Ldlr

Summary

Gene Symbol: Ldlr
Description: low density lipoprotein receptor
Alias: Hlb301, LDL receptor, low-density lipoprotein receptor
Species: mouse

Top Publications

  1. ncbi Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet
    Jawahar L Mehta
    Cardiovascular Medicine, Gene Therapy Program, University of Arkansas for Medical Sciences, Little Rock, AR 72205
    Circ Res 100:1634-42. 2007
  2. pmc LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor
    Noam Zelcer
    Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, University of California, Los Angeles UCLA, Los Angeles, CA 90095, USA
    Science 325:100-4. 2009
  3. ncbi Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice
    L Gu
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Mol Cell 2:275-81. 1998
  4. pmc A major role for VCAM-1, but not ICAM-1, in early atherosclerosis
    M I Cybulsky
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto General Research Institute, Toronto, Ontario, Canada
    J Clin Invest 107:1255-62. 2001
  5. pmc Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/- mice
    Debra L Rateri
    Saha Cardiovascular Research Center, BBSRB, Room 243, University of Kentucky, Lexington, KY 40536 0509, USA
    Circ Res 108:574-81. 2011
  6. pmc Synthetic LXR ligand inhibits the development of atherosclerosis in mice
    Sean B Joseph
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095 1662, USA
    Proc Natl Acad Sci U S A 99:7604-9. 2002
  7. pmc Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP
    Edward Thorp
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Cell Metab 9:474-81. 2009
  8. pmc Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden University, P O Box 9503, 2300 RA Leiden, The Netherlands
    Proc Natl Acad Sci U S A 99:6298-303. 2002
  9. pmc Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice
    Edwin Kanters
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Clin Invest 112:1176-85. 2003
  10. pmc The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques
    Janine M van Gils
    Marc and Ruti Bell Vascular Biology and Disease Program, Leon H Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, New York, USA
    Nat Immunol 13:136-43. 2012

Detail Information

Publications151 found, 100 shown here

  1. ncbi Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet
    Jawahar L Mehta
    Cardiovascular Medicine, Gene Therapy Program, University of Arkansas for Medical Sciences, Little Rock, AR 72205
    Circ Res 100:1634-42. 2007
    ..whether endothelial functional preservation might lead to reduction in atherogenesis, we crossed LOX-1 KO mice with LDLR KO mice and fed these mice 4% cholesterol/10% cocoa butter diet for 18 weeks...
  2. pmc LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor
    Noam Zelcer
    Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, University of California, Los Angeles UCLA, Los Angeles, CA 90095, USA
    Science 325:100-4. 2009
    ..LXR inhibits the LDL receptor (LDLR) pathway through transcriptional induction of Idol (inducible degrader of the LDLR), an E3 ubiquitin ..
  3. ncbi Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice
    L Gu
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Mol Cell 2:275-81. 1998
    ..Despite having the same amount of total and fractionated serum cholesterol as LDL receptor-deficient mice with wild-type MCP-1 alleles, LDL receptor/MCP-1-deficient mice had 83% less lipid deposition ..
  4. pmc A major role for VCAM-1, but not ICAM-1, in early atherosclerosis
    M I Cybulsky
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto General Research Institute, Toronto, Ontario, Canada
    J Clin Invest 107:1255-62. 2001
    ..After crossing into the LDL receptor-null background, Vcam1(+/+) and Vcam1(D4D/D4D) paired littermates were generated from heterozygous intercrosses ..
  5. pmc Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/- mice
    Debra L Rateri
    Saha Cardiovascular Research Center, BBSRB, Room 243, University of Kentucky, Lexington, KY 40536 0509, USA
    Circ Res 108:574-81. 2011
    ..In agreement with this associative evidence, we have published recently that Ang II infusion induces aneurysmal pathology in the ascending aorta...
  6. pmc Synthetic LXR ligand inhibits the development of atherosclerosis in mice
    Sean B Joseph
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095 1662, USA
    Proc Natl Acad Sci U S A 99:7604-9. 2002
    ..In LDLR(-/-) mice, GW3965 reduced lesion area by 53% in males and 34% in females...
  7. pmc Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP
    Edward Thorp
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Cell Metab 9:474-81. 2009
    ..Similar results were found in fat-fed Chop-/-;Ldlr-/- versus Chop+/+;Ldlr-/- mice...
  8. pmc Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden University, P O Box 9503, 2300 RA Leiden, The Netherlands
    Proc Natl Acad Sci U S A 99:6298-303. 2002
    ..the role of macrophage ABCA1 in atherosclerosis, we generated low-density lipoprotein (LDL) receptor knockout (LDLr(-/-)) mice that are selectively deficient in leukocyte ABCA1 (ABCA1(-/-)) by using bone marrow transfer (ABCA1(-/-) ..
  9. pmc Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice
    Edwin Kanters
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Clin Invest 112:1176-85. 2003
    ..To investigate the role of NF-kappaB activation in macrophages during atherogenesis, we used LDL receptor-deficient mice with a macrophage-restricted deletion of IkappaB kinase 2 (IKK2), which is essential for NF-..
  10. pmc The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques
    Janine M van Gils
    Marc and Ruti Bell Vascular Biology and Disease Program, Leon H Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, New York, USA
    Nat Immunol 13:136-43. 2012
    ..Thus, netrin-1 promoted atherosclerosis by retaining macrophages in the artery wall. Our results establish a causative role for negative regulators of leukocyte migration in chronic inflammation...
  11. pmc High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis
    T A McCaffrey
    Department of Medicine, Division of Hematology Oncology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 105:653-62. 2000
    ..Induction of atherosclerosis in LDL receptor-null mice by feeding them a high-fat diet resulted in a progressive increase in Egr-1 expression in the aorta...
  12. ncbi Heme oxygenase-1 inhibits atherosclerotic lesion formation in ldl-receptor knockout mice
    K Ishikawa
    First Department of Internal Medicine, Second Department of Anatomy, Fukushima Medical University, Fukushima, Japan
    Circ Res 88:506-12. 2001
    ..These results suggest that HO-1, induced under hyperlipidemia, functioned as an intrinsic protective factor against atherosclerotic lesion formation, possibly by inhibiting lipid peroxidation and influencing the nitric oxide pathway...
  13. pmc A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates
    Joyce C Y Chan
    Department of Metabolic Disorders, Amgen Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 106:9820-5. 2009
    ..convertase subtilisin/kexin type 9 (PCSK9) regulates serum LDL cholesterol (LDL-C) by interacting with the LDL receptor (LDLR) and is an attractive therapeutic target for LDL-C lowering...
  14. pmc Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9
    Shirya Rashid
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 102:5374-9. 2005
    ..likely due to a gain-of-function mechanism because overexpression of either WT or mutant PCSK9 reduces hepatic LDL receptor protein (LDLR) in mice...
  15. ncbi FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat Munster, Albert Schweizer Str 33, D 48129 Munster, Germany
    Circulation 115:501-8. 2007
    ..The present study was undertaken to investigate whether modulation of S1P signaling would affect atherosclerosis in a murine model of disease...
  16. doi Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions
    Pieter Goossens
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    Cell Metab 12:142-53. 2010
    ..Finally, we show that type I IFN signaling is upregulated in ruptured human atherosclerotic plaques. Hereby, we identify type I IFNs as proatherosclerotic cytokines that may serve as additional targets for prevention or treatment...
  17. pmc Identification of macrophage liver X receptors as inhibitors of atherosclerosis
    Rajendra K Tangirala
    X Ceptor Therapeutics, 4757 Nexus Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 99:11896-901. 2002
    ..These results identify LXRs as targets for intervention in cardiovascular disease...
  18. ncbi CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1
    Andreas Zirlik
    Donald W Reynolds Center, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 115:1571-80. 2007
    ..The present study aimed to characterize the contribution of CD40 signaling to atherogenesis...
  19. ncbi Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice
    R K Tangirala
    Department of Medicine, University of California, San Diego, La Jolla 92093 0682, USA
    J Lipid Res 36:2320-8. 1995
    ..In other models such as LDL receptor-deficient and apoE-deficient mice, diet-induced or spontaneous hypercholesterolemia and atherogenesis are much ..
  20. doi Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration
    Ahmed Zaid
    Laboratorie of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, affiliated to the University of Montreal, Montreal, Quebec, Canada
    Hepatology 48:646-54. 2008
    ..type 9 (PCSK9) is linked to familial hypercholesterolemia, as are those of the low-density lipoprotein receptor (LDLR) and apolipoprotein B. PCSK9 enhances LDLR degradation, resulting in low-density lipoprotein accumulation in plasma...
  21. ncbi Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice
    Mark J Graham
    Cardiovascular Group, Department of Antisense Drug Discovery, Isis Pharmaceuticals, Inc, Carlsbad, CA 92008, USA
    J Lipid Res 48:763-7. 2007
    ..type 9 (PCSK9) is a member of a family of proteases that is thought to promote the degradation of the low density lipoprotein receptor (LDLR) through an as yet undefined mechanism...
  22. ncbi Heme oxygenase-1 expression in macrophages plays a beneficial role in atherosclerosis
    Luz D Orozco
    Department of Medicine, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Circ Res 100:1703-11. 2007
    ..We conclude that HO-1 expression in macrophages constitutes an important component of the antiatherogenic effect by increasing antioxidant protection and decreasing the inflammatory component of atherosclerotic lesions...
  23. ncbi Bone marrow transplantation reveals that recipient AT1a receptors are required to initiate angiotensin II-induced atherosclerosis and aneurysms
    Lisa A Cassis
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY, USA
    Arterioscler Thromb Vasc Biol 27:380-6. 2007
    ..The purpose of this study was to define whether AngII interacts with receptors on infiltrating versus resident cells in promoting vascular pathologies...
  24. pmc MyD88 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation independent of signaling through Toll-like receptors 2 and 4
    A Phillip Owens
    Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY 40536 0509, USA
    Arterioscler Thromb Vasc Biol 31:2813-9. 2011
    ....
  25. pmc Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice
    U Schonbeck
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, LMRC 309, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:7458-63. 2000
    ..This study lends further support to the importance of this specific inflammatory signaling pathway in atherosclerosis and its complications...
  26. pmc Hyperglycemic Ins2AkitaLdlr⁻/⁻ mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease
    Changcheng Zhou
    Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York, NY, USA
    J Lipid Res 52:1483-93. 2011
    ..for studying diabetic macrovascular disease, we have generated type 1 diabetic Akita mice lacking the low density lipoprotein receptor (Ins2(Akita)Ldlr⁻/⁻)...
  27. doi Inhibition of glycosphingolipid synthesis induces a profound reduction of plasma cholesterol and inhibits atherosclerosis development in APOE*3 Leiden and low-density lipoprotein receptor-/- mice
    Florence Bietrix
    Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 30:931-7. 2010
    ....
  28. pmc Dynamic changes in regulatory T cells are linked to levels of diet-induced hypercholesterolemia
    Elena Maganto-Garcia
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 77 Ave Louis Pasteur, NRB 7, Boston, MA 02115, USA
    Circulation 124:185-95. 2011
    ..Regulatory T cells (Treg) are present in atherosclerotic lesions and can modulate disease. In this study we characterized changes in Treg responses associated with prolonged hypercholesterolemia and lesion progression...
  29. doi High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice
    Lakshmi Thirumangalakudi
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurochem 106:475-85. 2008
    ..Groups of normal C57BL/6 and low density lipoprotein receptor (LDLR)-deficient mice were fed a high fat/cholesterol diet for an 8-week period and tested for memory ..
  30. pmc Pioglitazone-induced reductions in atherosclerosis occur via smooth muscle cell-specific interaction with PPAR{gamma}
    Venkateswaran Subramanian
    Saha Cardiovascular Research Center, BBSRB, Room B243, University of Kentucky, Lexington, KY 40536 0509, USA
    Circ Res 107:953-8. 2010
    ..Peroxisome proliferator-activated receptor (PPAR)γ agonists attenuate atherosclerosis and abdominal aortic aneurysms (AAAs). PPARγ, a nuclear receptor, is expressed on many cell types including smooth muscle cells (SMCs)...
  31. ncbi Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus
    Monique Mulder
    Department of Molecular Cell Biology, Maastricht University and University Hospital Maastricht, Maastricht, The Netherlands
    Neurobiol Dis 16:212-9. 2004
    The low-density lipoprotein receptor (LDLR) is the first described receptor for apolipoprotein E (apoE). We hypothesize that the absence of the LDLR, similar to the absence of apoE, results in impaired learning and memory processes...
  32. pmc GM-CSF regulates intimal cell proliferation in nascent atherosclerotic lesions
    Su Ning Zhu
    Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada
    J Exp Med 206:2141-9. 2009
    ..analysis, and quantified intimal cell proliferation and Ly-6C(high) monocyte recruitment in low density lipoprotein receptor-null mice...
  33. pmc Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice
    Kristin I Stanford
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0687, USA
    J Clin Invest 119:3236-45. 2009
    ..These findings provide the first in vivo genetic evidence that syndecan-1 is the primary hepatocyte HSPG receptor mediating the clearance of both hepatic and intestinally derived triglyceride-rich lipoproteins...
  34. pmc LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression
    Jonathan E Feig
    Department of Medicine, Division of Cardiology, New York University School of Medicine, New York, New York, USA
    J Clin Invest 120:4415-24. 2010
    ..We conclude that LXR is required for maximal effects on plaque CD68+ cell expression of CCR7 and monocyte-derived cell egress during atherosclerosis regression in mice...
  35. ncbi A receptor-mediated pathway for cholesterol homeostasis
    M S Brown
    Science 232:34-47. 1986
  36. pmc Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
    S Ishibashi
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    J Clin Invest 92:883-93. 1993
    We employed homologous recombination in embryonic stem cells to produce mice lacking functional LDL receptor genes. Homozygous male and female mice lacking LDL receptors (LDLR-/- mice) were viable and fertile...
  37. ncbi Increased atherosclerotic lesion calcification in a novel mouse model combining insulin resistance, hyperglycemia, and hypercholesterolemia
    Suvi E Heinonen
    Department of Biotechnology and Molecular Medicine, A I Virtanen Institute, University of Kuopio, PO Box 1627, FI 70211, Kuopio, Finland
    Circ Res 101:1058-67. 2007
    ..background we used low-density lipoprotein receptor-deficient mice synthetizing only apolipoprotein B100 (LDLR(-/-) ApoB(100/100))...
  38. pmc Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1
    Jenny E Kanter
    Department of Pathology, Diabetes and Obesity Center of Excellence, University of Washington School of Medicine, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 109:E715-24. 2012
    ....
  39. doi Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice
    Kristiaan Wouters
    Department of Molecular Genetics, Institutes of Maastricht University Maastricht, Maastricht, The Netherlands
    FEBS Lett 584:1001-5. 2010
    ..Together, the results indicate a prominent role of cholesterol during the development, inhibition and reversal of hepatic inflammation in NASH and reveal potential new therapeutic strategies against NASH...
  40. pmc Increased expression of vascular endothelial growth factor associated with accumulation of lipids in Bruch's membrane of LDL receptor knockout mice
    M Rudolf
    University of Schleswig Holstein, Campus Kiel, Department of Ophthalmology, Hegewisch Strasse 2, 24105 Kiel, Germany
    Br J Ophthalmol 89:1627-30. 2005
    ..To investigate the pathogenesis of age related macular degeneration (ARM) with respect to lipid accumulation within Bruch's membrane (BrM) in a knockout model with low density lipoprotein (LDL) receptor deficiency...
  41. pmc A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo
    Nidhi Gupta
    Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    PLoS ONE 5:e10682. 2010
    ..PCSK9 accelerates the degradation of hepatic low density lipoprotein receptor (LDLR) and low levels of hepatic PCSK9 activity are associated with reduced levels of circulating LDL-..
  42. pmc A macrophage sterol-responsive network linked to atherogenesis
    Lev Becker
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Cell Metab 11:125-35. 2010
    ..Pharmacologic intervention with a statin or rosiglitazone and use of mice deficient in LDL receptor or apolipoprotein E implicated the network in atherosclerosis...
  43. pmc Hyperlipidemia and atherosclerotic lesion development in Ldlr-deficient mice on a long-term high-fat diet
    Yanling Ma
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 7:e35835. 2012
    Mice deficient in the LDL receptor (Ldlr(-/-) mice) have been widely used as a model to mimic human atherosclerosis...
  44. pmc PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain
    Mali Liu
    Neurology Department, Merck Research Laboratories, West Point, PA, USA
    J Lipid Res 51:2611-8. 2010
    ..subtilisin/kexin type 9 (PCSK9) is a secreted protein that regulates hepatic low-density lipoprotein receptor (LDLR) levels in humans...
  45. pmc LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease
    Veerle Bieghs
    Department of Molecular Genetics, Pathology, Physiology and Clinical Genetics of Nutrition and Toxicology Research NUTRIM Institute of Maastricht, University of Maastricht, Maastricht, The Netherlands
    PLoS ONE 7:e30668. 2012
    ..shown that 7-day high-fat-high-cholesterol (HFC) feeding induces steatosis and inflammation in both APOE2ki and Ldlr(-/-) mice...
  46. doi Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice
    Dan Ye
    Division of Biopharmaceutics, LACDR, Leiden University, The Netherlands
    Biochem Biophys Res Commun 395:387-94. 2010
    ..To determine the role of macrophage ATP-binding cassette transporter A5 (ABCA5) in cellular cholesterol homeostasis and atherosclerotic lesion development...
  47. pmc The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol
    Audrey Billon-Gales
    Institut de Medecine Moleculaire de Rangueil, Institut National de la Sante et de la Recherche Medicale, Unité 858, Universite Toulouse III Paul Sabatier, Centre Hospitalier Universitaire de Toulouse, 31432 Toulouse, France
    Proc Natl Acad Sci U S A 106:2053-8. 2009
    ..similarly decreased fatty streak deposits at the aortic root from both ovariectomized 18-week-old ERalphaAF-1(+/+) LDLr(-/-) (low-density lipoprotein receptor) and ERalphaAF-1(0) LDLr (-/-) mice fed with a hypercholesterolemic diet...
  48. ncbi Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions
    Chantal M C Dupasquier
    Canadian Center for Agri food Research in Health and Medicine, St Boniface Hospital Research Center, Winnipeg, Canada
    Am J Physiol Heart Circ Physiol 293:H2394-402. 2007
    ..capacity of flaxseed in an animal model that more closely represents the human atherosclerotic condition, the LDL receptor-deficient mouse (LDLrKO), and to identify the cellular mechanisms for these effects...
  49. pmc Plasma PCSK9 preferentially reduces liver LDL receptors in mice
    Aldo Grefhorst
    Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9046, USA
    J Lipid Res 49:1303-11. 2008
    Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that regulates the expression of LDL receptor (LDLR) protein...
  50. ncbi Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia
    H Yagyu
    Departments of Metabolic Diseases, Ophthalmology, Pathology, Faculty of Medicine, University of Tokyo, Hongo, Tokyo 113 8655, Japan
    J Biol Chem 275:21324-30. 2000
    ..in atherogenesis, we crossed the ACAT-1-/- mice with mice lacking apolipoprotein (apo) E or the low density lipoprotein receptor (LDLR), hyperlipidemic models susceptible to atherosclerosis...
  51. ncbi Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48-/-Lepob/ob mice devoid of ApoE or Ldlr
    David J Lloyd
    Department of Metabolic Disorders, Amgen Incorporated, Thousand Oaks, California 91320, USA
    Am J Physiol Endocrinol Metab 294:E496-505. 2008
    ..triple-knockout mice that are deficient in either apolipoprotein E (Apoe(-/-)) or low-density lipoprotein receptor (Ldlr(-/-)) and express no leptin (Lep(ob/ob)) or apolipoprotein B-48 but exclusively apolipoprotein B-100 (Apob(100/100))..
  52. pmc Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice
    Israel Gotsman
    Vascular Research Division, Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 117:2974-82. 2007
    ..T cell responses, we compared atherosclerotic lesion burden and phenotype in hypercholesterolemic PD-L1/2(-/-)LDLR(-/-) mice and LDLR(-/-) controls...
  53. ncbi A mouse model of human familial hypercholesterolemia: markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet
    L Powell-Braxton
    Cardiovascular Research, Genentech Inc, South San Francisco, California 94080, USA
    Nat Med 4:934-8. 1998
    ..In contrast, mice deficient for the LDL receptor (Ldlr-/-) have only mildly elevated LDL cholesterol levels and little atherosclerosis...
  54. ncbi Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice
    Dongfeng Cao
    Atherosclerosis Research Unit, Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Alabama at Birmingham, 1530 3rd Avenue South, BDB 658, Birmingham, AL 35294, USA
    Neurobiol Aging 27:1632-43. 2006
    ..Emerging evidence indicates that cholesterol metabolism affects the pathogenesis of Alzheimer's disease (AD). The LDL receptor (LDLR) is obligatory in maintaining cholesterol homeostasis in the periphery...
  55. ncbi Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice
    Marcia L E MacDonald
    Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    J Lipid Res 49:217-29. 2008
    ..the Scd1 gene product reduces plasma triglycerides and reduces weight gain in severely hyperlipidemic low density lipoprotein receptor (LDLR)-deficient mice challenged with a Western diet...
  56. pmc Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile
    Esther Lutgens
    Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht 6200 MD, Netherlands
    J Exp Med 207:391-404. 2010
    ....
  57. ncbi Reduction of isoprostanes and regression of advanced atherosclerosis by apolipoprotein E
    R K Tangirala
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 276:261-6. 2001
    ..Aged low density lipoprotein (LDL) receptor-deficient (LDLR(-/-)) mice were fed a western-type diet for 14 weeks to induce advanced atherosclerotic lesions...
  58. pmc Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1
    M Accad
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141, USA
    J Clin Invest 105:711-9. 2000
    ..In the setting of severe hypercholesterolemia caused by deficiency in apoE or the LDL receptor (LDLR), total ACAT1 deficiency led to marked alterations in cholesterol homeostasis and extensive deposition of ..
  59. pmc Tumor necrosis factor receptor-associated factor 1 (TRAF1) deficiency attenuates atherosclerosis in mice by impairing monocyte recruitment to the vessel wall
    Anna Missiou
    Department of Cardiology, University of Freiburg, Germany
    Circulation 121:2033-44. 2010
    ..Tumor necrosis factor receptor-associated factors (TRAFs) are cytoplasmic adaptor proteins for this group of cytokines...
  60. ncbi LRP: role in vascular wall integrity and protection from atherosclerosis
    Philippe Boucher
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
    Science 300:329-32. 2003
    ..Thus, LRP1 has a pivotal role in protecting vascular wall integrity and preventing atherosclerosis by controlling PDGFR activation...
  61. ncbi Hyperlipidemia and atherosclerotic lesion development in LDL receptor-deficient mice fed defined semipurified diets with and without cholate
    A H Lichtman
    Vascular Research Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 19:1938-44. 1999
    ..Similar diets have been routinely used in studies with LDL receptor-deficient (LDLR(-/-)) mice...
  62. ncbi ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome
    Jochen G Schneider
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell Metab 4:377-89. 2006
    ..These results suggest that ATM-dependent stress pathways mediate susceptibility to the metabolic syndrome and that chloroquine or related agents promoting ATM activity could modulate insulin resistance and decrease vascular disease...
  63. pmc Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis
    J Mark Brown
    Department of Pathology, Wake Forest University School of Medicine, Section on Lipid Sciences, Winston Salem, NC 27157 1040, USA
    Circulation 118:1467-75. 2008
    ..Stearoyl-coenzyme A desaturase 1 (SCD1) is a well-known enhancer of the metabolic syndrome. The purpose of the present study was to investigate the role of SCD1 in lipoprotein metabolism and atherosclerosis progression...
  64. pmc Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice
    Thomas A Lagace
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Invest 116:2995-3005. 2006
    ..Coimmunoprecipitation and ligand blotting studies indicated that PCSK9 and LDLR directly associate; both proteins colocalized to late endocytic compartments...
  65. pmc Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemia
    Alexander Kovacs
    Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 104:13768-73. 2007
    ..We bred atherosclerosis-prone mice (Apob(100/100)Ldlr(-/-)), which have human-like hypercholesterolemia, with hCRP transgenic mice (hCRP(+/0)) and studied lesion ..
  66. pmc Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice
    M M Veniant
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141 9100, USA
    J Clin Invest 102:1559-68. 1998
    The role of the low density lipoprotein receptor (LDLR) in the clearance of apo-B48-containing lipoproteins and the role of the LDLR-related protein (LRP) in the removal of apo-B100-containing lipoproteins have not been clearly defined...
  67. ncbi Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophages and distinct atherosclerosis at relatively low plasma cholesterol levels
    Ruud Out
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Einsteinweg 55, 2333CC Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 28:258-64. 2008
    ..The purpose of this study was to evaluate the effect of the combined deletion of ABCA1 and ABCG1 expression in macrophages on foam cell formation and atherosclerosis...
  68. doi Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation
    Miao Wang
    Institute for Translational Medicine and Therapeutics, 153 Johnson Pavilion, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Circulation 117:1302-9. 2008
    ..Deletion of mPGES-1 modulates experimentally evoked pain and inflammation and retards atherogenesis. The role of mPGES-1 in abdominal aortic aneurysm is unknown...
  69. doi ApoB100,LDLR-/- mice exhibit reduced electroretinographic response and cholesteryl esters deposits in the retina
    Lionel Bretillon
    INRA, UMR 1129 FLAVIC, Eye and Nutrition Research Group, F 21000 Dijon, France
    Invest Ophthalmol Vis Sci 49:1307-14. 2008
    To evaluate the retinal phenotype of 7- and 14-month-old apoB100,LDLR-/- mice, a relevant animal model of lipid metabolism dysfunction.
  70. doi Discoidin domain receptor 1 on bone marrow-derived cells promotes macrophage accumulation during atherogenesis
    Christopher Franco
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada
    Circ Res 105:1141-8. 2009
    ..Systemic deletion of Ddr1 in Ldlr(-/-) mice accelerated matrix accumulation and reduced plaque size and macrophage content...
  71. pmc Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root
    Daniel Teupser
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:17795-800. 2004
    ..ApoE(-/-) and B6.LDLR(-/-) backgrounds...
  72. ncbi Embryo implantation in mouse: fetomaternal coordination in the pattern of expression of uPA, uPAR, PAI-1 and alpha 2MR/LRP genes
    T Teesalu
    Dipartimento di Ricerca Biologica e Tecnologica DIBIT, Istituto Scientifico S Raffaele, Milano, Italy
    Mech Dev 56:103-16. 1996
    ..uPAR), plasminogen activator inhibitor type 1 (PAI-1) and alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein (alpha 2MR/LRP) transcripts were determined by in situ hybridization...
  73. ncbi Direct viewing of atherosclerosis in vivo: plaque invasion by leukocytes is initiated by the endothelial selectins
    E E Eriksson
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    FASEB J 15:1149-57. 2001
    ..This experimental technique and the data presented introduce a novel perspective for the study of pathophysiological events involved in large-vessel disease...
  74. ncbi Effect of macrophage-derived apolipoprotein E on hyperlipidemia and atherosclerosis of LDLR-deficient mice
    Weibin Shi
    Department of Radiology, University of Virginia, Charlottesville 22908, USA
    Biochem Biophys Res Commun 317:223-9. 2004
    b>LDL receptor-deficient (LDLR(-/-)) mice fed a Western diet exhibit severe hyperlipidemia and develop significant atherosclerosis. Apolipoprotein E (apoE) is a multifunctional protein synthesized by hepatocytes and macrophages...
  75. doi Increased cell and matrix accumulation during atherogenesis in mice with vessel wall-specific deletion of discoidin domain receptor 1
    Christopher Franco
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Medical Sciences Building, Room 6213, 1 King s College Circle, Toronto, ON M5S 1A8, Canada
    Circ Res 106:1775-83. 2010
    ..Systemic deletion of DDR1 resulted in attenuated plaque growth but accelerated matrix accumulation in LDLR-deficient mice...
  76. doi No effect of C-reactive protein on early atherosclerosis in LDLR-/- / human C-reactive protein transgenic mice
    Michael Torzewski
    Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University Mainz, Mainz, Germany
    Thromb Haemost 99:196-201. 2008
    ..Since knockout mice with a defect in low density lipoprotein receptor (LDLR(-/-)) may represent a better model of atherogenesis compared to ApoE(-/-) animals, we undertook ..
  77. pmc Provirus insertion in Tpl-1, an Ets-1-related oncogene, is associated with tumor progression in Moloney murine leukemia virus-induced rat thymic lymphomas
    S E Bear
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111
    Proc Natl Acad Sci U S A 86:7495-9. 1989
    ..2 +/- 0.9 centimorgans from the Ets-1 protooncogene. Although the genetic distance between Tpl-1 and Ets-1 indicates that they are different genes, analysis of Tpl-1 cDNA clones revealed that the two are closely related...
  78. pmc Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis
    Anna P Lillis
    Center for Vascular and Inflammatory Diseases and Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 181:364-73. 2008
    ....
  79. ncbi A direct role for the macrophage low density lipoprotein receptor in atherosclerotic lesion formation
    M F Linton
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 274:19204-10. 1999
    To evaluate the contribution of the macrophage low density lipoprotein receptor (LDLR) to atherosclerotic lesion formation, we performed bone marrow transplantation studies in different mouse strains...
  80. pmc The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brain
    Chen Zhang
    Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Pathol 174:586-94. 2009
    ..In summary, our results indicate that the interaction between tPA and LRP1 induces microglial activation with the generation of an inflammatory response in the ischemic brain, suggesting a cytokine-like role for tPA in the CNS...
  81. ncbi Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor
    A H Hasty
    Department of Metabolic Diseases, University of Tokyo, Tokyo, 113 8655, Japan
    J Biol Chem 276:37402-8. 2001
    ..In the current study, we show an unexpectedly severe hyperlipidemia in ob/ob mice on a background of low density lipoprotein receptor (LDLR) deficiency (-/-)...
  82. doi LOX-1 deletion decreases collagen accumulation in atherosclerotic plaque in low-density lipoprotein receptor knockout mice fed a high-cholesterol diet
    Changping Hu
    Department of Internal Medicine, Central Arkansas Veterans Healthcare System and University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 532, Little Rock, AR 72205, USA
    Cardiovasc Res 79:287-93. 2008
    ..We examine the hypothesis that LOX-1 deletion may inhibit collagen accumulation in atherosclerotic arteries in LDL receptor (LDLR) knockout (KO) mice.
  83. pmc Initial hepatic removal of chylomicron remnants is unaffected but endocytosis is delayed in mice lacking the low density lipoprotein receptor
    J Herz
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Proc Natl Acad Sci U S A 92:4611-5. 1995
    Two endocytic receptors, the low density lipoprotein (LDL) receptor (LDLR) and the LDLR-related protein (LRP), are thought to act in concert in the hepatic uptake of partially metabolized dietary lipoproteins, the chylomicron remnants...
  84. pmc Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis
    J Mark Brown
    Wake Forest University School of Medicine, Department of Pathology, Section on Lipid Sciences, Medical Center Blvd, Winston Salem, NC 27157 1040, USA
    Arterioscler Thromb Vasc Biol 30:24-30. 2010
    ..In this study we tested whether dietary fish oil supplementation could prevent the accelerated atherosclerosis caused by SCD1 inhibition...
  85. pmc Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size
    Cecilia M Devlin
    Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 99:6280-5. 2002
    ..IL-1ra transgenic/low-density lipoprotein receptor (LDLR) knockout mice fed a cholesterol-saturated fat diet for 10 wk showed a 40% increase in non-high-density lipoprotein ..
  86. pmc Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice
    Seongah Han
    Division of Molecular Medicine, Department of Medicine, Columbia University, 630 West 168th St, New York, New York 10032, USA
    J Clin Invest 119:1029-41. 2009
    ..both hepatic and peripheral insulin resistance contribute to atherogenesis, we crossed mice deficient for the LDL receptor (Ldlr-/- mice) with mice that express low levels of IR in the liver and lack IR in peripheral tissues (the L1B6 ..
  87. ncbi Hepatic secretion of small lipoprotein particles in apobec-1-/- mice is regulated by the LDL receptor
    Fatiha Nassir
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Lipid Res 45:1649-59. 2004
    Recent studies have examined the role of the LDL receptor (LDLR) in regulating murine hepatic lipoprotein production and apolipoprotein B (apoB) secretion, with divergent conclusions from in vivo versus in vitro approaches...
  88. pmc LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling
    Jerome Terrand
    CNRS, UMR7175, Universite de Strasbourg, Illkirch, F 67401 France
    J Biol Chem 284:381-8. 2009
    ..These results establish LRP1 as a novel integrator of adipogenic differentiation and fat storage signals...
  89. pmc Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo
    Wah Seng Lim
    Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Circulation 117:940-51. 2008
    ....
  90. doi Decreased lipoprotein clearance is responsible for increased cholesterol in LDL receptor knockout mice with streptozotocin-induced diabetes
    Ira J Goldberg
    Division of Preventive Medicine, Columbia University, New York, New York 10032, USA
    Diabetes 57:1674-82. 2008
    Patients with diabetes often have dyslipidemia and increased postprandial lipidmia. Induction of diabetes in LDL receptor (Ldlr(-/-)) knockout mice also leads to marked dyslipidemia. The reasons for this are unclear.
  91. pmc Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events
    Adam E Mullick
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 205:373-83. 2008
    ..flow, such as the lesser curvature region, in atherosclerosis-prone, low-density lipoprotein receptor-deficient (LDLr(-/-)) mice. Diet-induced hyperlipidemia in LDLr(-/-) mice increased this regional endothelial TLR2 expression...
  92. pmc mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors
    C Meyer
    Zentrum für Biochemie und Molekulare Zellbiologie, Dept Biochemie II, Universitat Gottingen, Heinrich Düker Weg 12, D 37073 Gottingen, Germany
    EMBO J 19:2193-203. 2000
    ..MPR46 fails to recycle back from the endosome to the TGN, indicating that AP-1 is required for retrograde endosome to TGN transport of the receptor...
  93. pmc Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: no accentuation by apolipoprotein(a)
    D A Sanan
    The Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, CA 94110, USA
    Proc Natl Acad Sci U S A 95:4544-9. 1998
    ..These mice have no functional LDL receptors [LDLR-/-] and express a human apolipoprotein B-100 (apoB) transgene [Tg(apoB+/+)] with or without an apo(a) transgene [Tg(..
  94. pmc Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants
    A Rohlmann
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Howard Hughes Medical Institute, Dallas, Texas 75235, USA
    J Clin Invest 101:689-95. 1998
    ..Inactivation of LRP in the livers of LDL receptor-deficient mice resulted in the accumulation of cholesterol-rich remnant lipoproteins in the circulation...
  95. pmc LRP1 functions as an atheroprotective integrator of TGFbeta and PDFG signals in the vascular wall: implications for Marfan syndrome
    Philippe Boucher
    Institut Gilbert Laustriat, UMR 7175 LC 1, Department of Pharmacology Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Medicale Université Louis Pasteur, Illkirch, France
    PLoS ONE 2:e448. 2007
    ..LRP1 is also a receptor for TGFbeta1 and is required for TGFbeta mediated inhibition of cell proliferation...
  96. ncbi Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9
    L Boring
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141 9100, USA
    J Biol Chem 271:7551-8. 1996
    ..The identification and cloning of two functional murine chemokine receptors provides important new tools for investigating the roles of these potent cytokines in vivo...
  97. pmc Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice
    S Ishibashi
    Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas 75235
    J Clin Invest 93:1885-93. 1994
    Mice that are homozygous for a targeted disruption of the LDL receptor gene (LDLR-/- mice) were fed a diet that contained 1.25% cholesterol, 7.5% cocoa butter, 7.5% casein, and 0.5% cholic acid...
  98. ncbi Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis
    Soraya Taleb
    Institut National de la Sante et de la Recherche Medicale, U689, 41 Bd de la Chapelle, Paris, France
    Arterioscler Thromb Vasc Biol 27:2691-8. 2007
    ..Obesity is a major risk factor for atherosclerosis and is associated with increased cardiovascular morbidity and mortality. However, the precise molecular pathways responsible for this close association remain poorly understood...
  99. ncbi Liver disease with altered bile acid transport in Niemann-Pick C mice on a high-fat, 1% cholesterol diet
    Robert P Erickson
    Department of Pediatrics, School of Health Sciences, University of Arizona, 1501 N Campbell Avenue, P O Box 245073, Tucson, AZ 85724 5073
    Am J Physiol Gastrointest Liver Physiol 289:G300-7. 2005
    ..We studied the influence of diet and the low density lipoprotein receptor (LDLR, Ldlr in mice, known to be the source of most of the stored cholesterol) on liver disease in ..
  100. pmc ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice
    Lisa A Cassis
    Rm 521b, Wethington Bldg, Graduate Center for Nutritional Sciences, Univ of Kentucky, Lexington, KY 40536 0200, USA
    Am J Physiol Heart Circ Physiol 296:H1660-5. 2009
    ..Male apolipoprotein E (apoE)- and LDL receptor (LDLr)-deficient mice were infused with ANG II (1,000 ng.kg(-1).min(-1)) or norepinephrine (NE; 5.6 mg.kg(-1)...
  101. ncbi Asialoglycoprotein receptor deficiency in mice lacking the minor receptor subunit
    S Ishibashi
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    J Biol Chem 269:27803-6. 1994
    ..Although these mice are completely unable to clear asialoorosomucoid, a high affinity ligand for asialoglycoprotein receptor, they do not accumulate desialylated glycoproteins or lipoproteins in their circulation...

Research Grants83

  1. The Role of Hepatic Lipase in Cholesterol Homeostatis
    HELEN DICHEK; Fiscal Year: 2005
    ..HL(hl-/-) and with h1-/- mice that are also deficient in the low density lipoprotein (LDL) receptor to generate Ldlr-/-hl-/- mice. (The Ldlr-/- mice serves as a model for diet-induced atherosclerosis)...
  2. ATHEROGENICITY OF APOB CONTAINING LIPOPROTEINS
    Ira Goldberg; Fiscal Year: 2003
    ..Moreover, the experiments are significant for our understanding of atherosclerosis development and may demonstrate molecular methods to alter apoB retention that could be used in treatment and preventative therapies. ..
  3. Mechanisms of fatty acid uptake by cardiac muscle
    Ira Goldberg; Fiscal Year: 2007
    ..Our overall objective is to understand how the heart derived energy from fat, how it compensates for a defect in fat uptake, and how excess fat leads to cardiac dysfunction and premature death. ..
  4. EXTRACELLULAR REGULATION OF LIPOPROTEIN LIPASE ACTIVITY
    IRA JAY GOLDBERG; Fiscal Year: 2010
    ..In addition, by understanding how fat regulates genes it is likely that better drugs can be developed for treatment of hypertriglyceridemia and insulin resistance. ..
  5. Creating Glucose Responsive Cardiovascular Complications
    Ira Goldberg; Fiscal Year: 2007
    ..in diabetic mice: Mild diabetes due to deficiency of Pdx1 or high fat diets did not alter atherosclerosis in Ldlr-/- mice. In addition, Pdx1 did not affect regression after transplant of arteries containing atherosclerosis...
  6. Hyperglycemia, Aldose Reducatse & Murine Atherosclerosis
    Ira Goldberg; Fiscal Year: 2005
    ..We discovered that LDL receptor knockout mice (Ldlr-/-) made diabetic with streptozotocin (STZ) treatment have accelerated atherosclerosis when ..
  7. EXTRACELLULAR REGULATION OF LIPOPROTEIN LIPASE ACTIVITY
    Ira Goldberg; Fiscal Year: 2007
    ..observed that LpL transcytosis across endothelial monolayers is reduced by RAP, the 39 kDa inhibitor of the LDL receptor related protein and other receptors in this family...
  8. Mechanisms of fatty acid uptake by cardiac muscle
    IRA JAY GOLDBERG; Fiscal Year: 2010
    ..The experiments in this application seek to understand how fats, including dietary fat, enter the heart and to determine which of these fats are responsible for heart failure. ..
  9. IMMUNOCHEMICAL STRUCTURE/FUNCTION OF APOLIPOPROTEIN A-I
    Linda Curtiss; Fiscal Year: 2007
    ..Our studies are performed in low density lipoprotein receptor-deficient (LDLr-/-) mice and involve 3 specific aims...
  10. Experimental COPD: remediation, mitigation
    DONALD JOHN MASSARO; Fiscal Year: 2010
    ..There is not treatment that slows the relentless progression of the disease or that reverses it. In this application, we use an animal model to investigate methods to slow progression and reverse the disease. ..
  11. IMMUNOBIOLOGY OF APOLIPOPROTEIN E
    Linda Curtiss; Fiscal Year: 2002
    ..of NK cell and T cell localization within lesions of apolipoprotein E-deficient (apo E -/-) and low density lipoprotein receptor-deficient (LDL-R-/-) mice with both moderate and severe hypercholesterolemia...
  12. The role of PON-2 and PON3 proteins in atherosclerosis
    Srinivasa Reddy; Fiscal Year: 2007
    ....
  13. Regulation of Proteasome Function in Cardiomyopathies
    Sharlene M Day; Fiscal Year: 2010
    ....
  14. MACROPHAGE EXPRESSION OF APOAI AND ATHEROSCLEROSIS
    Sergio Fazio; Fiscal Year: 2007
    ..These studies have the potential to uncover the basis for the therapeutic effect of HDL on the arterial plaque. ..
  15. Mechanisms How Adipocytes Affect Bone in Aging Mice
    FREDRIC KRAEMER; Fiscal Year: 2009
    ....
  16. Nuclear hormone receptor regulation of cholesterol absorption
    Joyce Repa; Fiscal Year: 2009
    ..Additional mechanisms to reduce the cholesterol transport protein, NPC1L1, particularly in an intestine-specific manner, may result in the development of safer drugs for the treatment of hypercholesterolemia and cholelithiasis. ..
  17. Inhalable amphotericin B nanodisk therapy for aspergillosis in HIV-infected patie
    Trudy Forte; Fiscal Year: 2007
    ..With inhalable ND-AMB we believe we will bring to bear an effective cure to a disease, wherein mortality rates are extremely high (> 75%). ..
  18. Nuclear hormone receptor regulation of cholesterol absorption
    Joyce J Repa; Fiscal Year: 2010
    ..Additional mechanisms to reduce the cholesterol transport protein, NPC1L1, particularly in an intestine-specific manner, may result in the development of safer drugs for the treatment of hypercholesterolemia and cholelithiasis. ..
  19. Angiotensin: A Link Between Obesity and Hypertension
    Lisa A Cassis; Fiscal Year: 2010
    ..Since the principal cause of death in obese patients is cardiovascular disease, results from these studies are clinically significant. ..
  20. Characterization of the Role of ARH on LDLR Function
    PETER A MICHAELY; Fiscal Year: 2010
    The clearance of low density lipoprotein (LDL) and very low density lipoprotein (VLDL) by LDL receptor (LDLR) mediated endocytosis plays a critical role in preventing atherosclerosis and vascular disease...
  21. The role of PON-2 and PON3 proteins in atherosclerosis
    Srinivasa Reddy; Fiscal Year: 2009
    ....
  22. FUNCTIONAL HIERARCHY OF REMNANT LIPOPROTEIN RECEPTORS
    Sergio Fazio; Fiscal Year: 2007
    ..effects of apolipoprotein E (apoE) expressed by macrophages, and delineated a unique hepatic axis between LDL receptor (LDLR) related protein (LRP) and apoE...
  23. FUNCTIONAL HIERARCHY OF REMNANT LIPOPROTEIN RECEPTORS
    Sergio Fazio; Fiscal Year: 2002
    ..but the same transplantation does not normalize lipids in animals that are deficient in both apo E and the LDL receptor. Apo E deficient animals who are homozygous for the LDL-R have a good response to BMT, but lipid values are ..
  24. ANGIOTENSIN, LEPTIN, AND THE SYMPATHETIC NERVOUS SYSTEM
    Lisa Cassis; Fiscal Year: 2001
    ....
  25. DIET, HDL, AND REVERSE CHOLESTEROL TRANSPORT
    DAVID SPADY; Fiscal Year: 2001
    ..abstract_text> ..
  26. FUNCTIONAL HIERARCHY OF REMNANT LIPOPROTEIN RECEPTORS
    Sergio Fazio; Fiscal Year: 2003
    ..effects of apolipoprotein E (apoE) expressed by macrophages, and delineated a unique hepatic axis between LDL receptor (LDLR) related protein (LRP) and apoE...
  27. Regulation of atherosclerosis susceptibility.
    Weibin Shi; Fiscal Year: 2006
    ..In Specific Aim 4, we will conduct molecular analysis to characterize the causative genes residing in the chromosomal regions that influence atherosclerotic lesion formation. ..
  28. The role of PON2 and PON3 proteins in Atherosclerosis
    Srinivasa Reddy; Fiscal Year: 2006
    ..Understanding the biology and function of the PON proteins will pave way for the discovery of novel therapeutic agents in the fight against atherosclerosis and other inflammatory diseases. ..
  29. Function and Signaling Mechanisms of Leptin Receptors
    Joyce Repa; Fiscal Year: 2005
    ..A better understanding of the signal transduction pathway used by leptin may reveal novel strategies to enhance or inhibit leptin's biological activities for therapeutic purposes. ..
  30. CONFERENCE ON ARTERIOSCLEROSIS AND VASCULAR BIOLOGY
    Trudy Forte; Fiscal Year: 2004
    ..abstract_text> ..
  31. Angiotensin/Sympathetic Interactions and Blood Pressure
    Lisa Cassis; Fiscal Year: 2004
    ..Moreover, novel interactions between AngII and leptin in the control of blood pressure may relate to hypertension in the obese population. ..