Gene Symbol: Lman1
Description: lectin, mannose-binding, 1
Alias: 2610020P13Rik, AI326273, AU043785, C730041J05, ERGIC53, F5F8D, MCFD1, MR60, P58, gp58, protein ERGIC-53, ER-Golgi intermediate compartment 53 kDa protein
Species: mouse
Products:     Lman1

Top Publications

  1. Renna M, Caporaso M, Bonatti S, Kaufman R, Remondelli P. Regulation of ERGIC-53 gene transcription in response to endoplasmic reticulum stress. J Biol Chem. 2007;282:22499-512 pubmed
    ..A molecular model for the transcriptional regulation of the ERGIC-53 gene is proposed. ..
  2. Nakajima K, Takei Y, Tanaka Y, Nakagawa T, Nakata T, Noda Y, et al. Molecular motor KIF1C is not essential for mouse survival and motor-dependent retrograde Golgi apparatus-to-endoplasmic reticulum transport. Mol Cell Biol. 2002;22:866-73 pubmed
    ..This retrograde membrane transport was further confirmed to be normal by time-lapse analysis. Consequently, KIF1C is dispensable for the motor-dependent retrograde transport from the Golgi apparatus to the ER. ..
  3. Nichols R, Traktman P. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. J Biol Chem. 2004;279:7934-46 pubmed
    ..Our findings provide the basis for further studies of the structure and function of this newly discovered family of protein kinases. ..
  4. Everett L, Cleuren A, Khoriaty R, Ginsburg D. Murine coagulation factor VIII is synthesized in endothelial cells. Blood. 2014;123:3697-705 pubmed publisher
    ..b>LMAN1 is a cargo receptor in the early secretory pathway that is responsible for the efficient secretion of factor V (FV)..
  5. Hao H, Gregorski J, Qian H, Li Y, Gao C, Idrees S, et al. In vivo function of the ER-Golgi transport protein LMAN1 in photoreceptor homeostasis. Adv Exp Med Biol. 2014;801:395-9 pubmed publisher
    b>LMAN1 is a type I transmembrane protein that selectively transports its cargo proteins from ER to ER-Golgi intermediate compartment (ERGIC) and Golgi. Lman1 is a direct target of the transcription factor NRL in mouse retina...
  6. Renna M, Faraonio R, Bonatti S, De Stefano D, Carnuccio R, Tajana G, et al. Nitric oxide-induced endoplasmic reticulum stress activates the expression of cargo receptor proteins and alters the glycoprotein transport to the Golgi complex. Int J Biochem Cell Biol. 2006;38:2040-8 pubmed
  7. Garver W, Heidenreich R, Erickson R, Thomas M, Wilson J. Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments. J Lipid Res. 2000;41:673-87 pubmed
  8. Esselens C, Oorschot V, Baert V, Raemaekers T, Spittaels K, Serneels L, et al. Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. J Cell Biol. 2004;166:1041-54 pubmed
    ..Collectively, PS1 deficiency affects in a gamma-secretase-independent fashion the turnover of TLN through autophagic vacuoles, most likely by an impaired capability to fuse with lysosomes. ..
  9. Valkova C, Albrizio M, Röder I, Schwake M, Betto R, Rudolf R, et al. Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled alpha-subunits. Proc Natl Acad Sci U S A. 2011;108:621-5 pubmed publisher
    ..Our data show that Rer1 is a functionally important unique factor that controls surface expression of muscle acetylcholine receptors by localizing unassembled ?-subunits to the early secretory pathway. ..

More Information


  1. Teng Y, Rezvani K, De Biasi M. UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP. Biochem Pharmacol. 2015;97:518-530 pubmed publisher
    ..Overall,we identify CHIP as an E3 ligase for α3 and UBXN2A as a protein that may efficiently regulate the stability of CHIP's client substrates. ..
  2. Nishiguchi S, Sakuma R, Nomura M, Zou Z, Jearanaisilavong J, Joh T, et al. A catalogue of genes in mouse embryonal carcinoma F9 cells identified with expressed sequence tags. J Biochem. 1996;119:749-67 pubmed
    ..Cataloguing of the genes expressed in the F9 cells paves the way for isolating genes involved in early mammalian development. ..
  3. Jang C, Shibata Y, Starmer J, Yee D, Magnuson T. Histone H3.3 maintains genome integrity during mammalian development. Genes Dev. 2015;29:1377-92 pubmed publisher
    ..In summary, our results reveal that an important function of H3.3 is to support chromosomal heterochromatic structures, thus maintaining genome integrity during mammalian development. ..
  4. Zhang B, Zheng C, Zhu M, Tao J, Vasievich M, Baines A, et al. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of ?1-antitrypsin. Blood. 2011;118:3384-91 pubmed publisher
    ..Mutations in either LMAN1 or MCFD2 cause the combined deficiency of factor V (FV) and factor VIII (FVIII; F5F8D), suggesting an ER-to-Golgi cargo receptor function for the LMAN1-MCFD2 complex...
  5. Merte J, Jensen D, Wright K, Sarsfield S, Wang Y, Schekman R, et al. Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure. Nat Cell Biol. 2010;12:41-6; sup pp 1-8 pubmed publisher
    ..Thus, during COPII vesicle formation, Sec24b shows cargo specificity for a core PCP component, Vangl2, of which proper ER-to-Golgi transport is essential for the establishment of PCP, convergent extension and closure of the neural tube. ..
  6. Palaniyar N, Nadesalingam J, Clark H, Shih M, Dodds A, Reid K. Nucleic acid is a novel ligand for innate, immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin. J Biol Chem. 2004;279:32728-36 pubmed
    ..Collectins may therefore play an important role in decreasing the inflammation caused by DNA in lungs and other tissues. ..
  7. Mattioli L, Anelli T, Fagioli C, Tacchetti C, Sitia R, Valetti C. ER storage diseases: a role for ERGIC-53 in controlling the formation and shape of Russell bodies. J Cell Sci. 2006;119:2532-41 pubmed
    ..Our findings identify a novel ERGIC-53 substrate, and indicate that interactions with light chains or ERGIC-53 seed muDeltaCH1 condensation in different stations of the early secretory pathway. ..
  8. Nori A, Bortoloso E, Frasson F, Valle G, Volpe P. Vesicle budding from endoplasmic reticulum is involved in calsequestrin routing to sarcoplasmic reticulum of skeletal muscles. Biochem J. 2004;379:505-12 pubmed
    ..It also appears that CS routing from ER to SR does not involve classical secretory pathways through ER-Golgi intermediate compartments, cis -medial Golgi and trans -Golgi network. ..
  9. Uemura K, Saka M, Nakagawa T, Kawasaki N, Thiel S, Jensenius J, et al. L-MBP is expressed in epithelial cells of mouse small intestine. J Immunol. 2002;169:6945-50 pubmed
    ..These findings suggest that L-MBP plays a role in mucosal innate immunity. ..
  10. Velloso L, Svensson K, Schneider G, Pettersson R, Lindqvist Y. Crystal structure of the carbohydrate recognition domain of p58/ERGIC-53, a protein involved in glycoprotein export from the endoplasmic reticulum. J Biol Chem. 2002;277:15979-84 pubmed
    b>p58/ERGIC-53 is an animal calcium-dependent lectin that cycles between the endoplasmic reticulum (ER) and the Golgi complex and appears to act as a cargo receptor for a subset of soluble glycoproteins exported from the ER...