Lif

Summary

Gene Symbol: Lif
Description: leukemia inhibitory factor
Alias: leukemia inhibitory factor, d factor, differentiation-stimulating factor, myeloid leukaemia inhibitory factor
Species: mouse
Products:     Lif

Top Publications

  1. Escary J, Perreau J, Dumenil D, Ezine S, Brulet P. Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation. Nature. 1993;363:361-4 pubmed
    Leukaemia inhibitory factor (LIF) has a variety of effects on different cell types in vitro, inhibiting the differentiation of embryonic stem cells and promoting the survival and/or proliferation of primitive haematopoietic precursors ..
  2. Yin T, Yang Y. Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells. J Biol Chem. 1994;269:3731-8 pubmed
    The mechanisms of signaling pathways shared by interleukin (IL)-11, IL-6, leukemia inhibitory factor (LIF), and oncostatin M (ONC) remain elusive...
  3. Waring P, Waring L, Billington T, Metcalf D. Leukemia inhibitory factor protects against experimental lethal Escherichia coli septic shock in mice. Proc Natl Acad Sci U S A. 1995;92:1337-41 pubmed
    b>Leukemia inhibitory factor (LIF) has recently been associated with septic shock in humans. In this study we sought to determine, in mice, the role of LIF in septic shock...
  4. Li Y, McClintick J, Zhong L, Edenberg H, Yoder M, Chan R. Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4. Blood. 2005;105:635-7 pubmed
    Embryonic stem (ES) cells homozygous for a Shp-2 mutation (Shp-2(Delta46-110)) demonstrate leukemia inhibitory factor (LIF) hypersensitivity and increased LIF-stimulated phosphorylation of signal transducer and activator of transcription (..
  5. Ueki Y, Wang J, Chollangi S, Ash J. STAT3 activation in photoreceptors by leukemia inhibitory factor is associated with protection from light damage. J Neurochem. 2008;105:784-96 pubmed
    Members of the interleukin-6 cytokine family, including leukemia inhibitory factor (LIF), signal through gp130...
  6. Niwa H, Ogawa K, Shimosato D, Adachi K. A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells. Nature. 2009;460:118-22 pubmed publisher
    The cytokine leukaemia inhibitory factor (LIF) integrates signals into mouse embryonic stem (ES) cells to maintain pluripotency...
  7. Fouladi Nashta A, Andreu C, Nijjar N, Heath J, Kimber S. Role of leukemia inhibitor factor (LIF) in decidualisation of murine uterine stromal cells in vitro. J Endocrinol. 2004;181:477-92 pubmed
    ..b>Leukemia inhibitory factor (LIF) was then examined, but it had no effect on PGE(2) secretion...
  8. Bauer S, Rasika S, Han J, Mauduit C, Raccurt M, Morel G, et al. Leukemia inhibitory factor is a key signal for injury-induced neurogenesis in the adult mouse olfactory epithelium. J Neurosci. 2003;23:1792-803 pubmed
    ..We find that, of many potential mitogenic signals, only leukemia inhibitory factor (LIF) is induced before the onset of neuronal progenitor proliferation...
  9. Emery B, Cate H, Marriott M, Merson T, Binder M, Snell C, et al. Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination. Proc Natl Acad Sci U S A. 2006;103:7859-64 pubmed
    Enhancement of oligodendrocyte survival through activation of leukemia inhibitory factor receptor (LIFR) signaling is a candidate therapeutic strategy for demyelinating disease...

More Information

Publications86

  1. Butzkueven H, Emery B, Cipriani T, Marriott M, Kilpatrick T. Endogenous leukemia inhibitory factor production limits autoimmune demyelination and oligodendrocyte loss. Glia. 2006;53:696-703 pubmed
    ..we utilize murine autoimmune encephalomyelitis (EAE) to focus on the effect of endogenously produced leukemia inhibitory factor (LIF) upon mature oligodendrocyte survival after demyelinating injury...
  2. Chesnokova V, Auernhammer C, Melmed S. Murine leukemia inhibitory factor gene disruption attenuates the hypothalamo-pituitary-adrenal axis stress response. Endocrinology. 1998;139:2209-16 pubmed
    ..human fetal pituitary, mouse corticotroph AtT20 cells, and murine hypothalamus and pituitary express leukemia inhibitory factor (LIF)...
  3. Boeuf H, Hauss C, Graeve F, Baran N, Kedinger C. Leukemia inhibitory factor-dependent transcriptional activation in embryonic stem cells. J Cell Biol. 1997;138:1207-17 pubmed
    ..The leukemia inhibitory factor (LIF) mediates pleiotropic and sometimes opposite effects both in vivo and in cultured cells...
  4. Bürgi S, Samardzija M, Grimm C. Endogenous leukemia inhibitory factor protects photoreceptor cells against light-induced degeneration. Mol Vis. 2009;15:1631-7 pubmed
    Expression of leukemia inhibitory factor (LIF) by a subset of Müller glia cells has recently been implicated in an endogenous survival response to photoreceptor injury in a model of inherited retinal degeneration...
  5. Bauer S, Patterson P. Leukemia inhibitory factor promotes neural stem cell self-renewal in the adult brain. J Neurosci. 2006;26:12089-99 pubmed
    ..We analyzed the effects of overexpressing the cytokine leukemia inhibitory factor (LIF) on adult neurogenesis in the normal brain...
  6. Mohamet L, Heath J, Kimber S. Determining the LIF-sensitive period for implantation using a LIF-receptor antagonist. Reproduction. 2009;138:827-36 pubmed publisher
    Uteri of Lif null mice do not support embryo implantation...
  7. Yang Z, Le S, Chen D, Cota J, Siero V, Yasukawa K, et al. Leukemia inhibitory factor, LIF receptor, and gp130 in the mouse uterus during early pregnancy. Mol Reprod Dev. 1995;42:407-14 pubmed
    b>Leukemia inhibitory factor (LIF) has been shown to play an important role in the implantation of mouse blastocysts...
  8. Ho L, Miller E, Ronan J, Ho W, Jothi R, Crabtree G. esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function. Nat Cell Biol. 2011;13:903-13 pubmed publisher
    Signalling by the cytokine LIF and its downstream transcription factor, STAT3, prevents differentiation of pluripotent embryonic stem cells (ESCs). This contrasts with most cell types where STAT3 signalling induces differentiation...
  9. Cartwright P, McLean C, Sheppard A, Rivett D, Jones K, Dalton S. LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism. Development. 2005;132:885-96 pubmed
    Murine ES cells can be maintained as a pluripotent, self-renewing population by LIF/STAT3-dependent signaling. The downstream effectors of this pathway have not been previously defined...
  10. Moidunny S, Dias R, Wesseling E, Sekino Y, Boddeke H, Sebastião A, et al. Interleukin-6-type cytokines in neuroprotection and neuromodulation: oncostatin M, but not leukemia inhibitory factor, requires neuronal adenosine A1 receptor function. J Neurochem. 2010;114:1667-77 pubmed publisher
    ..We now have investigated whether two other IL-6-type cytokines [oncostatin M (OSM) and leukemia inhibitory factor (LIF)] use a similar mechanism...
  11. Leibinger M, Müller A, Andreadaki A, Hauk T, Kirsch M, Fischer D. Neuroprotective and axon growth-promoting effects following inflammatory stimulation on mature retinal ganglion cells in mice depend on ciliary neurotrophic factor and leukemia inhibitory factor. J Neurosci. 2009;29:14334-41 pubmed publisher
    ..Interestingly, retinal LIF expression was correlated with CNTF expression after LI...
  12. Pitman M, Emery B, Binder M, Wang S, Butzkueven H, Kilpatrick T. LIF receptor signaling modulates neural stem cell renewal. Mol Cell Neurosci. 2004;27:255-66 pubmed
    Activation of the leukemia inhibitory factor (LIF) receptor has been reported to promote gliogenesis and also to support neural stem cell (NSC) renewal...
  13. Shimazaki T, Shingo T, Weiss S. The ciliary neurotrophic factor/leukemia inhibitory factor/gp130 receptor complex operates in the maintenance of mammalian forebrain neural stem cells. J Neurosci. 2001;21:7642-53 pubmed
    ..through the common receptor subunit gp130, including ciliary neurotrophic factor (CNTF), interleukin-6, leukemia inhibitory factor (LIF) and oncostatin M, have pleiotropic functions in CNS development...
  14. Holmberg K, Patterson P. Leukemia inhibitory factor is a key regulator of astrocytic, microglial and neuronal responses in a low-dose pilocarpine injury model. Brain Res. 2006;1075:26-35 pubmed
    ..One of these candidates is leukemia inhibitory factor (LIF), a pro-inflammatory cytokine that is induced in astrocytes by brain damage or seizure...
  15. Cohen J, Fields R. Activity-dependent neuron-glial signaling by ATP and leukemia-inhibitory factor promotes hippocampal glial cell development. Neuron Glia Biol. 2008;4:43-55 pubmed publisher
    ..The pro-inflammatory cytokine, leukemia-inhibitory factor (LIF), is transiently expressed postnatally by glial cells in the hippocampus and rapidly up-regulated by enhanced ..
  16. Ruan H, Zhu X, Luo Q, Liu A, Qian Y, Zhou C, et al. Ovarian stimulation with GnRH agonist, but not GnRH antagonist, partially restores the expression of endometrial integrin beta3 and leukaemia-inhibitory factor and improves uterine receptivity in mice. Hum Reprod. 2006;21:2521-9 pubmed
    ..effects of different OS on the expression of endometrial integrin beta3 subunit and leukaemia-inhibitory factor (LIF) during the implantation window and the implantation rate in mice were investigated...
  17. Bugga L, Gadient R, Kwan K, Stewart C, Patterson P. Analysis of neuronal and glial phenotypes in brains of mice deficient in leukemia inhibitory factor. J Neurobiol. 1998;36:509-24 pubmed
    b>Leukemia inhibitory factor (LIF) can regulate the survival and differentiation of certain neurons and glial cells in culture...
  18. Cao W, Yang Y, Wang Z, Liu A, Fang L, Wu F, et al. Leukemia inhibitory factor inhibits T helper 17 cell differentiation and confers treatment effects of neural progenitor cell therapy in autoimmune disease. Immunity. 2011;35:273-84 pubmed publisher
    ..b>Leukemia inhibitory factor (LIF) produced by NPCs was responsible for the observed EAE suppression...
  19. Shuya L, Menkhorst E, Yap J, Li P, Lane N, Dimitriadis E. Leukemia inhibitory factor enhances endometrial stromal cell decidualization in humans and mice. PLoS ONE. 2011;6:e25288 pubmed publisher
    ..Here, we investigated the role of leukemia inhibitory factor (LIF) in human and murine decidualization...
  20. Sendtner M, Gotz R, Holtmann B, Escary J, Masu Y, Carroll P, et al. Cryptic physiological trophic support of motoneurons by LIF revealed by double gene targeting of CNTF and LIF. Curr Biol. 1996;6:686-94 pubmed
    ..Leukaemia inhibitory factor (LIF) has been demonstrated to support motoneuron survival in vitro and in vivo under different experimental conditions...
  21. Joly S, Lange C, Thiersch M, Samardzija M, Grimm C. Leukemia inhibitory factor extends the lifespan of injured photoreceptors in vivo. J Neurosci. 2008;28:13765-74 pubmed publisher
    ..We show in two models of retinal degeneration that photoreceptor death strongly induces expression of leukemia inhibitory factor (LIF) in a subset of Muller glia cells in the inner nuclear layer of the retina...
  22. Stewart C, Kaspar P, Brunet L, Bhatt H, Gadi I, Kontgen F, et al. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature. 1992;359:76-9 pubmed
    ..We have previously shown that a cytokine, leukaemia inhibitory factor (LIF), is expressed in the uterine endometrial glands specifically on the fourth day of pregnancy...
  23. Quinton L, Mizgerd J, Hilliard K, Jones M, Kwon C, Allen E. Leukemia inhibitory factor signaling is required for lung protection during pneumonia. J Immunol. 2012;188:6300-8 pubmed publisher
    ..STAT3 signaling is essential for controlling lung injury during pneumonia. We previously identified LIF as a prominent STAT3-activating cytokine expressed in the airspaces of pneumonic lungs, but its physiological ..
  24. Brown M, Metcalf D, Gough N. Leukaemia inhibitory factor and interleukin 6 are expressed at very low levels in the normal adult mouse and are induced by inflammation. Cytokine. 1994;6:300-9 pubmed
    ..Using PCR, the in vivo expression patterns of the cytokines Leukaemia Inhibitory Factor (LIF) and Interleukin 6 (IL-6) in the normal adult mouse, have been examined...
  25. Piquet Pellorce C, Grey L, Mereau A, Heath J. Are LIF and related cytokines functionally equivalent?. Exp Cell Res. 1994;213:340-7 pubmed
    b>Leukemia inhibitory factor (LIF) is structurally related to interleukin-6 (IL-6), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF)...
  26. Weber M, Schnyder Candrian S, Schnyder B, Quesniaux V, Poli V, Stewart C, et al. Endogenous leukemia inhibitory factor attenuates endotoxin response. Lab Invest. 2005;85:276-84 pubmed
    b>Leukemia inhibitory factor (LIF) is induced in inflammation and likely plays a regulatory role. Using LIF-deficient mice (LIF-/-), we report here that endogenous LIF has a protective role in endotoxic shock and host defence...
  27. Rocha Resende C, Guedes de Jesus I, Roman Campos D, Miranda A, Alves F, Resende R, et al. Absence of suppressor of cytokine signaling 2 turns cardiomyocytes unresponsive to LIF-dependent increases in Ca2+ levels. Am J Physiol Cell Physiol. 2017;312:C478-C486 pubmed publisher
    ..We investigated the consequences of SOCS2 ablation for leukemia inhibitory factor (LIF)-induced enhancement of intracellular Ca2+ ([Ca2+]i) transient by ..
  28. Nicola N, Cross B, Simpson R. The disulfide bond arrangement of leukemia inhibitory factor: homology to oncostatin M and structural implications. Biochem Biophys Res Commun. 1993;190:20-6 pubmed
    Murine leukemia inhibitory factor (LIF) (the fully active recombinant form produced in E. coli) was digested in the unreduced state with trypsin and Staphylococcal V8 protease in 0.05% sodium dodecyl sulfate...
  29. Kanatsu Shinohara M, Inoue K, Ogonuki N, Miki H, Yoshida S, Toyokuni S, et al. Leukemia inhibitory factor enhances formation of germ cell colonies in neonatal mouse testis culture. Biol Reprod. 2007;76:55-62 pubmed
    ..In the present study, we examined the role of leukemia inhibitory factor (LIF) in GS cell culture...
  30. Wang S, Sun Y, Wu Y, Zhang T, Hu C, Zhang B, et al. Down-regulation of uterine LIF expression induced by the hormonal level disorder causes embryo implantation loss after mice exposed to carbon disulfide at peri-implantation. Biochem Biophys Res Commun. 2015;467:7-13 pubmed publisher
    ..b>Leukemia inhibitory factor (LIF) in maternal uterine tissue is involved in embryo implantation, which is produced by endometrium ..
  31. Quinn C, Detmar J, Casper R. Pinopodes are present in Lif null and Hoxa10 null mice. Fertil Steril. 2007;88:1021-8 pubmed
    To assess pinopode formation in Lif null and Hoxa10 null mice with infertility secondary to failed implantation. Controlled animal experiment. Animal research and laboratory facility...
  32. Zhao L, Hart S, Cheng J, Melenhorst J, Bierie B, Ernst M, et al. Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK. J Biol Chem. 2004;279:44093-100 pubmed
    ..death and tissue remodeling in the mouse mammary gland during involution, which is partially induced by IL6 and LIF. However, it is not clear whether Stat3 activation is mediated solely through the gp130 pathway or also through ..
  33. Tanigawa S, Sharma N, Hall M, Nishinakamura R, Perantoni A. Preferential Propagation of Competent SIX2+ Nephronic Progenitors by LIF/ROCKi Treatment of the Metanephric Mesenchyme. Stem Cell Reports. 2015;5:435-47 pubmed publisher
    ..we established a culture model that preferentially expands the MM SIX2+ progenitor pool using leukemia inhibitory factor (LIF), a Rho kinase inhibitor (ROCKi), and extracellular matrix...
  34. Zhao M, Chang C, Liu Z, Chen L, Chen Q. Treatment with low-dose aspirin increased the level LIF and integrin ?3 expression in mice during the implantation window. Placenta. 2010;31:1101-5 pubmed publisher
    ..Cell adhesion molecules like integrins, or soluble factors such as Leukemia inhibitory factor (LIF) have been identified to play an important role during the implantation period...
  35. Sendtner M, Gotz R, Holtmann B, Thoenen H. Endogenous ciliary neurotrophic factor is a lesion factor for axotomized motoneurons in adult mice. J Neurosci. 1997;17:6999-7006 pubmed
    ..This protective effect was absent in pmn mice lacking endogenous CNTF. Quantitative analysis of leukemia inhibitory factor (LIF) mRNA expression revealed that the dramatic upregulation seen in wild-type mice after peripheral ..
  36. Fischer R, Wajant H, Kontermann R, Pfizenmaier K, Maier O. Astrocyte-specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor. Glia. 2014;62:272-83 pubmed publisher
    ..increased the expression of neuroprotective genes, including that encoding the neurotrophic cytokine leukemia inhibitory factor (LIF)...
  37. Kucia M, Wojakowski W, Reca R, Machalinski B, Gozdzik J, Majka M, et al. The migration of bone marrow-derived non-hematopoietic tissue-committed stem cells is regulated in an SDF-1-, HGF-, and LIF-dependent manner. Arch Immunol Ther Exp (Warsz). 2006;54:121-35 pubmed
    ..we evaluated whether TCSCs respond to other motomorphogens, such as hepatocyte growth factor (HGF) and leukemia inhibitory factor (LIF)...
  38. Bottorff D, Stone J. The murine leukemia inhibition factor gene (Lif) is located on proximal chromosome 11, not chromosome 13. Mamm Genome. 1992;3:681-4 pubmed
    b>Lif, the murine gene encoding leukemia inhibition factor (LIF), has been previously localized to proximal Chromosome (Chr) 11. Hilda, the murine gene encoding "human interleukin in DA cells" (HILDA) has been localized to Chr 13...
  39. Molnar A, Wu P, Largespada D, Vortkamp A, Scherer S, Copeland N, et al. The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse. J Immunol. 1996;156:585-92 pubmed
    ..The high degree of conservation of the Ikaros gene at the genetic and expression levels strongly suggests that it plays a fundamental role in the ontogeny of the lymphopoietic system across species. ..
  40. Karls U, Muller U, Gilbert D, Copeland N, Jenkins N, Harbers K. Structure, expression, and chromosome location of the gene for the beta subunit of brain-specific Ca2+/calmodulin-dependent protein kinase II identified by transgene integration in an embryonic lethal mouse mutant. Mol Cell Biol. 1992;12:3644-52 pubmed
    ..Transgene integration is accompanied by a large deletion of cellular DNA; death is therefore most likely caused by the loss of a gene or genes that are important for early postimplantation development. ..
  41. Tanaka M, Hara T, Copeland N, Gilbert D, Jenkins N, Miyajima A. Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor beta subunit. Blood. 1999;93:804-15 pubmed
    ..Of these family members, leukemia inhibitory factor (LIF) is most closely related to OSM, and various overlapping biologic activities have been described ..
  42. Moidunny S, Vinet J, Wesseling E, Bijzet J, Shieh C, Van IJzendoorn S, et al. Adenosine A2B receptor-mediated leukemia inhibitory factor release from astrocytes protects cortical neurons against excitotoxicity. J Neuroinflammation. 2012;9:198 pubmed
    Neuroprotective and neurotrophic properties of leukemia inhibitory factor (LIF) have been widely reported...
  43. Aubert J, Dessolin S, Belmonte N, Li M, McKenzie F, Staccini L, et al. Leukemia inhibitory factor and its receptor promote adipocyte differentiation via the mitogen-activated protein kinase cascade. J Biol Chem. 1999;274:24965-72 pubmed
    ..It is shown herein that expression of leukemia inhibitory factor (LIF) and LIF receptor is developmentally regulated during adipocyte differentiation...
  44. Matsushita K, Itoh S, Ikeda S, Yamamoto Y, Yamauchi Y, Hayashi M. LIF/STAT3/SOCS3 signaling pathway in murine bone marrow stromal cells suppresses osteoblast differentiation. J Cell Biochem. 2014;115:1262-8 pubmed publisher
    b>Leukemia inhibitory factor (LIF) is a pleiotropic cytokine that belongs to the interleukin-6 family and is expressed by multiple tissue types...
  45. Linker R, Kruse N, Israel S, Wei T, Seubert S, Hombach A, et al. Leukemia inhibitory factor deficiency modulates the immune response and limits autoimmune demyelination: a new role for neurotrophic cytokines in neuroinflammation. J Immunol. 2008;180:2204-13 pubmed
    The neurotrophic cytokines ciliary neurotrophic factor and leukemia inhibitory factor (LIF) play a key role in neuronal and oligodendrocyte survival and as protective factors in neuroinflammation...
  46. Moon C, Yoo J, Matarazzo V, Sung Y, Kim E, Ronnett G. Leukemia inhibitory factor inhibits neuronal terminal differentiation through STAT3 activation. Proc Natl Acad Sci U S A. 2002;99:9015-20 pubmed
    ..We have investigated the role of leukemia inhibitory factor (LIF) in postnatal neuronal development by using ORNs as a model...
  47. Abdel Majid R, Leong W, Schalkwyk L, Smallman D, Wong S, Storm D, et al. Loss of adenylyl cyclase I activity disrupts patterning of mouse somatosensory cortex. Nat Genet. 1998;19:289-91 pubmed
    ..These results provide the first evidence for involvement of cAMP signalling pathways in pattern formation of the brain. ..
  48. Ozturk G. Regulation of calcitonin gene-related peptide expression in vitro: possibility of a new role for leukemia inhibitory factor. Brain Res. 2002;931:74-80 pubmed
    ..factors, mainly of nerve growth factor though positive effect of other factors, for example that of leukemia inhibitory factor on galanin has also been demonstrated...
  49. Laszlo G, Nathanson N. Src family kinase-independent signal transduction and gene induction by leukemia inhibitory factor. J Biol Chem. 2003;278:27750-7 pubmed
    ..control fibroblasts displayed similar activation of signaling intermediates following stimulation with leukemia inhibitory factor (LIF)...
  50. Cheng T, Huang C, Chen C, Liu C, Hsieh Y, Huang C, et al. Leukemia inhibitory factor antisense oligonucleotide inhibits the development of murine embryos at preimplantation stages. Biol Reprod. 2004;70:1270-6 pubmed
    b>Leukemia inhibitory factor (LIF) is an essential factor for implantation and establishment of pregnancy. However, its role in the development of preimplantation embryos remains controversial...
  51. Kubota Y, Hirashima M, Kishi K, Stewart C, Suda T. Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in mice. J Clin Invest. 2008;118:2393-403 pubmed publisher
    ..Here, we showed that leukemia inhibitory factor (LIF) was predominantly expressed in developing endothelium, while its receptor was expressed in ..
  52. Fouladi Nashta A, Mohamet L, Heath J, Kimber S. Interleukin 1 signaling is regulated by leukemia inhibitory factor (LIF) and is aberrant in Lif-/- mouse uterus. Biol Reprod. 2008;79:142-53 pubmed publisher
    ..regulation of the interleukin 1 (IL1) system in the murine uterine luminal epithelium (LE) and stroma by leukemia inhibitory factor (LIF)...
  53. Cui S, Selwood L. cDNA cloning, characterization, expression and recombinant protein production of leukemia inhibitory factor (LIF) from the marsupial, the brushtail possum (Trichosurus vulpecula). Gene. 2000;243:167-78 pubmed
    ..polymerase chain reaction (RT-PCR) was used to clone the cDNA fragment encoding the amino acid sequence of mature LIF protein of the marsupial, the brushtail possum, Trichosurus vulpecula...
  54. Gresle M, Butzkueven H, Perreau V, Jonas A, Xiao J, Thiem S, et al. Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factor. Glia. 2015;63:1005-20 pubmed publisher
    ..to characterize changes in OC gene expression after exposure to the cytokines neurotrophin3, insulin, or leukemia inhibitory factor (LIF) in vitro...
  55. Agca C, Grimm C. Leukemia inhibitory factor signaling in degenerating retinas. Adv Exp Med Biol. 2014;801:389-94 pubmed publisher
    ..In many mouse models for retinal degeneration, expression of LIF in glial cells in response to a disease condition is crucial for the activation of an elaborate protective system...
  56. Stahl J, Gearing D, Willson T, Brown M, King J, Gough N. Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions. J Biol Chem. 1990;265:8833-41 pubmed
    b>Leukemia inhibitory factor, LIF, is a glycoprotein with multiple activities in both the adult and the embryo...
  57. Akita S, Malkin J, Melmed S. Disrupted murine leukemia inhibitory factor (LIF) gene attenuates adrenocorticotropic hormone (ACTH) secretion. Endocrinology. 1996;137:3140-3 pubmed
    b>Leukemia Inhibitory Factor (LIF) and its receptors in human and mouse pituicytes are expressed abundantly in corticotrophs and somatotrophs...
  58. Barnes J, Lim J, Godard A, Blanchard F, Wells L, Steet R. Extensive mannose phosphorylation on leukemia inhibitory factor (LIF) controls its extracellular levels by multiple mechanisms. J Biol Chem. 2011;286:24855-64 pubmed publisher
    ..In this study, we investigated the mannose phosphorylation status of leukemia inhibitory factor (LIF), a previously identified high affinity ligand for the cation-independent mannose 6-phosphate ..
  59. Mohri T, Fujio Y, Maeda M, Ito T, Iwakura T, Oshima Y, et al. Leukemia inhibitory factor induces endothelial differentiation in cardiac stem cells. J Biol Chem. 2006;281:6442-7 pubmed
    ..Here we describe that leukemia inhibitory factor (LIF), a member of IL-6-related cytokines, activated STAT3 and ERK1/2 in cardiac Sca-1+ stem cells...
  60. Bader A, Al Dubai H, Weitzer G. Leukemia inhibitory factor modulates cardiogenesis in embryoid bodies in opposite fashions. Circ Res. 2000;86:787-94 pubmed
    ..One of these factors, leukemia inhibitory factor (LIF), a member of the interleukin-6 family of cytokines, is expressed in embryonic and neonatal ..
  61. Hinds M, Maurer T, Zhang J, Nicola N, Norton R. Solution structure of leukemia inhibitory factor. J Biol Chem. 1998;273:13738-45 pubmed
    The solution structure of a murine-human chimera of leukemia inhibitory factor (LIF), a 180-residue cytokine with a molecular mass of 20 kDa, has been determined using multidimensional heteronuclear NMR techniques...
  62. Layton M, Lock P, Metcalf D, Nicola N. Cross-species receptor binding characteristics of human and mouse leukemia inhibitory factor suggest a complex binding interaction. J Biol Chem. 1994;269:17048-55 pubmed
    b>Leukemia inhibitory factor (LIF) is a pleiotropic cytokine whose activities appear to be mediated through a single heterodimeric receptor complex...
  63. Ohtsuka S, Niwa H. The differential activation of intracellular signaling pathways confers the permissiveness of embryonic stem cell derivation from different mouse strains. Development. 2015;142:431-7 pubmed publisher
    The requirement of leukemia inhibitory factor (LIF) for the establishment and maintenance of mouse embryonic stem cells (ESCs) depends on the genetic background of the ESC origin...
  64. Oshima K, Teo D, Senn P, Starlinger V, Heller S. LIF promotes neurogenesis and maintains neural precursors in cell populations derived from spiral ganglion stem cells. BMC Dev Biol. 2007;7:112 pubmed
    ..features of inner ear-derived neural stem cells and their derivatives, we investigated the effects of leukemia inhibitory factor (LIF), a neurokine that has been shown to promote self-renewal of other neural stem cells and to affect ..
  65. Do D, Ueda J, Messerschmidt D, Lorthongpanich C, Zhou Y, Feng B, et al. A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo. Genes Dev. 2013;27:1378-90 pubmed publisher
    ..Using leukemia inhibitory factor (Lif)-null embryos, we found that STAT3 phosphorylation is dependent on LIF in four-cell stage embryos...
  66. Carter M, Shah C, Muller C, Crawley J, Carneiro A, Veenstra Vanderweele J. Absence of preference for social novelty and increased grooming in integrin ?3 knockout mice: initial studies and future directions. Autism Res. 2011;4:57-67 pubmed publisher
    ..Further work is needed to fully characterize these behavioral changes and the underlying brain mechanisms. ..
  67. Gresle M, Alexandrou E, Wu Q, Egan G, Jokubaitis V, Ayers M, et al. Leukemia inhibitory factor protects axons in experimental autoimmune encephalomyelitis via an oligodendrocyte-independent mechanism. PLoS ONE. 2012;7:e47379 pubmed publisher
    b>Leukemia inhibitory factor (LIF) and Ciliary Neurotrophic factor (CNTF) are members of the interleukin-6 family of cytokines, defined by use of the gp130 molecule as an obligate receptor...
  68. Wang C, Lee J, Cho Y, Xiao Y, Jin Q, Liu C, et al. UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Proc Natl Acad Sci U S A. 2012;109:15324-9 pubmed
  69. Wysoczynski M, Miekus K, Jankowski K, Wanzeck J, Bertolone S, Janowska Wieczorek A, et al. Leukemia inhibitory factor: a newly identified metastatic factor in rhabdomyosarcomas. Cancer Res. 2007;67:2131-40 pubmed
    ..Because leukemia inhibitory factor (LIF), like SDF-1, is secreted by bone marrow stroma and directs the regeneration of skeletal muscles, ..
  70. Holtmann B, Wiese S, Samsam M, Grohmann K, Pennica D, Martini R, et al. Triple knock-out of CNTF, LIF, and CT-1 defines cooperative and distinct roles of these neurotrophic factors for motoneuron maintenance and function. J Neurosci. 2005;25:1778-87 pubmed
    Members of the ciliary neurotrophic factor (CNTF)-leukemia inhibitory factor (LIF) gene family play an essential role for survival of developing and postnatal motoneurons...
  71. Teuscher C, Butterfield R, Ma R, Zachary J, Doerge R, Blankenhorn E. Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic enceph. J Immunol. 1999;163:2262-6 pubmed
    ..S/DvTe alleles. Sequence polymorphisms were not seen in Lif and IL12 beta, candidate genes for eae6a and eae6b, respectively...
  72. Francis N, Asmus S, Landis S. CNTF and LIF are not required for the target-directed acquisition of cholinergic and peptidergic properties by sympathetic neurons in vivo. Dev Biol. 1997;182:76-87 pubmed
    ..Neuropoietic cytokines, including ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF), induce the same phenotypic changes in sympathetic neurons in vitro as sweat glands and periosteum ..
  73. Wang F, Xiao M, Lin X, Muhammad S, Piao X, Liu L. Expression of Heme Oxygenase-1 and Leukemia Inhibitory Factor in Maternal Plasma and Placental Tissue in a Lipopolysaccharide-Induced Late Pregnancy Preterm Birth Mouse Model. J Reprod Med. 2016;61:39-46 pubmed
    To investigate the expression of heme oxygenase-1 (HO-1) and leukemia inhibitory factor (LIF) in maternal plasma and placental tissue in intrauterine infection-induced preterm birth...
  74. Spinsanti P, De Vita T, Di Castro S, Storto M, Formisano P, Nicoletti F, et al. Endogenously activated mGlu5 metabotropic glutamate receptors sustain the increase in c-Myc expression induced by leukaemia inhibitory factor in cultured mouse embryonic stem cells. J Neurochem. 2006;99:299-307 pubmed
    ..undifferentiated state in D3 mouse embryonic stem cells cultured in the presence of leukaemia inhibitory factor (LIF)...
  75. Laterza C, Merlini A, De Feo D, Ruffini F, Menon R, Onorati M, et al. iPSC-derived neural precursors exert a neuroprotective role in immune-mediated demyelination via the secretion of LIF. Nat Commun. 2013;4:2597 pubmed publisher
    ..While proposing a novel mechanism of action, our results further expand the therapeutic potential of NPCs derived from iPSCs in myelin disorders. ..
  76. Liang X, Deng W, Li M, Zhao Z, Wang T, Feng X, et al. Egr1 protein acts downstream of estrogen-leukemia inhibitory factor (LIF)-STAT3 pathway and plays a role during implantation through targeting Wnt4. J Biol Chem. 2014;289:23534-45 pubmed publisher
    ..factor early growth response 1 (Egr1) is regulated by estrogen as a downstream target through leukemia inhibitory factor (LIF) signal transducer and activator of transcription 3 (STAT3) pathway in mouse uterus...
  77. Moreno Barriuso N, López Malpartida A, de Pablo F, Pichel J. Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos. Dev Dyn. 2006;235:2040-50 pubmed
    Previous studies on double deficient mice for leukemia inhibitory factor (LIF) and insulin-like growth factor I (IGF-I) reported that they died of respiratory failure, with abnormal lung histology and altered expression of pulmonary ..