Lck

Summary

Gene Symbol: Lck
Description: lymphocyte protein tyrosine kinase
Alias: Hck-3, Lsk, Lskt, p56, p56Lck, proto-oncogene tyrosine-protein kinase LCK, leukocyte C-terminal Src kinase, lymphocyte cell-specific protein-tyrosine kinase
Species: mouse
Products:     Lck

Top Publications

  1. Freiberg B, Kupfer H, Maslanik W, Delli J, Kappler J, Zaller D, et al. Staging and resetting T cell activation in SMACs. Nat Immunol. 2002;3:911-7 pubmed
    ..in SMACs by three-dimensional immunofluorescence microscopic localization of CD3, CD45, talin, phosphotyrosine, Lck and phosphorylated ZAP-70 in T cell-APC conjugates...
  2. Trobridge P, Forbush K, Levin S. Positive and negative selection of thymocytes depends on Lck interaction with the CD4 and CD8 coreceptors. J Immunol. 2001;166:809-18 pubmed
    Considerable evidence supports a role for the Src family protein tyrosine kinase Lck in regulating multiple aspects of thymocyte development...
  3. Wallace V, Kawai K, Levelt C, Kishihara K, Molina T, Timms E, et al. T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR beta locus is incomplete but thymocyte development is not restored by TcR beta or TcR alpha beta transgenes. Eur J Immunol. 1995;25:1312-8 pubmed
    The protein tyrosine kinase, p56lck, is involved in signal transduction in mature T cells and in the molecular events controlling early thymocyte differentiation...
  4. Abraham N, Miceli M, Parnes J, Veillette A. Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck. Nature. 1991;350:62-6 pubmed
    Lymphocyte-specific tyrosine protein kinase p56lck is physically associated with CD4 and CD8 T-cell surface molecules, suggesting that it may transduce CD4/CD8-triggered tyrosine phosphorylation signals during antigen stimulation...
  5. Yasuda K, Nagafuku M, Shima T, Okada M, Yagi T, Yamada T, et al. Cutting edge: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells. J Immunol. 2002;169:2813-7 pubmed
    ..By analyzing T cells from Fyn-/- mice, we clearly demonstrated that Fyn, but not Lck, has its kinase activity in membrane rafts, and plays a critical role in Cbp phosphorylation, Cbp-Csk interaction, ..
  6. Alexandropoulos K, Cheng G, Baltimore D. Proline-rich sequences that bind to Src homology 3 domains with individual specificities. Proc Natl Acad Sci U S A. 1995;92:3110-4 pubmed
    ..The rules governing in vivo usage of particular sites by particular SH3 domains are not clear, but one binding orientation may be more specific than another. ..
  7. Garvin A, Pawar S, Marth J, Perlmutter R. Structure of the murine lck gene and its rearrangement in a murine lymphoma cell line. Mol Cell Biol. 1988;8:3058-64 pubmed
    The lck gene encodes a lymphocyte-specific protein-tyrosine kinase that is implicated in neoplastic transformation...
  8. Seddon B, Legname G, Tomlinson P, Zamoyska R. Long-term survival but impaired homeostatic proliferation of Naïve T cells in the absence of p56lck. Science. 2000;290:127-31 pubmed
    ..The peripheral T cell pool of p56lck (lck)-deficient mice was reconstituted by the expression of an inducible lck transgene...
  9. Mombaerts P, Anderson S, Perlmutter R, Mak T, Tonegawa S. An activated lck transgene promotes thymocyte development in RAG-1 mutant mice. Immunity. 1994;1:261-7 pubmed
    ..The protein tyrosine kinase p56lck has been implicated in the regulation of early thymocyte differentiation and of allelic exclusion at the TCR beta ..

More Information

Publications87

  1. Levelt C, Mombaerts P, Wang B, Kohler H, Tonegawa S, Eichmann K, et al. Regulation of thymocyte development through CD3: functional dissociation between p56lck and CD3 sigma in early thymic selection. Immunity. 1995;3:215-22 pubmed
    We studied the extent of functional linkage between CD3 sigma and p56lck in pre-TCR-dependent thymocyte development...
  2. Wildin R, Garvin A, Pawar S, Lewis D, Abraham K, Forbush K, et al. Developmental regulation of lck gene expression in T lymphocytes. J Exp Med. 1991;173:383-93 pubmed
    In the mouse and human, mRNA transcripts encoding the lymphocyte-specific protein tyrosine kinase p56lck are derived from two separate promoters resulting in heterogeneity in the 5' untranslated region sequence...
  3. Seddon B, Zamoyska R. TCR signals mediated by Src family kinases are essential for the survival of naive T cells. J Immunol. 2002;169:2997-3005 pubmed
    ..Here we examine the role of the Src family kinases, p56(lck) (Lck) and p59(fyn) (Fyn), in the survival of naive T cells...
  4. Turner J, Brodsky M, Irving B, Levin S, Perlmutter R, Littman D. Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs. Cell. 1990;60:755-65 pubmed
    b>p56lck, a lymphocyte-specific member of the src family of cytoplasmic protein-tyrosine kinases, is associated noncovalently with the cell surface glycoproteins CD4 and CD8, which are expressed on functionally distinct subpopulations of T ..
  5. Marth J, Peet R, Krebs E, Perlmutter R. A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA. Cell. 1985;43:393-404 pubmed
    ..This gene, encoded by a genetic locus defined here as lskT, is rearranged and overexpressed in the murine T cell lymphoma LSTRA...
  6. van Oers N, Lowin Kropf B, Finlay D, Connolly K, Weiss A. alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. Immunity. 1996;5:429-36 pubmed
    ..b>Lck is the major Src family member required for thymopoiesis, since there is a severe deficit of CD4+CD8+ thymocytes ..
  7. Penninger J, Kishihara K, Molina T, Wallace V, Timms E, Hedrick S, et al. Requirement for tyrosine kinase p56lck for thymic development of transgenic gamma delta T cells. Science. 1993;260:358-61 pubmed
    The Src-related protein tyrosine kinase p56lck is essential for antigen-specific signal transduction and thymic maturation of T cells that have an alpha beta T cell receptor (TCR), presumably by physical association with CD4 or CD8 ..
  8. Anderson S, Levin S, Perlmutter R. Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor beta-chain genes. Nature. 1993;365:552-4 pubmed
    ..is unknown, studies in transgenic animals have suggested that the lymphocyte-specific protein tyrosine kinase p56lck may impinge on a similar signalling pathway...
  9. Lovatt M, Filby A, Parravicini V, Werlen G, Palmer E, Zamoyska R. Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response. Mol Cell Biol. 2006;26:8655-65 pubmed
    The src family kinases p56lck (Lck) and p59fyn (Fyn) are the most proximal signaling molecules to be activated downstream of the T-cell receptor...
  10. Groves T, Smiley P, Cooke M, Forbush K, Perlmutter R, Guidos C. Fyn can partially substitute for Lck in T lymphocyte development. Immunity. 1996;5:417-28 pubmed
    b>Lck, a Src family tyrosine kinase, transduces signals important for the development of alphabeta and gammadelta T cells...
  11. Omri B, Blancher C, Neron B, Marty M, Rutin J, Molina T, et al. Retinal dysplasia in mice lacking p56lck. Oncogene. 1998;16:2351-6 pubmed
    The product of the proto-oncogene p56lck is a non-receptor tyrosine kinase member of the Src family. It is found in T cells (Marth et al., 1985, 1988) and in the mouse brain (Omri et al., 1996; Van Tan et al., 1996)...
  12. Legname G, Seddon B, Lovatt M, Tomlinson P, Sarner N, Tolaini M, et al. Inducible expression of a p56Lck transgene reveals a central role for Lck in the differentiation of CD4 SP thymocytes. Immunity. 2000;12:537-46 pubmed
    The T lymphocyte-specific protein tyrosine kinase p56lck (Lck) is an essential component of the TCR-mediated signal transduction complex...
  13. Straus D, Weiss A. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell. 1992;70:585-93 pubmed
    ..which is defective in the induction of tyrosine phosphorylation, revealed a defect in the expression of functional lck tyrosine kinase. The lack of lck activity was caused in part by a splicing defect...
  14. Kawai K, Kishihara K, Molina T, Wallace V, Mak T, Ohashi P. Impaired development of V gamma 3 dendritic epidermal T cells in p56lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient mice. J Exp Med. 1995;181:345-9 pubmed
    To determine whether p56lck protein tyrosine kinase and CD45 protein tyrosine phosphatase are involved in the signal transduction during intrathymic differentiation of gamma/delta T cells, we have examined the development of T cells ..
  15. Marth J, Cooper J, King C, Ziegler S, Tinker D, Overell R, et al. Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck). Mol Cell Biol. 1988;8:540-50 pubmed
    The lck proto-oncogene encodes a lymphocyte-specific member of the src family of protein tyrosine kinases...
  16. Molina T, Kishihara K, Siderovski D, van Ewijk W, Narendran A, Timms E, et al. Profound block in thymocyte development in mice lacking p56lck. Nature. 1992;357:161-4 pubmed
    The protein Lck (p56lck) has a relative molecular mass of 56,000 and belongs to the Src family of tyrosine kinases. It is expressed exclusively in lymphoid cells, predominantly in thymocytes and peripheral T cells...
  17. Trobridge P, Levin S. Lck plays a critical role in Ca(2+) mobilization and CD28 costimulation in mature primary T cells. Eur J Immunol. 2001;31:3567-79 pubmed
    To investigate the signaling function of the Src-family protein tyrosine kinase Lck in mature T cells, we generated transgenic mice that expressed Lck in thymocytes but not in peripheral lymphocytes...
  18. Abraham K, Levin S, Marth J, Forbush K, Perlmutter R. Thymic tumorigenesis induced by overexpression of p56lck. Proc Natl Acad Sci U S A. 1991;88:3977-81 pubmed
    The lck gene encodes a membrane-associated protein tyrosine kinase (p56lck) that is believed to participate in lymphocyte-specific signal transduction pathways...
  19. Seddon B, Tomlinson P, Zamoyska R. Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat Immunol. 2003;4:680-6 pubmed
    ..Thus, IL-7 contributes to the maintenance of all naive and memory T cell subsets, and therefore controls the overall size of the T cell pool. ..
  20. Voronova A, Adler H, Sefton B. Two lck transcripts containing different 5' untranslated regions are present in T cells. Mol Cell Biol. 1987;7:4407-13 pubmed
    b>p56lck is a new member of the src family of cellular tyrosine protein kinases...
  21. Page S, van Oers N, Perlmutter R, Weiss A, Pullen A. Differential contribution of Lck and Fyn protein tyrosine kinases to intraepithelial lymphocyte development. Eur J Immunol. 1997;27:554-62 pubmed
    ..We used mice deficient in Lck, Fyn, or both Lck and Fyn to analyze the role that these src-family PTK play in IEL development...
  22. Choi Y, Kim C, Yun Y. Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation. J Immunol. 1999;163:5242-9 pubmed
    T cell-specific Src family tyrosine kinase, p56lck, plays crucial roles in T cell differentiation, activation, and proliferation...
  23. Chiang Y, Hodes R. T-cell development is regulated by the coordinated function of proximal and distal Lck promoters active at different developmental stages. Eur J Immunol. 2016;46:2401-2408 pubmed publisher
    Expression of Lck, a T-cell lineage-specific tyrosine kinase critical for T-cell development and activation, can be mediated by either proximal or distal lck promoter...
  24. Pathak B, Shull G, Jenkins N, Copeland N. Mouse chromosomal location of four Na/H exchanger isoform genes. Genomics. 1996;31:261-3 pubmed
    ..These loci map to previously defined homologous regions between human and mouse chromosomes and provide additional information regarding human/mouse comparative mapping. ..
  25. Felberg J, Lefebvre D, Lam M, Wang Y, Ng D, Birkenhead D, et al. Subdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylation. J Biol Chem. 2004;279:3455-62 pubmed
    ..The Src family kinase, Lck, is a major CD45 substrate in T cells and CD45 dephosphorylation of Lck is important for both T cell development ..
  26. Siracusa L, Buchberg A, Copeland N, Jenkins N. Recombinant inbred strain and interspecific backcross analysis of molecular markers flanking the murine agouti coat color locus. Genetics. 1989;122:669-79 pubmed
    ..The Psp-2 locus maps to mouse chromosome 14. The Hck-2 locus maps near the centromere of mouse chromosome 4 and may identify the Lyn locus. The Hck-3 locus maps near the distal end of mouse chromosome 4 and may identify the Lck locus.
  27. Ilan N, Cheung L, Miller S, Mohsenin A, Tucker A, Madri J. Pecam-1 is a modulator of stat family member phosphorylation and localization: lessons from a transgenic mouse. Dev Biol. 2001;232:219-32 pubmed
    ..We suggest that by serving as a scaffolding, PECAM-1 can bring substrates (STAT5a) and enzymes (a kinase) into close proximity, thereby modulating phosphorylation levels of selected proteins, as previously noted for beta-catenin. ..
  28. Bahary N, Leibel R, Joseph L, Friedman J. Molecular mapping of the mouse db mutation. Proc Natl Acad Sci U S A. 1990;87:8642-6 pubmed
    ..to generate a gene order of: centromere-brown (Mt4)-P lambda Mm3(2)-Ifa (Inta)-Cjun-db-D4Rp1-Glut1-Mtv-13-Lck. Several of the genes that are linked to db [Cjun, glucose transporter (Glut1) and Lck] map to human chromosome 1p, ..
  29. Christy B, Sanders L, Lau L, Copeland N, Jenkins N, Nathans D. An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene. Proc Natl Acad Sci U S A. 1991;88:1815-9 pubmed
    ..On the basis of its structural and functional similarity to Id, we suggest that HLH462 may inhibit the activities of helix-loop-helix transcription factors during the cellular growth response and during development. ..
  30. Kobayashi N, Hong C, Klinman D, Shirota H. Oligodeoxynucleotides expressing polyguanosine motifs promote antitumor activity through the upregulation of IL-2. J Immunol. 2013;190:1882-9 pubmed publisher
    ..Mechanistically, poly-G ODN directly induced the phosphorylation of Lck (an essential element of the T cell-signaling pathway), thereby enhancing the production of IL-2 and CD8 T cell ..
  31. Visan I, Yuan J, Liu Y, Stanley P, Guidos C. Lunatic fringe enhances competition for delta-like Notch ligands but does not overcome defective pre-TCR signaling during thymocyte beta-selection in vivo. J Immunol. 2010;185:4609-17 pubmed publisher
    ..Collectively, our data reveal that Lfng enhances DN3b precursor competition for intrathymic DL ligands to maximize Notch-induced clonal expansion during the earliest stage of ?-selection. ..
  32. Fournel M, Davidson D, Weil R, Veillette A. Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes. J Exp Med. 1996;183:301-6 pubmed
    ..FynT, but not Lck, also associated with c-Cbl in activated T cells...
  33. Engelmann S, Togni M, Thielitz A, Reichardt P, Kliche S, Reinhold D, et al. T cell-independent modulation of experimental autoimmune encephalomyelitis in ADAP-deficient mice. J Immunol. 2013;191:4950-9 pubmed publisher
    ..Thus, our data identify a T cell-independent mechanism of EAE modulation in ADAP-deficient mice. ..
  34. Griff I, Reed R. The genetic basis for specific anosmia to isovaleric acid in the mouse. Cell. 1995;83:407-14 pubmed
    ..High resolution genetic mapping provides a novel approach to the identification of genes critical for the detection of particular odorants. ..
  35. Danciger M, Brady J, Adamson M, Farber D, Piatigorsky J, Kozak C. Chromosomal localization of the genes for five zinc finger proteins expressed in mouse lens. Genomics. 1995;28:39-43 pubmed
    ..Because the zinc finger proteins encoded by these genes may be involved in regulating other genes that are expressed in lens, they can be considered candidates for the large number of yet unmapped cataract loci. ..
  36. Lai W, Pakes S, Bennett M. Natural resistance to Mycoplasma pulmonis infection in mice: host resistance gene(s) map to chromosome 4. Nat Immun. 1996;15:241-8 pubmed
  37. Bachmaier K, Krawczyk C, Kozieradzki I, Kong Y, Sasaki T, Oliveira dos Santos A, et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 2000;403:211-6 pubmed
    ..Cbl-b is thus a key regulator of activation thresholds in mature lymphocytes and immunological tolerance and autoimmunity. ..
  38. Santos J, Pellicer A. Novel RFLPs at protooncogene and cancer-related gene loci on mouse chromosomes. Cytogenet Cell Genet. 1993;62:217-9 pubmed
    DNA probes for the NRAS, HRAS, KRAS2, LCK, RAF1, MET, MYCL1, MYCN, MYB, ERBB2, FOS, CSF1R, and SRC protooncogene loci; the retinoblastoma gene locus (RB1); the tumor virus integration sites INT2, PVT1, and MLV12; and the locus of the ..
  39. Tewari K, Walent J, Svaren J, Zamoyska R, Suresh M. Differential requirement for Lck during primary and memory CD8+ T cell responses. Proc Natl Acad Sci U S A. 2006;103:16388-93 pubmed
    ..events during antigen-stimulated TCR signaling include activation of the Src-family protein tyrosine kinase, p56(Lck) (Lck), which is an integral component of the TCR signaling complex by its association with the cytoplasmic tails ..
  40. Morahan G, Rakar S. Localization of the mouse Na+/H+ exchanger gene on distal chromosome 4. Genomics. 1993;15:231-2 pubmed
    ..Comparison with previously reported strain distribution patterns shows that the gene encoding the mouse Na+/H+ exchanger maps to distal mouse Chromosome 4, between Lck and Akp-2.
  41. Sato T, Kishihara K, Mak T, Habu S. Beta-selection of immature thymocytes is less dependent on CD45 tyrosinephosphatase. Immunol Lett. 1998;64:133-8 pubmed
    Tyrosine kinase p56lck plays a pivotal role in beta-selection from CD4-8- (DN) to CD4+8+ (DP) developing pathway, but it is unclear how CD45 transmembrane tyrosinephosphatase is involved in this process although CD45 activates p56lck by ..
  42. Burns C, Sakaguchi K, Appella E, Ashwell J. CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases. J Biol Chem. 1994;269:13594-600 pubmed
    Previous analyses have suggested that the CD45 tyrosine phosphatase activates src family tyrosine kinases p56lck and p59fyn by dephosphorylating regulatory COOH-terminal residues...
  43. Molina T, Perrot J, Penninger J, Ramos A, Audouin J, Briand P, et al. Differential requirement for p56lck in fetal and adult thymopoiesis. J Immunol. 1998;160:3828-34 pubmed
    The protein tyrosine kinase p56lck is critical for the generation of mature thymocytes in adult mice. However its requirement during the maturation of thymocytes from the fetal to the adult stage has not been clearly defined...
  44. Watts J, Wilson G, Ettenhadieh E, Clark Lewis I, Kubanek C, Astell C, et al. Purification and initial characterization of the lymphocyte-specific protein-tyrosyl kinase p56lck from a baculovirus expression system. J Biol Chem. 1992;267:901-7 pubmed
    ..expression system has been used to express large quantities of the lymphocyte-specific protein-tyrosyl kinase p56lck. A series of chromatographic steps, including the novel application of metalchelate affinity chromatography for ..
  45. Truett G, Jacob H, Miller J, Drouin G, Bahary N, Smoller J, et al. Genetic map of rat chromosome 5 including the fatty (fa) locus. Mamm Genome. 1995;6:25-30 pubmed
    ..One locus, D1S85h, was found to lie only 0.4 cM from fa, close enough to serve as a reliable marker for the prediction of phenotype from genotype, and will be useful also for studies on the development of obesity in the fatty rat. ..
  46. Mason L, Willette Brown J, Taylor L, McVicar D. Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45. J Immunol. 2006;176:6615-23 pubmed
    ..1) inhibition of Src family kinases suppresses DAP12 phosphorylation and downstream DAP12 signals; 2) both Fyn and Lck are capable of phosphorylating DAP12; and 3) both kinases coimmunoprecipitate with the Ly-49D/DAP12 complex in NK ..
  47. Carow B, Gao Y, Coquet J, Reilly M, Rottenberg M. lck-Driven Cre Expression Alters T Cell Development in the Thymus and the Frequencies and Functions of Peripheral T Cell Subsets. J Immunol. 2016;197:2261-8 pubmed publisher
    ..Mice transgenic for Cre under the control of the lck gene promoter are used to study the role of loxP-targeted genes in T cell development and function...
  48. Ping P, Song C, Zhang J, Guo Y, Cao X, Li R, et al. Formation of protein kinase C(epsilon)-Lck signaling modules confers cardioprotection. J Clin Invest. 2002;109:499-507 pubmed
    ..Here we report that Lck, a member of the Src family of tyrosine kinases, forms a functional signaling module with PKCepsilon...
  49. Bae O, Rajanikant K, Min J, Smith J, Baek S, Serfozo K, et al. Lymphocyte cell kinase activation mediates neuroprotection during ischemic preconditioning. J Neurosci. 2012;32:7278-86 pubmed publisher
    ..We investigated whether lymphocyte cell kinase (Lck), a member of the Src kinases family, mediates PC...
  50. Nasertorabi F, Tars K, Becherer K, Kodandapani R, Liljas L, Vuori K, et al. Molecular basis for regulation of Src by the docking protein p130Cas. J Mol Recognit. 2006;19:30-8 pubmed
    ..759MEDpYDYVHL767 containing the key phosphotyrosine was crystallized in complex with the SH3-SH2 domain of the SFK Lck. The results provide the first structural data for this protein-protein interaction...
  51. Würch A, Biro J, Potocnik A, Falk I, Mossmann H, Eichmann K. Requirement of CD3 complex-associated signaling functions for expression of rearranged T cell receptor beta VDJ genes in early thymic development. J Exp Med. 1998;188:1669-78 pubmed
    ..In mice single deficient and double deficient for CD3zeta/eta and/or p56(lck), we observe a pronounced reduction in the proportions of CD25(+) DN thymocytes that express intracellular TCR-beta ..
  52. Todd J, Aitman T, Cornall R, Ghosh S, Hall J, Hearne C, et al. Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Nature. 1991;351:542-7 pubmed
    ..On the basis of comparative maps of the mouse and human genomes, the homologue of Idd-3 may reside on human chromosomes 1 or 4 and Idd-4 on chromosome 17. ..
  53. Filipp D, Moemeni B, Ferzoco A, Kathirkamathamby K, Zhang J, Ballek O, et al. Lck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid rafts. J Biol Chem. 2008;283:26409-22 pubmed publisher
    Mechanisms regulating the activation and delivery of function of Lck and Fyn are central to the generation of the most proximal signaling events emanating from the T cell antigen receptor (TcR) complex...
  54. McClive P, Morahan G. Assignment of the mouse homologues of 6 loci from HSA1p to chromosomes 3 and 4. Genomics. 1994;23:243-6 pubmed
  55. Huang J, Tilly D, Altman A, Sugie K, Grey H. T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase. Proc Natl Acad Sci U S A. 2000;97:10923-9 pubmed
    ..In this study, we investigated the role played by the protein tyrosine kinases Fyn, Lck, and ZAP-70 in antagonist-induced signaling pathway...
  56. Gorska M, Stafford S, Cen O, Sur S, Alam R. Unc119, a novel activator of Lck/Fyn, is essential for T cell activation. J Exp Med. 2004;199:369-79 pubmed
    The first step in T cell receptor for antigen (TCR) signaling is the activation of the receptor-bound Src kinases, Lck and Fyn. The exact mechanism of this process is unknown...
  57. Park D, Lee E, Jang E, Jeong H, Kim B, Ha Y, et al. Identification of the dichotomous role of age-related LCK in calorie restriction revealed by integrative analysis of cDNA microarray and interactome. Age (Dordr). 2013;35:1045-60 pubmed publisher
    ..One of these key molecules is lymphocyte-specific protein tyrosine kinase (LCK)...
  58. Chrobak P, Simard M, Bouchard N, Ndolo T, Guertin J, Hanna Z, et al. HIV-1 Nef disrupts maturation of CD4+ T cells through CD4/Lck modulation. J Immunol. 2010;185:3948-59 pubmed publisher
    ..in absence of the CD4 tail, in double-Tg (Nef × CD4(tailless)) mice or in the presence of constitutively active Tg Lck(Y505F). These rescue strategies also resulted in reversal of peripheral CD4(+) T cell lymphopenia...
  59. Shenoy Scaria A, Gauen L, Kwong J, Shaw A, Lublin D. Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins. Mol Cell Biol. 1993;13:6385-92 pubmed
    ..We and others have shown an association between GPI-anchored proteins and the protein tyrosine kinases (PTKs) p56lck and p59fyn, suggesting a pathway for signaling through GPI-anchored proteins...
  60. Sicinska E, Aifantis I, Le Cam L, Swat W, Borowski C, Yu Q, et al. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell. 2003;4:451-61 pubmed
    ..These studies point to cyclin D3 as a potential target for therapeutic intervention in specific human malignancies. ..
  61. Engel I, Murre C. E2A proteins enforce a proliferation checkpoint in developing thymocytes. EMBO J. 2004;23:202-11 pubmed
    ..and proliferation observed in thymocytes with defects in proteins that mediate pre-TCR signaling, including LAT, Lck and Fyn...
  62. Liao X, Littman D, Weiss A. Itk and Fyn make independent contributions to T cell activation. J Exp Med. 1997;186:2069-73 pubmed
    ..b>Lck and Fyn are the Src-family nonreceptor PTKs that are involved in TCR signaling...
  63. Takaki S, Watts J, Forbush K, Nguyen N, Hayashi J, Alberola Ila J, et al. Characterization of Lnk. An adaptor protein expressed in lymphocytes. J Biol Chem. 1997;272:14562-70 pubmed
    ..Together these studies suggest that Lnk participates in signaling from receptors other than antigen receptors in lymphocytes. ..
  64. Molina T, Bachmann M, Kundig T, Zinkernagel R, Mak T. Peripheral T cells in mice lacking p56lck do not express significant antiviral effector functions. J Immunol. 1993;151:699-706 pubmed
    Mutant mice lacking p56lck, the T cell-specific protein tyrosine kinase, have a profound thymic atrophy and possess only an immature thymocyte population...
  65. Lesage S, Steff A, Philippoussis F, Page M, Trop S, Mateo V, et al. CD4+ CD8+ thymocytes are preferentially induced to die following CD45 cross-linking, through a novel apoptotic pathway. J Immunol. 1997;159:4762-71 pubmed
    ..We propose that during T cell development, CD45 ligation could induce the death of those immature thymocytes that do not fulfill the requirements for positive selection. ..
  66. Hashimoto Tane A, Yokosuka T, Ishihara C, Sakuma M, Kobayashi W, Saito T. T-cell receptor microclusters critical for T-cell activation are formed independently of lipid raft clustering. Mol Cell Biol. 2010;30:3421-9 pubmed publisher
  67. Tan Y, Sementino E, Pei J, Kadariya Y, Ito T, Testa J. Co-targeting of Akt and Myc inhibits viability of lymphoma cells from Lck-Dlx5 mice. Cancer Biol Ther. 2015;16:580-8 pubmed publisher
    ..We previously demonstrated that expression of a constitutively active form of Lck-Akt2 alone is sufficient to initiate T-cell lymphoma in mice, and that tumor formation typically requires up ..
  68. Koegl M, Zlatkine P, Ley S, Courtneidge S, Magee A. Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif. Biochem J. 1994;303 ( Pt 3):749-53 pubmed
    ..We have investigated whether the Src, Fyn, Yes and Lck gene products are palmitoylated. Src was not labelled with [3H]palmitate when endogenously expressed in COS cells...
  69. Gimferrer I, Hu T, Simmons A, Wang C, Souabni A, Busslinger M, et al. Regulation of GATA-3 expression during CD4 lineage differentiation. J Immunol. 2011;186:3892-8 pubmed publisher
  70. Carrera A, Alexandrov K, Roberts T. The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP. Proc Natl Acad Sci U S A. 1993;90:442-6 pubmed
    ..These results suggest that the region including Lys-273 of subdomain II is involved in the enzymatic process of phosphate transfer, rather than in anchoring ATP. ..
  71. Borger J, Filby A, Zamoyska R. Differential polarization of C-terminal Src kinase between naive and antigen-experienced CD8+ T cells. J Immunol. 2013;190:3089-99 pubmed publisher
    ..CD8 associates with the Src-family kinase (SFK) Lck, which, in turn, initiates the rapid tyrosine phosphorylation events that drive cellular activation...
  72. Beier D, Dushkin H, Sussman D. Mapping genes in the mouse using single-strand conformation polymorphism analysis of recombinant inbred strains and interspecific crosses. Proc Natl Acad Sci U S A. 1992;89:9102-6 pubmed
    ..These results were confirmed using single-strand conformation polymorphism analysis of an interspecific backcross. ..
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