Lhx8

Summary

Gene Symbol: Lhx8
Description: LIM homeobox protein 8
Alias: Lhx7, LIM/homeobox protein Lhx8, LIM homeo box protein 8, LIM homeobox protein 7, LIM/homeobox protein Lhx7
Species: mouse
Products:     Lhx8

Top Publications

  1. Matsumoto K, Tanaka T, Furuyama T, Kashihara Y, Ishii N, Tohyama M, et al. Differential expression of LIM-homeodomain genes in the embryonic murine brain. Neurosci Lett. 1996;211:147-50 pubmed
    ..These mRNAs showed mutually exclusive expression patterns suggesting that these factors may be involved in region-specific differentiation in the developing brain. ..
  2. Flandin P, Zhao Y, Vogt D, Jeong J, Long J, POTTER G, et al. Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors. Neuron. 2011;70:939-50 pubmed publisher
    Lhx6 and Lhx8 transcription factor coexpression in early-born MGE neurons is required to induce neuronal Shh expression. We provide evidence that these transcription factors regulate expression of a Shh enhancer in MGE neurons...
  3. Mori T, Yuxing Z, Takaki H, Takeuchi M, Iseki K, Hagino S, et al. The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons. Eur J Neurosci. 2004;19:3129-41 pubmed
    ..A recent report demonstrated that some BFCNs in adult rat are positive for L3/Lhx8, a LIM homeobox transcription factor...
  4. Denaxa M, Sharpe P, Pachnis V. The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian dentition. Dev Biol. 2009;333:324-36 pubmed publisher
    ..Two closely related members of this family, Lhx6 and Lhx7, are expressed in the ectomesenchyme of the maxillary and mandibular processes and have been suggested to control ..
  5. Choi Y, Ballow D, Xin Y, Rajkovic A. Lim homeobox gene, lhx8, is essential for mouse oocyte differentiation and survival. Biol Reprod. 2008;79:442-9 pubmed publisher
    b>Lhx8 is a member of the LIM-homeobox transcription factor family and preferentially expressed in oocytes and germ cells within the mouse ovary. We discovered that Lhx8 knockout females lose oocytes within 7 days after birth...
  6. Elshatory Y, Gan L. The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons. J Neurosci. 2008;28:3291-7 pubmed publisher
    ..Together, these results demonstrate the requirement for Isl1 in the development of restricted telencephalic cholinergic neurons and link the development of cholinergic neurons in anatomically disparate sites to Isl1 function. ..
  7. Zhao Y, Guo Y, Tomac A, Taylor N, Grinberg A, Lee E, et al. Isolated cleft palate in mice with a targeted mutation of the LIM homeobox gene lhx8. Proc Natl Acad Sci U S A. 1999;96:15002-6 pubmed
    ..Loss-of-function analysis has linked a growing number of genes to this process. Here we report that Lhx8, a recently identified LIM homeobox gene, is expressed in the mesenchyme of the mouse palatal structures throughout ..
  8. Zhao Y, Marin O, Hermesz E, Powell A, Flames N, Palkovits M, et al. The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain. Proc Natl Acad Sci U S A. 2003;100:9005-10 pubmed
    ..that control development of these neurons suggest that most of them are derived from the basal telencephalon where Lhx8, a LIM-homeobox gene, is expressed...
  9. Matsumoto K, Tanaka T, Furuyama T, Kashihara Y, Mori T, Ishii N, et al. L3, a novel murine LIM-homeodomain transcription factor expressed in the ventral telencephalon and the mesenchyme surrounding the oral cavity. Neurosci Lett. 1996;204:113-6 pubmed

More Information

Publications72

  1. Chen L, Chatterjee M, Li J. The mouse homeobox gene Gbx2 is required for the development of cholinergic interneurons in the striatum. J Neurosci. 2010;30:14824-34 pubmed publisher
    ..Together, our data demonstrate that Gbx2 is required for the development of striatal cholinergic interneurons, perhaps by regulating tangential migration of the striatal cholinergic precursors...
  2. Trumpp A, Depew M, Rubenstein J, Bishop J, Martin G. Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev. 1999;13:3136-48 pubmed
    ..Because the mutant mice resemble humans with first arch syndromes that include agnathia, our results raise the possibility that some of these syndromes are caused by mutations that affect FGF8 signaling in BA1 ectoderm...
  3. Fragkouli A, van Wijk N, Lopes R, Kessaris N, Pachnis V. LIM homeodomain transcription factor-dependent specification of bipotential MGE progenitors into cholinergic and GABAergic striatal interneurons. Development. 2009;136:3841-51 pubmed publisher
    ..precursor into mature SIN subtypes is regulated by the combinatorial activity of the LIM homeodomain proteins Lhx6, Lhx7 (Lhx8) and Isl1...
  4. Fragkouli A, Hearn C, Errington M, Cooke S, Grigoriou M, Bliss T, et al. Loss of forebrain cholinergic neurons and impairment in spatial learning and memory in LHX7-deficient mice. Eur J Neurosci. 2005;21:2923-38 pubmed
    ..Here we have generated a targeted allele of the LIM-homeodomain-encoding gene Lhx7 by replacing exons 3-5 with a LacZ reporter...
  5. Grigoriou M, Tucker A, Sharpe P, Pachnis V. Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development. Development. 1998;125:2063-74 pubmed
    ..We have identified two genes belonging to a novel subfamily of mammalian Lhx genes, designated Lhx6 and Lhx7. Whole-mount in situ hybridisation showed that Lhx6 and Lhx7 were expressed during mouse embryogenesis in ..
  6. Kitanaka J, Takemura M, Matsumoto K, Mori T, Wanaka A. Structure and chromosomal localization of a murine LIM/homeobox gene, Lhx8. Genomics. 1998;49:307-9 pubmed
    b>Lhx8 is a LIM-homeodomain protein, containing two tandemly repeated LIM motifs and a hemeodomain...
  7. Pangas S, Choi Y, Ballow D, Zhao Y, Westphal H, Matzuk M, et al. Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8. Proc Natl Acad Sci U S A. 2006;103:8090-5 pubmed
    ..In addition, we show that Lhx8 is downstream of Sohlh1 and critical in fertility...
  8. Shibaguchi T, Kato J, Abe M, Tamamura Y, Tabata M, Liu J, et al. Expression and role of Lhx8 in murine tooth development. Arch Histol Cytol. 2003;66:95-108 pubmed
    We examined the expression and possible functions of Lhx8, a member of the LIM-homeobox gene family, during tooth morphogenesis of the mouse...
  9. Fode C, Ma Q, Casarosa S, Ang S, Anderson D, Guillemot F. A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons. Genes Dev. 2000;14:67-80 pubmed
  10. Tucker A, Yamada G, Grigoriou M, Pachnis V, Sharpe P. Fgf-8 determines rostral-caudal polarity in the first branchial arch. Development. 1999;126:51-61 pubmed
  11. Lopes R, Verhey van Wijk N, Neves G, Pachnis V. Transcription factor LIM homeobox 7 (Lhx7) maintains subtype identity of cholinergic interneurons in the mammalian striatum. Proc Natl Acad Sci U S A. 2012;109:3119-24 pubmed publisher
    ..b>Lhx7-depleted cholinergic interneurons extinguish expression of several subtype-specific markers, including choline ..
  12. Remedios R, Subramanian L, Tole S. LIM genes parcellate the embryonic amygdala and regulate its development. J Neurosci. 2004;24:6986-90 pubmed
    ..The combinatorial expression patterns of LIM genes suggest a comprehensive mechanism for patterning this structure. ..
  13. Ballow D, Meistrich M, Matzuk M, Rajkovic A. Sohlh1 is essential for spermatogonial differentiation. Dev Biol. 2006;294:161-7 pubmed
    ..Etv5, Taf4b, Zfp148, and Plzf, overexpress a novel Tohlh2 bHLH transcription factor, but lack LIM homeobox gene Lhx8 and show reduced expression of Ngn3...
  14. Oommen S, Francois M, Kawasaki M, Murrell M, Kawasaki K, Porntaveetus T, et al. Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function. PLoS ONE. 2012;7:e43857 pubmed publisher
    ..Our data suggest that SOXF transcription factors play a role in regulating formation of cytoplasmic plaque protein assembly, and that disrupted SOXF function results in epidermolysis bullosa-like skin phenotypes. ..
  15. Sun Y, Teng I, Huo R, Rosenfeld M, Olson L, Li X, et al. Asymmetric requirement of surface epithelial ?-catenin during the upper and lower jaw development. Dev Dyn. 2012;241:663-74 pubmed publisher
    ..In addition, these findings suggest that evolutionary changes of the canonical Wnt/?-catenin signaling pathway may lead to innovation of jaws. ..
  16. Magno L, Kretz O, Bert B, Ersözlü S, Vogt J, Fink H, et al. The integrity of cholinergic basal forebrain neurons depends on expression of Nkx2-1. Eur J Neurosci. 2011;34:1767-82 pubmed publisher
    ..These degenerative changes are accompanied by partial denervation of their target structures and results in a discrete impairment of spatial memory. ..
  17. Taglialatela P, Soria J, Caironi V, Moiana A, Bertuzzi S. Compromised generation of GABAergic interneurons in the brains of Vax1-/- mice. Development. 2004;131:4239-49 pubmed
  18. Osterberg N, Wiehle M, Oehlke O, Heidrich S, Xu C, Fan C, et al. Sim1 is a novel regulator in the differentiation of mouse dorsal raphe serotonergic neurons. PLoS ONE. 2011;6:e19239 pubmed publisher
    ..Moreover, the transcription factor Lhx8 and the modulator of 5-HT(1A)-mediated neurotransmitter release, Rgs4, exhibit significant higher expression in ..
  19. Cesario J, Almaidhan A, Jeong J. Expression of forkhead box transcription factor genes Foxp1 and Foxp2 during jaw development. Gene Expr Patterns. 2016;20:111-9 pubmed publisher
    ..Recently, we discovered that transcription factors LIM homeobox (LHX) 6 and LHX8, which are key regulators of oral development, repressed the expression of the genes encoding forkhead box ..
  20. Hu J, Vogt D, Lindtner S, Sandberg M, Silberberg S, Rubenstein J. Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons. Development. 2017;144:2837-2851 pubmed publisher
    ..These results have identified, in mouse, a transcriptional pathway that controls SST-PV fate. ..
  21. Flames N, Pla R, Gelman D, Rubenstein J, Puelles L, Marin O. Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes. J Neurosci. 2007;27:9682-95 pubmed
    ..Furthermore, the results of microtransplantation experiments in vivo corroborate that anatomically defined regions of the mouse subpallium, such as the medial ganglionic eminence, can be subdivided into functionally distinct domains. ..
  22. Shin Y, Ren Y, Suzuki H, Golnoski K, Ahn H, Mico V, et al. Transcription factors SOHLH1 and SOHLH2 coordinate oocyte differentiation without affecting meiosis I. J Clin Invest. 2017;127:2106-2117 pubmed publisher
    ..NOBOX oogenesis homeobox (NOBOX) and LIM homeobox protein 8 (LHX8), two important regulators of postnatal oogenesis, were coexpressed with SOHLH1...
  23. Shin Y, Choi Y, Erdin S, Yatsenko S, Kloc M, Yang F, et al. Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis. PLoS Genet. 2010;6:e1001190 pubmed publisher
    ..HORMAD1 is therefore a critical component of the synaptonemal complex that affects synapsis, recombination, and meiotic sex chromosome inactivation and transcriptional silencing...
  24. Zhang L, Pan B, Chen B, Zhang X, Liang G, Feng Y, et al. Expression and epigenetic dynamics of transcription regulator Lhx8 during mouse oogenesis. Gene. 2012;506:1-9 pubmed publisher
    ..In this study, we characterized the correlation between the expression and epigenetic dynamics of Lhx8, a germ cell specific transcription factor during mouse oogenesis...
  25. Fragkouli A, Pachnis V, Stylianopoulou F. Sex differences in water maze performance and cortical neurotrophin levels of LHX7 null mutant mice. Neuroscience. 2009;158:1224-33 pubmed publisher
    Mice lacking both alleles of the LIM-homeobox gene Lhx7 display dramatically reduced number of forebrain cholinergic neurons...
  26. Gutin G, Fernandes M, Palazzolo L, Paek H, Yu K, Ornitz D, et al. FGF signalling generates ventral telencephalic cells independently of SHH. Development. 2006;133:2937-46 pubmed
    ..Moreover, the Fgfr1;Fgfr2 phenotype, unlike the Shh phenotype, is not rescued by loss of Gli3, further indicating that FGFs act downstream of Shh and Gli3 to generate ventral telencephalic cell types. ..
  27. Zhou C, Yang G, Chen M, He L, Xiang L, Ricupero C, et al. Lhx6 and Lhx8: cell fate regulators and beyond. FASEB J. 2015;29:4083-91 pubmed publisher
    ..Undoubtedly, future investigations of Lhx6 and -8 biology will continue to yield fascinating insights into tissue development and homeostasis, in addition to their putative roles in tissue regeneration and ageing. ..
  28. Marin O, Anderson S, Rubenstein J. Origin and molecular specification of striatal interneurons. J Neurosci. 2000;20:6063-76 pubmed
    ..We also present evidence implicating the Lhx6 and Lhx7 LIM-homeobox genes in the development of distinct interneuron subtypes...
  29. Singh R, Braga M, Reddy S, Lee S, Parveen M, Grijalva V, et al. Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues. Endocrinology. 2017;158:1217-1230 pubmed publisher
    ..mouse BAT cells treated with rFst show dramatic increase in Myf5 protein levels as well as upregulation of Zic1 and Lhx8 gene expression...
  30. Colasante G, Sessa A, Crispi S, Calogero R, Mansouri A, Collombat P, et al. Arx acts as a regional key selector gene in the ventral telencephalon mainly through its transcriptional repression activity. Dev Biol. 2009;334:59-71 pubmed publisher
    ..Together, these data provide new insights into the molecular pathways regulated by Arx during telencephalon development. ..
  31. Sato A, Shibuya H. WNK signaling is involved in neural development via Lhx8/Awh expression. PLoS ONE. 2013;8:e55301 pubmed publisher
    ..Here, we identify a new target gene in WNK signaling, Arrowhead and Lhx8, which is a mammalian homologue of Drosophila Arrowhead...
  32. Cesario J, Landin Malt A, Deacon L, Sandberg M, Vogt D, Tang Z, et al. Lhx6 and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2. Hum Mol Genet. 2015;24:5024-39 pubmed publisher
    ..Lhx6 and Lhx8 encode LIM homeodomain transcription factors, and inactivation of both genes in mice resulted in profound ..
  33. Kitamura K, Itou Y, Yanazawa M, Ohsawa M, Suzuki Migishima R, Umeki Y, et al. Three human ARX mutations cause the lissencephaly-like and mental retardation with epilepsy-like pleiotropic phenotypes in mice. Hum Mol Genet. 2009;18:3708-24 pubmed publisher
  34. Nandi S, Gutin G, Blackwood C, Kamatkar N, Lee K, Fishell G, et al. FGF-Dependent, Context-Driven Role for FRS Adapters in the Early Telencephalon. J Neurosci. 2017;37:5690-5698 pubmed publisher
    ..Differential engagement of FRS and non-FRS intracellular adapters downstream of FGFRs could therefore in principle explain how FGFs play several distinct roles in other developing tissues and developmental stages. ..
  35. Eckalbar W, Schlebusch S, Mason M, Gill Z, Parker A, Booker B, et al. Transcriptomic and epigenomic characterization of the developing bat wing. Nat Genet. 2016;48:528-36 pubmed publisher
    ..In combination, our work outlines multiple genetic components that likely contribute to bat wing formation, providing insights into this morphological innovation. ..
  36. Allaway K, Machold R. Developmental specification of forebrain cholinergic neurons. Dev Biol. 2017;421:1-7 pubmed publisher
    ..We also discuss the heterogeneity of these populations and its possible developmental origins. ..
  37. Zhang Y, Mori T, Takaki H, Takeuch M, Iseki K, Hagino S, et al. Comparison of the expression patterns of two LIM-homeodomain genes, Lhx6 and L3/Lhx8, in the developing palate. Orthod Craniofac Res. 2002;5:65-70 pubmed
    To compare and contrast the gene expression of two LIM-homeobox type transcription factors, Lhx6 and L3/Lhx8, in secondary palate formation...
  38. Colombo E, Collombat P, Colasante G, Bianchi M, Long J, Mansouri A, et al. Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation. J Neurosci. 2007;27:4786-98 pubmed
    ..Altogether, these results highlight the critical functions of Arx in promoting neural migration and regulating basal ganglia differentiation in mice, consistent with the phenotype of XLAG patients...
  39. Fragkouli A, Stamatakis A, Zographos E, Pachnis V, Stylianopoulou F. Sexually dimorphic effects of the Lhx7 null mutation on forebrain cholinergic function. Neuroscience. 2006;137:1153-64 pubmed
    It has been reported recently that mice lacking both alleles of the LIM-homeobox gene Lhx7, display dramatically reduced number of forebrain cholinergic neurons...
  40. Landin Malt A, Cesario J, Tang Z, Brown S, Jeong J. Identification of a face enhancer reveals direct regulation of LIM homeobox 8 (Lhx8) by wingless-int (WNT)/β-catenin signaling. J Biol Chem. 2014;289:30289-301 pubmed publisher
    ..We characterized in detail one of the enhancers (Lhx8_enh1) located upstream of Lhx8, a key regulatory gene for craniofacial development...
  41. Zhao H, Oka K, Bringas P, Kaartinen V, Chai Y. TGF-beta type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent manner. Dev Biol. 2008;320:19-29 pubmed publisher
    ..There is an intrinsic requirement for Alk5 signal in regulating the fate of CNC cells during tooth and mandible development. ..
  42. Ko H, Chen S, Chen H, Hao H, Liu F. Cell type-selective expression of the zinc finger-containing gene Nolz-1/Zfp503 in the developing mouse striatum. Neurosci Lett. 2013;548:44-9 pubmed publisher
    ..Notably, Nolz-1 protein was not expressed in Nkx2.1-positive interneuron progenitors, Lhx8-positive cholinergic interneuron progenitors, nNOS and calretinin-positive interneurons in E18.5 striatum...
  43. Zhao M, Gupta V, Raj L, Roussel M, Bei M. A network of transcription factors operates during early tooth morphogenesis. Mol Cell Biol. 2013;33:3099-112 pubmed publisher
    ..Here, we show that Msx1, Snail, Lhx6, Lhx8, Sp3, and Lef1 interact in vitro and in vivo, revealing the existence of a novel context-specific protein network...
  44. Aggarwal V, Carpenter C, Freyer L, Liao J, Petti M, Morrow B. Mesodermal Tbx1 is required for patterning the proximal mandible in mice. Dev Biol. 2010;344:669-81 pubmed publisher
    ..5. This occurs without significant changes in cell proliferation or apoptosis at the same stage. Our results elucidate a new function for the non-neural crest core mesoderm and specifically, mesodermal Tbx1, in shaping the lower jaw. ..
  45. Xu Q, Wonders C, Anderson S. Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon. Development. 2005;132:4987-98 pubmed
    ..These results combine in vitro and ex vivo analyses to link embryonic abnormalities in Shh signaling to postnatal alterations in cortical interneuron composition. ..
  46. Takaishi M, Huh N. A tetratricopeptide repeat-containing protein gene, tpis, whose expression is induced with differentiation of spermatogenic cells. Biochem Biophys Res Commun. 1999;264:81-5 pubmed
    ..Chromosomal localization of the tpis gene was determined as 18.10 cM of chromosome 15. ..
  47. Sussel L, Marin O, Kimura S, Rubenstein J. Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum. Development. 1999;126:3359-70 pubmed
    ..We present evidence that these phenotypes result from a ventral-to-dorsal transformation of the pallidal primordium into a striatal-like anlage. ..
  48. Cho H, Cargnin F, Kim Y, Lee B, Kwon R, Nam H, et al. Isl1 directly controls a cholinergic neuronal identity in the developing forebrain and spinal cord by forming cell type-specific complexes. PLoS Genet. 2014;10:e1004280 pubmed publisher
    ..We found that Isl1 forms two related, but distinct types of complexes, the Isl1-Lhx3-hexamer in MNs and the Isl1-Lhx8-hexamer in FCNs...
  49. Shin Y, McGuire M, Rajkovic A. Mouse HORMAD1 is a meiosis i checkpoint protein that modulates DNA double- strand break repair during female meiosis. Biol Reprod. 2013;89:29 pubmed
    ..Moreover, Hormad1 deficiency rescued Dmc1(?/?) oocytes. These results indicate that Hormad1 deficiency promotes DMC1-independent DSB repairs, which in turn helps asynaptic Hormad1(?/?) oocytes resist perinatal loss. ..
  50. Kawase Koga Y, Otaegi G, Sun T. Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system. Dev Dyn. 2009;238:2800-12 pubmed publisher
    ..Our studies of different timings of Dicer deletion demonstrate the importance of the Dicer-mediated microRNA pathway in regulating distinct phases of neurogenesis and gliogenesis during the CNS development. ..
  51. Edlund R, Ohyama T, Kantarci H, Riley B, Groves A. Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers. Dev Biol. 2014;390:1-13 pubmed publisher
    ..Our results suggest that Foxi3 may play a role in the establishment of signaling centers in the branchial arches that are required for neural crest survival, patterning and the subsequent development of branchial arch derivatives. ..
  52. Choi Y, Yuan D, Rajkovic A. Germ cell-specific transcriptional regulator sohlh2 is essential for early mouse folliculogenesis and oocyte-specific gene expression. Biol Reprod. 2008;79:1176-82 pubmed publisher
    ..Our findings show that Sohlh2 is a critical factor for maintenance and differentiation of the oocyte during early oogenesis. ..
  53. Hernández Miranda L, Cariboni A, Faux C, Ruhrberg C, Cho J, Cloutier J, et al. Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain. J Neurosci. 2011;31:6174-87 pubmed publisher
    ..Thus, we show for the first time that Robo1 interacts with Nrp1 to modulate semaphorin signaling in the developing forebrain and direct the migration of interneurons through the subpallium and into the cortex. ..
  54. Zhao Y, Flandin P, Vogt D, Blood A, Hermesz E, Westphal H, et al. Ldb1 is essential for development of Nkx2.1 lineage derived GABAergic and cholinergic neurons in the telencephalon. Dev Biol. 2014;385:94-106 pubmed publisher
    ..We have shown previously that two LIM-homeodomain (LIM-HD) transcription factors, Lhx6 and Lhx8, that are downstream of Nkx2.1, are critical for the development of telencephalic GABAergic and cholinergic neurons...
  55. D Souza C, Chopra V, Varhol R, Xie Y, Bohacec S, Zhao Y, et al. Identification of a set of genes showing regionally enriched expression in the mouse brain. BMC Neurosci. 2008;9:66 pubmed publisher
    ..This set of markers may also serve as a resource for further studies of gene regulatory elements influencing brain expression. ..
  56. Ren Y, Suzuki H, Jagarlamudi K, Golnoski K, McGuire M, Lopes R, et al. Lhx8 regulates primordial follicle activation and postnatal folliculogenesis. BMC Biol. 2015;13:39 pubmed publisher
    ..Previously, we discovered that global knockouts of germ cell-specific transcriptional co-regulators Sohlh1, Sohlh2, Lhx8, and Nobox, cause rapid oocyte loss and ovarian failure...
  57. Puelles L, Morales Delgado N, Merchán P, Castro Robles B, Martínez de la Torre M, Díaz C, et al. Radial and tangential migration of telencephalic somatostatin neurons originated from the mouse diagonal area. Brain Struct Funct. 2016;221:3027-65 pubmed publisher
    ..5 onward, comparing their topography with the expression patterns of the genes Dlx5, Gbx2, Lhx7-8, Nkx2.1, Nkx5.1 (Hmx3), and Shh, which variously label parts of the subpallium...
  58. Paschou P, Stylianopoulou E, Karagiannidis I, Rizzo R, Tarnok Z, Wolanczyk T, et al. Evaluation of the LIM homeobox genes LHX6 and LHX8 as candidates for Tourette syndrome. Genes Brain Behav. 2012;11:444-51 pubmed publisher
    ..The role of Lhx6 and Lhx8 in the development of the striatal interneurons, prompted us to investigate them as novel candidate genes for TS...
  59. Wheeler F, Fernandez L, Carlson K, Wolf M, Rockman H, Marchuk D. QTL mapping in a mouse model of cardiomyopathy reveals an ancestral modifier allele affecting heart function and survival. Mamm Genome. 2005;16:414-23 pubmed
    ..Identification of the genes at these QTLs in the mouse will provide novel candidate genes that can be evaluated for their role in human heart failure. ..
  60. Gohlke J, Armant O, Parham F, Smith M, Zimmer C, Castro D, et al. Characterization of the proneural gene regulatory network during mouse telencephalon development. BMC Biol. 2008;6:15 pubmed publisher
    ..Together, these data shed light on the molecular pathways regulated by proneural genes and demonstrate that the integration of experimentation with bioinformatics can guide both hypothesis testing and hypothesis generation. ..
  61. Bildsoe H, Loebel D, Jones V, Chen Y, Behringer R, Tam P. Requirement for Twist1 in frontonasal and skull vault development in the mouse embryo. Dev Biol. 2009;331:176-88 pubmed publisher
    ..In contrast, the formation of other mesodermal skeletal derivatives such as the occipital bones and most of the chondrocranium are not affected by the loss of Twist1 in the neural crest cells. ..
  62. Manabe T, Tatsumi K, Inoue M, Matsuyoshi H, Makinodan M, Yamauchi T, et al. Knockdown of the L3/Lhx8 gene suppresses cholinergic differentiation of murine embryonic stem cell-derived spheres. Int J Dev Neurosci. 2008;26:249-52 pubmed publisher
    L3/Lhx8, a member of the Lim-homeobox gene family, is selectively and specifically expressed in the murine embryonic medial ganglionic eminence (MGE)...
  63. García López M, Abellan A, Legaz I, Rubenstein J, Puelles L, Medina L. Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development. J Comp Neurol. 2008;506:46-74 pubmed
    ..1, Lhx6, Lhx7/8, Lhx9, Shh, and Gbx1), as well as genes considered markers for specific subpallial neuronal subpopulations...