  18. Curtis D, McCormack M. The molecular basis of Lmo2-induced T-cell acute lymphoblastic leukemia. Clin Cancer Res. 2010;16:5618-23 pubmed publisher
    ..In a mouse model of one such oncogene, LMO2, the cellular effect is to induce self-renewal of committed T cells in the thymus, which persist long-term while ..
  19. Redmond L, Dumur C, Archer K, Haar J, Lloyd J. Identification of erythroid-enriched gene expression in the mouse embryonic yolk sac using microdissected cells. Dev Dyn. 2008;237:436-46 pubmed publisher
    ..One of these networks contains RBTN2/LMO2, SCL/TAL1, and EKLF/KLF1, three of the very few genes required for primitive erythropoiesis...
  20. Robb L, Lyons I, Li R, Hartley L, Kontgen F, Harvey R, et al. Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci U S A. 1995;92:7075-9 pubmed
    ..Transcripts of GATA-1 and PU.1 transcription factors were absent from RNA from scl-/- yolk sacs and embryos. These results implicate scl as a crucial regulator of early hematopoiesis. ..
  21. Deane J, Mackay J, Kwan A, Sum E, Visvader J, Matthews J. Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4. EMBO J. 2003;22:2224-33 pubmed
    b>LMO2 and LMO4 are members of a small family of nuclear transcriptional regulators that are important for both normal development and disease processes...
  22. Kenny D, Jurata L, Saga Y, Gill G. Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis. Proc Natl Acad Sci U S A. 1998;95:11257-62 pubmed
    LMO4 is a novel member of the LIM-only (LMO) subfamily of LIM domain-containing transcription factors. LMO1, LMO2, and LMO4 have distinct expression patterns in adult tissue, and we demonstrate that nuclear retention of LMO proteins is ..
  23. Bach I, Rodriguez Esteban C, Carriere C, Bhushan A, Krones A, Rose D, et al. RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat Genet. 1999;22:394-9 pubmed
    ..We conclude that Rlim is a novel corepressor that recruits histone deacetylase-containing complexes to the LIM domain. ..
  24. Calero Nieto F, Joshi A, Bonadies N, Kinston S, Chan W, Gudgin E, et al. HOX-mediated LMO2 expression in embryonic mesoderm is recapitulated in acute leukaemias. Oncogene. 2013;32:5471-80 pubmed publisher
    The Lim Domain Only 2 (LMO2) leukaemia oncogene encodes an LIM domain transcriptional cofactor required for early haematopoiesis...
  25. Remedios R, Subramanian L, Tole S. LIM genes parcellate the embryonic amygdala and regulate its development. J Neurosci. 2004;24:6986-90 pubmed
    ..The combinatorial expression patterns of LIM genes suggest a comprehensive mechanism for patterning this structure. ..
  26. Stanulovic V, Cauchy P, Assi S, Hoogenkamp M. LMO2 is required for TAL1 DNA binding activity and initiation of definitive haematopoiesis at the haemangioblast stage. Nucleic Acids Res. 2017;45:9874-9888 pubmed publisher
    b>LMO2 is a bridging factor within a DNA binding complex and is required for definitive haematopoiesis to occur. The developmental stage of the block in haematopoietic specification is not known...
  27. Maki K, Yamagata T, Asai T, Yamazaki I, Oda H, Hirai H, et al. Dysplastic definitive hematopoiesis in AML1/EVI1 knock-in embryos. Blood. 2005;106:2147-55 pubmed
    ..Maintained expression of PU.1 gene and decreased expression of LMO2 and SCL genes may explain the aberrant hematopoiesis in AML1/EVI1/+ fetal liver.
  28. Visvader J, Mao X, Fujiwara Y, Hahm K, Orkin S. The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. Proc Natl Acad Sci U S A. 1997;94:13707-12 pubmed
    The nuclear LIM domain protein LMO2, a T cell oncoprotein, is essential for embryonic erythropoiesis. LIM-only proteins are presumed to act primarily through protein-protein interactions...
  29. Draheim K, Hermance N, Yang Y, Arous E, Calvo J, Kelliher M. A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice. Oncogene. 2011;30:1252-60 pubmed publisher
    The most common translocation in childhood T-cell acute lymphoblastic leukemia (T-ALL) involves the LMO2 locus, resulting in ectopic expression of the LMO2 gene in human thymocytes...
  30. Dastmalchi S, Wilkinson White L, Kwan A, Gamsjaeger R, Mackay J, Matthews J. Solution structure of a tethered Lmo2(LIM2) /Ldb1(LID) complex. Protein Sci. 2012;21:1768-74 pubmed publisher
    LIM-only protein 2, Lmo2, is a regulatory protein that is essential for hematopoietic development and inappropriate overexpression of Lmo2 in T-cells contributes to T-cell leukemia...
  31. Maretzky T, McIlwain D, Issuree P, Li X, Malapeira J, Amin S, et al. iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding. Proc Natl Acad Sci U S A. 2013;110:11433-8 pubmed publisher
    ..Taken together, these findings uncover functions for iRhom2 in the regulation of EGFR signaling and in controlling the activation and substrate selectivity of ADAM17-dependent shedding events. ..
  32. Cano F, Pannel R, Follows G, Rabbitts T. Preclinical modeling of cytosine arabinoside response in Mll-Enl translocator mouse leukemias. Mol Cancer Ther. 2008;7:730-5 pubmed publisher
    ..This translocator model should therefore prove useful for future drug assessments against the recurrent mixed-lineage leukemia-associated translocations. ..
  33. Coma S, Allard Ratick M, Akino T, van Meeteren L, Mammoto A, Klagsbrun M. GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2. Angiogenesis. 2013;16:939-52 pubmed publisher
    GATA-binding protein 2 (GATA2) and LIM domain only 2 (Lmo2) form common transcription complexes during hematopoietic differentiation...
  34. Smith S, Tripathi R, Goodings C, Cleveland S, MATHIAS E, Hardaway J, et al. LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways. PLoS ONE. 2014;9:e85883 pubmed publisher
    The LMO2 oncogene is deregulated in the majority of human T-cell leukemia cases and in most gene therapy-induced T-cell leukemias. We made transgenic mice with enforced expression of Lmo2 in T-cells by the CD2 promoter/enhancer...
  35. Cleveland S, Goodings C, Tripathi R, Elliott N, Thompson M, Guo Y, et al. LMO2 induces T-cell leukemia with epigenetic deregulation of CD4. Exp Hematol. 2014;42:581-93.e5 pubmed publisher
    In this study, we present a remarkable clonal cell line, 32080, derived from a CD2-Lmo2- transgenic T-cell leukemia with differentiation arrest at the transition from the intermediate single positive to double positive stages of T-cell ..
  36. Shields B, Alserihi R, Nasa C, Bogue C, Alexander W, McCormack M. Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice. Leukemia. 2015;29:927-38 pubmed publisher
    b>Lmo2 is an oncogenic transcription factor that is frequently overexpressed in T-cell acute leukemias, in particular poor prognosis early T-cell precursor-like (ETP-) acute lymphoblastic leukemia (ALL)...
  37. Neale G, Rehg J, Goorha R. Ectopic expression of rhombotin-2 causes selective expansion of CD4-CD8- lymphocytes in the thymus and T-cell tumors in transgenic mice. Blood. 1995;86:3060-71 pubmed
  38. Lowsky R, DeCoteau J, Reitmair A, Ichinohasama R, Dong W, Xu Y, et al. Defects of the mismatch repair gene MSH2 are implicated in the development of murine and human lymphoblastic lymphomas and are associated with the aberrant expression of rhombotin-2 (Lmo-2) and Tal-1 (SCL). Blood. 1997;89:2276-82 pubmed
    ..Our findings implicate defects in the MMR system with the aberrant expression of T-cell specific proto-oncogenes and define a new pathway of human lymphomagenesis. ..
  39. Serewko Auret M, Mould A, Loffler K, Duncan R, Kay G, Hayward N. Alterations in gene expression in MEN1-associated insulinoma development. Pancreas. 2010;39:1140-6 pubmed publisher
    ..To identify gene expression alterations associated with insulinoma formation and progression in 2 mouse models of multiple endocrine neoplasia type 1...
  40. Nam C, Lobato M, Appert A, Drynan L, Tanaka T, Rabbitts T. An antibody inhibitor of the LMO2-protein complex blocks its normal and tumorigenic functions. Oncogene. 2008;27:4962-8 pubmed publisher
    The LIM-domain protein LMO2 is a T-cell oncogenic protein first recognized by gene activation through chromosomal translocations, but it is also responsible for leukaemias arising as secondary, adverse effects in an X-SCID gene therapy ..
  41. Drynan L, Pannell R, Forster A, Chan N, Cano F, Daser A, et al. Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis. EMBO J. 2005;24:3136-46 pubmed
    ..Therefore, a permissive cellular environment is required for oncogenicity of Mll-associated translocations and Mll fusions can influence haematopoietic lineage commitment. ..
  42. Wilkinson D, Neale G, Mao S, Naeve C, Goorha R. Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia. Leukemia. 1997;11:86-96 pubmed
    ..In contrast, when RBTN-2 is inappropriately expressed in T cells, RBTN-2 would interact predominantly with elf-2b; this interaction may lead to T cell proliferation. ..
  43. Tsunoda T, Takashima Y, Tanaka Y, Fujimoto T, Doi K, Hirose Y, et al. Immune-related zinc finger gene ZFAT is an essential transcriptional regulator for hematopoietic differentiation in blood islands. Proc Natl Acad Sci U S A. 2010;107:14199-204 pubmed publisher
    TAL1 plays pivotal roles in vascular and hematopoietic developments through the complex with LMO2 and GATA1...
  44. Barlow J, Drynan L, Hewett D, Holmes L, Lorenzo Abalde S, Lane A, et al. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Nat Med. 2010;16:59-66 pubmed publisher
    ..This mouse model suggests that a p53-dependent mechanism underlies the pathophysiology of the 5q- syndrome. ..
  45. Horos R, Ijspeert H, Pospisilova D, Sendtner R, Andrieu Soler C, Taskesen E, et al. Ribosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblasts. Blood. 2012;119:262-72 pubmed publisher
    ..Our data suggest that impaired internal ribosomal entry site-mediated translation of mRNAs expressed at increased levels in erythroblasts contributes to the erythroid phenotype of DBA. ..
  46. Giroux S, Alves Leiva C, Lecluse Y, Martin P, Albagli O, Godin I. Gene transfer to pre-hematopoietic and committed hematopoietic precursors in the early mouse yolk sac: a comparative study between in situ electroporation and retroviral transduction. BMC Dev Biol. 2007;7:79 pubmed
    ..We thus designed and compared transduction protocols to target either native extra-embryonic precursors, or hematopoietic precursors...
  47. Deng M, Pan L, Xie X, Gan L. Differential expression of LIM domain-only (LMO) genes in the developing mouse inner ear. Gene Expr Patterns. 2006;6:857-63 pubmed
    ..b>LMO2 expression is detected in the periotic mesenchyme of the developing mouse cochlea from E12.5 to E14.5...
  48. Lecuyer E, Larivière S, Sincennes M, Haman A, Lahlil R, Todorova M, et al. Protein stability and transcription factor complex assembly determined by the SCL-LMO2 interaction. J Biol Chem. 2007;282:33649-58 pubmed
    ..The basic helix-loop-helix factor SCL and the LIM-only protein LMO2 are components of transcription factor complexes that are essential for hematopoiesis...
  49. Bulchand S, Grove E, Porter F, Tole S. LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem. Mech Dev. 2001;100:165-75 pubmed
    ..The defect in the Lhx2-/- telencephalon appears to be at this step. ..
  50. Meier N, Krpic S, Rodriguez P, Strouboulis J, Monti M, Krijgsveld J, et al. Novel binding partners of Ldb1 are required for haematopoietic development. Development. 2006;133:4913-23 pubmed
    ..It interacts with Gata1, Tal1, E2A and Lmo2 to form a transcription factor complex regulating late erythroid genes...
  51. Brooke Bisschop T, Savory J, Foley T, Ringuette R, Lohnes D. Essential roles for Cdx in murine primitive hematopoiesis. Dev Biol. 2017;422:115-124 pubmed publisher
    ..These findings demonstrate critical roles for Cdx members in murine primitive hematopoiesis upstream of Scl. ..
  52. Harel I, Maezawa Y, Avraham R, Rinon A, Ma H, Cross J, et al. Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis. Proc Natl Acad Sci U S A. 2012;109:18839-44 pubmed publisher
    ..We suggest that PM-derived cardiogenesis and myogenesis are network properties rather than properties specific to individual PM members. These findings shed new light on the developmental underpinnings of congenital defects. ..
  53. Koyano Nakagawa N, Kweon J, Iacovino M, Shi X, Rasmussen T, Borges L, et al. Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression. Stem Cells. 2012;30:1611-23 pubmed publisher
    ..induces the hematopoietic and the endothelial lineages, and transcriptional profiling in this context identifies Lmo2 as a downstream target...
  54. Tondeleir D, Drogat B, Slowicka K, Bakkali K, Bartunkova S, Goossens S, et al. Beta-Actin Is Involved in Modulating Erythropoiesis during Development by Fine-Tuning Gata2 Expression Levels. PLoS ONE. 2013;8:e67855 pubmed publisher
    ..These results provide new molecular insights for a novel function of beta-actin in erythropoiesis by modulating the expression levels of Gata2 in vivo. ..
  55. Beisaw A, Tsaytler P, Koch F, Schmitz S, Melissari M, Senft A, et al. BRACHYURY directs histone acetylation to target loci during mesoderm development. EMBO Rep. 2018;19:118-134 pubmed publisher
    ..We show that this role of T is mediated, at least in part, through activation of a distal Lmo2 enhancer.
  56. Nagamachi A, Htun P, Ma F, Miyazaki K, Yamasaki N, Kanno M, et al. A 5' untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model. Dev Biol. 2010;345:226-36 pubmed publisher
    ..The findings reported here demonstrate the essential roles of the IRES element in Runx1 function under physiological and pathological conditions. ..
  57. Venkitachalam S, Chueh F, Yu C. Nuclear localization of lymphocyte-specific protein tyrosine kinase (Lck) and its role in regulating LIM domain only 2 (Lmo2) gene. Biochem Biophys Res Commun. 2012;417:1058-62 pubmed publisher
    b>LIM domain only protein 2 (Lmo2) is a transcription factor that plays a critical role in the development of T-acute lymphoblastic leukemia (T-ALL)...
  58. Terano T, Zhong Y, Toyokuni S, Hiai H, Yamada Y. Transcriptional control of fetal liver hematopoiesis: dominant negative effect of the overexpression of the LIM domain mutants of LMO2. Exp Hematol. 2005;33:641-51 pubmed
    The LIM-finger protein LMO2 forms a transcription factor complex with other hematopoietic regulator proteins, such as TAL1 (SCL), LDB1, GATA1, 2, and 3, in the promoters of several erythroid genes...
  59. McCormack M, Shields B, Jackson J, Nasa C, Shi W, Slater N, et al. Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL. Blood. 2013;122:2093-103 pubmed publisher
    b>Lmo2 is an oncogenic transcription factor that is frequently overexpressed in T-cell acute lymphoblastic leukemia (T-ALL), including early T-cell precursor ALL (ETP-ALL) cases with poor prognosis...
  60. Landry J, Kinston S, Knezevic K, de Bruijn M, Wilson N, Nottingham W, et al. Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver. Blood. 2008;111:3005-14 pubmed publisher
    Transcription factors such as Scl/Tal1, Lmo2, and Runx1 are essential for the development of hematopoietic stem cells (HSCs)...
  61. Bulchand S, Subramanian L, Tole S. Dynamic spatiotemporal expression of LIM genes and cofactors in the embryonic and postnatal cerebral cortex. Dev Dyn. 2003;226:460-9 pubmed
    ..These results suggest multiple and distinct roles for LIM-HD, Lmo, and Clim genes in cortical development, and also support a LIM-HD-independent role for some Lmo and Clim members. ..
  62. Delassus S, Titley I, Enver T. Functional and molecular analysis of hematopoietic progenitors derived from the aorta-gonad-mesonephros region of the mouse embryo. Blood. 1999;94:1495-503 pubmed
    ..Additionally, most cells coexpress the stem cell-associated transcriptional regulators AML-1, PU.1, GATA-2 and Lmo2, as well as the granulocyte colony-stimulating factor receptor (G-CSF-R)...
  63. Tremblay C, Brown F, Collett M, Saw J, Chiu S, Sonderegger S, et al. Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling. Leukemia. 2016;30:1993-2001 pubmed publisher
    ..To determine the effects of DNM2 mutations in T-ALL, we bred the Dnm2V265G mice with the Lmo2 transgenic mouse model of T-ALL...
  64. Shivdasani R, Mayer E, Orkin S. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature. 1995;373:432-4 pubmed
    ..belong to diverse protein families and may normally be expressed widely (for example, Ttg-1/rbtn1, Ttg-2/rbtn2), exclusively outside the haematopoietic system (for example, Hox11), or specifically in haematopoietic cells and ..
  65. Hinks G, Shah B, French S, Campos L, Staley K, Hughes J, et al. Expression of LIM protein genes Lmo1, Lmo2, and Lmo3 in adult mouse hippocampus and other forebrain regions: differential regulation by seizure activity. J Neurosci. 1997;17:5549-59 pubmed
    ..Lmo1, Lmo2, and Lmo3 are LIM-only genes originally identified as putative oncogenes that have been implicated in the control ..