Ldha

Summary

Gene Symbol: Ldha
Description: lactate dehydrogenase A
Alias: Ldh1, Ldhm, l7R2, L-lactate dehydrogenase A chain, LDH muscle subunit, LDH-M, M-LDH, lactate dehydrogenase 1, A chain, lactate dehydrogenase A4, lactate dehydrogenase-A
Species: mouse

Top Publications

  1. ncbi Assignment of the gene for lactic dehydrogenase A to mouse chromosome 7 using mouse-human hybrids
    D O'BRIEN
    Cytogenet Cell Genet 21:72-6. 1978
  2. ncbi A new pyruvate kinase mutation with hyperactivity in the mouse
    D J Charles
    Biochem Genet 22:1103-17. 1984
  3. pmc A mutation affecting the lactate dehydrogenase locus Ldh-1 in the mouse. II. Mechanism of the LDH-A deficiency associated with hemolytic anemia
    W Pretsch
    GSF Forschungszentrum für Umwelt und Gesundheit, Institut fur Saugetiergenetik, Neuherberg, Germany
    Genetics 135:161-70. 1993
  4. pmc Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A
    Serge Summermatter
    Division of Pharmacology Neurobiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 110:8738-43. 2013
  5. doi Antioxidant α-tocopherol checks lymphoma promotion via regulation of expression of protein kinase C-α and c-Myc genes and glycolytic metabolism
    Renu Sharma
    Banaras Hindu University, Varanasi, India
    Leuk Lymphoma 53:1203-10. 2012
  6. pmc The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2
    Zhenji Gan
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida 32827, USA
    Genes Dev 25:2619-30. 2011
  7. pmc Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling
    Akanksha Chhabra
    Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Dev Cell 22:651-9. 2012
  8. pmc Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis
    Lisa M Nilsson
    Department of Molecular Biology, Umea University, Umea, Sweden
    PLoS Genet 8:e1002573. 2012
  9. doi A systematic analysis of a deep mouse epididymal sperm proteome
    Theodore Chauvin
    School of Molecular Biosciences, Washington State University, Spokane, Washington 99201, USA
    Biol Reprod 87:141. 2012
  10. ncbi Interaction of heterotrimeric G protein Galphao with Purkinje cell protein-2. Evidence for a novel nucleotide exchange factor
    Y Luo
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 274:10685-8. 1999

Research Grants

Scientific Experts

  • M Kaundal
  • Wen Ping Sun
  • Jaime M Ross
  • Cymbeline T Culiat
  • L B Russell
  • D K Johnson
  • Walter Pretsch
  • E M Rinchik
  • Yoichi Mizukami
  • Sofija Jovanovic
  • Serge Summermatter
  • Yefei Rong
  • Renu Sharma
  • Lisa M Nilsson
  • Akanksha Chhabra
  • Theodore Chauvin
  • Takuya Kuchiiwa
  • Zhenji Gan
  • Russell M Crawford
  • Valeria R Fantin
  • Michelle Krisfalusi
  • Aleksandar Jovanovic
  • Simone B Scheurer
  • Per G Olsson
  • Mark H G Verheijen
  • Girish V Putcha
  • Patricia A Pioli
  • Christoph Handschin
  • Xiaoling Ni
  • Wenhui Lou
  • Wenchuan Wu
  • Dayong Jin
  • Gesa Santos
  • Joaquín Pérez-Schindler
  • Dansong Wang
  • Tiantao Kuang
  • Manjula Vinayak
  • Hanna K A Mikkola
  • Sara Rimpi
  • Asha Acharya
  • Andrew J Lechner
  • Masaya Ueno
  • Tao Liu
  • Michelle D Tallquist
  • Richard D Smith
  • Yanling Wang
  • Ben Van Handel
  • M Hellstrom
  • M Luisa Iruela-Arispe
  • Jonas A Nilsson
  • David G Camp
  • Christiane Kreutzer
  • Carrie D Nicora
  • Kenneth P Roberts
  • Tacha Zi Plym Forshell
  • Georg W Bornkamm
  • Fang Xie
  • Feng Yang
  • Brian Finck
  • Teresa C Leone
  • Takaji Yajima
  • Junko Nio-Kobayashi
  • Toshihiko Iwanaga
  • Daniel P Kelly
  • Dong Ho Han
  • Hiromi Takahashi-Iwanaga
  • Eileen M Burkart-Hartman
  • Julio E Ayala
  • John Holloszy
  • Emily Y Smith
  • Y Luo
  • C Leimeister
  • E Goldberg
  • S Li
  • Julie St-Pierre
  • DEBORAH A O'BRIEN
  • Kiyoshi Miki
  • Patricia L Magyar
  • Philip Leder
  • Christoph Rösli
  • N P Rathour
  • Jascha N Rybak
  • Dario Neri
  • Giuliano Elia
  • Roman Chrast
  • Patrick Burrola
  • Erwin Goldberg
  • Jose Luis Millan
  • Greg Lemke
  • Sonoko Narisawa

Detail Information

Publications62

  1. ncbi Assignment of the gene for lactic dehydrogenase A to mouse chromosome 7 using mouse-human hybrids
    D O'BRIEN
    Cytogenet Cell Genet 21:72-6. 1978
    ..Concordant segregation of the expression of mouse GPI-1 and LDH-1 was observed in 61 independent hybrid clones. These results indicate that the gene coding for LDH-A is located on mouse chromosome 7...
  2. ncbi A new pyruvate kinase mutation with hyperactivity in the mouse
    D J Charles
    Biochem Genet 22:1103-17. 1984
    ..It is suggested that the regulatory locus of PK-1 is affected by this mutation. The observations support also the theory of one structural locus for the erythrocyte and liver isozymes...
  3. pmc A mutation affecting the lactate dehydrogenase locus Ldh-1 in the mouse. II. Mechanism of the LDH-A deficiency associated with hemolytic anemia
    W Pretsch
    GSF Forschungszentrum für Umwelt und Gesundheit, Institut fur Saugetiergenetik, Neuherberg, Germany
    Genetics 135:161-70. 1993
    ..This discrepancy is likely due to the fact that in human erythrocytes both LDH-A and LDH-B subunits are expressed such that homozygotes for a LDH-A or LDH-B deficiency would not result in a comparably extreme LDH activity deficiency...
  4. pmc Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A
    Serge Summermatter
    Division of Pharmacology Neurobiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 110:8738-43. 2013
    ....
  5. doi Antioxidant α-tocopherol checks lymphoma promotion via regulation of expression of protein kinase C-α and c-Myc genes and glycolytic metabolism
    Renu Sharma
    Banaras Hindu University, Varanasi, India
    Leuk Lymphoma 53:1203-10. 2012
    ..Almost all cancers exhibit a high expression of lactate dehydrogenase A (LDH-A) to ensure a high energy supply...
  6. pmc The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2
    Zhenji Gan
    Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, Florida 32827, USA
    Genes Dev 25:2619-30. 2011
    ..Transcriptional profiling revealed that the lactate dehydrogenase b (Ldhb)/Ldha gene expression ratio is increased in MCK-PPARβ/δ muscle, an isoenzyme shift that diverts pyruvate into the ..
  7. pmc Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling
    Akanksha Chhabra
    Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Dev Cell 22:651-9. 2012
    ..These data provide genetic evidence of a signaling pathway that is required to restrict erythroid differentiation to specific anatomical niches during development...
  8. pmc Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis
    Lisa M Nilsson
    Department of Molecular Biology, Umea University, Umea, Sweden
    PLoS Genet 8:e1002573. 2012
    ..transgenic mice, Apc(Min) mice, and p53 knockout mice with mouse models carrying inactivating alleles of Lactate dehydrogenase A (Ldha), 3-Phosphoglycerate dehydrogenase (Phgdh) and Serine hydroxymethyltransferase 1 (Shmt1), we ..
  9. doi A systematic analysis of a deep mouse epididymal sperm proteome
    Theodore Chauvin
    School of Molecular Biosciences, Washington State University, Spokane, Washington 99201, USA
    Biol Reprod 87:141. 2012
    ..This proteome should prove a useful tool for assembly and testing of protein networks important for sperm function...
  10. ncbi Interaction of heterotrimeric G protein Galphao with Purkinje cell protein-2. Evidence for a novel nucleotide exchange factor
    Y Luo
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 274:10685-8. 1999
    ..These findings define a novel nucleotide exchange function for Pcp2 and suggest that the interaction between Pcp2 and Galphao is important to Purkinje cell function...
  11. doi Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer cells
    Yefei Rong
    Pancreatic Cancer Group, General Surgery Department, Zhongshan Hospital, Fudan University, 180th Feng Lin Road, Shanghai, 200031, China
    Tumour Biol 34:1523-30. 2013
    ..b>Lactate dehydrogenase A (LDHA) executes the final step of aerobic glycolysis and has been reported to be involved in the tumor ..
  12. pmc M-LDH serves as a sarcolemmal K(ATP) channel subunit essential for cell protection against ischemia
    Russell M Crawford
    Tayside Institute of Child Health, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    EMBO J 21:3936-48. 2002
    ....
  13. ncbi Lactate dehydrogenase is an AU-rich element-binding protein that directly interacts with AUF1
    Patricia A Pioli
    Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Biol Chem 277:35738-45. 2002
    ..The interaction between LDH and AUF1 is direct as it can be demonstrated in vitro with purified proteins. Collectively these data implicate a role for LDH in the post-transcriptional regulation of gene expression...
  14. pmc Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice
    Girish V Putcha
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 157:441-53. 2002
    ..e., BID and BAD) do not contribute to BAX-dependent cyt c release or apoptosis caused by TFD...
  15. ncbi Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    Valeria R Fantin
    Department of Genetics, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Cancer Cell 9:425-34. 2006
    ..To diminish the ability of malignant cells to metabolize pyruvate to lactate, lactate dehydrogenase A (LDH-A) levels were knocked down by means of LDH-A short hairpin RNAs...
  16. pmc Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: a fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15
    Eugene M Rinchik
    Life Sciences Division, Oak Ridge National Laboratory, P O Box 2009, Oak Ridge, TN 37831 8077, USA
    Proc Natl Acad Sci U S A 99:844-9. 2002
    ....
  17. pmc Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, SE 405 30 Goteborg, Sweden
    J Cell Biol 153:543-53. 2001
    ....
  18. ncbi Enzyme-activity mutants in Mus musculus. I. Phenotypic description and genetic characterization of ethylnitrosourea-induced mutations
    W Pretsch
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Mamm Genome 11:537-42. 2000
    ..Genetic and biochemical characterizations were routinely performed. These mutants provide insight into the mechanism of ENU mutagenesis and can serve as models for structure-function studies of the corresponding enzymes...
  19. ncbi Screen for genes regulated during early kidney morphogenesis
    C Leimeister
    Department of Physiological Chemistry I, Theodor Boveri Institute Biocenter, University of Wuerzburg, Germany
    Dev Genet 24:273-83. 1999
    ..The large fraction of novel genetags from the present screening that have not yet been analyzed provides a rich resource to clone genetic networks regulating early nephrogenesis...
  20. ncbi Molecular, genetic and biochemical characterization of lactate dehydrogenase-A enzyme activity mutations in Mus musculus
    W Pretsch
    GSF National Research Center for Environment and Health, Institute for Mammalian Genetics, Neuherberg, Germany
    Mamm Genome 9:144-9. 1998
    ..A1a319-->Glu and Thr321-->Ser, respectively, located in the alpha H helix structure of the COOH tail of LDHA. We suggest that the mutation in the result of a gene conversion event between Ldh1a wild-type gene and the ..
  21. pmc Local regulation of fat metabolism in peripheral nerves
    Mark H G Verheijen
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Genes Dev 17:2450-64. 2003
    ....
  22. ncbi Abundance of repetitive sequence elements in the mouse testis-specific lactate dehydrogenase-C gene
    Per G Olsson
    Department of Medical Biosciences, Medical Genetics, Umea University, Umea, Sweden
    J Androl 24:918-20. 2003
    We have cloned and sequenced the entire mouse ldhc gene and mapped it physically in relation to the somatic ldha gene...
  23. ncbi Analysis of isoproterenol-induced changes in gastrocnemius muscle and serum lactate dehydrogenase expression in mice
    M Kaundal
    Department of Biosciences, Himachal Pradesh University, Summer Hill, Shimla 171005, Himachal Pradesh, India
    Singapore Med J 52:274-82. 2011
    ..Muscle growth effects are thought to result from beta-2 adrenoceptor activation. This study attempted to characterise muscle (gastrocnemius) tissue damage following the administration of isoproterenol...
  24. doi Cellular expression of monocarboxylate transporters in the female reproductive organ of mice: implications for the genital lactate shuttle
    Takuya Kuchiiwa
    Laboratory of Histology and Cytology, Graduate School of Medicine, Hokkaido University, Kita 15 Nishi 7, Sapporo, Japan
    Histochem Cell Biol 135:351-60. 2011
    ....
  25. pmc High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio
    Jaime M Ross
    Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 107:20087-92. 2010
    ..The mtDNA mutator mouse allows us to conclude that the increased LDH-A/LDH-B ratio causes high brain lactate levels, which, in turn, are predictive of aging phenotypes...
  26. ncbi [Effects of cocaine on activities of ATPase, LDH and SDH in mouse splenocytes]
    Wen Ping Sun
    Department of Forensic Pathology, Taishan Medical College, Taian 271000, China
    Fa Yi Xue Za Zhi 26:81-3. 2010
    ..To examine the effects of cocaine on the activities of ATPase, LDH and SDH in cultured mouse splenocytes in vitro...
  27. doi Identification and physiological activity of survival factor released from cardiomyocytes during ischaemia and reperfusion
    Yoichi Mizukami
    Center for Gene Research, Yamaguchi University, Yamaguchi 755 8505, Japan
    Cardiovasc Res 79:589-99. 2008
    ....
  28. ncbi Beta-agonists enhance the lactic dehydrogenase (LDH) expression in serum and ventricular myocytes of mice
    M Kaundal
    Department of Biosciences, Himachal Pradesh University, Summer Hill, Shimla 171005, India
    Acta Physiol Hung 94:249-59. 2007
    ..Increase in total LDH in serum is not due to release from heart but from some other tissues having anaerobic metabolism...
  29. ncbi M-LDH serves as a regulatory subunit of the cytosolic substrate-channelling complex in vivo
    Sofija Jovanovic
    Maternal and Child Health Sciences, University of Dundee, Ninewells Hospital, Dundee, DD1 9SY, UK
    J Mol Biol 371:349-61. 2007
    ....
  30. ncbi Multiple glycolytic enzymes are tightly bound to the fibrous sheath of mouse spermatozoa
    Michelle Krisfalusi
    Laboratory for Reproductive Biology, University of North Carolina School of Medicine, NC 27599, USA
    Biol Reprod 75:270-8. 2006
    ..identified GAPDHS and two additional glycolytic enzyme subunits, the A isoform of aldolase 1 (ALDOA) and lactate dehydrogenase A (LDHA), in isolated fibrous sheaths...
  31. ncbi Identification of mutations from phenotype-driven ENU mutagenesis in mouse chromosome 7
    Cymbeline T Culiat
    Life Sciences Division, Oak Ridge National Laboratory, Bethel Valley Road, P O Box 2008, Oak Ridge, Tennessee, 37831 6445, USA
    Mamm Genome 16:555-66. 2005
    ..Our data demonstrate that rapid mutation scanning with TGCE, followed by sequence verification only of detected positives, is an efficient approach to the identification of point mutations in the mouse genome...
  32. ncbi Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic study
    Simone B Scheurer
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Proteomics 4:1737-60. 2004
    ..g., CXCR4, claudin 3, CD24, tetranectin, Del-1, procollagen lysyl hydroxylase 1 and 2) which are transcriptionally upregulated in hypoxic conditions...
  33. ncbi Changes in LDH isozyme pattern in uterine fluid of mice during early pregnancy
    N P Rathour
    University Department of Zoology, T M Bhagalpur University, India
    Horm Metab Res 29:462-4. 1997
    ....
  34. ncbi In situ hybridization mapping of LDHA and IGF2 to cattle chromosome 29
    S M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada
    Mamm Genome 7:473. 1996
  35. ncbi Chromosomal mapping of beta-globin and albino loci in the domestic cat. A conserved mammalian chromosome group
    S J O'Brien
    J Hered 77:374-8. 1986
    ..The placement of the albino locus on conserved syntenic groups of several markers (HBB, HRAS, LDHA) in both cat and mouse strongly indicates the conservative placement of the as yet unmapped human albino locus in ..
  36. ncbi Analysis of recombination in the centromere region of mouse chromosome 7 using ovarian teratoma and backcross methods
    J T Eppig
    Jackson Laboratory, Bar Harbor, ME 04609
    J Hered 79:425-9. 1988
    ..No recombinants were detected among 410 offspring produced from a backcross mating segregating for Ldh-1 and ru-2 (ruby-eye-2). Thus, the gene order of Ldh-1 and ru-2 on chromosome 7 remains uncertain...
  37. ncbi Human tyrosinase gene, mapped to chromosome 11 (q14----q21), defines second region of homology with mouse chromosome 7
    D E Barton
    Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510
    Genomics 3:17-24. 1988
    ..Comparison of the genetic maps of human chromosome 11 and mouse chromosome 7 leads to hypotheses regarding the evolution of human chromosome 11...
  38. pmc Complete nucleotide sequence of the mouse lactate dehydrogenase-A functional gene: comparison of the exon-intron organization of dehydrogenase genes
    K M Fukasawa
    Genetics 116:99-105. 1987
    ..The exon-intron organization of mouse LDH-A gene is compared with the organizations of other dehydrogenase genes, and the molecular evolution of the nicotinamide adenine dinucleotide binding domains is discussed...
  39. pmc Nucleotide sequence of the putative regulatory region of mouse lactate dehydrogenase-A gene
    K M Fukasawa
    Biochem J 235:435-9. 1986
    ..Thus, mouse LDH-A gene containing seven introns spans approx. 11 kilobases and its length of mature mRNA is 1582 nucleotides, excluding the poly(A) tail...
  40. ncbi Isolation and characterization of a cDNA and a pseudogene for mouse lactate dehydrogenase-A isozyme
    K Akai
    Int J Biochem 17:645-8. 1985
    ..This pseudogene showed 81.6% homology at 713 positions compared with the LDH-A cDNA sequence. The divergence of this pseudogene was estimated to have occurred 39 million years ago...
  41. ncbi Chromosomal and regional localization of the genes for UMPH2, APRT, PEPD, PEPS, PSP, and PGP in mink: comparison with man and mouse
    S D Pack
    Institute of Cytology and Genetics, Academy of Sciences of the USSR, Siberian Department, Novosibirsk
    Cytogenet Cell Genet 50:127-31. 1989
    ..The present data is compared with that previously established for man and mouse with reference to the conservation of syntenic gene groups and G-band homoeologies of chromosomes in mammals...
  42. ncbi Eight independent Ldh-1 mutations of the mouse recovered in mutagenicity experiments: biochemical characteristics and chromosomal localization
    W Pretsch
    Genet Res 53:101-4. 1989
    ..Using two chromosome-7 marker genes pooled recombination frequencies are estimated as c-14.4 +/- 0.8-p-6.9 +/- 0.6-Ldh-1...
  43. ncbi Developmental regulation of expression of the lactate dehydrogenase (LDH) multigene family during mouse spermatogenesis
    K Thomas
    Division of Biology, California Institute of Technology, Pasadena 91125
    Development 109:483-93. 1990
    ..Experimental observations made in this study provide new insight into the order and sequence of events involved in the regulation of gene expression of the LDH gene family during spermatogenesis...
  44. pmc Hereditary lactate dehydrogenase A-subunit deficiency as cause of early postimplantation death of homozygotes in Mus musculus
    S Merkle
    Institut fur Saugetiergenetik, GSF Forschungszentrum für Umwelt und Gesundheit GmbH, Neuherberg, Germany
    Genetics 131:413-21. 1992
    ..The distinct physiological consequences of the total absence of a functioning LDH-A subunit in mice and humans are discussed.(ABSTRACT TRUNCATED AT 250 WORDS)..
  45. ncbi Characterization of two electrophoretic lactate dehydrogenase-A mutants in Mus musculus
    S Merkle
    GSF Forschungszentrum für Umwelt und Gesundheit GmbH, Institut fur Saugetiergenetik, Neuherberg, Germany
    Biochem Genet 30:49-59. 1992
    ....
  46. ncbi Comparative gene mapping in man and mouse: assignment of the genes for lactate dehydrogenase-A, peptidase-D, and isocitrate dehydrogenase-2 to mouse chromosome 7
    P A Lalley
    Cytogenet Cell Genet 22:577-80. 1978
  47. ncbi Conservation of autosomal gene synteny groups in mouse and man
    P A Lalley
    Nature 274:160-3. 1978
  48. ncbi Mechanisms of compensation of hemolytic anemia in a lactate dehydrogenase mouse mutant
    J P Kremer
    Exp Hematol 15:664-70. 1987
    ....
  49. ncbi Linear dose-response relationship of erythrocyte enzyme-activity mutations in offspring of ethylnitrosourea-treated mice
    D J Charles
    Mutat Res 176:81-91. 1987
    ..The recovered mouse mutants might be used as animal models to study corresponding genetic diseases in humans...
  50. ncbi Protein structure and gene organization of mouse lactate dehydrogenase-A isozyme
    S S Li
    Eur J Biochem 149:215-25. 1985
    ..The relationships between the exon-intron organization of LDH-A gene and the structural-functional domains of the protein are discussed...
  51. pmc Molecular analysis of 36 mutations at the mouse pink-eyed dilution (p) locus
    D K Johnson
    Biology Division, Oak Ridge National Laboratory, Tennessee 37831 8077, USA
    Genetics 141:1563-71. 1995
    ....
  52. pmc Complementation analyses for 45 mutations encompassing the pink-eyed dilution (p) locus of the mouse
    L B Russell
    Biology Division, Oak Ridge National Laboratory, Tennessee 37831 8077, USA
    Genetics 141:1547-62. 1995
    ..The alleles specifying mottling or darker pigment (generically, pm and px, respectively) probably do not represent deletions of p-coding sequences but could be small rearrangements involving proximal regulatory elements...
  53. ncbi Organization of the region encompassing the human serum amyloid A (SAA) gene family on chromosome 11p15.1
    G C Sellar
    Department of Genetics, Trinity College, University of Dublin, Ireland
    Genomics 23:492-5. 1994
    ..Interphase FISH was used to orientate the region relative to the centromere: cen-LDHC-LDHA-SAA1-SAA2-SAA4-SAA3-TP H-D11S18- KCNC1-MYOD1-pter.
  54. ncbi Clustering of six human 11p15 gene homologs within a 500-kb interval of proximal mouse chromosome 7
    L Stubbs
    Biology Division, Oak Ridge National Laboratory, Tennessee 37831 8077
    Genomics 24:324-32. 1994
    ..the most proximal HSA11p15/Mmu7 homology region, including Ldh3 (encoding lactate dehydrogenase C), Ldh1 (lactate dehydrogenase A), Myod1 (myogenic differentiation factor-1), Tph (tryptophan hydroxylase), Saa1 (serum amyloid-A-1), and ..
  55. ncbi Molecular analysis of four lactate dehydrogenase-A mutants in the mouse
    R Sandulache
    Institut fur Saugetiergenetik, GSF Forschungszentrum für Umwelt und Gesundheit, Neuherberg, Oberschleissheim, Germany
    Mamm Genome 5:777-80. 1994
    ..All ENU-induced mutations were A/T-->G/C transitions. The mutation events could be correlated with the biochemical and physiological alterations observed in affected mice...
  56. ncbi Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7
    R L Stallings
    Somatic Cell Genet 7:683-98. 1981
    ..The assignments provide markers for the study of the genetic consequences of chromosomal rearrangements in Chinese hamster cell lines and support the concept of conservation of mammalian autosomal linkage groups...
  57. ncbi A mutation affecting the lactate dehydrogenase locus Ldh-1 in the mouse-I. Genetical and electrophoretical characterization
    D J Charles
    Biochem Genet 19:301-9. 1981
    ..It is concluded that the mutation affects the locus coding for LDH of the muscle type. Ldh-1c is proposed as the allele symbol...
  58. ncbi Genetic mapping in mammals: chromosome map of domestic cat
    S J O'Brien
    Science 216:257-65. 1982
    ..Many of these same linkage groups have not been conserved in the murine genome. The genetic and evolutionary implications of comparative mapping analysis among mammalian species are discussed...
  59. ncbi Allelically-determined isozyme polymorphisms in laboratory populations of mice
    F H Ruddle
    Ann N Y Acad Sci 151:531-9. 1968
  60. ncbi Human times mouse hybrid cells segregating mouse chromosomes and isozymes
    J D Minna
    Nature 252:401-4. 1974
  61. ncbi Transgenic mice demonstrate a testis-specific promoter for lactate dehydrogenase, LDHC
    S Li
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 273:31191-4. 1998
    The mammalian genome encodes a family of lactate dehydrogenase (LDH) isozymes. Two of these, ldha and ldhb, are expressed ubiquitously. The ldhc gene is active only in the germinal epithelium during spermatogenesis...
  62. ncbi Posttranscriptional regulation of primate Ldhc mRNA by its AUUUA-like elements
    K Salehi-Ashtiani
    Department of Biochemistry, Molecular Biology, and Cell Biology Northwestern University Evanston, Illinois 60208, USA
    Mol Endocrinol 9:1782-90. 1995
    ..Because AU-rich motifs similar to these are found in many mRNAs, these findings may have broad implications...

Research Grants1

  1. Mutagenesis of the Mammalian Imprinting Process(es)
    Eugene Rinchik; Fiscal Year: 2002
    ..abstract_text> ..