Ldlr

Summary

Gene Symbol: Ldlr
Description: low density lipoprotein receptor
Alias: Hlb301, LDL receptor, low-density lipoprotein receptor
Species: mouse

Top Publications

  1. ncbi Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet
    Jawahar L Mehta
    Cardiovascular Medicine, Gene Therapy Program, University of Arkansas for Medical Sciences, Little Rock, AR 72205
    Circ Res 100:1634-42. 2007
  2. ncbi High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis
    T A McCaffrey
    Department of Medicine, Division of Hematology Oncology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 105:653-62. 2000
  3. ncbi CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1
    Andreas Zirlik
    Donald W Reynolds Center, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 115:1571-80. 2007
  4. ncbi Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus
    Monique Mulder
    Department of Molecular Cell Biology, Maastricht University and University Hospital Maastricht, Maastricht, The Netherlands
    Neurobiol Dis 16:212-9. 2004
  5. ncbi Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions
    Pieter Goossens
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    Cell Metab 12:142-53. 2010
  6. ncbi A receptor-mediated pathway for cholesterol homeostasis
    M S Brown
    Science 232:34-47. 1986
  7. ncbi A major role for VCAM-1, but not ICAM-1, in early atherosclerosis
    M I Cybulsky
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto General Research Institute, Toronto, Ontario, Canada
    J Clin Invest 107:1255-62. 2001
  8. ncbi Tumor necrosis factor receptor-associated factor 1 (TRAF1) deficiency attenuates atherosclerosis in mice by impairing monocyte recruitment to the vessel wall
    Anna Missiou
    Department of Cardiology, University of Freiburg, Germany
    Circulation 121:2033-44. 2010
  9. ncbi Plasma PCSK9 preferentially reduces liver LDL receptors in mice
    Aldo Grefhorst
    Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9046, USA
    J Lipid Res 49:1303-11. 2008
  10. ncbi Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia
    H Yagyu
    Departments of Metabolic Diseases, Ophthalmology, Pathology, Faculty of Medicine, University of Tokyo, Hongo, Tokyo 113 8655, Japan
    J Biol Chem 275:21324-30. 2000

Research Grants

  1. The Role of Hepatic Lipase in Cholesterol Homeostatis
    HELEN DICHEK; Fiscal Year: 2005
  2. Nuclear hormone receptor regulation of cholesterol absorption
    Joyce J Repa; Fiscal Year: 2010
  3. Characterization of the Role of ARH on LDLR Function
    PETER A MICHAELY; Fiscal Year: 2010
  4. Inhalable amphotericin B nanodisk therapy for aspergillosis in HIV-infected patie
    Trudy Forte; Fiscal Year: 2007
  5. The role of PON-2 and PON3 proteins in atherosclerosis
    Srinivasa Reddy; Fiscal Year: 2007
  6. Regulation of Proteasome Function in Cardiomyopathies
    Sharlene M Day; Fiscal Year: 2010
  7. Creating Glucose Responsive Cardiovascular Complications
    Ira Goldberg; Fiscal Year: 2007
  8. EXTRACELLULAR REGULATION OF LIPOPROTEIN LIPASE ACTIVITY
    IRA JAY GOLDBERG; Fiscal Year: 2010
  9. MACROPHAGE EXPRESSION OF APOAI AND ATHEROSCLEROSIS
    Sergio Fazio; Fiscal Year: 2007
  10. EXTRACELLULAR REGULATION OF LIPOPROTEIN LIPASE ACTIVITY
    Ira Goldberg; Fiscal Year: 2007

Detail Information

Publications117 found, 100 shown here

  1. ncbi Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet
    Jawahar L Mehta
    Cardiovascular Medicine, Gene Therapy Program, University of Arkansas for Medical Sciences, Little Rock, AR 72205
    Circ Res 100:1634-42. 2007
    ..whether endothelial functional preservation might lead to reduction in atherogenesis, we crossed LOX-1 KO mice with LDLR KO mice and fed these mice 4% cholesterol/10% cocoa butter diet for 18 weeks...
  2. ncbi High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis
    T A McCaffrey
    Department of Medicine, Division of Hematology Oncology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 105:653-62. 2000
    ..Induction of atherosclerosis in LDL receptor-null mice by feeding them a high-fat diet resulted in a progressive increase in Egr-1 expression in the aorta...
  3. ncbi CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1
    Andreas Zirlik
    Donald W Reynolds Center, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 115:1571-80. 2007
    ..The present study aimed to characterize the contribution of CD40 signaling to atherogenesis...
  4. ncbi Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus
    Monique Mulder
    Department of Molecular Cell Biology, Maastricht University and University Hospital Maastricht, Maastricht, The Netherlands
    Neurobiol Dis 16:212-9. 2004
    The low-density lipoprotein receptor (LDLR) is the first described receptor for apolipoprotein E (apoE). We hypothesize that the absence of the LDLR, similar to the absence of apoE, results in impaired learning and memory processes...
  5. ncbi Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions
    Pieter Goossens
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    Cell Metab 12:142-53. 2010
    ..Finally, we show that type I IFN signaling is upregulated in ruptured human atherosclerotic plaques. Hereby, we identify type I IFNs as proatherosclerotic cytokines that may serve as additional targets for prevention or treatment...
  6. ncbi A receptor-mediated pathway for cholesterol homeostasis
    M S Brown
    Science 232:34-47. 1986
  7. ncbi A major role for VCAM-1, but not ICAM-1, in early atherosclerosis
    M I Cybulsky
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto General Research Institute, Toronto, Ontario, Canada
    J Clin Invest 107:1255-62. 2001
    ..After crossing into the LDL receptor-null background, Vcam1(+/+) and Vcam1(D4D/D4D) paired littermates were generated from heterozygous intercrosses ..
  8. ncbi Tumor necrosis factor receptor-associated factor 1 (TRAF1) deficiency attenuates atherosclerosis in mice by impairing monocyte recruitment to the vessel wall
    Anna Missiou
    Department of Cardiology, University of Freiburg, Germany
    Circulation 121:2033-44. 2010
    ..Tumor necrosis factor receptor-associated factors (TRAFs) are cytoplasmic adaptor proteins for this group of cytokines...
  9. ncbi Plasma PCSK9 preferentially reduces liver LDL receptors in mice
    Aldo Grefhorst
    Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9046, USA
    J Lipid Res 49:1303-11. 2008
    Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that regulates the expression of LDL receptor (LDLR) protein...
  10. ncbi Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia
    H Yagyu
    Departments of Metabolic Diseases, Ophthalmology, Pathology, Faculty of Medicine, University of Tokyo, Hongo, Tokyo 113 8655, Japan
    J Biol Chem 275:21324-30. 2000
    ..in atherogenesis, we crossed the ACAT-1-/- mice with mice lacking apolipoprotein (apo) E or the low density lipoprotein receptor (LDLR), hyperlipidemic models susceptible to atherosclerosis...
  11. ncbi Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48-/-Lepob/ob mice devoid of ApoE or Ldlr
    David J Lloyd
    Department of Metabolic Disorders, Amgen Incorporated, Thousand Oaks, California 91320, USA
    Am J Physiol Endocrinol Metab 294:E496-505. 2008
    ..triple-knockout mice that are deficient in either apolipoprotein E (Apoe(-/-)) or low-density lipoprotein receptor (Ldlr(-/-)) and express no leptin (Lep(ob/ob)) or apolipoprotein B-48 but exclusively apolipoprotein B-100 (Apob(100/100))..
  12. ncbi Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice
    Kristin I Stanford
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0687, USA
    J Clin Invest 119:3236-45. 2009
    ..These findings provide the first in vivo genetic evidence that syndecan-1 is the primary hepatocyte HSPG receptor mediating the clearance of both hepatic and intestinally derived triglyceride-rich lipoproteins...
  13. ncbi Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice
    Israel Gotsman
    Vascular Research Division, Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 117:2974-82. 2007
    ..T cell responses, we compared atherosclerotic lesion burden and phenotype in hypercholesterolemic PD-L1/2(-/-)LDLR(-/-) mice and LDLR(-/-) controls...
  14. ncbi Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions
    Chantal M C Dupasquier
    Canadian Center for Agri food Research in Health and Medicine, St Boniface Hospital Research Center, Winnipeg, Canada
    Am J Physiol Heart Circ Physiol 293:H2394-402. 2007
    ..capacity of flaxseed in an animal model that more closely represents the human atherosclerotic condition, the LDL receptor-deficient mouse (LDLrKO), and to identify the cellular mechanisms for these effects...
  15. ncbi Direct viewing of atherosclerosis in vivo: plaque invasion by leukocytes is initiated by the endothelial selectins
    E E Eriksson
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    FASEB J 15:1149-57. 2001
    ..This experimental technique and the data presented introduce a novel perspective for the study of pathophysiological events involved in large-vessel disease...
  16. ncbi Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root
    Daniel Teupser
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:17795-800. 2004
    ..ApoE(-/-) and B6.LDLR(-/-) backgrounds...
  17. ncbi LRP: role in vascular wall integrity and protection from atherosclerosis
    Philippe Boucher
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
    Science 300:329-32. 2003
    ..Thus, LRP1 has a pivotal role in protecting vascular wall integrity and preventing atherosclerosis by controlling PDGFR activation...
  18. ncbi Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice
    Dongfeng Cao
    Atherosclerosis Research Unit, Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Alabama at Birmingham, 1530 3rd Avenue South, BDB 658, Birmingham, AL 35294, USA
    Neurobiol Aging 27:1632-43. 2006
    ..Emerging evidence indicates that cholesterol metabolism affects the pathogenesis of Alzheimer's disease (AD). The LDL receptor (LDLR) is obligatory in maintaining cholesterol homeostasis in the periphery...
  19. ncbi Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice
    Marcia L E MacDonald
    Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    J Lipid Res 49:217-29. 2008
    ..the Scd1 gene product reduces plasma triglycerides and reduces weight gain in severely hyperlipidemic low density lipoprotein receptor (LDLR)-deficient mice challenged with a Western diet...
  20. ncbi A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates
    Joyce C Y Chan
    Department of Metabolic Disorders, Amgen Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 106:9820-5. 2009
    ..convertase subtilisin/kexin type 9 (PCSK9) regulates serum LDL cholesterol (LDL-C) by interacting with the LDL receptor (LDLR) and is an attractive therapeutic target for LDL-C lowering...
  21. ncbi Embryo implantation in mouse: fetomaternal coordination in the pattern of expression of uPA, uPAR, PAI-1 and alpha 2MR/LRP genes
    T Teesalu
    Dipartimento di Ricerca Biologica e Tecnologica DIBIT, Istituto Scientifico S Raffaele, Milano, Italy
    Mech Dev 56:103-16. 1996
    ..uPAR), plasminogen activator inhibitor type 1 (PAI-1) and alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein (alpha 2MR/LRP) transcripts were determined by in situ hybridization...
  22. ncbi Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile
    Esther Lutgens
    Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht 6200 MD, Netherlands
    J Exp Med 207:391-404. 2010
    ....
  23. ncbi Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis
    J Mark Brown
    Department of Pathology, Wake Forest University School of Medicine, Section on Lipid Sciences, Winston Salem, NC 27157 1040, USA
    Circulation 118:1467-75. 2008
    ..Stearoyl-coenzyme A desaturase 1 (SCD1) is a well-known enhancer of the metabolic syndrome. The purpose of the present study was to investigate the role of SCD1 in lipoprotein metabolism and atherosclerosis progression...
  24. ncbi Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophages and distinct atherosclerosis at relatively low plasma cholesterol levels
    Ruud Out
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Einsteinweg 55, 2333CC Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 28:258-64. 2008
    ..The purpose of this study was to evaluate the effect of the combined deletion of ABCA1 and ABCG1 expression in macrophages on foam cell formation and atherosclerosis...
  25. ncbi Increased cell and matrix accumulation during atherogenesis in mice with vessel wall-specific deletion of discoidin domain receptor 1
    Christopher Franco
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Medical Sciences Building, Room 6213, 1 King s College Circle, Toronto, ON M5S 1A8, Canada
    Circ Res 106:1775-83. 2010
    ..Systemic deletion of DDR1 resulted in attenuated plaque growth but accelerated matrix accumulation in LDLR-deficient mice...
  26. ncbi Discoidin domain receptor 1 on bone marrow-derived cells promotes macrophage accumulation during atherogenesis
    Christopher Franco
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada
    Circ Res 105:1141-8. 2009
    ..Systemic deletion of Ddr1 in Ldlr(-/-) mice accelerated matrix accumulation and reduced plaque size and macrophage content...
  27. ncbi Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemia
    Alexander Kovacs
    Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 104:13768-73. 2007
    ..We bred atherosclerosis-prone mice (Apob(100/100)Ldlr(-/-)), which have human-like hypercholesterolemia, with hCRP transgenic mice (hCRP(+/0)) and studied lesion ..
  28. ncbi Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice
    Edwin Kanters
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Clin Invest 112:1176-85. 2003
    ..To investigate the role of NF-kappaB activation in macrophages during atherogenesis, we used LDL receptor-deficient mice with a macrophage-restricted deletion of IkappaB kinase 2 (IKK2), which is essential for NF-..
  29. ncbi The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brain
    Chen Zhang
    Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Pathol 174:586-94. 2009
    ..In summary, our results indicate that the interaction between tPA and LRP1 induces microglial activation with the generation of an inflammatory response in the ischemic brain, suggesting a cytokine-like role for tPA in the CNS...
  30. ncbi A direct role for the macrophage low density lipoprotein receptor in atherosclerotic lesion formation
    M F Linton
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 274:19204-10. 1999
    To evaluate the contribution of the macrophage low density lipoprotein receptor (LDLR) to atherosclerotic lesion formation, we performed bone marrow transplantation studies in different mouse strains...
  31. ncbi Effect of macrophage-derived apolipoprotein E on hyperlipidemia and atherosclerosis of LDLR-deficient mice
    Weibin Shi
    Department of Radiology, University of Virginia, Charlottesville 22908, USA
    Biochem Biophys Res Commun 317:223-9. 2004
    b>LDL receptor-deficient (LDLR(-/-)) mice fed a Western diet exhibit severe hyperlipidemia and develop significant atherosclerosis. Apolipoprotein E (apoE) is a multifunctional protein synthesized by hepatocytes and macrophages...
  32. ncbi High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice
    Lakshmi Thirumangalakudi
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurochem 106:475-85. 2008
    ..Groups of normal C57BL/6 and low density lipoprotein receptor (LDLR)-deficient mice were fed a high fat/cholesterol diet for an 8-week period and tested for memory ..
  33. ncbi Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis
    Anna P Lillis
    Center for Vascular and Inflammatory Diseases and Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 181:364-73. 2008
    ....
  34. ncbi Provirus insertion in Tpl-1, an Ets-1-related oncogene, is associated with tumor progression in Moloney murine leukemia virus-induced rat thymic lymphomas
    S E Bear
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111
    Proc Natl Acad Sci U S A 86:7495-9. 1989
    ..2 +/- 0.9 centimorgans from the Ets-1 protooncogene. Although the genetic distance between Tpl-1 and Ets-1 indicates that they are different genes, analysis of Tpl-1 cDNA clones revealed that the two are closely related...
  35. ncbi Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice
    R K Tangirala
    Department of Medicine, University of California, San Diego, La Jolla 92093 0682, USA
    J Lipid Res 36:2320-8. 1995
    ..In other models such as LDL receptor-deficient and apoE-deficient mice, diet-induced or spontaneous hypercholesterolemia and atherogenesis are much ..
  36. ncbi No effect of C-reactive protein on early atherosclerosis in LDLR-/- / human C-reactive protein transgenic mice
    Michael Torzewski
    Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University Mainz, Mainz, Germany
    Thromb Haemost 99:196-201. 2008
    ..Since knockout mice with a defect in low density lipoprotein receptor (LDLR(-/-)) may represent a better model of atherogenesis compared to ApoE(-/-) animals, we undertook ..
  37. ncbi Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice
    U Schonbeck
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, LMRC 309, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:7458-63. 2000
    ..This study lends further support to the importance of this specific inflammatory signaling pathway in atherosclerosis and its complications...
  38. ncbi Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor
    A H Hasty
    Department of Metabolic Diseases, University of Tokyo, Tokyo, 113 8655, Japan
    J Biol Chem 276:37402-8. 2001
    ..In the current study, we show an unexpectedly severe hyperlipidemia in ob/ob mice on a background of low density lipoprotein receptor (LDLR) deficiency (-/-)...
  39. ncbi Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9
    Shirya Rashid
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 102:5374-9. 2005
    ..likely due to a gain-of-function mechanism because overexpression of either WT or mutant PCSK9 reduces hepatic LDL receptor protein (LDLR) in mice...
  40. ncbi Liver disease with altered bile acid transport in Niemann-Pick C mice on a high-fat, 1% cholesterol diet
    Robert P Erickson
    Department of Pediatrics, School of Health Sciences, University of Arizona, 1501 N Campbell Avenue, P O Box 245073, Tucson, AZ 85724 5073
    Am J Physiol Gastrointest Liver Physiol 289:G300-7. 2005
    ..We studied the influence of diet and the low density lipoprotein receptor (LDLR, Ldlr in mice, known to be the source of most of the stored cholesterol) on liver disease in ..
  41. ncbi Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis
    J Mark Brown
    Wake Forest University School of Medicine, Department of Pathology, Section on Lipid Sciences, Medical Center Blvd, Winston Salem, NC 27157 1040, USA
    Arterioscler Thromb Vasc Biol 30:24-30. 2010
    ..In this study we tested whether dietary fish oil supplementation could prevent the accelerated atherosclerosis caused by SCD1 inhibition...
  42. ncbi LRP1 functions as an atheroprotective integrator of TGFbeta and PDFG signals in the vascular wall: implications for Marfan syndrome
    Philippe Boucher
    Institut Gilbert Laustriat, UMR 7175 LC 1, Department of Pharmacology Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Medicale Université Louis Pasteur, Illkirch, France
    PLoS ONE 2:e448. 2007
    ..LRP1 is also a receptor for TGFbeta1 and is required for TGFbeta mediated inhibition of cell proliferation...
  43. ncbi Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis
    Soraya Taleb
    Institut National de la Sante et de la Recherche Medicale, U689, 41 Bd de la Chapelle, Paris, France
    Arterioscler Thromb Vasc Biol 27:2691-8. 2007
    ..Obesity is a major risk factor for atherosclerosis and is associated with increased cardiovascular morbidity and mortality. However, the precise molecular pathways responsible for this close association remain poorly understood...
  44. ncbi LOX-1 deletion decreases collagen accumulation in atherosclerotic plaque in low-density lipoprotein receptor knockout mice fed a high-cholesterol diet
    Changping Hu
    Department of Internal Medicine, Central Arkansas Veterans Healthcare System and University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 532, Little Rock, AR 72205, USA
    Cardiovasc Res 79:287-93. 2008
    ..We examine the hypothesis that LOX-1 deletion may inhibit collagen accumulation in atherosclerotic arteries in LDL receptor (LDLR) knockout (KO) mice.
  45. ncbi Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice
    Seongah Han
    Division of Molecular Medicine, Department of Medicine, Columbia University, 630 West 168th St, New York, New York 10032, USA
    J Clin Invest 119:1029-41. 2009
    ..both hepatic and peripheral insulin resistance contribute to atherogenesis, we crossed mice deficient for the LDL receptor (Ldlr-/- mice) with mice that express low levels of IR in the liver and lack IR in peripheral tissues (the L1B6 ..
  46. ncbi LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling
    Jerome Terrand
    CNRS, UMR7175, Universite de Strasbourg, Illkirch, F 67401 France
    J Biol Chem 284:381-8. 2009
    ..These results establish LRP1 as a novel integrator of adipogenic differentiation and fat storage signals...
  47. ncbi Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo
    Wah Seng Lim
    Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Circulation 117:940-51. 2008
    ....
  48. ncbi Decreased lipoprotein clearance is responsible for increased cholesterol in LDL receptor knockout mice with streptozotocin-induced diabetes
    Ira J Goldberg
    Division of Preventive Medicine, Columbia University, New York, New York 10032, USA
    Diabetes 57:1674-82. 2008
    Patients with diabetes often have dyslipidemia and increased postprandial lipidmia. Induction of diabetes in LDL receptor (Ldlr(-/-)) knockout mice also leads to marked dyslipidemia. The reasons for this are unclear.
  49. ncbi Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration
    Ahmed Zaid
    Laboratorie of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, affiliated to the University of Montreal, Montreal, Quebec, Canada
    Hepatology 48:646-54. 2008
    ..type 9 (PCSK9) is linked to familial hypercholesterolemia, as are those of the low-density lipoprotein receptor (LDLR) and apolipoprotein B. PCSK9 enhances LDLR degradation, resulting in low-density lipoprotein accumulation in plasma...
  50. ncbi Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events
    Adam E Mullick
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 205:373-83. 2008
    ..flow, such as the lesser curvature region, in atherosclerosis-prone, low-density lipoprotein receptor-deficient (LDLr(-/-)) mice. Diet-induced hyperlipidemia in LDLr(-/-) mice increased this regional endothelial TLR2 expression...
  51. ncbi Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: no accentuation by apolipoprotein(a)
    D A Sanan
    The Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, CA 94110, USA
    Proc Natl Acad Sci U S A 95:4544-9. 1998
    ..These mice have no functional LDL receptors [LDLR-/-] and express a human apolipoprotein B-100 (apoB) transgene [Tg(apoB+/+)] with or without an apo(a) transgene [Tg(..
  52. ncbi Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size
    Cecilia M Devlin
    Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 99:6280-5. 2002
    ..IL-1ra transgenic/low-density lipoprotein receptor (LDLR) knockout mice fed a cholesterol-saturated fat diet for 10 wk showed a 40% increase in non-high-density lipoprotein ..
  53. ncbi mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors
    C Meyer
    Zentrum für Biochemie und Molekulare Zellbiologie, Dept Biochemie II, Universitat Gottingen, Heinrich Düker Weg 12, D 37073 Gottingen, Germany
    EMBO J 19:2193-203. 2000
    ..MPR46 fails to recycle back from the endosome to the TGN, indicating that AP-1 is required for retrograde endosome to TGN transport of the receptor...
  54. ncbi Hyperlipidemia and atherosclerotic lesion development in LDL receptor-deficient mice fed defined semipurified diets with and without cholate
    A H Lichtman
    Vascular Research Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 19:1938-44. 1999
    ..Similar diets have been routinely used in studies with LDL receptor-deficient (LDLR(-/-)) mice...
  55. ncbi Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants
    A Rohlmann
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Howard Hughes Medical Institute, Dallas, Texas 75235, USA
    J Clin Invest 101:689-95. 1998
    ..Inactivation of LRP in the livers of LDL receptor-deficient mice resulted in the accumulation of cholesterol-rich remnant lipoproteins in the circulation...
  56. ncbi Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9
    L Boring
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141 9100, USA
    J Biol Chem 271:7551-8. 1996
    ..The identification and cloning of two functional murine chemokine receptors provides important new tools for investigating the roles of these potent cytokines in vivo...
  57. ncbi Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice
    S Ishibashi
    Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas 75235
    J Clin Invest 93:1885-93. 1994
    Mice that are homozygous for a targeted disruption of the LDL receptor gene (LDLR-/- mice) were fed a diet that contained 1.25% cholesterol, 7.5% cocoa butter, 7.5% casein, and 0.5% cholic acid...
  58. ncbi Reduction of isoprostanes and regression of advanced atherosclerosis by apolipoprotein E
    R K Tangirala
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 276:261-6. 2001
    ..Aged low density lipoprotein (LDL) receptor-deficient (LDLR(-/-)) mice were fed a western-type diet for 14 weeks to induce advanced atherosclerotic lesions...
  59. ncbi Hepatic secretion of small lipoprotein particles in apobec-1-/- mice is regulated by the LDL receptor
    Fatiha Nassir
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Lipid Res 45:1649-59. 2004
    Recent studies have examined the role of the LDL receptor (LDLR) in regulating murine hepatic lipoprotein production and apolipoprotein B (apoB) secretion, with divergent conclusions from in vivo versus in vitro approaches...
  60. ncbi Heme oxygenase-1 inhibits atherosclerotic lesion formation in ldl-receptor knockout mice
    K Ishikawa
    First Department of Internal Medicine, Second Department of Anatomy, Fukushima Medical University, Fukushima, Japan
    Circ Res 88:506-12. 2001
    ..These results suggest that HO-1, induced under hyperlipidemia, functioned as an intrinsic protective factor against atherosclerotic lesion formation, possibly by inhibiting lipid peroxidation and influencing the nitric oxide pathway...
  61. ncbi Initial hepatic removal of chylomicron remnants is unaffected but endocytosis is delayed in mice lacking the low density lipoprotein receptor
    J Herz
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Proc Natl Acad Sci U S A 92:4611-5. 1995
    Two endocytic receptors, the low density lipoprotein (LDL) receptor (LDLR) and the LDLR-related protein (LRP), are thought to act in concert in the hepatic uptake of partially metabolized dietary lipoproteins, the chylomicron remnants...
  62. ncbi Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden University, P O Box 9503, 2300 RA Leiden, The Netherlands
    Proc Natl Acad Sci U S A 99:6298-303. 2002
    ..the role of macrophage ABCA1 in atherosclerosis, we generated low-density lipoprotein (LDL) receptor knockout (LDLr(-/-)) mice that are selectively deficient in leukocyte ABCA1 (ABCA1(-/-)) by using bone marrow transfer (ABCA1(-/-) ..
  63. ncbi Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1
    M Accad
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141, USA
    J Clin Invest 105:711-9. 2000
    ..In the setting of severe hypercholesterolemia caused by deficiency in apoE or the LDL receptor (LDLR), total ACAT1 deficiency led to marked alterations in cholesterol homeostasis and extensive deposition of ..
  64. ncbi Atherosclerosis progression in LDL receptor-deficient and apolipoprotein E-deficient mice is independent of genetic alterations in plasminogen activator inhibitor-1
    H Sjöland
    Division of Cardiology, Department of Internal Medicine, Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor 48109 0644, USA
    Arterioscler Thromb Vasc Biol 20:846-52. 2000
    ..Mice lacking apolipoprotein E (apoE-/-) and mice lacking the low density lipoprotein receptor (LDLR-/-) were crossbred with transgenic mice overexpressing PAI-1 (resulting in PAI-1 Tg(+)/apoE-/- ..
  65. ncbi ApoB100,LDLR-/- mice exhibit reduced electroretinographic response and cholesteryl esters deposits in the retina
    Lionel Bretillon
    INRA, UMR 1129 FLAVIC, Eye and Nutrition Research Group, F 21000 Dijon, France
    Invest Ophthalmol Vis Sci 49:1307-14. 2008
    To evaluate the retinal phenotype of 7- and 14-month-old apoB100,LDLR-/- mice, a relevant animal model of lipid metabolism dysfunction.
  66. ncbi Effect of aging on aortic expression of the vascular cell adhesion molecule-1 and atherosclerosis in murine models of atherosclerosis
    S Merat
    Department of Medicine, University of California San Diego, La Jolla, USA
    J Gerontol A Biol Sci Med Sci 55:B85-94. 2000
    ..In chow-fed low-density lipoprotein receptor-deficient (LDLR-/-) mice, plasma total cholesterol levels increased with age (250 +/- 52 mg/dl in young, 276 +/- 58 in mature, and ..
  67. ncbi Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice
    K R Coenen
    Vanderbilt University Medical Centre, Room 702 Light Hall, Nashville, TN 37232 0615, USA
    Diabetologia 52:318-28. 2009
    ....
  68. ncbi Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice
    Fredrik Johansson
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:2082-7. 2008
    ..We therefore used an LDL receptor-deficient mouse model, in which type 1 diabetes can be induced at will, to investigate the effects of diabetes ..
  69. ncbi Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice
    D Pratico
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Proc Natl Acad Sci U S A 98:3358-63. 2001
    ..Because deletion of the PGI(2) receptor accelerates atherogenesis in the fat-fed low density lipoprotein receptor knockout mouse, we wished to determine whether selective inhibition of COX-2 would accelerate ..
  70. ncbi Microsomal triglyceride transfer protein enhances cellular cholesteryl esterification by relieving product inhibition
    Jahangir Iqbal
    Department of Anatomy and Cell Biology and Pediatrics, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    J Biol Chem 283:19967-80. 2008
    ..We speculate that non-lipoprotein-producing cells may use different mechanisms to alleviate product inhibition and modulate cholesteryl ester biosynthesis...
  71. ncbi Effects of hypercholesterolemia on myocardial ischemia-reperfusion injury in LDL receptor-deficient mice
    W G Girod
    Department of Surgery, LSU Medical Center, Shreveport, LA 71130, USA
    Arterioscler Thromb Vasc Biol 19:2776-81. 1999
    ..We subjected low density lipoprotein receptor-deficient (LDLr -/-) and control (wild-type) mice to 30 minutes of myocardial ischemia and 120 ..
  72. ncbi Absence of hyperlipidemia in LDL receptor-deficient mice having apolipoprotein B100 without the putative receptor-binding sequences
    Lance A Johnson
    Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
    Arterioscler Thromb Vasc Biol 28:1745-52. 2008
    To examine the effects of apoB100 structure, specifically a mutation in the LDLr binding region, on the production of LDL and development of atherosclerosis in vivo.
  73. ncbi Increased response to cholesterol feeding in apolipoprotein C1-deficient mice
    J H van Ree
    MGC Department of Human Genetics, Leiden University, The Netherlands
    Biochem J 305:905-11. 1995
    ..006 g/ml are poor competitors for 125I-labelled LDL binding to the LDL receptor on HepG2 cells...
  74. ncbi Asialoglycoprotein receptor deficiency in mice lacking the minor receptor subunit
    S Ishibashi
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    J Biol Chem 269:27803-6. 1994
    ..Although these mice are completely unable to clear asialoorosomucoid, a high affinity ligand for asialoglycoprotein receptor, they do not accumulate desialylated glycoproteins or lipoproteins in their circulation...
  75. ncbi PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities
    Majambu Mbikay
    Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    FEBS Lett 584:701-6. 2010
    ..hepatic uptake of low-density lipoprotein (LDL) cholesterol by promoting the degradation of LDL receptors (LDLR)...
  76. ncbi Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient mice
    Myles J Lewis
    BHF Cardiovascular Medicine Unit, National Heart and Lung Institute, Imperial College, Hammersmith Hospital, Du Cane Rd, London, W12 0NN, UK
    Circulation 120:417-26. 2009
    ..We have directly investigated the requirement for IgM by studying the effects of IgM deficiency in LDL receptor-deficient (Ldlr(-/-)) mice.
  77. ncbi Prostaglandin F2alpha elevates blood pressure and promotes atherosclerosis
    Ying Yu
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 106:7985-90. 2009
    ..deletion of the FP, despite the absence of detectable receptor expression in aorta or in atherosclerotic lesions in Ldlr KOs...
  78. ncbi Low density lipoprotein (LDL)-mediated suppression of Lewis lung carcinoma in hypercholesterolemic LDL receptor-deficient mice
    V N Trieu
    Department of Cardiovascular Biology, Department of Molecular Epidemiology, Hughes Institute, St Paul, Minnesota 55113, USA
    Biochem Biophys Res Commun 255:377-81. 1999
    ..models of hypercholesterolemia: Pluronic treated mice, apolipoprotein E (ApoE) deficient mice, and low density lipoprotein receptor (LDL-R) deficient mice...
  79. ncbi ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice
    Lisa A Cassis
    Rm 521b, Wethington Bldg, Graduate Center for Nutritional Sciences, Univ of Kentucky, Lexington, KY 40536 0200, USA
    Am J Physiol Heart Circ Physiol 296:H1660-5. 2009
    ..Male apolipoprotein E (apoE)- and LDL receptor (LDLr)-deficient mice were infused with ANG II (1,000 ng.kg(-1).min(-1)) or norepinephrine (NE; 5.6 mg.kg(-1)...
  80. ncbi Protection against atherosclerosis by estrogen is independent of plasma cholesterol levels in LDL receptor-deficient mice
    M M Marsh
    Department of Immunology, The Scripps Research Institute, La Jolla, CA, 92037, USA
    J Lipid Res 40:893-900. 1999
    ..Although plasma cholesterol levels were reduced by exogenous E2 despite the absence of the LDL receptor, endogenous E2 was not associated with any cholesterol changes...
  81. ncbi Up-regulated expression of the CXCR2 ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression
    William A Boisvert
    Department of Immunology, The Scripps Research Institute, La Jolla, California, USA
    Am J Pathol 168:1385-95. 2006
    ..KC/GRO-alpha(-/-) mice were generated and mated with the atherosclerosis-prone LDLR(-/-) mice...
  82. ncbi Leukocyte adhesion molecules in atherogenesis
    M I Cybulsky
    Department of Laboratory Medicine and Pathobiology, University of Toronto, The Toronto General Hospital Research Institute, ON, Canada
    Clin Chim Acta 286:207-18. 1999
    ..cholesterol metabolism and atherosclerotic lesion formation, including apolipoprotein E knockout and low density lipoprotein receptor knockout (LDLR-/-) mice, are reviewed...
  83. ncbi Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progression
    Cecilia M Devlin
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 28:1723-30. 2008
    ..We now sought to test a direct causative role for acid SMase in lipoprotein retention and atherogenesis in vivo...
  84. ncbi Whole body hyperthermia accelerates atherogenesis in low-density lipoprotein receptor deficient mice
    A Afek
    Institute of Pathology, Sheba Medical Center, Tel Hashomer, Israel
    Exp Mol Pathol 71:63-72. 2001
    ..Thus, induction of WBH, which affords protection in models of arterial injury, appears to have a proatherogenic role in murine atherosclerosis, despite its upregulatory influence on the expression of HSP70...
  85. ncbi Increased smooth muscle cell activation and neointima formation in response to injury in AIF-1 transgenic mice
    Laura J Sommerville
    Department of Physiology, Independence Blue Cross Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Arterioscler Thromb Vasc Biol 28:47-53. 2008
    ..A transgenic mouse in which AIF-1 expression was driven by a VSMC-specific SM22alpha promoter was generated to establish a direct relationship between AIF-1 expression and intimal hyperplasia...
  86. ncbi Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development in LDL receptor knockout mice
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    Circ Res 100:678-85. 2007
    ..To investigate the role of macrophage CETP in atherosclerosis, LDL receptor knockout mice were transplanted with bone marrow from CETP transgenic mice, which express the human CETP ..
  87. ncbi Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice
    Mark J Graham
    Cardiovascular Group, Department of Antisense Drug Discovery, Isis Pharmaceuticals, Inc, Carlsbad, CA 92008, USA
    J Lipid Res 48:763-7. 2007
    ..type 9 (PCSK9) is a member of a family of proteases that is thought to promote the degradation of the low density lipoprotein receptor (LDLR) through an as yet undefined mechanism...
  88. ncbi Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia
    Christopher Jones
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Clin Invest 117:165-74. 2007
    ..Mutations in the LDL receptor (LDLR) cause familial hypercholesterolemia (FH), the most severe form of genetic hypercholesterolemia...
  89. ncbi Effects of lipoprotein lipase and statins on cholesterol uptake into heart and skeletal muscle
    Masayoshi Yokoyama
    Department of Medicine, Columbia University, New York, NY 10032, USA
    J Lipid Res 48:646-55. 2007
    Regulation of cholesterol metabolism in cultured cells and in the liver is dependent on actions of the LDL receptor. However, nonhepatic tissues have multiple pathways of cholesterol uptake...
  90. ncbi Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor
    Gilles Lambert
    Universite de Nantes, UFR de Medecine, Institut National de la Sante et de la Recherche Medicale, Unité 539, Centre Hospitalier Universitaire Hotel Dieu, 44093 Nantes, France
    Endocrinology 147:4985-95. 2006
    ..hypercholesterolemia by virtue of its role as a negative modulator of the low-density lipoprotein receptor (LDLr)...
  91. ncbi Reduced connexin43 expression limits neointima formation after balloon distension injury in hypercholesterolemic mice
    Christos E Chadjichristos
    Division of Cardiology, Department of Internal Medicine, Geneva University Hospitals, 64 Avenue de la Roseraie, CH 1211 Geneva, Switzerland
    Circulation 113:2835-43. 2006
    ..However, the relevance of Cx43 after acute vascular injury remains unclear...
  92. ncbi Increased expression of glutathione reductase in macrophages decreases atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice
    Mu Qiao
    Division of Nephrology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Arterioscler Thromb Vasc Biol 27:1375-82. 2007
    ..We investigated if strengthening the glutathione-dependent antioxidant system in macrophages by overexpressing glutathione reductase (GR) decreases the severity of atherosclerosis...
  93. ncbi Estrogen receptor-alpha mediates gender differences in atherosclerosis induced by HIV protease inhibitors
    Kimberly F Allred
    Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    J Biol Chem 281:1419-25. 2006
    ..We have previously demonstrated that in male low density lipoprotein receptor (LDL-R) null mice, HIV protease inhibitors induce atherosclerotic lesions and cholesterol ..
  94. ncbi Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol
    Sonia M S Espirito Santo
    TNO Prevention and Health, Leiden, The Netherlands
    Blood 103:3777-82. 2004
    ..Mice that allow inducible inactivation of hepatic LRP were combined with LDL receptor and APOE double-deficient mice (MX1Cre(+)LRP(flox/flox)LDLR(-/-)APOE(-/-))...
  95. ncbi Increased cholesterol deposition, expression of scavenger receptors, and response to chemotactic factors in Abca1-deficient macrophages
    Omar L Francone
    Pfizer Global Research and Development, Department of Cardiovascular and Metabolic Diseases, Groton, CT 06340
    Arterioscler Thromb Vasc Biol 25:1198-205. 2005
    ..Therefore, we examined whether the absence of ABCA1 affects the morphology, properties, and functional activities of macrophages that could be related to the development of atherosclerosis...
  96. ncbi Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis
    Christian Wolfrum
    The Laboratory of Metabolic Diseases, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Med 11:418-22. 2005
    ..Overexpression of apoM in Ldlr(-/-) mice protected against atherosclerosis when the mice were challenged with a cholesterol-enriched diet, showing ..
  97. ncbi Divergent effects of the catalytic and bridging functions of hepatic lipase on atherosclerosis
    HELEN L DICHEK
    Department of Pediatrics, Box 356320, University of Washington, 1959 NE Pacific Street, Seattle WA 98195, USA
    Arterioscler Thromb Vasc Biol 24:1696-702. 2004
    ..a catalytically inactive (ci) HL clears plasma cholesterol in mice deficient in low-density lipoprotein receptors (LDLr) and murine HL. We hypothesized that increased expression of both HL and ciHL reduces atherosclerosis in these mice.
  98. ncbi Liver gene expression associated with diet and lesion development in atherosclerosis-prone mice: induction of components of alternative complement pathway
    Adrian Recinos
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    Physiol Genomics 19:131-42. 2004
    ..to diet-induced atherosclerosis, we applied high-density microarray technology in a mouse model of atherosclerosis (LDLR-/- mouse)...
  99. ncbi Elevation of ceramide in serum lipoproteins during acute phase response in humans and mice: role of serine-palmitoyl transferase
    Sandy Lightle
    Department of Physiology, University of Kentucky, Lexington, KY 40536, USA
    Arch Biochem Biophys 419:120-8. 2003
    ..ASMase knockout mice retained LPS-induced increases in serum ceramide, thus suggesting that the elevation of VLDL and LDL ceramide content is attributed at least in part to activation of de novo synthesis of ceramide in the liver...
  100. ncbi Elevated plasma cholesterol does not affect brain Abeta in mice lacking the low-density lipoprotein receptor
    Gregory A Elder
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Neurochem 102:1220-31. 2007
    ..cholesterol influences Abeta production in mice with a null mutation of the low-density lipoprotein receptor (LDLR)...
  101. ncbi Disruption of autosomal recessive hypercholesterolemia gene shows different phenotype in vitro and in vivo
    Mariko Harada-Shiba
    Department of Bioscience, National Cardiovascular Center Research Institute, Fujishiro dai, Suita, Osaka 565 8565, Japan
    Circ Res 95:945-52. 2004
    ..having severe hypercholesterolemia and retarded plasma low-density lipoprotein (LDL) clearance despite normal LDL receptor (LDLR) function in their cultured fibroblasts, and we identified a mutation in the ARH locus in these patients...

Research Grants63

  1. The Role of Hepatic Lipase in Cholesterol Homeostatis
    HELEN DICHEK; Fiscal Year: 2005
    ..HL(hl-/-) and with h1-/- mice that are also deficient in the low density lipoprotein (LDL) receptor to generate Ldlr-/-hl-/- mice. (The Ldlr-/- mice serves as a model for diet-induced atherosclerosis)...
  2. Nuclear hormone receptor regulation of cholesterol absorption
    Joyce J Repa; Fiscal Year: 2010
    ..Additional mechanisms to reduce the cholesterol transport protein, NPC1L1, particularly in an intestine-specific manner, may result in the development of safer drugs for the treatment of hypercholesterolemia and cholelithiasis. ..
  3. Characterization of the Role of ARH on LDLR Function
    PETER A MICHAELY; Fiscal Year: 2010
    The clearance of low density lipoprotein (LDL) and very low density lipoprotein (VLDL) by LDL receptor (LDLR) mediated endocytosis plays a critical role in preventing atherosclerosis and vascular disease...
  4. Inhalable amphotericin B nanodisk therapy for aspergillosis in HIV-infected patie
    Trudy Forte; Fiscal Year: 2007
    ..With inhalable ND-AMB we believe we will bring to bear an effective cure to a disease, wherein mortality rates are extremely high (> 75%). ..
  5. The role of PON-2 and PON3 proteins in atherosclerosis
    Srinivasa Reddy; Fiscal Year: 2007
    ....
  6. Regulation of Proteasome Function in Cardiomyopathies
    Sharlene M Day; Fiscal Year: 2010
    ....
  7. Creating Glucose Responsive Cardiovascular Complications
    Ira Goldberg; Fiscal Year: 2007
    ..in diabetic mice: Mild diabetes due to deficiency of Pdx1 or high fat diets did not alter atherosclerosis in Ldlr-/- mice. In addition, Pdx1 did not affect regression after transplant of arteries containing atherosclerosis...
  8. EXTRACELLULAR REGULATION OF LIPOPROTEIN LIPASE ACTIVITY
    IRA JAY GOLDBERG; Fiscal Year: 2010
    ..In addition, by understanding how fat regulates genes it is likely that better drugs can be developed for treatment of hypertriglyceridemia and insulin resistance. ..
  9. MACROPHAGE EXPRESSION OF APOAI AND ATHEROSCLEROSIS
    Sergio Fazio; Fiscal Year: 2007
    ..These studies have the potential to uncover the basis for the therapeutic effect of HDL on the arterial plaque. ..
  10. EXTRACELLULAR REGULATION OF LIPOPROTEIN LIPASE ACTIVITY
    Ira Goldberg; Fiscal Year: 2007
    ..observed that LpL transcytosis across endothelial monolayers is reduced by RAP, the 39 kDa inhibitor of the LDL receptor related protein and other receptors in this family...
  11. FUNCTIONAL HIERARCHY OF REMNANT LIPOPROTEIN RECEPTORS
    Sergio Fazio; Fiscal Year: 2007
    ..effects of apolipoprotein E (apoE) expressed by macrophages, and delineated a unique hepatic axis between LDL receptor (LDLR) related protein (LRP) and apoE...
  12. Regulation of atherosclerosis susceptibility.
    Weibin Shi; Fiscal Year: 2006
    ..In Specific Aim 4, we will conduct molecular analysis to characterize the causative genes residing in the chromosomal regions that influence atherosclerotic lesion formation. ..
  13. Nuclear hormone receptor regulation of cholesterol absorption
    Joyce Repa; Fiscal Year: 2009
    ..Additional mechanisms to reduce the cholesterol transport protein, NPC1L1, particularly in an intestine-specific manner, may result in the development of safer drugs for the treatment of hypercholesterolemia and cholelithiasis. ..
  14. Mechanisms How Adipocytes Affect Bone in Aging Mice
    FREDRIC KRAEMER; Fiscal Year: 2009
    ....
  15. The role of PON-2 and PON3 proteins in atherosclerosis
    Srinivasa Reddy; Fiscal Year: 2009
    ....
  16. Angiotensin: A Link Between Obesity and Hypertension
    Lisa A Cassis; Fiscal Year: 2010
    ..Since the principal cause of death in obese patients is cardiovascular disease, results from these studies are clinically significant. ..
  17. The role of PON2 and PON3 proteins in Atherosclerosis
    Srinivasa Reddy; Fiscal Year: 2006
    ..Understanding the biology and function of the PON proteins will pave way for the discovery of novel therapeutic agents in the fight against atherosclerosis and other inflammatory diseases. ..
  18. ANGIOTENSIN, LEPTIN, AND THE SYMPATHETIC NERVOUS SYSTEM
    Lisa Cassis; Fiscal Year: 2001
    ....
  19. DIET, HDL, AND REVERSE CHOLESTEROL TRANSPORT
    DAVID SPADY; Fiscal Year: 2001
    ..abstract_text> ..
  20. FUNCTIONAL HIERARCHY OF REMNANT LIPOPROTEIN RECEPTORS
    Sergio Fazio; Fiscal Year: 2002
    ..but the same transplantation does not normalize lipids in animals that are deficient in both apo E and the LDL receptor. Apo E deficient animals who are homozygous for the LDL-R have a good response to BMT, but lipid values are ..
  21. Angiotensin/Sympathetic Interactions and Blood Pressure
    Lisa Cassis; Fiscal Year: 2004
    ..Moreover, novel interactions between AngII and leptin in the control of blood pressure may relate to hypertension in the obese population. ..
  22. Function and Signaling Mechanisms of Leptin Receptors
    Joyce Repa; Fiscal Year: 2005
    ..A better understanding of the signal transduction pathway used by leptin may reveal novel strategies to enhance or inhibit leptin's biological activities for therapeutic purposes. ..
  23. CONFERENCE ON ARTERIOSCLEROSIS AND VASCULAR BIOLOGY
    Trudy Forte; Fiscal Year: 2004
    ..abstract_text> ..
  24. FUNCTIONAL HIERARCHY OF REMNANT LIPOPROTEIN RECEPTORS
    Sergio Fazio; Fiscal Year: 2003
    ..effects of apolipoprotein E (apoE) expressed by macrophages, and delineated a unique hepatic axis between LDL receptor (LDLR) related protein (LRP) and apoE...