Gene Symbol: Ldlr
Description: low density lipoprotein receptor
Alias: Hlb301, low-density lipoprotein receptor, LDL receptor
Species: mouse
Products:     Ldlr

Top Publications

  1. Weber C, Meiler S, Döring Y, Koch M, Drechsler M, Megens R, et al. CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice. J Clin Invest. 2011;121:2898-910 pubmed publisher
    ..Our data identify DC-derived CCL17 as a central regulator of Treg homeostasis, implicate DCs and their effector functions in atherogenesis, and suggest that CCL17 might be a target for vascular therapy. ..
  2. van Gils J, Derby M, Fernandes L, Ramkhelawon B, Ray T, Rayner K, et al. The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques. Nat Immunol. 2012;13:136-43 pubmed publisher
    ..Thus, netrin-1 promoted atherosclerosis by retaining macrophages in the artery wall. Our results establish a causative role for negative regulators of leukocyte migration in chronic inflammation. ..
  3. Bieghs V, van Gorp P, Wouters K, Hendrikx T, Gijbels M, van Bilsen M, et al. LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease. PLoS ONE. 2012;7:e30668 pubmed publisher
    ..shown that 7-day high-fat-high-cholesterol (HFC) feeding induces steatosis and inflammation in both APOE2ki and Ldlr(-/-) mice...
  4. Spann N, Garmire L, McDonald J, Myers D, Milne S, Shibata N, et al. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell. 2012;151:138-52 pubmed publisher
    ..this relationship, we utilized lipidomic and transcriptomic methods to evaluate the effect of diet and LDL receptor genotype on macrophage foam cell formation within the peritoneal cavities of mice...
  5. Zhang X, Thatcher S, Rateri D, Bruemmer D, Charnigo R, Daugherty A, et al. Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms. Circ Res. 2012;110:e73-85 pubmed publisher
    ..These data reveal an unrecognized role of transient sex hormone exposures during neonatal development as long-lasting mediators of regional aortic AT1aR expression and sexual dimorphism of AAAs. ..
  6. Bieghs V, Verheyen F, van Gorp P, Hendrikx T, Wouters K, Lutjohann D, et al. Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells. PLoS ONE. 2012;7:e34378 pubmed publisher
    ..b>Ldlr(-/-) mice were transplanted with wild-type (Wt), Cd36(-/-) or Msr1(-/-) bone marrow and fed a Western diet for 3 ..
  7. Go G, Srivastava R, Hernandez Ono A, Gang G, Smith S, Booth C, et al. The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue. Cell Metab. 2014;19:209-20 pubmed publisher
    ..These findings identify Wnt signaling as a regulator of plasma lipids and a target for treatment of hyperlipidemia. ..
  8. Murphy A, Akhtari M, Tolani S, Pagler T, Bijl N, Kuo C, et al. ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice. J Clin Invest. 2011;121:4138-49 pubmed publisher
    ..Although endogenous apoA-I was ineffective, pharmacologic approaches to increasing cholesterol efflux suppressed stem cell proliferative responses...
  9. Rensing K, de Jager S, Stroes E, Vos M, Twickler M, Dallinga Thie G, et al. Akt2/LDLr double knockout mice display impaired glucose tolerance and develop more complex atherosclerotic plaques than LDLr knockout mice. Cardiovasc Res. 2014;101:277-87 pubmed publisher
    To characterize the phenotype of Akt2/low-density-lipoprotein receptor double knockout (dKO) (Akt2/LDLr dKO) mice with respect to insulin resistance and features of atherosclerotic plaque progression...

More Information


  1. Umemoto T, Han C, Mitra P, Averill M, Tang C, Goodspeed L, et al. Apolipoprotein AI and high-density lipoprotein have anti-inflammatory effects on adipocytes via cholesterol transporters: ATP-binding cassette A-1, ATP-binding cassette G-1, and scavenger receptor B-1. Circ Res. 2013;112:1345-54 pubmed publisher
    ..However, little is known concerning anti-inflammatory effects of HDL and apoAI on adipocytes...
  2. Klingenberg R, Gerdes N, Badeau R, Gisterå A, Strodthoff D, Ketelhuth D, et al. Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis. J Clin Invest. 2013;123:1323-34 pubmed publisher
    ..Lethally irradiated, atherosclerosis-prone, low-density lipoprotein receptor-deficient (Ldlr(-/-)) mice received DEREG bone marrow and were injected with DT to eliminate FOXP3(+) Tregs...
  3. Rong S, Cao Q, Liu M, Seo J, Jia L, Boudyguina E, et al. Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis. J Lipid Res. 2012;53:686-95 pubmed publisher
    ..We evaluated atherosclerosis development and lipid metabolism in 12/15LO-LDL receptor (LDLr) double knockout (DK) vs...
  4. Döring Y, Manthey H, Drechsler M, Lievens D, Megens R, Soehnlein O, et al. Auto-antigenic protein-DNA complexes stimulate plasmacytoid dendritic cells to promote atherosclerosis. Circulation. 2012;125:1673-83 pubmed publisher
    ..These key factors may thus represent novel therapeutic targets. ..
  5. Liao X, Sluimer J, Wang Y, Subramanian M, Brown K, Pattison J, et al. Macrophage autophagy plays a protective role in advanced atherosclerosis. Cell Metab. 2012;15:545-53 pubmed publisher
    ..Most importantly, macrophage ATG5 deficiency in fat-fed Ldlr(-/-) mice increases apoptosis and oxidative stress in advanced lesional macrophages, promotes plaque necrosis, and ..
  6. Björkegren J, Hägg S, Talukdar H, Foroughi Asl H, Jain R, Cedergren C, et al. Plasma cholesterol-induced lesion networks activated before regression of early, mature, and advanced atherosclerosis. PLoS Genet. 2014;10:e1004201 pubmed publisher
    ..In atherosclerotic aortic wall from Ldlr(-/-)Apob (100/100) Mttp (flox/flox)Mx1-Cre mice, atherosclerosis regressed after PCL regardless of lesion stage...
  7. Choi J, Cheong C, Dandamudi D, Park C, Rodriguez A, Mehandru S, et al. Flt3 signaling-dependent dendritic cells protect against atherosclerosis. Immunity. 2011;35:819-31 pubmed publisher
    ..Both types expanded during atherosclerosis. By crossing Flt3(-/-) to Ldlr(-/-) atherosclerosis-prone mice, we developed a selective and marked deficiency of classical CD103(+) aortic DCs, ..
  8. Hilgendorf I, Theurl I, Gerhardt L, Robbins C, Weber G, Gonen A, et al. Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity. Circulation. 2014;129:1677-87 pubmed publisher
    ..Granulocyte macrophage colony-stimulating factor-producing IRA B cells alter adaptive immune processes and shift the leukocyte response toward a T helper-1-associated milieu that aggravates atherosclerosis. ..
  9. Rateri D, Moorleghen J, Knight V, Balakrishnan A, Howatt D, Cassis L, et al. Depletion of endothelial or smooth muscle cell-specific angiotensin II type 1a receptors does not influence aortic aneurysms or atherosclerosis in LDL receptor deficient mice. PLoS ONE. 2012;7:e51483 pubmed publisher
    ..AT1a receptor floxed mice were developed in an LDL receptor -/- background...
  10. Barish G, Yu R, Karunasiri M, Becerra D, Kim J, Tseng T, et al. The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis. Cell Metab. 2012;15:554-62 pubmed publisher
    ..We show that the transcriptional repressor Bcl6 is an anti-inflammatory regulator whose loss in bone marrow of Ldlr(-/-) mice results in severe atherosclerosis and xanthomatous tendonitis, a virtually pathognomonic complication in ..
  11. Subramanian M, Thorp E, Hansson G, Tabas I. Treg-mediated suppression of atherosclerosis requires MYD88 signaling in DCs. J Clin Invest. 2013;123:179-88 pubmed publisher
    ..We transplanted bone marrow containing Myd88-deficient CD11c+ DCs into Western diet-fed LDL receptor knockout mice and found that the transplanted mice had decreased activation of effector T cells in the ..
  12. Robbins C, Chudnovskiy A, Rauch P, Figueiredo J, Iwamoto Y, Gorbatov R, et al. Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions. Circulation. 2012;125:364-74 pubmed publisher
    ..Our findings indicate that extramedullary sites supplement the hematopoietic function of the bone marrow by producing circulating inflammatory cells that infiltrate atherosclerotic lesions. ..
  13. Rousselet E, Marcinkiewicz J, Kriz J, Zhou A, Hatten M, Prat A, et al. PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke. J Lipid Res. 2011;52:1383-91 pubmed publisher
    ..type 9 (PCSK9) plays a major role in cholesterol homeostasis through enhanced degradation of the LDL receptor (LDLR) in liver...
  14. Maganto Garcia E, Tarrio M, Grabie N, Bu D, Lichtman A. Dynamic changes in regulatory T cells are linked to levels of diet-induced hypercholesterolemia. Circulation. 2011;124:185-95 pubmed publisher
    ..Therefore, cholesterol-lowering therapies may induce dynamic and beneficial changes in Treg:effector T cell ratios in atherosclerotic lesions. ..
  15. Robbins C, Hilgendorf I, Weber G, Theurl I, Iwamoto Y, Figueiredo J, et al. Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med. 2013;19:1166-72 pubmed publisher
    ..Our study reveals macrophage proliferation as a key event in atherosclerosis and identifies macrophage self-renewal as a therapeutic target for cardiovascular disease. ..
  16. Park S, Sui Y, Gizard F, Xu J, Rios Pilier J, Helsley R, et al. Myeloid-specific I?B kinase ? deficiency decreases atherosclerosis in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2012;32:2869-76 pubmed publisher
    ..we generated myeloid-specific IKK?-deficient low-density lipoprotein receptor-deficient mice (IKK?(?Mye)LDLR(-/-))...
  17. Poti F, Costa S, Bergonzini V, Galletti M, Pignatti E, Weber C, et al. Effect of sphingosine 1-phosphate (S1P) receptor agonists FTY720 and CYM5442 on atherosclerosis development in LDL receptor deficient (LDL-R?/?) mice. Vascul Pharmacol. 2012;57:56-64 pubmed publisher
    ..atheroprotective effects in vitro, while FTY720, a non-selective S1P mimetic inhibits atherosclerosis in LDL receptor-deficient (LDL-R?/?) mice under conditions of severe hypercholesterolemia...
  18. Hanna R, Shaked I, Hubbeling H, Punt J, Wu R, Herrley E, et al. NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis. Circ Res. 2012;110:416-27 pubmed publisher
    ..Nur77(-/-) chimeric mice on a Ldlr(-/-) background showed a 3-fold increase in atherosclerosis development when fed a Western diet for 20 weeks, ..
  19. Gordts S, Van Craeyveld E, Muthuramu I, Singh N, Jacobs F, De Geest B. Lipid lowering and HDL raising gene transfer increase endothelial progenitor cells, enhance myocardial vascularity, and improve diastolic function. PLoS ONE. 2012;7:e46849 pubmed publisher
    ..cell (EPC) number and function after lipid lowering or HDL raising gene transfer in C57BL/6 low density lipoprotein receptor deficient (LDLr(-/-)) mice may be associated with an enhanced relative vascularity in the myocardium ..
  20. Lammers B, Zhao Y, Hoekstra M, Hildebrand R, Ye D, Meurs I, et al. Augmented atherogenesis in LDL receptor deficient mice lacking both macrophage ABCA1 and ApoE. PLoS ONE. 2011;6:e26095 pubmed publisher
    ..In contrast to apoA-I, apoE is secreted by macrophages and can, like apoA-I, induce ABCA1-mediated cholesterol efflux. Yet, the combined effect of macrophage ABCA1 and apoE on lesion development is unexplored...
  21. Uchida H, Poduri A, Subramanian V, Cassis L, Daugherty A. Urokinase-type plasminogen activator deficiency in bone marrow-derived cells augments rupture of angiotensin II-induced abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol. 2011;31:2845-52 pubmed publisher
    ..The uPA-uPAR axis has no effect on the formation of Ang II-induced AAAs, but uPA deficiency promotes aneurysmal rupture. ..
  22. Goossens P, Vergouwe M, Gijbels M, Curfs D, van Woezik J, Hoeksema M, et al. Myeloid I?B? deficiency promotes atherogenesis by enhancing leukocyte recruitment to the plaques. PLoS ONE. 2011;6:e22327 pubmed publisher
    ..This staining confirms that in I?B?(del) mice more leukocytes are attracted to the plaques. In conclusion, we show that I?B? deletion in myeloid cells promotes atherogenesis, probably through an induced leukocyte recruitment to plaques. ..
  23. Ouimet M, Franklin V, Mak E, Liao X, Tabas I, Marcel Y. Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase. Cell Metab. 2011;13:655-67 pubmed publisher
    ..We conclude that, in macrophage foam cells, lysosomal hydrolysis contributes to the mobilization of LD-associated cholesterol for reverse cholesterol transport...
  24. Meurs I, Lammers B, Zhao Y, Out R, Hildebrand R, Hoekstra M, et al. The effect of ABCG1 deficiency on atherosclerotic lesion development in LDL receptor knockout mice depends on the stage of atherogenesis. Atherosclerosis. 2012;221:41-7 pubmed publisher
    ..The objective of this study was to define the effect of ABCG1 deficiency during atherosclerotic lesion progression in LDL receptor knockout (LDLr(-/-)) mice.
  25. Hamers A, Vos M, Rassam F, Marinković G, Marincovic G, Kurakula K, et al. Bone marrow-specific deficiency of nuclear receptor Nur77 enhances atherosclerosis. Circ Res. 2012;110:428-38 pubmed publisher
    ..The effect of bone marrow-specific deficiency of Nur77 on atherosclerosis was studied in low density lipoprotein receptor-deficient (Ldlr(-/-)) mice...
  26. Denis M, Marcinkiewicz J, Zaid A, Gauthier D, Poirier S, Lazure C, et al. Gene inactivation of proprotein convertase subtilisin/kexin type 9 reduces atherosclerosis in mice. Circulation. 2012;125:894-901 pubmed publisher
    ..We investigated the role of PCSK9 in atherosclerosis in C57BL/6 wild-type (WT), apolipoprotein E-deficient, and LDL receptor-deficient mouse models...
  27. Owens A, Rateri D, Howatt D, Moore K, Tobias P, Curtiss L, et al. MyD88 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation independent of signaling through Toll-like receptors 2 and 4. Arterioscler Thromb Vasc Biol. 2011;31:2813-9 pubmed publisher
    ..AngII was infused into either apoE(-/-) or LDL receptor (LDLR)(-/-) male mice that were either MyD88(+/+) or (-/-)...
  28. Okayasu M, Nakayachi M, Hayashida C, Ito J, Kaneda T, Masuhara M, et al. Low-density lipoprotein receptor deficiency causes impaired osteoclastogenesis and increased bone mass in mice because of defect in osteoclastic cell-cell fusion. J Biol Chem. 2012;287:19229-41 pubmed publisher
    ..Here, we used low-density lipoprotein receptor knockout (LDLR(-/-)) mice to elucidate the role of LDLR in regulating the differentiation of osteoclasts, which are responsible ..
  29. Parathath S, Grauer L, Huang L, Sanson M, Distel E, Goldberg I, et al. Diabetes adversely affects macrophages during atherosclerotic plaque regression in mice. Diabetes. 2011;60:1759-69 pubmed publisher
    ..Reversa mice are LDL receptor-deficient mice that develop atherosclerosis...
  30. Zhou C, Pridgen B, King N, Xu J, Breslow J. Hyperglycemic Ins2AkitaLdlr?/? mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease. J Lipid Res. 2011;52:1483-93 pubmed publisher
    ..for studying diabetic macrovascular disease, we have generated type 1 diabetic Akita mice lacking the low density lipoprotein receptor (Ins2(Akita)Ldlr?/?)...
  31. Poduri A, Owens A, Howatt D, Moorleghen J, Balakrishnan A, Cassis L, et al. Regional variation in aortic AT1b receptor mRNA abundance is associated with contractility but unrelated to atherosclerosis and aortic aneurysms. PLoS ONE. 2012;7:e48462 pubmed publisher
    ..whether absence of AT1b receptors influenced aortic pathologies, we bred AT1b receptor deficient mice into an LDL receptor deficient background. Mice were fed a diet enriched in saturated fat and infused with AngII (1,000 ng/kg/min)...
  32. Ma Y, Wang W, Zhang J, Lu Y, Wu W, Yan H, et al. Hyperlipidemia and atherosclerotic lesion development in Ldlr-deficient mice on a long-term high-fat diet. PLoS ONE. 2012;7:e35835 pubmed publisher
    Mice deficient in the LDL receptor (Ldlr(-/-) mice) have been widely used as a model to mimic human atherosclerosis...
  33. Katsouri L, Georgopoulos S. Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model. PLoS ONE. 2011;6:e21880 pubmed publisher
    ..The low-density lipoprotein receptor (LDLR) regulates ApoE levels in the periphery and in the central nervous system...
  34. Ishibashi S, Brown M, Goldstein J, Gerard R, Hammer R, Herz J. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest. 1993;92:883-93 pubmed
    We employed homologous recombination in embryonic stem cells to produce mice lacking functional LDL receptor genes. Homozygous male and female mice lacking LDL receptors (LDLR-/- mice) were viable and fertile...
  35. Cybulsky M, Iiyama K, Li H, Zhu S, Chen M, Iiyama M, et al. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest. 2001;107:1255-62 pubmed
    ..After crossing into the LDL receptor-null background, Vcam1(+/+) and Vcam1(D4D/D4D) paired littermates were generated from heterozygous intercrosses ..
  36. Lloyd D, McCormick J, Helmering J, Kim K, Wang M, Fordstrom P, et al. Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48-/-Lepob/ob mice devoid of ApoE or Ldlr. Am J Physiol Endocrinol Metab. 2008;294:E496-505 pubmed
    ..triple-knockout mice that are deficient in either apolipoprotein E (Apoe(-/-)) or low-density lipoprotein receptor (Ldlr(-/-)) and express no leptin (Lep(ob/ob)) or apolipoprotein B-48 but exclusively apolipoprotein B-100 (Apob(100/100))..
  37. Mullick A, Soldau K, Kiosses W, Bell T, Tobias P, Curtiss L. Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events. J Exp Med. 2008;205:373-83 pubmed publisher
    ..flow, such as the lesser curvature region, in atherosclerosis-prone, low-density lipoprotein receptor-deficient (LDLr(-/-)) mice. Diet-induced hyperlipidemia in LDLr(-/-) mice increased this regional endothelial TLR2 expression...
  38. Mulvihill E, Assini J, Sutherland B, Dimattia A, Khami M, Koppes J, et al. Naringenin decreases progression of atherosclerosis by improving dyslipidemia in high-fat-fed low-density lipoprotein receptor-null mice. Arterioscler Thromb Vasc Biol. 2010;30:742-8 pubmed publisher
  39. Ye D, Meurs I, Ohigashi M, Calpe Berdiel L, Habets K, Zhao Y, et al. Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice. Biochem Biophys Res Commun. 2010;395:387-94 pubmed publisher
    ..To determine the role of macrophage ATP-binding cassette transporter A5 (ABCA5) in cellular cholesterol homeostasis and atherosclerotic lesion development...
  40. Zhang Y, Wang X, Vales C, Lee F, Lee H, Lusis A, et al. FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice. Arterioscler Thromb Vasc Biol. 2006;26:2316-21 pubmed
    ..Consequently we generated Fxr-/- Ldlr-/- (DKO) mice and compared lesion development with Ldlr-/- mice...
  41. Fazio S, Babaev V, Burleigh M, Major A, Hasty A, Linton M. Physiological expression of macrophage apoE in the artery wall reduces atherosclerosis in severely hyperlipidemic mice. J Lipid Res. 2002;43:1602-9 pubmed
    We have previously reported that the introduction of macrophage apoE into mice lacking both apoE and the LDL receptor (apoE(-)(/-)/LDLR(-)(/-)) through bone marrow transplantation (apoE(+)(/+)/LDLR(-)(/-)-->apoE(-)(/-)/LDLR(-)(/-)) ..
  42. Lo J, Wang Y, Tumanov A, Bamji M, Yao Z, Reardon C, et al. Lymphotoxin beta receptor-dependent control of lipid homeostasis. Science. 2007;316:285-8 pubmed
    ..These results suggest that the immune system directly influences lipid metabolism and that LT modulating agents may represent a novel therapeutic route for the treatment of dyslipidemia. ..
  43. Becker M, Rabe K, Lebherz C, Zugwurst J, Goke B, Parhofer K, et al. Expression of human chemerin induces insulin resistance in the skeletal muscle but does not affect weight, lipid levels, and atherosclerosis in LDL receptor knockout mice on high-fat diet. Diabetes. 2010;59:2898-903 pubmed publisher
    ..This study aimed to examine the effect of chemerin on weight, glucose and lipid metabolism, as well as atherosclerosis in vivo...
  44. Tangirala R, Bischoff E, Joseph S, Wagner B, Walczak R, Laffitte B, et al. Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci U S A. 2002;99:11896-901 pubmed
    ..These results identify LXRs as targets for intervention in cardiovascular disease. ..
  45. Fougerat A, Gayral S, Gourdy P, Schambourg A, Ruckle T, Schwarz M, et al. Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes. Circulation. 2008;117:1310-7 pubmed publisher
  46. Lu X, Chen D, Endresz V, Xia M, Faludi I, Burian K, et al. Immunization with a combination of ApoB and HSP60 epitopes significantly reduces early atherosclerotic lesion in Apobtm2SgyLdlrtm1Her/J mice. Atherosclerosis. 2010;212:472-80 pubmed publisher
    ..This approach offers promise as a novel strategy for developing anti-atherosclerotic agents. ..
  47. Subramanian V, Golledge J, Ijaz T, Bruemmer D, Daugherty A. Pioglitazone-induced reductions in atherosclerosis occur via smooth muscle cell-specific interaction with PPAR{gamma}. Circ Res. 2010;107:953-8 pubmed publisher
    ..Low-density lipoprotein receptor (LDLR)(-/-) mice with SMC-specific PPAR? deficiency were developed using PPAR? floxed (PPAR?(f/f)) and SM22 Cre(+) mice...
  48. Out R, Hoekstra M, Habets K, Meurs I, De Waard V, Hildebrand R, et al. Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophages and distinct atherosclerosis at relatively low plasma cholesterol levels. Arterioscler Thromb Vasc Biol. 2008;28:258-64 pubmed
    ..The purpose of this study was to evaluate the effect of the combined deletion of ABCA1 and ABCG1 expression in macrophages on foam cell formation and atherosclerosis...
  49. Lillis A, Greenlee M, Mikhailenko I, Pizzo S, Tenner A, Strickland D, et al. Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis. J Immunol. 2008;181:364-73 pubmed
  50. Yun S, Leung V, Botto M, Boyle J, Haskard D. Brief report: accelerated atherosclerosis in low-density lipoprotein receptor-deficient mice lacking the membrane-bound complement regulator CD59. Arterioscler Thromb Vasc Biol. 2008;28:1714-6 pubmed publisher
    ..CD59 gene targeted mice (CD59a(-/-)) mice were crossed with low-density lipoprotein receptor-deficient (Ldlr(-/-)) mice...
  51. Terrand J, Bruban V, Zhou L, Gong W, El Asmar Z, May P, et al. LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling. J Biol Chem. 2009;284:381-8 pubmed publisher
    ..These results establish LRP1 as a novel integrator of adipogenic differentiation and fat storage signals. ..
  52. Coenen K, Gruen M, Lee Young R, Puglisi M, Wasserman D, Hasty A. Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice. Diabetologia. 2009;52:318-28 pubmed publisher
    ..Bone marrow transplantation of agouti, LDL-receptor deficient (A(y)/a; Ldlr (-/-)) mice with marrow from either C57BL/6 or Tlr4 (-/-) mice was performed...
  53. Skogsberg J, Lundström J, Kovacs A, Nilsson R, Noori P, Maleki S, et al. Transcriptional profiling uncovers a network of cholesterol-responsive atherosclerosis target genes. PLoS Genet. 2008;4:e1000036 pubmed publisher
    ..atherosclerosis-prone mice with human-like hypercholesterolemia and a genetic switch to lower plasma lipoproteins (Ldlr(-/-)Apo(100/100)Mttp(flox/flox) Mx1-Cre)...
  54. Zelcer N, Hong C, Boyadjian R, Tontonoz P. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science. 2009;325:100-4 pubmed publisher
    ..LXR inhibits the LDL receptor (LDLR) pathway through transcriptional induction of Idol (inducible degrader of the LDLR), an E3 ubiquitin ..
  55. Van Eck M, Bos I, Kaminski W, Orso E, Rothe G, Twisk J, et al. Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues. Proc Natl Acad Sci U S A. 2002;99:6298-303 pubmed
    ..the role of macrophage ABCA1 in atherosclerosis, we generated low-density lipoprotein (LDL) receptor knockout (LDLr(-/-)) mice that are selectively deficient in leukocyte ABCA1 (ABCA1(-/-)) by using bone marrow transfer (ABCA1(-/-) ..
  56. Wang S, Zhang M, Liang B, Xu J, Xie Z, Liu C, et al. AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes. Circ Res. 2010;106:1117-28 pubmed publisher
    ..Consistently, we found that genetic deletion of AMPKalpha2 in low-density lipoprotein receptor knockout (LDLr(-/-)) strain markedly increased 26S proteasome activity, IkappaB degradation, NF-kappaB transactivation, NAD(P)H ..
  57. Zhao Y, Pennings M, Hildebrand R, Ye D, Calpe Berdiel L, Out R, et al. Enhanced foam cell formation, atherosclerotic lesion development, and inflammation by combined deletion of ABCA1 and SR-BI in Bone marrow-derived cells in LDL receptor knockout mice on western-type diet. Circ Res. 2010;107:e20-31 pubmed publisher
  58. Hartvigsen K, Binder C, Hansen L, Rafia A, Juliano J, Horkko S, et al. A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndrome. Arterioscler Thromb Vasc Biol. 2007;27:878-85 pubmed
    ..Male LDL receptor-deficient mice were fed regular chow (RC; 0.01% cholesterol/4...
  59. Shaposhnik Z, Wang X, Weinstein M, Bennett B, Lusis A. Granulocyte macrophage colony-stimulating factor regulates dendritic cell content of atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2007;27:621-7 pubmed
  60. Rateri D, Moorleghen J, Balakrishnan A, Owens A, Howatt D, Subramanian V, et al. Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/- mice. Circ Res. 2011;108:574-81 pubmed publisher
    ..Male LDL receptor(-/-) mice were fed a saturated fat-enriched diet for 1 week before osmotic mini-pump implantation and infused ..
  61. Schneider J, Finck B, Ren J, Standley K, Takagi M, Maclean K, et al. ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metab. 2006;4:377-89 pubmed
    ..These results suggest that ATM-dependent stress pathways mediate susceptibility to the metabolic syndrome and that chloroquine or related agents promoting ATM activity could modulate insulin resistance and decrease vascular disease. ..
  62. Yoshimatsu M, Terasaki Y, Sakashita N, Kiyota E, Sato H, van der Laan L, et al. Induction of macrophage scavenger receptor MARCO in nonalcoholic steatohepatitis indicates possible involvement of endotoxin in its pathogenic process. Int J Exp Pathol. 2004;85:335-43 pubmed
    ..role of hyperlipidaemia and high-fat diet, we compared C57BL/6 mice with inherited hyperlipidaemic model mice (LDLR(-/-)mice and ApoE(-/-) mice) fed a normal or a high-fat diet...
  63. Tangirala R, Pratico D, Fitzgerald G, Chun S, Tsukamoto K, Maugeais C, et al. Reduction of isoprostanes and regression of advanced atherosclerosis by apolipoprotein E. J Biol Chem. 2001;276:261-6 pubmed
    ..Aged low density lipoprotein (LDL) receptor-deficient (LDLR(-/-)) mice were fed a western-type diet for 14 weeks to induce advanced atherosclerotic lesions...
  64. Malloy S, Altenburg M, Knouff C, Lanningham Foster L, Parks J, Maeda N. Harmful effects of increased LDLR expression in mice with human APOE*4 but not APOE*3. Arterioscler Thromb Vasc Biol. 2004;24:91-7 pubmed
    Increased expression of the low-density lipoprotein receptor (LDLR) is generally considered beneficial for reducing plasma cholesterol and atherosclerosis, and its downregulation has been thought to explain the association between ..
  65. Wu D, Yang H, Xiang W, Zhou L, Shi M, Julies G, et al. Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice. J Lipid Res. 2005;46:1380-7 pubmed
    ..levels and atherosclerosis intensity using ATM(+/-), ATM(+)(/+) (wild type), ATM(+)(/+)/LDLR(-)(/-) (low density lipoprotein receptor knockout), ATM(+)(/-)/LDLR(-)(/-), ATM(+)(/+)/ApoE(-)(/-) (apolipoprotein E knockout), and ATM(+)(/-)/..
  66. Han S, Liang C, DeVries Seimon T, Ranalletta M, Welch C, Collins Fletcher K, et al. Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions. Cell Metab. 2006;3:257-66 pubmed
    ..To evaluate the possibility that decreased insulin signaling in macrophage foam cells might worsen atherosclerosis, Ldlr(-/-) mice were transplanted with insulin receptor Insr(+/+) or Insr(-/-) bone marrow...
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