Ldlr

Summary

Gene Symbol: Ldlr
Description: low density lipoprotein receptor
Alias: Hlb301, LDL receptor, low-density lipoprotein receptor
Species: mouse

Publications

  1. Prostaglandin F2alpha elevates blood pressure and promotes atherosclerosis
    Ying Yu
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 106:7985-90
  2. Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet
    Jawahar L Mehta
    Cardiovascular Medicine, Gene Therapy Program, University of Arkansas for Medical Sciences, Little Rock, AR 72205
    Circ Res 100:1634-42
  3. Elevated plasma cholesterol does not affect brain Abeta in mice lacking the low-density lipoprotein receptor
    Gregory A Elder
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Neurochem 102:1220-31
  4. Increased expression of glutathione reductase in macrophages decreases atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice
    Mu Qiao
    Division of Nephrology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Arterioscler Thromb Vasc Biol 27:1375-82
  5. Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development in LDL receptor knockout mice
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    Circ Res 100:678-85
  6. Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice
    Mark J Graham
    Cardiovascular Group, Department of Antisense Drug Discovery, Isis Pharmaceuticals, Inc, Carlsbad, CA 92008, USA
    J Lipid Res 48:763-7
  7. Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia
    Christopher Jones
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Clin Invest 117:165-74
  8. Effects of lipoprotein lipase and statins on cholesterol uptake into heart and skeletal muscle
    Masayoshi Yokoyama
    Department of Medicine, Columbia University, New York, NY 10032, USA
    J Lipid Res 48:646-55
  9. Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor
    Gilles Lambert
    Université de Nantes, UFR de Médecine, Institut National de la Santé et de la Recherche Médicale, Unité 539, Centre Hospitalier Universitaire Hôtel Dieu, 44093 Nantes, France
    Endocrinology 147:4985-95
  10. Reduced connexin43 expression limits neointima formation after balloon distension injury in hypercholesterolemic mice
    Christos E Chadjichristos
    Division of Cardiology, Department of Internal Medicine, Geneva University Hospitals, 64 Avenue de la Roseraie, CH 1211 Geneva, Switzerland
    Circulation 113:2835-43

Scientific Experts

Detail Information

Publications62

  1. Prostaglandin F2alpha elevates blood pressure and promotes atherosclerosis
    Ying Yu
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 106:7985-90
    ..deletion of the FP, despite the absence of detectable receptor expression in aorta or in atherosclerotic lesions in Ldlr KOs...
  2. Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet
    Jawahar L Mehta
    Cardiovascular Medicine, Gene Therapy Program, University of Arkansas for Medical Sciences, Little Rock, AR 72205
    Circ Res 100:1634-42
    ..whether endothelial functional preservation might lead to reduction in atherogenesis, we crossed LOX-1 KO mice with LDLR KO mice and fed these mice 4% cholesterol/10% cocoa butter diet for 18 weeks...
  3. Elevated plasma cholesterol does not affect brain Abeta in mice lacking the low-density lipoprotein receptor
    Gregory A Elder
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Neurochem 102:1220-31
    ..cholesterol influences Abeta production in mice with a null mutation of the low-density lipoprotein receptor (LDLR)...
  4. Increased expression of glutathione reductase in macrophages decreases atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice
    Mu Qiao
    Division of Nephrology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Arterioscler Thromb Vasc Biol 27:1375-82
    ....
  5. Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development in LDL receptor knockout mice
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    Circ Res 100:678-85
    ..To investigate the role of macrophage CETP in atherosclerosis, LDL receptor knockout mice were transplanted with bone marrow from CETP transgenic mice, which express the human CETP ..
  6. Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice
    Mark J Graham
    Cardiovascular Group, Department of Antisense Drug Discovery, Isis Pharmaceuticals, Inc, Carlsbad, CA 92008, USA
    J Lipid Res 48:763-7
    ..type 9 (PCSK9) is a member of a family of proteases that is thought to promote the degradation of the low density lipoprotein receptor (LDLR) through an as yet undefined mechanism...
  7. Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia
    Christopher Jones
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Clin Invest 117:165-74
    ..Mutations in the LDL receptor (LDLR) cause familial hypercholesterolemia (FH), the most severe form of genetic hypercholesterolemia...
  8. Effects of lipoprotein lipase and statins on cholesterol uptake into heart and skeletal muscle
    Masayoshi Yokoyama
    Department of Medicine, Columbia University, New York, NY 10032, USA
    J Lipid Res 48:646-55
    Regulation of cholesterol metabolism in cultured cells and in the liver is dependent on actions of the LDL receptor. However, nonhepatic tissues have multiple pathways of cholesterol uptake...
  9. Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor
    Gilles Lambert
    Université de Nantes, UFR de Médecine, Institut National de la Santé et de la Recherche Médicale, Unité 539, Centre Hospitalier Universitaire Hôtel Dieu, 44093 Nantes, France
    Endocrinology 147:4985-95
    ..hypercholesterolemia by virtue of its role as a negative modulator of the low-density lipoprotein receptor (LDLr)...
  10. Reduced connexin43 expression limits neointima formation after balloon distension injury in hypercholesterolemic mice
    Christos E Chadjichristos
    Division of Cardiology, Department of Internal Medicine, Geneva University Hospitals, 64 Avenue de la Roseraie, CH 1211 Geneva, Switzerland
    Circulation 113:2835-43
    ..reducing Cx43 expression would affect neointima formation in vivo, we subjected hypercholesterolemic Cx43+/- LDL receptor-deficient (LDLR-/-) mice and Cx43+/+LDLR-/- control littermates to carotid balloon distension injury, which ..
  11. Immune dysregulation accelerates atherosclerosis and modulates plaque composition in systemic lupus erythematosus
    Aleksandar K Stanic
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6300, USA
    Proc Natl Acad Sci U S A 103:7018-23
    ..We addressed this problem by transferring lupus susceptibility to low-density lipoprotein (LDL) receptor-deficient (LDLr-/-) mice, an established model of atherosclerosis, creating radiation chimeras with NZM2410-derived, lupus-..
  12. Up-regulated expression of the CXCR2 ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression
    William A Boisvert
    Department of Immunology, The Scripps Research Institute, La Jolla, California, USA
    Am J Pathol 168:1385-95
    ..KC/GRO-alpha(-/-) mice were generated and mated with the atherosclerosis-prone LDLR(-/-) mice...
  13. Estrogen receptor-alpha mediates gender differences in atherosclerosis induced by HIV protease inhibitors
    Kimberly F Allred
    Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    J Biol Chem 281:1419-25
    ..We have previously demonstrated that in male low density lipoprotein receptor (LDL-R) null mice, HIV protease inhibitors induce atherosclerotic lesions and cholesterol ..
  14. Increased cholesterol deposition, expression of scavenger receptors, and response to chemotactic factors in Abca1-deficient macrophages
    Omar L Francone
    Pfizer Global Research and Development, Department of Cardiovascular and Metabolic Diseases, Groton, CT 06340
    Arterioscler Thromb Vasc Biol 25:1198-205
    ..These changes, together with the proinflammatory condition present in ABCA1-deficient mice and increased reactivity of macrophages to chemotactic factors, play a key role in the development and progression of atherosclerosis...
  15. Identification of a VLDL-induced, FDNPVY-independent internalization mechanism for the LDLR
    Peter Michaely
    Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    EMBO J 26:3273-82
    The low-density lipoprotein (LDL) receptor (LDLR) binds to and internalizes lipoproteins that contain apolipoproteinB100 (apoB100) or apolipoproteinE (apoE)...
  16. Nano-sized carbon black exposure exacerbates atherosclerosis in LDL-receptor knockout mice
    Yasuharu Niwa
    Department of Epidemiology, Research Institute, National Cardiovascular Center, Suita, Japan
    Circ J 71:1157-61
    ..The present study was undertaken in low-density lipoprotein receptor knockout (LDLR/KO) mice to test the hypothesis that long-term exposure to a high dose of nano-sized carbon black (CB) exacerbates ..
  17. LDL receptor deficiency results in decreased cell proliferation and presynaptic bouton density in the murine hippocampus
    Monique Mulder
    Department of Molecular Cell Biology, University of Maastricht, Maastricht, The Netherlands
    Neurosci Res 59:251-6
    ..The LDL receptor (LDLR) regulates plasma cholesterol levels and recently we and others obtained evidence that it is also ..
  18. The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brain
    Chen Zhang
    Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Pathol 174:586-94
    ..In summary, our results indicate that the interaction between tPA and LRP1 induces microglial activation with the generation of an inflammatory response in the ischemic brain, suggesting a cytokine-like role for tPA in the CNS...
  19. Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice
    K R Coenen
    Vanderbilt University Medical Centre, Room 702 Light Hall, Nashville, TN 37232 0615, USA
    Diabetologia 52:318-28
    ..METHODS: Bone marrow transplantation of agouti, LDL-receptor deficient (A(y)/a; Ldlr (-/-)) mice with marrow from either C57BL/6 or Tlr4 (-/-) mice was performed...
  20. Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progression
    Cecilia M Devlin
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 28:1723-30
    ..RESULTS: We studied atherogenesis and lipoprotein retention in Asm(-/-) versus Asm(+/+) mice on the Apoe(-/-) and Ldlr(-/-) backgrounds...
  21. Absence of hyperlipidemia in LDL receptor-deficient mice having apolipoprotein B100 without the putative receptor-binding sequences
    Lance A Johnson
    Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
    Arterioscler Thromb Vasc Biol 28:1745-52
    OBJECTIVE: To examine the effects of apoB100 structure, specifically a mutation in the LDLr binding region, on the production of LDL and development of atherosclerosis in vivo...
  22. Microsomal triglyceride transfer protein enhances cellular cholesteryl esterification by relieving product inhibition
    Jahangir Iqbal
    Department of Anatomy and Cell Biology and Pediatrics, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    J Biol Chem 283:19967-80
    ..We speculate that non-lipoprotein-producing cells may use different mechanisms to alleviate product inhibition and modulate cholesteryl ester biosynthesis...
  23. High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice
    Lakshmi Thirumangalakudi
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurochem 106:475-85
    ..Groups of normal C57BL/6 and low density lipoprotein receptor (LDLR)-deficient mice were fed a high fat/cholesterol diet for an 8-week period and tested for memory ..
  24. ApoB100,LDLR-/- mice exhibit reduced electroretinographic response and cholesteryl esters deposits in the retina
    Lionel Bretillon
    INRA, UMR 1129 FLAVIC, Eye and Nutrition Research Group, F 21000 Dijon, France
    Invest Ophthalmol Vis Sci 49:1307-14
    ..CONCLUSIONS: The exclusive expression of apoB100 in LDL receptor-null mouse altered the ERG profile, without modifying the visual cycle of retinoids and led to cholesterol ..
  25. Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice
    Fredrik Johansson
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:2082-7
    ..We therefore used an LDL receptor-deficient mouse model, in which type 1 diabetes can be induced at will, to investigate the effects of diabetes ..
  26. Increased smooth muscle cell activation and neointima formation in response to injury in AIF-1 transgenic mice
    Laura J Sommerville
    Department of Physiology, Independence Blue Cross Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Arterioscler Thromb Vasc Biol 28:47-53
    ..05). CONCLUSIONS: These data indicate that AIF-1 expression results in increased signal transduction, neointimal formation, and VSMC proliferation in injured mouse carotid arteries...
  27. Systemic deficiency of the MAP kinase-activated protein kinase 2 reduces atherosclerosis in hypercholesterolemic mice
    Kumaravelu Jagavelu
    Department of Cardiology and Angiology, Hannover Medical School, Carl Neuberg Str 01, 30625 Hannover, Germany
    Circ Res 101:1104-12
    ..detected in the endothelium and macrophage-rich plaque areas within aortas of hypercholesterolemic LDL receptor-deficient mice (ldlr(-/-))...
  28. Atherogenic, enlarged, and dysfunctional HDL in human PLTP/apoA-I double transgenic mice
    Matthijs Moerland
    Department of Cell Biology and Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Lipid Res 48:2622-31
    In low density lipoprotein receptor (LDLR)-deficient mice, overexpression of human plasma phospholipid transfer protein (PLTP) results in increased atherosclerosis...
  29. Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice
    Vladimir R Babaev
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Circulation 116:1404-12
    ..by bone marrow-derived cells in atherosclerosis, male and female low-density lipoprotein receptor-deficient (LDLR(-/-)) mice were reconstituted with bone marrow from PPARalpha(-/-) or PPARalpha(+/+) mice and challenged with a ..
  30. Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis
    Christian Wolfrum
    The Laboratory of Metabolic Diseases, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Med 11:418-22
    ..Overexpression of apoM in Ldlr(-/-) mice protected against atherosclerosis when the mice were challenged with a cholesterol-enriched diet, showing ..
  31. Liver disease with altered bile acid transport in Niemann-Pick C mice on a high-fat, 1% cholesterol diet
    Robert P Erickson
    Department of Pediatrics, School of Health Sciences, University of Arizona, 1501 N Campbell Avenue, P O Box 245073, Tucson, AZ 85724 5073
    Am J Physiol Gastrointest Liver Physiol 289:G300-7
    ..We studied the influence of diet and the low density lipoprotein receptor (LDLR, Ldlr in mice, known to be the source of most of the stored cholesterol) on liver disease in ..
  32. mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors
    C Meyer
    Zentrum für Biochemie und Molekulare Zellbiologie, Dept Biochemie II, Universität Göttingen, Heinrich Düker Weg 12, D 37073 Göttingen, Germany
    EMBO J 19:2193-203
    ..MPR46 fails to recycle back from the endosome to the TGN, indicating that AP-1 is required for retrograde endosome to TGN transport of the receptor...
  33. Effect of aging on aortic expression of the vascular cell adhesion molecule-1 and atherosclerosis in murine models of atherosclerosis
    S Merat
    Department of Medicine, University of California San Diego, La Jolla, USA
    J Gerontol A Biol Sci Med Sci 55:B85-94
    ..In chow-fed low-density lipoprotein receptor-deficient (LDLR-/-) mice, plasma total cholesterol levels increased with age (250 +/- 52 mg/dl in young, 276 +/- 58 in mature, and ..
  34. Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1
    M Accad
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141, USA
    J Clin Invest 105:711-9
    ..In the setting of severe hypercholesterolemia caused by deficiency in apoE or the LDL receptor (LDLR), total ACAT1 deficiency led to marked alterations in cholesterol homeostasis and extensive deposition of ..
  35. Effects of hypercholesterolemia on myocardial ischemia-reperfusion injury in LDL receptor-deficient mice
    W G Girod
    Department of Surgery, LSU Medical Center, Shreveport, LA 71130, USA
    Arterioscler Thromb Vasc Biol 19:2776-81
    ..We subjected low density lipoprotein receptor-deficient (LDLr -/-) and control (wild-type) mice to 30 minutes of myocardial ischemia and 120 ..
  36. Analysis of expression of genes involved in apolipoprotein E-based lipoprotein metabolism in pregnant mice deficient in the receptor-associated protein, the low density lipoprotein receptor, or apolipoprotein E
    L Umans
    Experimental Genetics Group, Center for Human Genetics CME, Flemish Institute for Biotechnology VIB, Katholieke Universiteit Leuven, Campus Gasthuisberg, B 3000 Leuven, Belgium
    Biol Reprod 61:1216-25
    ..E (apoE)-based mechanisms in RAP-deficient mice and compared this to results in mice deficient in low density lipoprotein receptor (LDLR) or apoE...
  37. Leukocyte adhesion molecules in atherogenesis
    M I Cybulsky
    Department of Laboratory Medicine and Pathobiology, University of Toronto, The Toronto General Hospital Research Institute, ON, Canada
    Clin Chim Acta 286:207-18
    ..cholesterol metabolism and atherosclerotic lesion formation, including apolipoprotein E knockout and low density lipoprotein receptor knockout (LDLR-/-) mice, are reviewed...
  38. Protection against atherosclerosis by estrogen is independent of plasma cholesterol levels in LDL receptor-deficient mice
    M M Marsh
    Department of Immunology, The Scripps Research Institute, La Jolla, CA, 92037, USA
    J Lipid Res 40:893-900
    ..Although plasma cholesterol levels were reduced by exogenous E2 despite the absence of the LDL receptor, endogenous E2 was not associated with any cholesterol changes...
  39. Low density lipoprotein (LDL)-mediated suppression of Lewis lung carcinoma in hypercholesterolemic LDL receptor-deficient mice
    V N Trieu
    Department of Cardiovascular Biology, Department of Molecular Epidemiology, Hughes Institute, St Paul, Minnesota 55113, USA
    Biochem Biophys Res Commun 255:377-81
    ..models of hypercholesterolemia: Pluronic treated mice, apolipoprotein E (ApoE) deficient mice, and low density lipoprotein receptor (LDL-R) deficient mice...
  40. Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9
    L Boring
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141 9100, USA
    J Biol Chem 271:7551-8
    ..The identification and cloning of two functional murine chemokine receptors provides important new tools for investigating the roles of these potent cytokines in vivo...
  41. Asialoglycoprotein receptor deficiency in mice lacking the minor receptor subunit
    S Ishibashi
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    J Biol Chem 269:27803-6
    ..Although these mice are completely unable to clear asialoorosomucoid, a high affinity ligand for asialoglycoprotein receptor, they do not accumulate desialylated glycoproteins or lipoproteins in their circulation...
  42. Heme oxygenase-1 inhibits atherosclerotic lesion formation in ldl-receptor knockout mice
    K Ishikawa
    First Department of Internal Medicine, Second Department of Anatomy, Fukushima Medical University, Fukushima, Japan
    Circ Res 88:506-12
    ..These results suggest that HO-1, induced under hyperlipidemia, functioned as an intrinsic protective factor against atherosclerotic lesion formation, possibly by inhibiting lipid peroxidation and influencing the nitric oxide pathway...
  43. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis
    M I Cybulsky
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto General Research Institute, Toronto, Ontario, Canada
    J Clin Invest 107:1255-62
    ..After crossing into the LDL receptor-null background, Vcam1(+/+) and Vcam1(D4D/D4D) paired littermates were generated from heterozygous intercrosses ..
  44. Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor
    A H Hasty
    Department of Metabolic Diseases, University of Tokyo, Tokyo, 113 8655, Japan
    J Biol Chem 276:37402-8
    ..In the current study, we show an unexpectedly severe hyperlipidemia in ob/ob mice on a background of low density lipoprotein receptor (LDLR) deficiency (-/-)...
  45. Disruption of autosomal recessive hypercholesterolemia gene shows different phenotype in vitro and in vivo
    Mariko Harada Shiba
    Department of Bioscience, National Cardiovascular Center Research Institute, Fujishiro dai, Suita, Osaka 565 8565, Japan
    Circ Res 95:945-52
    ..having severe hypercholesterolemia and retarded plasma low-density lipoprotein (LDL) clearance despite normal LDL receptor (LDLR) function in their cultured fibroblasts, and we identified a mutation in the ARH locus in these patients...
  46. Liver gene expression associated with diet and lesion development in atherosclerosis-prone mice: induction of components of alternative complement pathway
    Adrian Recinos
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    Physiol Genomics 19:131-42
    ..to diet-induced atherosclerosis, we applied high-density microarray technology in a mouse model of atherosclerosis (LDLR-/- mouse)...
  47. Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol
    Sonia M S Espirito Santo
    TNO Prevention and Health, Leiden, The Netherlands
    Blood 103:3777-82
    ..Mice that allow inducible inactivation of hepatic LRP were combined with LDL receptor and APOE double-deficient mice (MX1Cre(+)LRP(flox/flox)LDLR(-/-)APOE(-/-))...
  48. Dual benefit of reduced Cx43 on atherosclerosis in LDL receptor-deficient mice
    Cindy W Wong
    Division of Cardiology, Department of Medicine, University Hospital, Geneva, Switzerland
    Cell Commun Adhes 10:395-400
    ..Atherosclerosis-susceptible LDL receptor-deficient (LDLR(-/-)) mice were intercrossed with mice heterozygous for Cx43 (Cx43(+/-) mice)...
  49. Elevation of ceramide in serum lipoproteins during acute phase response in humans and mice: role of serine-palmitoyl transferase
    Sandy Lightle
    Department of Physiology, University of Kentucky, Lexington, KY 40536, USA
    Arch Biochem Biophys 419:120-8
    ..ASMase knockout mice retained LPS-induced increases in serum ceramide, thus suggesting that the elevation of VLDL and LDL ceramide content is attributed at least in part to activation of de novo synthesis of ceramide in the liver...
  50. Hematopoietic NF-kappaB1 deficiency results in small atherosclerotic lesions with an inflammatory phenotype
    Edwin Kanters
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht UNS50 11, Universiteitssingel 50, 6229ER Maastricht, The Netherlands
    Blood 103:934-40
    ..marrow from mice targeted in the NF-kappaB1 gene encoding for the p50 subunit was used to reconstitute irradiated LDLR(-/-) mice as a model for atherosclerosis...
  51. Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretion
    Hsiao D Lieu
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94141 9100, USA
    Circulation 107:1315-21
    BACKGROUND: LDL receptor-deficient "apolipoprotein (apo)-B100-only" mice (Ldlr-/-Apob100/100 have elevated LDL cholesterol levels on a chow diet and develop severe aortic atherosclerosis...
  52. Normal production rate of apolipoprotein B in LDL receptor-deficient mice
    John S Millar
    Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Arterioscler Thromb Vasc Biol 22:989-94
    ..Results from in vitro studies in primary mouse hepatocytes suggest that the LDL receptor may also have a role in the regulation of very low density lipoprotein (VLDL) production...
  53. Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size
    Cecilia M Devlin
    Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 99:6280-5
    ..IL-1ra transgenic/low-density lipoprotein receptor (LDLR) knockout mice fed a cholesterol-saturated fat diet for 10 wk showed a 40% increase in non-high-density lipoprotein ..
  54. Lecithin:cholesterol acyltransferase deficiency increases atherosclerosis in the low density lipoprotein receptor and apolipoprotein E knockout mice
    James W Furbee
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, North Carolina 27157 1040, USA
    J Biol Chem 277:3511-9
    ..LCAT) deficiency would accelerate atherosclerosis development in low density lipoprotein (LDL) receptor (LDLr-/-) and apoE (apoE-/-) knockout mice. After 16 weeks of atherogenic diet (0...
  55. Spontaneous plaque rupture and secondary thrombosis in apolipoprotein E-deficient and LDL receptor-deficient mice
    F Calara
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0682, USA
    J Pathol 195:257-63
    Apolipoprotein E-deficient (apoE(-/-)) and LDL receptor-deficient (LDLR(-/-)) mice develop extensive atherosclerosis, but the occurrence of spontaneous plaque rupture and secondary thrombosis in these models has not been established...
  56. Whole body hyperthermia accelerates atherogenesis in low-density lipoprotein receptor deficient mice
    A Afek
    Institute of Pathology, Sheba Medical Center, Tel Hashomer, Israel
    Exp Mol Pathol 71:63-72
    ..Thus, induction of WBH, which affords protection in models of arterial injury, appears to have a proatherogenic role in murine atherosclerosis, despite its upregulatory influence on the expression of HSP70...
  57. Increased response to cholesterol feeding in apolipoprotein C1-deficient mice
    J H van Ree
    MGC Department of Human Genetics, Leiden University, The Netherlands
    Biochem J 305:905-11
    ..006 g/ml are poor competitors for 125I-labelled LDL binding to the LDL receptor on HepG2 cells...