Genomes and Genes
Gene Symbol: Lep
Alias: obese, leptin, obesity factor
Publications198 found, 100 shown here
- Weight-reducing effects of the plasma protein encoded by the obese geneJ L Halaas
Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockfeller University, New York, NY 10021, USA
Science 269:543-6. 1995..2 to 0.7 percent. These data suggest that the OB protein serves an endocrine function to regulate body fat stores...
- Effects of the obese gene product on body weight regulation in ob/ob miceM A Pelleymounter
Department of Neurobiology, Amgen, Inc, Thousand Oaks, CA 91320, USA
Science 269:540-3. 1995C57BL/6J mice with a mutation in the obese (ob) gene are obese, diabetic, and exhibit reduced activity, metabolism, and body temperature...
- Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistanceHaiyan Xu
Millennium Pharmaceuticals, Cambridge, Massachusetts, USA
J Clin Invest 112:1821-30. 2003..there is evidence of significant infiltration of macrophages, but not neutrophils and lymphocytes, into WAT of obese mice, with signs of adipocyte lipolysis and formation of multinucleate giant cells...
- Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjectsM Maffei
Laboratory of Molecular Genetics, Rockefeller University, New York, New York 10021, USA
Nat Med 1:1155-61. 1995b>Leptin, the gene product of the obese gene, may play an important role in regulating body weight by signalling the size of the adipose tissue mass...
- A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditureVijay K Yadav
Department of Genetics and Development, Columbia University, New York, NY 10032, USA
Cell 138:976-89. 2009b>Leptin inhibition of bone mass accrual requires the integrity of specific hypothalamic neurons but not expression of its receptor on these neurons. The same is true for its regulation of appetite and energy expenditure...
- STAT3 signalling is required for leptin regulation of energy balance but not reproductionSarah H Bates
Research Division, Joslin Diabetes Center, Harvard Medical School, 1 Joslin Place, Boston, Massachusetts 02215, USA
Nature 421:856-9. 2003Secretion of leptin from adipocytes communicates body energy status to the brain by activating the leptin receptor long form (LRb)...
- Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animalsDavid Patsouris
Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, California, USA
Cell Metab 8:301-9. 2008b>Obese adipose tissue is characterized by infiltration of macrophages. We and others recently showed that a specific subset of macrophages is recruited to obese adipose and muscle tissue...
- Identification of SOCS-3 as a potential mediator of central leptin resistanceC Bjørbaek
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Mol Cell 1:619-25. 1998b>Leptin affects food intake and body weight by actions on the hypothalamus. Although leptin resistance is common in obesity, mechanisms have not been identified...
- Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypesKimihiko Matsusue
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Frederick, Maryland 20892, USA
J Clin Invest 111:737-47. 2003To elucidate the function of PPARgamma in leptin-deficient mouse (ob/ob) liver, a PPARgamma liver-null mouse on an ob/ob background, ob/ob-PPARgamma(fl/fl)AlbCre(+), was produced using a floxed PPARgamma allele, PPARgamma(fl/fl), and Cre ..
- Obesity induces a phenotypic switch in adipose tissue macrophage polarizationCarey N Lumeng
Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
J Clin Invest 117:175-84. 2007..To this end, we found a novel F4/80(+)CD11c(+) population of ATMs in adipose tissue of obese mice that was not seen in lean mice...
- Hyperleptinemia is required for the development of leptin resistanceZachary A Knight
Howard Hughes Medical Institute, Laboratory of Molecular Genetics, The Rockefeller University, New York, New York, United States of America
PLoS ONE 5:e11376. 2010b>Leptin regulates body weight by signaling to the brain the availability of energy stored as fat. This negative feedback loop becomes disrupted in most obese individuals, resulting in a state known as leptin resistance...
- Leptin regulates proinflammatory immune responsesS Loffreda
Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
FASEB J 12:57-65. 1998..Decreased expression of leptin or of functional leptin receptors results in hyperphagia, decreased energy expenditure, and obesity...
- Inflammation and adipose tissue macrophages in lipodystrophic miceLaura Herrero
Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:240-5. 2010..Although ATMs are even more abundant in lipodystrophy than in obesity, they have distinct phenotypes and likely roles in tissue remodeling, but do not appear to be involved in the pathogenesis of insulin resistance...
- Regulation of expression of ob mRNA and protein by glucocorticoids and cAMPL J Slieker
Endocrine Research and Technology Core Divisions, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Biol Chem 271:5301-4. 1996..It has been demonstrated that exogenous human OB protein (leptin) treatment reduces food intake and weight gain, as well as insulin, glucose, and corticosterone levels in ob/ob ..
- Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinaseYasuhiko Minokoshi
Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Nature 415:339-43. 2002b>Leptin is a hormone secreted by adipocytes that plays a pivotal role in regulating food intake, energy expenditure and neuroendocrine function...
- Hypothalamic Angptl4/Fiaf is a novel regulator of food intake and body weightHyun Kyong Kim
Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea
Diabetes 59:2772-80. 2010..In the present study, we investigated the physiological role of Angptl4 in central regulation of body weight homeostasis...
- The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesisHaibo Sha
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
Cell Metab 9:556-64. 2009..Taken together, our data show that the IRE1alpha-XBP1 pathway plays a key role in adipocyte differentiation by acting as a critical regulator of the morphological and functional transformations during adipogenesis...
- Myeloid-specific estrogen receptor alpha deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion developmentVicent Ribas
David Geffen School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, University of California, Los Angeles, CA 90095 7073, USA
Proc Natl Acad Sci U S A 108:16457-62. 2011..A similar obese phenotype and increased atherosclerotic lesion area was displayed in LDL receptor-KO mice transplanted with ERα(-/..
- Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertilityQi Wu
Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 109:3155-60. 2012b>Leptin-deficient (Lep(ob/ob)) mice are obese, diabetic, and infertile. Ablation of neurons that make agouti-related protein (AgRP) in moderately obese adult Lep(ob/ob) mice caused severe anorexia...
- Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1J C Yoon
Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 413:131-8. 2001..These results implicate PGC-1 as a key modulator of hepatic gluconeogenesis and as a central target of the insulin-cAMP axis in liver...
- The adipoinsular axis: effects of leptin on pancreatic beta-cellsT J Kieffer
Departments of Medicine and Physiology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
Am J Physiol Endocrinol Metab 278:E1-E14. 2000..for the existence of an adipoinsular axis, a dual hormonal feedback loop involving the hormones insulin and leptin produced by pancreatic beta-cells and adipose tissue, respectively...
- Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscleAgnieszka Dobrzyn
Dept of Biochemistry, Univ of Wisconsin, 433 Babcock Dr, Madison, WI 53706, USA
Am J Physiol Endocrinol Metab 288:E599-607. 2005..significantly increases insulin sensitivity in skeletal muscles and corrects the hypometabolic phenotype of leptin-deficient ob/ob mice, indicating the direct antilipotoxic action of SCD1 deficiency...
- Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal transducer and activator of transcription 3Hui Gao
Department of Biosciences and Nutrition, Karolinska Institutet, Novum, S 14157 Huddinge, Sweden
Mol Endocrinol 20:1287-99. 2006..We propose that this may be mediated, at least partially, via estrogen stimulation of the hepatic expression of Stat3, leading to decreased expression of hepatic lipogenic genes, and thereby to antidiabetic effects...
- Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob miceYaron Ilan
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:9765-70. 2010b>Leptin-deficient ob/ob mice are overweight, develop insulin resistance, and serve as a model for type 2 diabetes (T2D)...
- Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in miceMichael M Scott
Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9077, USA
J Clin Invest 121:2413-21. 2011b>Leptin is an adipose-derived hormone that signals to inform the brain of nutrient status; loss of leptin signaling results in marked hyperphagia and obesity...
- A leptin missense mutation associated with hypogonadism and morbid obesityA Strobel
Nat Genet 18:213-5. 1998
- FGF-21 as a novel metabolic regulatorAlexei Kharitonenkov
Lilly Research Laboratories, Division of Eli Lilly and Co, Indianapolis, Indiana 46285, USA
J Clin Invest 115:1627-35. 2005..Thus, we conclude that FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes...
- Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptinF F Chehab
Department of Laboratory Medicine, University of California, San Francisco, 94143 0134, USA
Nat Genet 12:318-20. 1996..We show here that repeated administration of only the recombinant human ob protein, leptin, into homozygous female ob/ob mice can correct their sterility, thus resulting in ovulation, pregnancy and ..
- Regulation of PPAR gamma gene expression by nutrition and obesity in rodentsA Vidal-Puig
Department of Medicine, Beth Israel Hospital, Boston, Massachusetts 02215, USA
J Clin Invest 97:2553-61. 1996..Probes for detection of adipocyte P2, the obese gene product, leptin, and 18S mRNAs were also employed. Both gamma l and gamma 2 mRNAs were abundantly expressed in adipose tissue...
- Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdalaRebecca L Leshan
Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 30:5713-23. 2010b>Leptin acts via its receptor (LepRb) to regulate neural circuits in concert with body energy stores. In addition to acting on a number of hypothalamic structures, leptin modulates the mesolimbic dopamine (DA) system...
- Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neuronsGwendolyn W Louis
Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 30:11278-87. 2010b>Leptin, the adipose-derived hormonal signal of body energy stores, acts via the leptin receptor (LepRb) on neurons in multiple brain regions...
- The farnesoid X receptor regulates adipocyte differentiation and function by promoting peroxisome proliferator-activated receptor-gamma and interfering with the Wnt/beta-catenin pathwaysMouaadh Abdelkarim
Universite Lille Nord de France, F 59000 Lille, France
J Biol Chem 285:36759-67. 2010..Our results show that genetically obese FXR(-/-)/ob/ob mice displayed a resistance to rosiglitazone treatment...
- Leptin induces phosphorylation of neuronal nitric oxide synthase in defined hypothalamic neuronsJose Donato
Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Endocrinology 151:5415-27. 2010Studies have indicated that the neurotransmitter nitric oxide (NO) mediates leptin's effects in the neuroendocrine reproductive axis. However, the neurons involved in these effects and their regulation by leptin is still unknown...
- Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neuronsJose Donato
Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9077, USA
J Clin Invest 121:355-68. 2011..The adipocyte-derived hormone leptin is a key metabolic signal to the neuroendocrine reproductive axis...
- Leptin action in pubertal development: recent advances and unanswered questionsCarol F Elias
Department of Internal Medicine, Division of Hypothalamic Research and Green Center for Reproductive Biology Sciences, University of Texas Southwestern UTSW Medical Center, Dallas, TX 75390, USA
Trends Endocrinol Metab 23:9-15. 2012..This review will focus on recent data unveiling the sites of leptin action in pubertal development that were generated using novel molecular techniques and genetically engineered ..
- Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in miceJennifer W Hill
Division of Hypothalamic Research, Department of Internal Medicine and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Clin Invest 118:1796-805. 2008Normal food intake and body weight homeostasis require the direct action of leptin on hypothalamic proopiomelanocortin (POMC) neurons. It has been proposed that leptin action requires PI3K activity...
- Leptin administration favors muscle mass accretion by decreasing FoxO3a and increasing PGC-1alpha in ob/ob miceNeira Sainz
Metabolic Research Laboratory, University of Navarra, Pamplona, Spain
PLoS ONE 4:e6808. 2009Absence of leptin has been associated with reduced skeletal muscle mass in leptin-deficient ob/ob mice. The aim of our study was to examine the effect of leptin on the catabolic and anabolic pathways regulating muscle mass...
- Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptinY Ogawa
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
Diabetes 48:1822-9. 1999..b>Leptin is an adipocyte-derived satiety factor that plays an important role in the regulation of energy homeostasis, and ..
- Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob miceJ K Howard
Endocrine Unit and Department of Immunology, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom
J Clin Invest 104:1051-9. 1999..Prevention of the fasting-induced fall in the level of the adipocyte-derived hormone leptin by administering exogenous recombinant leptin protected mice from these starvation-induced thymic changes...
- Genetically obese MMTV-TGF-alpha/Lep(ob)Lep(ob) female mice do not develop mammary tumorsMargot P Cleary
The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Breast Cancer Res Treat 77:205-15. 2003..mice are not a good model to evaluate the effect of body weight on MT development possibly due to leptin deficiency...
- Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2)Ruben R Gonzalez
Boston Biomedical Research Institute, Watertown, Massachusetts 02472, USA
J Biol Chem 281:26320-8. 2006To gain insight into the mechanism(s) by which leptin contributes to mammary tumor (MT) development we investigated the effects of leptin, kinase inhibitors, and/or leptin receptor antagonists (LPrA2) on 4T1 mouse mammary cancer cells in ..
- Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancerRuben Rene Gonzalez
Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
Breast Cancer Res 11:R36. 2009We have shown previously that treatment with pegylated leptin peptide receptor antagonist 2 (PEG-LPrA2) reduced the expression of vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor type 2 (VEGFR2) and ..
- On raising energy expenditure in ob/ob miceJ Himms-Hagen
Science 276:1132-3. 1997
- Increased high density lipoprotein (HDL), defective hepatic catabolism of ApoA-I and ApoA-II, and decreased ApoA-I mRNA in ob/ob mice. Possible role of leptin in stimulation of HDL turnoverD L Silver
Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
J Biol Chem 274:4140-6. 1999..was to evaluate mechanisms responsible for increased HDL in ob/ob mice and to assess potential reversibility by leptin administration. ob/ob mice were found to have increased HDL cholesterol (2-fold), apoA-I (1...
- Genetic and genomic studies of the BTBR ob/ob mouse model of type 2 diabetesSusanne M Clee
Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
Am J Ther 12:491-8. 2005The BTBR mouse strain harbors alleles promoting insulin resistance. When made genetically obese (ob/ob), these mice develop severe type 2 diabetes (fasting glucose >400 mg/dL)...
- Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetesK Ebihara
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
Diabetes 50:1440-8. 2001..We have also produced transgenic "skinny" mice that have hepatic overexpression of leptin (LepTg/+) and no adipocyte triglyceride stores, and are hypophagic and show increased insulin sensitivity...
- Altered insulin signaling in retinal tissue in diabetic statesTatsuya Kondo
Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 279:37997-8006. 2004..Furthermore, insulin signaling in retinal endothelial cells is differentially altered in diabetes and is also differentially regulated from insulin signaling in classical target tissues such as liver...
- Endoplasmic reticulum stress plays a central role in development of leptin resistanceLale Ozcan
Division of Endocrinology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Cell Metab 9:35-51. 2009b>Leptin has not evolved as a therapeutic modality for the treatment of obesity due to the prevalence of leptin resistance in a majority of the obese population...
- Endocrine regulation of energy metabolism by the skeletonNa Kyung Lee
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Cell 130:456-69. 2007..By revealing that the skeleton exerts an endocrine regulation of sugar homeostasis this study expands the biological importance of this organ and our understanding of energy metabolism...
- Normalization of obesity-associated insulin resistance through immunotherapyShawn Winer
Department of Pediatrics and Immunology, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Nat Med 15:921-9. 2009..In obese WT and ob/ob (leptin-deficient) mice, brief treatment with CD3-specific antibody or its F(ab')(2) fragment, reduces the predominance of ..
- Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db miceC Vaisse
Laboratory of Metabolic Diseases, Rockefeller University, New York, New York 10021, USA
Nat Genet 14:95-7. 1996b>Leptin, a hormone secreted by adipocytes, regulates the size of the adipose tissue mass through effects on satiety and energy metabolism. Leptin's precise sites of action are not known...
- The leptin receptorL A Tartaglia
Millenium Pharmaceuticals, Cambridge, Massachusetts 02139, USA
J Biol Chem 272:6093-6. 1997
- Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumoniaPeter Mancuso
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA
J Immunol 168:4018-24. 2002b>Leptin is an adipocyte-derived hormone that is secreted in correlation with total body lipid stores. Serum leptin levels are lowered by the loss of body fat mass that would accompany starvation and malnutrition...
- Reduced cholesterol accumulation by leptin deficient (ob/ob) mouse macrophagesM Kjerrulf
Dept of Molecular Pharmacology, AstraZeneca R and D, Molndal, Sweden
Inflamm Res 55:300-9. 2006Although presenting many aspects of the metabolic syndrome, leptin deficient (ob/ob) mice do not spontaneously develop atherosclerosis...
- Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese miceJianping Ye
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Am J Physiol Endocrinol Metab 293:E1118-28. 2007..In this study, we provide experimental evidence that hypoxia occurs in adipose tissue in obese mice and that adipose hypoxia may contribute to the endocrine alterations...
- Identification of a physiological role for leptin in the regulation of ambulatory activity and wheel running in miceGregory J Morton
Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, USA
Am J Physiol Endocrinol Metab 300:E392-401. 2011..We evaluated ambulatory activity and wheel running in leptin-deficient ob/ob mice and in wild-type mice rendered hypoleptinemic by fasting in both the presence and absence of ..
- Leptin inhibits bone formation through a hypothalamic relay: a central control of bone massP Ducy
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Cell 100:197-207. 2000..To test this hypothesis, we studied leptin-deficient and leptin receptor-deficient mice that are obese and hypogonadic...
- Leptin regulates bone formation via the sympathetic nervous systemShu Takeda
Department of Molecular and Human Genetics, One Baylor Plaza, Houston, TX 77030, USA
Cell 111:305-17. 2002We previously showed that leptin inhibits bone formation by an undefined mechanism...
- Leptin prevents the metabolic effects of adiponectin in L6 myotubesX Fang
Department of Biology, York University, Toronto, ON, Canada
Diabetologia 52:2190-200. 2009Adiponectin and leptin are negatively and positively correlated with human obesity respectively, and have both been shown to regulate energy metabolism in skeletal muscle...
- Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexiaP Sarraf
Surgical Metabolism Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Exp Med 185:171-5. 1997..and, to a lesser extent, leukemia inhibitory factor (LIF), produced a prompt and dose-dependent increase in serum leptin levels and leptin mRNA expression in fat...
- Effect of leptin deficiency on metabolic rate in ob/ob miceM J Breslow
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Am J Physiol 276:E443-9. 1999Reduced metabolic rate may contribute to weight gain in leptin-deficient (ob/ob) mice; however, available studies have been criticized for referencing O2 consumption (VO2) to estimated rather than true lean body mass...
- Abnormal regulation of the leptin gene in the pathogenesis of obesityE Ioffe
Howard Hughes Medical Institute, 1230 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 95:11852-7. 1998A subset of obese humans has relatively low plasma levels of leptin. This finding has suggested that in some cases abnormal regulation of the leptin gene in adipose tissue is etiologic in the pathogenesis of the obese state...
- Development of intestinal inflammation in double IL-10- and leptin-deficient miceBritta Siegmund
Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Germany
J Leukoc Biol 76:782-6. 2004b>Leptin-deficient (ob/ob) mice are resistant in different models of autoimmunity and inflammation, suggesting that leptin regulates immunity and inflammation...
- Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppressionG M Lord
Imperial College School of Medicine, Department of Immunology, The Hammersmith Hospital, London, UK
Nature 394:897-901. 1998..The cloning of the obese gene and identification of its protein product leptin has provided fundamental insight into the hypothalamic regulation of body weight...
- Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility lociJ P Stoehr
Department of Biochemistry, University of Wisconsin Madison, USA
Diabetes 49:1946-54. 2000..We hypothesized that the genetic determinants of the insulin resistance syndrome might also predispose genetically obese mice to severe diabetes...
- Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndromeLydia E Kuo
Department of Physiology and Biophysics, Georgetown University Medical Center, 3900 Reservoir Rd NW, BSB 234, Washington, DC 20057, USA
Nat Med 13:803-11. 2007..Thus, manipulations of NPY2R activity within fat tissue offer new ways to remodel fat and treat obesity and metabolic syndrome...
- Thermogenesis in diabetes-obesity syndromes in mutant miceD L Coleman
Diabetologia 22:205-11. 1982The two mouse mutants, obese (ob) and diabetes (db), cause similar diabetes-obesity syndromes that are characterized by a marked increase in apparent metabolic efficiency with regard to utilization of energy...
- Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide YJ C Erickson
Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Box 357370, Seattle, WA 98195 7370, USA
Science 274:1704-7. 1996The obesity syndrome of ob/ob mice results from lack of leptin, a hormone released by fat cells that acts in the brain to suppress feeding and stimulate metabolism...
- LPS-induced anorexia in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) miceR Faggioni
Department of Medicine, University of California, USA
Am J Physiol 273:R181-6. 1997Administration of endotoxin (lipopolysaccharide, LPS) induces profound anorexia. Injection of leptin decreases food intake in mice. Recently, we reported that LPS and cytokines increase leptin levels in hamsters...
- A leptin dose-response study in obese (ob/ob) and lean (+/?) miceR B Harris
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
Endocrinology 139:8-19. 1998This experiment determined the amount of leptin required to correct different abnormalities in leptin-deficient ob/ob mice...
- Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophyI Shimomura
Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235 9046, USA
Nature 401:73-6. 1999..tissue from these mice was markedly deficient in messenger RNAs encoding several fat-specific proteins, including leptin, a fat-derived hormone that regulates food intake and energy metabolism...
- Torpor in mice is induced by both leptin-dependent and -independent mechanismsO Gavrilova
Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 96:14623-8. 1999We tested the effect of chronic leptin treatment on fasting-induced torpor in leptin-deficient A-ZIP/F-1 and ob/ob mice...
- Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawalJason M Montez
Chromocell Corporation, 675 US Highway One, North Brunswick, NJ 08902 USA
Proc Natl Acad Sci U S A 102:2537-42. 2005Food restriction and weight loss result in reduced plasma leptin, which is associated with a pleiotropic biologic response...
- Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophyUtpal B Pajvani
Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
Nat Med 11:797-803. 2005..responsive to glucose-stimulated insulin secretion and show increased food intake independent of the effects of leptin. Most importantly, we show that functional adipocytes can be recovered upon cessation of treatment, allowing the ..
- Tomosyn is expressed in beta-cells and negatively regulates insulin exocytosisWei Zhang
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
Diabetes 55:574-81. 2006..Hence, in the pancreatic beta-cell, tomosyn negatively regulates insulin exocytosis...
- A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cellsKe Ning
Neurosciences Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
EMBO J 25:2377-87. 2006In obesity and diabetes, the ability of hypothalamic neurons to sense and transduce changes in leptin and insulin levels is compromised...
- Maintenance of adiponectin attenuates insulin resistance induced by dietary conjugated linoleic acid in miceAparna Purushotham
Department of Human Nutrition, Ohio State University, Columbus, OH 43210, USA
J Lipid Res 48:444-52. 2007..Our objective was to determine whether the maintenance of adipokines, mainly leptin and adiponectin, by either removing CLA from diets or using an adiponectin enhancer, rosiglitazone (ROSI), could ..
- Leptin-induced matrix metalloproteinase-2 secretion is suppressed by trans-10,cis-12 conjugated linoleic acidHyun Seuk Moon
School of Agricultural Biotechnology, Seoul National University, Seoul 151 921, Republic of Korea
Biochem Biophys Res Commun 356:955-60. 2007It has long been recognized that leptin, a hormone made by adipocytes, is an important circulating signal for the regulation of body weight...
- Thermoregulation and non-shivering thermogenesis in the genetically obese (ob/ob) mouseP Trayhurn
Pflugers Arch 373:189-93. 19781. The capacity ofr thermoregulation and thermogenesis in lean and genetically obese (ob/ob) mice has been investigated. 2...
- Laboratory animals exhibiting obesity and diabetes syndromesL Herberg
Metabolism 26:59-99. 1977..The metabolic peculiarities can be due to a dominant gene, as for the yellow obese, or a single recessive gene, as in the obese and the diabetes mouse; or they can be of polygenic origin, as for ..
- Thermogenic defect in pre-obese ob/ob miceP Trayhurn
Nature 266:60-2. 1977
- The influence of genetic background on the expression of the obese (Ob) gene in the mouseD L Coleman
Diabetologia 9:287-93. 1973
- Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networksL A Campfield
Department of Metabolic Diseases, Hoffmann La Roche Incorporated, Nutley, NJ 07110, USA
Science 269:546-9. 1995..administration of microgram doses of OB protein reduced food intake and body weight of ob/ob and diet-induced obese mice but not in db/db obese mice...
- Positional cloning of the mouse obese gene and its human homologueY Zhang
Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
Nature 372:425-32. 1994The mechanisms that balance food intake and energy expenditure determine who will be obese and who will be lean. One of the molecules that regulates energy balance in the mouse is the obese (ob) gene...
- Genetic typing of the mouse ob mutation by PCR and restriction enzyme analysisT Hirasawa
Center for Experimental Animals Development, Shionogi and Co, Ltd, Shiga, Japan
Exp Anim 46:75-8. 1997A genetic typing method for the mouse obese (ob) mutation by PCR and restriction fragment length polymorphism (RFLP) analysis was developed. Three genotypes (ob/ob, ob/+ and +/+) of the ob mouse are rapidly differentiated with this assay...
- Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 geneD J Good
Acquired Gene Rearrangement Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20889, USA
Nat Genet 15:397-401. 1997..Nhlh2 is expressed in the ventral-medial and lateral hypothalamus, Rathke's pouch and in the anterior lobe of the adult pituitary. Our results support a role for Nhlh2 in the onset of puberty and the regulation of body weight metabolism...
- Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stressM L Heiman
Endocrine Division, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46250, USA
Endocrinology 138:3859-63. 1997b>Leptin is a newly identified protein hormone that is synthesized and secreted by adipose tissue. Absence of the mature hormone is responsible for the obese phenotype of ob/ob mice...
- Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine functionR S Ahima
Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 101:1020-7. 1998b>Leptin is thought to regulate energy balance through effects on food intake and thermogenesis...
- Increased expression of mRNA for the long form of the leptin receptor in the hypothalamus is associated with leptin hypersensitivity and fastingD G Baskin
Department of Veterans Affairs Puget Sound Health Care System, Department of Medicine, University of Washington, Seattle 98108, USA
Diabetes 47:538-43. 1998The responsiveness of the hypothalamus to the inhibitory effects of leptin on food intake and body weight is influenced by multiple factors, including deficiency of either leptin or leptin receptors (Ob-R)...
- Induction of uncoupling protein expression in brown and white adipose tissue by leptinS P Commins
Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
Endocrinology 140:292-300. 1999..In ob/ob mice, the absence of leptin affects both components of the energy balance equation, and the mice become morbidly obese after weaning...
- Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob miceJ Seufert
The Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 96:674-9. 1999b>Leptin controls feeding behavior and insulin secretion from pancreatic beta-cells. Insulin stimulates the production of leptin, thereby establishing an adipoinsular axis...
- Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fastingT M Mizuno
Fishberg Center for Neurobiology, Department of Geriatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
Endocrinology 140:814-7. 1999..Y (NPY) messenger RNA (mRNA), AGRP mRNA is produced in the hypothalamic arcuate nucleus and is elevated in leptin-deficient ob/ob and leptin-resistant db/db mice...
- Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker ratsA Enriquez
Department of Medicine, University of Sydney, Westmead Hospital, New South Wales, Australia
Biochem Biophys Res Commun 255:300-6. 1999..obesity-related (type II) diabetes, we analyzed the hepatic expression of CYP2E1 and CYP4A in ob/ob mice which are leptin deficient, and fa/fa Zucker rats which have defective leptin receptor function...
- Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitusI Shimomura
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9046, USA
J Biol Chem 274:30028-32. 1999..In the current studies, we measured the content of SREBPs in livers from two mouse models of diabetes, obese ob/ob mice and transgenic aP2-SREBP-1c436 (aP2-SREBP-1c) mice that overexpress nuclear SREBP-1c only in adipose ..
- Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese miceA L Mark
Specialized Center of Research in Hypertension Genetics and the Cardiovascular Center, Department of Internal Medicine, University of Iowa, Iowa City, USA
J Hypertens 17:1949-53. 1999..ob/ob(Lep(ob)/Lep(ob)) mice have a mutation in the ob gene and are leptin-deficient...
- Requirement for leptin in the induction and progression of autoimmune encephalomyelitisG Matarese
Cattedra di Immunologia, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Napoli, Italy
J Immunol 166:5909-16. 2001Recent evidence indicates that leptin modifies T cell immunity, and may provide a key link between nutritional deficiency and immune dysfunction...
- Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IkkbetaM Yuan
Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
Science 293:1673-7. 2001We show that high doses of salicylates reverse hyperglycemia, hyperinsulinemia, and dyslipidemia in obese rodents by sensitizing insulin signaling...
- Role for stearoyl-CoA desaturase-1 in leptin-mediated weight lossPaul Cohen
Laboratory of Molecular Genetics, Center for Studies in Physics and Biology, Rogosin Institute, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Science 297:240-3. 2002b>Leptin elicits a metabolic response that cannot be explained by its anorectic effects alone. To examine the mechanism underlying leptin's metabolic actions, we used transcription profiling to identify leptin-regulated genes in ob/ob liver...
- Gene expression profiles of nondiabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibilityHong Lan
Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
Diabetes 52:688-700. 2003..We have previously reported that in adipose tissue of obese (ob/ob) mice, the expression of adipogenic genes is decreased...
- Rapid recruitment of inflammatory monocytes is independent of neutrophil migrationRobert B Henderson
Leukocyte Adhesion Laboratory, Cancer Research United Kingdom London Research Institute, Lincoln s Inn Fields Laboratories, London WC2A 3PX, UK
Blood 102:328-35. 2003..The murine monocyte therefore responds rapidly to chemokines produced in situ by tissue cells at the site of inflammation with no requirement for prior influx of neutrophils...
- Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1cMitsuhiro Watanabe
Institut de Génétique et Biologie Moléculaire et Cellulaire, CNRS INSERM ULP, Illkirch, France
J Clin Invest 113:1408-18. 2004..These results suggest that strategies aimed at increasing FXR activity and the repressive effects of SHP should be explored to correct hypertriglyceridemia...
- Transport of neurotrophic cytokines after spinal cord injuryWeihong Pan; Fiscal Year: 2007..Understanding the mechanisms of cytokine transport at this regulatory interface would help in the design of new approaches to treat SCI. ..
- Transport of TNFalpha across the BBBWeihong Pan; Fiscal Year: 2008..These transporters could be novel drug targets and therefore provide promising therapeutic potential. [unreadable] [unreadable]..
- Conference on ObesityMichael Schwartz; Fiscal Year: 2003..Energy homeostasis involves humoral signals such as leptin that create a circuit between peripheral tissues involved in energy storage and utilization and central networks ..
- HYPOTHALAMIC PEPTIDES, FOOD INTAKE, AND DIABETESMichael Schwartz; Fiscal Year: 2006..neuronal systems in the arcuate nucleus (ARC) of the hypothalamus are regulated by hormones such as insulin and leptin that circulate in proportion to body fat mass has received strong support from studies using this model...
- TRH in mediating the bradycardia of caloric restrictionSteven Swoap; Fiscal Year: 2005..attention being paid to the cardiovascular disease risk linked to the tachycardia that is commonly seen in obese patients...
- Integration of Long- and Short-Term Control of FeedingMichael Schwartz; Fiscal Year: 2004..Following the cloning of the ob gene, this model was expanded to include the adipocyte hormone, leptin. It has subsequently become evident that many of leptin's CNS effects overlap with those induced by insulin, and ..
- Mentored Clinical Research Scholar Program at IowaALLYN MARK; Fiscal Year: 2007..These and other University research programs extend into the community--statewide and beyond--and include numerous disease registers and a broad network of collaborating institutions. [unreadable] [unreadable] [unreadable]..
- ApoB-Proteoglycan Interaction and AtherosclerosisZhouji Chen; Fiscal Year: 2006..Such information will advance our understanding of mechanisms of atherosclerosis and, in turn, facilitate developing new therapeutic strategies to treat atherosclerotic diseases. [unreadable] [unreadable]..
- Effect of Leptin on Trophoblast InvasivenessLaura Schulz; Fiscal Year: 2006I propose to investigate the relationship between leptin and trophobiast invasion...
- Role of Leucine Metabolism in Leucine SignalingCHRISTOPHER JOHN LYNCH; Fiscal Year: 2010..The implication of our ongoing research is that blocking the first step in BCAA metabolism with a drug, or to a less extent increasing dietary BCAAs, will promote weight loss. ..
- Opiate Addiction and HIV-1 Induced Release of CytokinesWilliam Banks; Fiscal Year: 2006....
- ENERGY HOMEOSTASIS IN HUMAN OBESITYRudolph Leibel; Fiscal Year: 2001One third of the U.S. population over the age of 20 (58 million individuals) is obese. The prevalence of obesity in children is approximately 20% and rates of obesity are disproportionately high among Black and Hispanic women...
- Regulation of Pulmonary Host Defense by LeptinPeter Mancuso; Fiscal Year: 2010..b>Leptin is hormone produced by adipose tissue that is reduced in the energy malnourished and is known to regulate innate ..
- A model of obesity-associated severe acute pancreatitisGiamila Fantuzzi; Fiscal Year: 2007..of AP patients - for 3 to 5 days induces mild pancreatic damage in non-obese wild type mice, but very severe AP in leptin-deficient, massively obese ob/ob mice...
- MOLECULAR DETERMINANTS OF LEPTIN RECEPTOR/JAK2 SIGNALINGMartin Myers; Fiscal Year: 2007This application, entitled, "Molecular Determinants of Leptin Receptor/Jak2 Signaling," is a revised competitive renewal of DK56731...
- Matrix Metalloproteinases, Exercise, and Muscle DamageDavid Allen; Fiscal Year: 2008..Finally, subjects will be genotyped for known functional MMP promoter polymorphisms, which will be correlated with MMP levels and muscle damage and soreness following eccentric exercise. ..
- REGULATION OF ADIPOCYTE PROTEIN SYNTHESIS BY AMINO ACIDSChristopher Lynch; Fiscal Year: 2007..it regulates have critical roles in translational regulation of protein synthesis, adipocyte differentiation, leptin, de novo lipogenesis, cell cycle progression, hypertrophic growth of post-mitotic tissues and tissue morphogenesis...
- Role of Leptin in murine modeles of IBDGiamila Fantuzzi; Fiscal Year: 2007The goal of this project is to investigate the mechanisms by which leptin deficiency regulates susceptibility to intestinal inflammation in mice...
- Prevention of skin cancer by green tea polyphenolsSantosh Katiyar; Fiscal Year: 2009..Importantly, worldwide interest in green tea as a cancer chemopreventive agent for humans is increasing because it is non-toxic, affordable, popular beverage and is effective in a wide range of organs. ..
- Intermittent food restriction prevents mammary tumorsMARGOT CLEARY; Fiscal Year: 2008..1- The protective effect of intermittent restriction/refeeding is mediated by decreased serum IGF-I and leptin and effects on signaling pathways and/or proliferation/apoptosis; 2-The protective effect of intermittent ..
- Prion Transport Across the Blood-Brain BarrierWilliam Banks; Fiscal Year: 2009..To cause disease, prions must cross the blood-brain barrier to enter the brain. We will determine how prions cross the BBB. Knowing how prions enter the brain should lead to strategies on how to prevent prion diseases. ..
- Role of Acetaldehyde in Alcoholic CardiomyopathyJun Ren; Fiscal Year: 2008..Our long-term goal is to establish the toxic mechanism of acetaldehyde in the development of alcoholic cardiomyopathy so that prevention and treatment can be optimized [unreadable] [unreadable]..
- Leptin Signaling in Cardiac HypertrophyLILI BAROUCH; Fiscal Year: 2008..b>Leptin, the ob gene product, is a hormone that regulates energy balance and adipose stores while also exerting ..
- ANGIOTENSIN AND CENTRAL NEUROHUMORAL ACTIVATION IN CHFRobert Felder; Fiscal Year: 2005..This work will provide new information concerning the role of the central nervous system in the pathophysiology of CHF and will draw attention to the possibility of CNS directed drug therapy for heart failure. ..
- Prevention of Photocarcinogenesis by antioxidantSantosh Katiyar; Fiscal Year: 2003..abstract_text> ..
- Role of glucocorticoids in hypoglycemia unawarenessLauren Jacobson; Fiscal Year: 2003..abstract_text> ..
- IGF-1, Oxidative Stress and Cardiovascular AgingJun Ren; Fiscal Year: 2002..Our long-term goal is to establish the causal link among IGF-1 deficiency, enhanced oxidative damage and ventricular dysfunction in the progression of cardiovascular aging so that hormonal or antioxidant therapy can be optimized...
- CNS Counterregulatory MechanismsLauren Jacobson; Fiscal Year: 2004..These studies will provide novel information on the neuropharmacology of glucose control that may reveal therapeutic strategies to prevent hypoglycemia unawareness. ..
- PTS1 Regulation of Brain Met Enk Levels in AlcoholismWilliam Banks; Fiscal Year: 2004..abstract_text> ..
- Determinants of Tolerance to Nitrous Oxide HypothermiaKarl Kaiyala; Fiscal Year: 2004..These studies have theoretical importance for understanding the mechanisms of drug tolerance and will begin to suggest the physiological basis of individual differences in vulnerability to addiction and drug abuse. ..
- Mechanisms of HIV Transport Across the BBBWilliam Banks; Fiscal Year: 2004....
- Prevention of UV-carcinogenesis by antioxidantSantosh Katiyar; Fiscal Year: 2004..abstract_text> ..
- Sleep Disordered Breathing and Glucose RegulationVsevolod Polotsky; Fiscal Year: 2006..Furthermore, the absence of the metabolic hormone leptin resulted in a more pronounced hyperglycemic phase in response to IH compared to wildtype mice...
- Conference on ObesityRudolph Leibel; Fiscal Year: 2004....
- UCP2 in the pathogenesis of steatohepatitisGYORGY BAFFY; Fiscal Year: 2005..Knowledge of the biochemical actions and genetic regulation of UCP2 in the liver will advance our understanding about the role of UCP2 and the pathophysiology of SH. ..
- ODORANT-RECEPTOR INTERACTIONS IN OLFACTORY NEURONSThomas Getchell; Fiscal Year: 2005..Understanding the signaling regulating neurogenesis in the OE will yield insights into mechanisms for restoring olfactory function compromised by aging, trauma, and neurodegenerative diseases. ..
- In Vivo Kinetic Biomarkers of Hepatic ToxicityScott Turner; Fiscal Year: 2005..This work will provide a solid foundation for regulatory approval of our toxicity screen, for extension of our work to other end organs, and for use in humans. ..
- Kinetic Biomarkers of Joint Space Molecules in OAScott Turner; Fiscal Year: 2005..These tools may allow significant advances in our basic understanding of the biology of the extracellular matrix in the joint space, with potential application to the prevention and treatment of arthritic disorders. ..
- Proanthocyanidins: Novel Skin Cancer Preventive AgentSantosh Katiyar; Fiscal Year: 2006..Prevention of skin cancer risk will result to protect and prolong the human health and lives. ..
- PHOSPHOINOSITIDE HYDROLYSIS AND BETA CELL SECRETIONWalter Zawalich; Fiscal Year: 2006..These aims will be accomplished by using sound principles of experimentation and employing isolated islets that retain their in vivo sensitivity to glucose. ..
- Neuroadaptive Substrates for Nitrous Oxide ToleranceKarl Kaiyala; Fiscal Year: 2006..This work will be the first to identify brain areas activated by a drug-induced hypothermic stimulus and its adaptive consequences. These studies have theoretical importance for understanding and treating drug addiction. ..
- Effects of Myostatin Deficiency on Bone StrengthMark Hamrick; Fiscal Year: 2007..abstract_text> ..