Lgals3

Summary

Gene Symbol: Lgals3
Description: lectin, galactose binding, soluble 3
Alias: GBP, L-34, Mac-2, gal3, galectin-3, 35 kDa lectin, CBP 35, L-34 galactoside-binding lectin, carbohydrate-binding protein 35, gal-3, galactose-specific lectin 3, igE-binding protein, laminin-binding protein, lectin L-29, mac-2 antigen
Species: mouse
Products:     Lgals3

Top Publications

  1. Sano H, Hsu D, Apgar J, Yu L, Sharma B, Kuwabara I, et al. Critical role of galectin-3 in phagocytosis by macrophages. J Clin Invest. 2003;112:389-97 pubmed
    ..Compared with wild-type macrophages, galectin-3-deficient (gal3-/-) cells exhibited reduced phagocytosis of IgG-opsonized erythrocytes and apoptotic thymocytes in vitro...
  2. Chen H, Sharma B, Yu L, Zuberi R, Weng I, Kawakami Y, et al. Role of galectin-3 in mast cell functions: galectin-3-deficient mast cells exhibit impaired mediator release and defective JNK expression. J Immunol. 2006;177:4991-7 pubmed
    ..role of galectin-3 in the function of mast cells, we studied bone marrow-derived mast cells (BMMC) from wild-type (gal3(+/+)) and galectin-3-deficient (gal3(-/-)) mice...
  3. Delacour D, Koch A, Ackermann W, Eude Le Parco I, Elsässer H, Poirier F, et al. Loss of galectin-3 impairs membrane polarisation of mouse enterocytes in vivo. J Cell Sci. 2008;121:458-65 pubmed publisher
    ..Further investigations revealed that gal3-null enterocytes also exhibit striking cytoarchitecture defects, with the presence of numerous and regular ..
  4. Goetz J, Joshi B, Lajoie P, Strugnell S, Scudamore T, Kojic L, et al. Concerted regulation of focal adhesion dynamics by galectin-3 and tyrosine-phosphorylated caveolin-1. J Cell Biol. 2008;180:1261-75 pubmed publisher
    ..Thus, transmembrane crosstalk between the galectin lattice and pY14Cav1 promotes FA turnover by stabilizing FAK within FAs defining previously unknown, interdependent roles for galectin-3 and pY14Cav1 in tumor cell migration. ..
  5. Oliveira F, Brand C, Paula A, Arcanjo K, Hsu D, Liu F, et al. Lack of galectin-3 disturbs mesenteric lymph node homeostasis and B cell niches in the course of Schistosoma mansoni infection. PLoS ONE. 2011;6:e19216 pubmed publisher
    ..mansoni. ..
  6. Colnot C, Ripoche M, Milon G, Montagutelli X, Crocker P, Poirier F. Maintenance of granulocyte numbers during acute peritonitis is defective in galectin-3-null mutant mice. Immunology. 1998;94:290-6 pubmed
  7. Liu W, Hsu D, Chen H, Yang R, Carraway K, Isseroff R, et al. Galectin-3 regulates intracellular trafficking of EGFR through Alix and promotes keratinocyte migration. J Invest Dermatol. 2012;132:2828-37 pubmed publisher
    ..Our results suggest that galectin-3 is potentially a critical regulator of a number of important cellular responses through its intracellular control of trafficking of cell surface receptors. ..
  8. Silva Monteiro E, Reis Lorenzato L, Kenji Nihei O, Junqueira M, Rabinovich G, Hsu D, et al. Altered expression of galectin-3 induces cortical thymocyte depletion and premature exit of immature thymocytes during Trypanosoma cruzi infection. Am J Pathol. 2007;170:546-56 pubmed
    ..Our findings provide evidence of a novel role for galectin-3 in the regulation of thymus physiology and identify a potential mechanism based on protein-glycan interactions in thymic atrophy associated with acute T. cruzi infection. ..
  9. Wang Y, Kim S, Baek J, Lee H, Jeong S, Chun K. Galectin-3 increases the motility of mouse melanoma cells by regulating matrix metalloproteinase-1 expression. Exp Mol Med. 2012;44:387-93 pubmed publisher
    ..Taken together, galectin- 3 facilitates cell migration and invasion in melanoma in vitro and can induce metastasis in vivo, in part through, regulating the transcription activity of AP-1 and thereby up-regulating MMP-1 expression. ..

More Information

Publications72

  1. Cao Z, Said N, Amin S, Wu H, Bruce A, Garate M, et al. Galectins-3 and -7, but not galectin-1, play a role in re-epithelialization of wounds. J Biol Chem. 2002;277:42299-305 pubmed
    ..models of corneal wound healing, re-epithelialization of wounds was significantly slower in galectin-3-deficient (gal3(-/-)) mice compared with wild-type (gal3(+/+)) mice...
  2. Lalancette Hébert M, Swarup V, Beaulieu J, Bohacek I, Abdelhamid E, Weng Y, et al. Galectin-3 is required for resident microglia activation and proliferation in response to ischemic injury. J Neurosci. 2012;32:10383-95 pubmed publisher
    ..Next, our results revealed that contrary to WT cells, the Gal3-KO microglia failed to proliferate in response to IGF-1...
  3. Ge X, Bahaie N, Kang B, Hosseinkhani M, Ha S, Frenzel E, et al. Allergen-induced airway remodeling is impaired in galectin-3-deficient mice. J Immunol. 2010;185:1205-14 pubmed publisher
  4. Boscher C, Zheng Y, Lakshminarayan R, Johannes L, Dennis J, Foster L, et al. Galectin-3 protein regulates mobility of N-cadherin and GM1 ganglioside at cell-cell junctions of mammary carcinoma cells. J Biol Chem. 2012;287:32940-52 pubmed
  5. Doverhag C, Hedtjarn M, Poirier F, Mallard C, Hagberg H, Karlsson A, et al. Galectin-3 contributes to neonatal hypoxic-ischemic brain injury. Neurobiol Dis. 2010;38:36-46 pubmed publisher
    ..Galectin-3-deficient mice (gal3-/-) were protected from injury particularly in hippocampus and striatum...
  6. Chiu M, Johnson T, Woolf A, Dahm Vicker E, Long D, Guay Woodford L, et al. Galectin-3 associates with the primary cilium and modulates cyst growth in congenital polycystic kidney disease. Am J Pathol. 2006;169:1925-38 pubmed
    ..These data raise the possibility that galectin-3 may act as a natural brake on cystogenesis in cpk mice, perhaps via ciliary roles...
  7. Alves C, Silva D, Azzolini A, Marzocchi Machado C, Carvalho J, Pajuaba A, et al. Galectin-3 plays a modulatory role in the life span and activation of murine neutrophils during early Toxoplasma gondii infection. Immunobiology. 2010;215:475-85 pubmed publisher
    ..gondii infection. In conclusion, Gal-3 plays an important modulatory role by interfering in Nphi life span and activation during early T. gondii infection. ..
  8. Oliveira F, Frazao P, Chammas R, Hsu D, Liu F, Borojevic R, et al. Kinetics of mobilization and differentiation of lymphohematopoietic cells during experimental murine schistosomiasis in galectin-3 -/- mice. J Leukoc Biol. 2007;82:300-10 pubmed
  9. Radosavljevic G, Jovanovic I, Majstorovic I, Mitrovic M, Lisnic V, Arsenijevic N, et al. Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity. Clin Exp Metastasis. 2011;28:451-62 pubmed publisher
  10. Zuberi R, Hsu D, Kalayci O, Chen H, Sheldon H, Yu L, et al. Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma. Am J Pathol. 2004;165:2045-53 pubmed
    ..We investigated the role of galectin-3 in the allergic airway response by comparing galectin-3-deficient (gal3(-/-)) mice and wild-type (gal3(+/+)) mice...
  11. Colnot C, Fowlis D, Ripoche M, Bouchaert I, Poirier F. Embryonic implantation in galectin 1/galectin 3 double mutant mice. Dev Dyn. 1998;211:306-13 pubmed
    Galectin 1 and galectin 3 are first expressed in the trophectoderm cells of the implanting embryo and have been implicated in the process of implantation...
  12. Kim H, Lee J, Hyun J, Park J, Joo H, Shin T. Expression and immunohistochemical localization of galectin-3 in various mouse tissues. Cell Biol Int. 2007;31:655-62 pubmed
    ..These findings suggest that galectin-3 is differentially expressed in a variety of organs in the mouse. This study provides valuable information for research on galectin-3. ..
  13. Song Y, Billiar T, Lee Y. Role of galectin-3 in breast cancer metastasis: involvement of nitric oxide. Am J Pathol. 2002;160:1069-75 pubmed
    ..In conclusion, galectin-3 enhances the metastatic potential of BT549 cells through resistance to the products of iNOS, possibly through its bcl-2-like antiapoptotic function. ..
  14. Calvier L, Miana M, Reboul P, Cachofeiro V, Martínez Martínez E, de Boer R, et al. Galectin-3 mediates aldosterone-induced vascular fibrosis. Arterioscler Thromb Vasc Biol. 2013;33:67-75 pubmed publisher
    ..Our data indicate that Gal-3 is required for inflammatory and fibrotic responses to Aldo in vascular smooth muscle cells in vitro and in vivo, suggesting a key role for Gal-3 in vascular fibrosis. ..
  15. Dumic J, Dabelic S, Flogel M. Galectin-3: an open-ended story. Biochim Biophys Acta. 2006;1760:616-35 pubmed
    ..The review attempts to summarize the existing information on structural, biochemical and intriguing functional properties of galectin-3. ..
  16. Salomonsson E, Carlsson M, Osla V, Hendus Altenburger R, Kahl Knutson B, Oberg C, et al. Mutational tuning of galectin-3 specificity and biological function. J Biol Chem. 2010;285:35079-91 pubmed publisher
    ..Finally, the mutants have helped to define the differences in fine specificity shown by Xenopus, mouse, and human galectin-3 and, as such, the evidence for adaptive change during evolution...
  17. Jeon S, Yoon H, Chang C, Koh H, Jeon S, Park E. Galectin-3 exerts cytokine-like regulatory actions through the JAK-STAT pathway. J Immunol. 2010;185:7037-46 pubmed publisher
  18. Pugliese G, Pricci F, Iacobini C, Leto G, Amadio L, Barsotti P, et al. Accelerated diabetic glomerulopathy in galectin-3/AGE receptor 3 knockout mice. FASEB J. 2001;15:2471-9 pubmed
    ..These results show that the galectin-3-regulated AGE receptor pathway is operating in vivo and protects toward AGE-induced tissue injury in contrast to that through RAGE. ..
  19. Colnot C, Sidhu S, Balmain N, Poirier F. Uncoupling of chondrocyte death and vascular invasion in mouse galectin 3 null mutant bones. Dev Biol. 2001;229:203-14 pubmed
    b>Galectin 3 is a beta-galactoside binding protein which localizes to the cytoplasm of proliferative, mature, and hypertrophic chondrocytes in the growth plate cartilage of developing long bones...
  20. Iacobini C, Menini S, Ricci C, Scipioni A, Sansoni V, Cordone S, et al. Accelerated lipid-induced atherogenesis in galectin-3-deficient mice: role of lipoxidation via receptor-mediated mechanisms. Arterioscler Thromb Vasc Biol. 2009;29:831-6 pubmed publisher
  21. Menon S, Kang C, Beningo K. Galectin-3 secretion and tyrosine phosphorylation is dependent on the calpain small subunit, Calpain 4. Biochem Biophys Res Commun. 2011;410:91-6 pubmed publisher
    ..We have found that Calpain 4 is essential for the tyrosine phosphorylation of galectin-3, and its ultimate secretion from the cell, and speculate that its secretion interferes with the production of traction forces. ..
  22. Nakanishi Y, Tsuneyama K, Nomoto K, Fujimoto M, Salunga T, Nakajima T, et al. Nonalcoholic steatohepatitis and hepatocellular carcinoma in galectin-3 knockout mice. Hepatol Res. 2008;38:1241-51 pubmed publisher
    ..We previously reported that 6-month-old male galectin-3 knockout (gal3(-/-)) mice developed clinicopathological features similar to those of NAFLD in humans...
  23. Mackinnon A, Farnworth S, Hodkinson P, Henderson N, Atkinson K, Leffler H, et al. Regulation of alternative macrophage activation by galectin-3. J Immunol. 2008;180:2650-8 pubmed
    ..Pharmacological modulation of galectin-3 function represents a novel therapeutic strategy in pathologies associated with alternatively activated macrophages. ..
  24. Breuilh L, Vanhoutte F, Fontaine J, van Stijn C, Tillie Leblond I, Capron M, et al. Galectin-3 modulates immune and inflammatory responses during helminthic infection: impact of galectin-3 deficiency on the functions of dendritic cells. Infect Immun. 2007;75:5148-57 pubmed
  25. Zeng Y, Danielson K, Albert T, Shapiro I, Risbud M. HIF-1 alpha is a regulator of galectin-3 expression in the intervertebral disc. J Bone Miner Res. 2007;22:1851-61 pubmed
    ..In nucleus pulposus cells, suppression of gal-3 expression promoted FasL-mediated apoptosis. Together, these studies showed that gal-3 is a HIF-1-regulated lectin that plays an important role in nucleus pulposus cell survival. ..
  26. Pajoohesh Ganji A, Knoblach S, Faden A, Byrnes K. Characterization of inflammatory gene expression and galectin-3 function after spinal cord injury in mice. Brain Res. 2012;1475:96-105 pubmed publisher
  27. Nieminen J, St Pierre C, Bhaumik P, Poirier F, Sato S. Role of galectin-3 in leukocyte recruitment in a murine model of lung infection by Streptococcus pneumoniae. J Immunol. 2008;180:2466-73 pubmed
    ..Thus, taken together, our data suggest that galectin-3 plays a role as a soluble adhesion molecule in the recruitment of neutrophils to lungs infected by S. pneumoniae, which induces beta(2)-integrin-independent migration. ..
  28. Tadokoro T, Ikekita M, Toda T, Ito H, Sato T, Nakatani R, et al. Involvement of Galectin-3 with vascular cell adhesion molecule-1 in growth regulation of mouse BALB/3T3 cells. J Biol Chem. 2009;284:35556-63 pubmed publisher
  29. Villa Verde D, Silva Monteiro E, Jasiulionis M, Farias de Oliveira D, Brentani R, Savino W, et al. Galectin-3 modulates carbohydrate-dependent thymocyte interactions with the thymic microenvironment. Eur J Immunol. 2002;32:1434-44 pubmed
    ..Our data indicate that intrathymically produced galectin-3 disrupts thymocyte/microenvironmental cell interactions, thus acting as a de-adhesion molecule. ..
  30. Iacobini C, Menini S, Oddi G, Ricci C, Amadio L, Pricci F, et al. Galectin-3/AGE-receptor 3 knockout mice show accelerated AGE-induced glomerular injury: evidence for a protective role of galectin-3 as an AGE receptor. FASEB J. 2004;18:1773-5 pubmed
  31. Darrow A, Shohet R, Maresh J. Transcriptional analysis of the endothelial response to diabetes reveals a role for galectin-3. Physiol Genomics. 2011;43:1144-52 pubmed publisher
    ..Endothelial transcripts upregulated by HFD included galectin-3 (Lgals3), 5-lipoxygenase-activating protein, and chemokine ligands 8 and 9...
  32. Farnworth S, Henderson N, Mackinnon A, Atkinson K, Wilkinson T, Dhaliwal K, et al. Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function. Am J Pathol. 2008;172:395-405 pubmed publisher
  33. Iacobini C, Oddi G, Menini S, Amadio L, Ricci C, Di Pippo C, et al. Development of age-dependent glomerular lesions in galectin-3/AGE-receptor-3 knockout mice. Am J Physiol Renal Physiol. 2005;289:F611-21 pubmed
  34. Koch A, Poirier F, Jacob R, Delacour D. Galectin-3, a novel centrosome-associated protein, required for epithelial morphogenesis. Mol Biol Cell. 2010;21:219-31 pubmed publisher
    ..Collectively, these data establish galectin-3 as a key determinant in epithelial morphogenesis via its effect on centrosome biology. ..
  35. Partridge E, Le Roy C, Di Guglielmo G, Pawling J, Cheung P, Granovsky M, et al. Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis. Science. 2004;306:120-4 pubmed
    ..Thus, conditional regulation of N-glycan processing drives synchronous modification of cytokine receptors, which balances their surface retention against loss via endocytosis. ..
  36. Iacobini C, Menini S, Ricci C, Scipioni A, Sansoni V, Mazzitelli G, et al. Advanced lipoxidation end-products mediate lipid-induced glomerular injury: role of receptor-mediated mechanisms. J Pathol. 2009;218:360-9 pubmed publisher
    ..Mice knocked out for galectin-3 (Gal3(-/-)), an AGE receptor previously shown to protect from AGE-induced renal injury, and the corresponding wild-type (..
  37. Jiang H, Al Rasebi Z, Mensah Brown E, Shahin A, Xu D, Goodyear C, et al. Galectin-3 deficiency reduces the severity of experimental autoimmune encephalomyelitis. J Immunol. 2009;182:1167-73 pubmed
  38. Ahmad N, Gabius H, Andre S, Kaltner H, Sabesan S, Roy R, et al. Galectin-3 precipitates as a pentamer with synthetic multivalent carbohydrates and forms heterogeneous cross-linked complexes. J Biol Chem. 2004;279:10841-7 pubmed
    ..This contrasts with galectin-1 and many plant lectins that form homogeneous, organized cross-linked complexes. The results are discussed in terms of the biological properties of galectin-3. ..
  39. Hsu D, Yang R, Pan Z, Yu L, Salomon D, Fung Leung W, et al. Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses. Am J Pathol. 2000;156:1073-83 pubmed
    ..elucidating the physiological and pathological functions of this protein, we have generated galectin-3-deficient (gal3(-/-)) mice by targeted interruption of the galectin-3 gene...
  40. Nomoto K, Nishida T, Nakanishi Y, Fujimoto M, Takasaki I, Tabuchi Y, et al. Deficiency in galectin-3 promotes hepatic injury in CDAA diet-induced nonalcoholic fatty liver disease. ScientificWorldJournal. 2012;2012:959824 pubmed publisher
    ..We investigated whether galectin-3 is involved in the development of NASH by comparing galectin-3 knockout (gal3(-/-)) mice and wild-type (gal3(+/+)) mice with choline-deficient L-amino-acid-defined (CDAA) diet-induced NAFLD/..
  41. Nomoto K, Tsuneyama K, Abdel Aziz H, Takahashi H, Murai Y, Cui Z, et al. Disrupted galectin-3 causes non-alcoholic fatty liver disease in male mice. J Pathol. 2006;210:469-77 pubmed
    ..Thus, this study investigated the role of galectin-3 in NAFLD by comparing galectin-3 knockout (gal3(-/-)) mice and wild-type (gal3(+/+)) mice...
  42. Li Y, Komai Koma M, Gilchrist D, Hsu D, Liu F, Springall T, et al. Galectin-3 is a negative regulator of lipopolysaccharide-mediated inflammation. J Immunol. 2008;181:2781-9 pubmed
    ..Thus, galectin-3 is a previously unrecognized, naturally occurring, negative regulator of LPS function, which protects the host from endotoxin shock but, conversely, favors Salmonella survival. ..
  43. Markowska A, Liu F, Panjwani N. Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response. J Exp Med. 2010;207:1981-93 pubmed publisher
    ..in vitro and that VEGF- and bFGF-mediated angiogenic response is reduced in galectin-3 knockdown cells and Gal3(-/-) animals...
  44. Pang J, Rhodes D, Pini M, Akasheh R, Castellanos K, Cabay R, et al. Increased adiposity, dysregulated glucose metabolism and systemic inflammation in Galectin-3 KO mice. PLoS ONE. 2013;8:e57915 pubmed publisher
    ..In conclusion, Gal-3 is an important modulator of glucose metabolism, adiposity and inflammation. ..
  45. Jia W, Kidoya H, Yamakawa D, Naito H, Takakura N. Galectin-3 accelerates M2 macrophage infiltration and angiogenesis in tumors. Am J Pathol. 2013;182:1821-31 pubmed publisher
    ..Here, we analyzed the function of galectin-3 (Gal-3; gene LGALS3, alias Gal3) for macrophage chemotaxis using Gal3(-/-) mice as hosts, and a tumor allograft model...
  46. Bernardes E, Silva N, Ruas L, Mineo J, Loyola A, Hsu D, et al. Toxoplasma gondii infection reveals a novel regulatory role for galectin-3 in the interface of innate and adaptive immunity. Am J Pathol. 2006;168:1910-20 pubmed
    In attempts to investigate the role of galectin-3 in innate immunity, we studied galectin-3-deficient (gal3-/-) mice with regard to their response to Toxoplasma gondii infection, which is characterized by inflammation in affected organs, ..
  47. Chen H, Fermin A, Vardhana S, Weng I, Lo K, Chang E, et al. Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse. Proc Natl Acad Sci U S A. 2009;106:14496-501 pubmed publisher
    We have investigated the function of endogenous galectin-3 in T cells. Galectin-3-deficient (gal3(-/-)) CD4(+) T cells secreted more IFN-gamma and IL-4 than gal3(+/+)CD4(+) T cells after T-cell receptor (TCR) engagement...
  48. Yang E, Shim J, Woo H, Kim K, Kwon H. Aminopeptidase N/CD13 induces angiogenesis through interaction with a pro-angiogenic protein, galectin-3. Biochem Biophys Res Commun. 2007;363:336-41 pubmed
    ..Finally, exogenous addition of galectin-3 into HUVECs induced angiogenesis in an APN-dependent manner, implying that APN is a crucial mediator of galectin-3-induced angiogenesis in endothelial cells. ..
  49. ARGUESO P, Guzman Aranguez A, Mantelli F, Cao Z, Ricciuto J, Panjwani N. Association of cell surface mucins with galectin-3 contributes to the ocular surface epithelial barrier. J Biol Chem. 2009;284:23037-45 pubmed publisher
    ..Taken together, these results suggest that galectin-3 plays a key role in maintaining mucosal barrier function through carbohydrate-dependent interactions with cell surface mucins. ..
  50. Henderson N, Mackinnon A, Farnworth S, Poirier F, Russo F, Iredale J, et al. Galectin-3 regulates myofibroblast activation and hepatic fibrosis. Proc Natl Acad Sci U S A. 2006;103:5060-5 pubmed
    ..Finally, in vivo siRNA knockdown of Galectin-3 inhibited myofibroblast activation after hepatic injury and may therefore provide an alternative therapeutic approach to the prevention and treatment of liver fibrosis. ..
  51. Pejnovic N, Pantic J, Jovanovic I, Radosavljevic G, Milovanovic M, Nikolic I, et al. Galectin-3 deficiency accelerates high-fat diet-induced obesity and amplifies inflammation in adipose tissue and pancreatic islets. Diabetes. 2013;62:1932-44 pubmed publisher
    ..Obese LGALS3(-/-) mice have increased body weight, amount of total visceral adipose tissue (VAT), fasting blood glucose and ..
  52. Rotshenker S, Reichert F, Gitik M, Haklai R, Elad Sfadia G, Kloog Y. Galectin-3/MAC-2, Ras and PI3K activate complement receptor-3 and scavenger receptor-AI/II mediated myelin phagocytosis in microglia. Glia. 2008;56:1607-13 pubmed publisher
    ..An explanation may thus be offered for deficient phagocytosis by microglia that express CR3/MAC-1 and SRAI/II without Galectin-3/MAC-2 and efficient phagocytosis when CR3/MAC-1 and SRAI/II are co-expressed with Galectin-3/MAC-2...
  53. Sato S, Ouellet N, Pelletier I, Simard M, Rancourt A, Bergeron M. Role of galectin-3 as an adhesion molecule for neutrophil extravasation during streptococcal pneumonia. J Immunol. 2002;168:1813-22 pubmed
    ..Thus, based on our results, we propose that galectin-3 plays a role in beta(2) integrin-independent neutrophil extravasation, which occurs during alveolar infection with Streptococcus pneumoniae. ..
  54. Saravanan C, Liu F, Gipson I, Panjwani N. Galectin-3 promotes lamellipodia formation in epithelial cells by interacting with complex N-glycans on alpha3beta1 integrin. J Cell Sci. 2009;122:3684-93 pubmed publisher
    Recent studies have shown that galectin-3 (Gal-3; also known as LGALS3), a beta-galactoside-binding lectin, promotes cell migration during re-epithelialization of corneal wounds...
  55. Fowlis D, Colnot C, Ripoche M, Poirier F. Galectin-3 is expressed in the notochord, developing bones, and skin of the postimplantation mouse embryo. Dev Dyn. 1995;203:241-51 pubmed
    ..Finally, we find that galectin-3, which is identical to the macrophage marker Mac-2, is also expressed in embryonic macrophages. ..
  56. Oliveira F, Chammas R, Ricon L, Fermino M, Bernardes E, Hsu D, et al. Galectin-3 regulates peritoneal B1-cell differentiation into plasma cells. Glycobiology. 2009;19:1248-58 pubmed publisher
    ..We have shown that in the absence of galectin-3, B1-cell differentiation into plasma cells is favored and the dynamic equilibrium of B1-cell populations in the peritoneum is maintained through a compensatory increase in B1b lymphocytes. ..
  57. Mensah Brown E, Al Rabesi Z, Shahin A, Al Shamsi M, Arsenijevic N, Hsu D, et al. Targeted disruption of the galectin-3 gene results in decreased susceptibility to multiple low dose streptozotocin-induced diabetes in mice. Clin Immunol. 2009;130:83-8 pubmed publisher
    b>Galectin 3 (Gal-3) is an antiapoptotic and a proinflammatory lectin. We hypothesized that the proinflammatory properties of Gal-3 may influence disease induction in the multiple low doses of streptozotocin model of diabetes...
  58. Henderson N, Mackinnon A, Farnworth S, Kipari T, Haslett C, Iredale J, et al. Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis. Am J Pathol. 2008;172:288-98 pubmed publisher
    ..Therefore, we demonstrate for the first time that galectin-3 expression and secretion by macrophages is a major mechanism linking macrophages to the promotion of renal fibrosis. ..
  59. Hsu D, Chernyavsky A, Chen H, Yu L, Grando S, Liu F. Endogenous galectin-3 is localized in membrane lipid rafts and regulates migration of dendritic cells. J Invest Dermatol. 2009;129:573-83 pubmed publisher
    ..First, galectin-3-deficient (gal3(-/-)) bone marrow-derived dendritic cells exhibited defective chemotaxis compared to gal3(+/+) cells...
  60. Brand C, Oliveira F, Takiya C, Palumbo A, Hsu D, Liu F, et al. The involvement of the spleen during chronic phase of Schistosoma mansoni infection in galectin-3-/- mice. Histol Histopathol. 2012;27:1109-20 pubmed publisher
    ..Thus, we propose that galectin-3 plays a role in splenic architecture, controlling distinct events such as apoptosis, macrophage activity, B cell differentiation and plasmacytogenesis in the course of S. mansoni infection. ..
  61. Acosta Rodriguez E, Montes C, Motran C, Zuniga E, Liu F, Rabinovich G, et al. Galectin-3 mediates IL-4-induced survival and differentiation of B cells: functional cross-talk and implications during Trypanosoma cruzi infection. J Immunol. 2004;172:493-502 pubmed
    ..cruzi infection. Thus, the present study provides evidence of a novel role for Gal-3 as an intracellular mediator of B cell survival and a checkpoint in IL-4-induced B cell commitment toward a memory phenotype. ..
  62. Ferraz L, Bernardes E, Oliveira A, Ruas L, Fermino M, Soares S, et al. Lack of galectin-3 alters the balance of innate immune cytokines and confers resistance to Rhodococcus equi infection. Eur J Immunol. 2008;38:2762-75 pubmed publisher
    ..equi infection. The bacterial challenge of galectin-3-deficient mice (gal3-/-) and their wild-type counterpart (gal3+/+) revealed that the LD50 for the gal3(-/-) mice was about seven times ..
  63. Volarevic V, Milovanovic M, Ljujic B, Pejnovic N, Arsenijevic N, Nilsson U, et al. Galectin-3 deficiency prevents concanavalin A-induced hepatitis in mice. Hepatology. 2012;55:1954-64 pubmed publisher