Lbp

Summary

Gene Symbol: Lbp
Description: lipopolysaccharide binding protein
Alias: Bpifd2, Ly88, lipopolysaccharide-binding protein
Species: mouse
Products:     Lbp

Top Publications

  1. Wurfel M, Monks B, Ingalls R, Dedrick R, Delude R, Zhou D, et al. Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact. J Exp Med. 1997;186:2051-6 pubmed
    ..Cellular responses to LPS are markedly potentiated by the LPS-binding protein (LBP), a lipid-transfer protein that binds LPS aggregates and transfers LPS monomers to CD14...
  2. Lengacher S, Jongeneel C, Le Roy D, Lee J, Kravchenko V, Ulevitch R, et al. Reactivity of murine and human recombinant LPS-binding protein (LBP) within LPS and gram negative bacteria. J Inflamm. 1995;47:165-72 pubmed
    The serum lipopolysaccharide (LPS) binding protein, LBP, has been shown to greatly enhance cellular responses to low concentrations of LPS...
  3. Knapp S, von Aulock S, Leendertse M, Haslinger I, Draing C, Golenbock D, et al. Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor. J Immunol. 2008;180:3478-84 pubmed
    ..In vitro data indicate roles for TLR2, platelet-activating factor receptor (PAFR), CD14, and LPS-binding protein (LBP) in cellular responsiveness to LTA, whereas the mechanisms contributing to LTA effects in vivo have never been ..
  4. Wang X, Wu L, Wu K, Zhang R, Dong Y. Roles of endotoxin-related signaling molecules in the progression of acute necrotizing pancreatitis in mice. Pancreas. 2005;31:251-7 pubmed
    To study the potential roles of lipopolysaccharide (LPS) signaling molecules, LPS-binding protein (LBP), CD14, and Toll-like receptor 4 (TLR4) in mice with acute necrotizing pancreatitis (ANP)...
  5. Branger J, Florquin S, Knapp S, Leemans J, Pater J, Speelman P, et al. LPS-binding protein-deficient mice have an impaired defense against Gram-negative but not Gram-positive pneumonia. Int Immunol. 2004;16:1605-11 pubmed
    LPS-binding protein (LBP) can facilitate the transfer of cell wall components of both Gram-negative bacteria (LPS) and Gram-positive bacteria (lipoteichoic acid) to inflammatory cells...
  6. Jin C, Engstler A, Ziegenhardt D, Bischoff S, Trautwein C, Bergheim I. Loss of lipopolysaccharide-binding protein attenuates the development of diet-induced non-alcoholic fatty liver disease in mice. J Gastroenterol Hepatol. 2017;32:708-715 pubmed publisher
    ..Eight-week-old lipopolysaccharide-binding protein (LBP)-/- and wild-type (WT) mice were pair fed either a liquid diet rich in fat, fructose, and cholesterol (Western-..
  7. Tanimura N, Saitoh S, Ohto U, Akashi Takamura S, Fujimoto Y, Fukase K, et al. The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane. Int Immunol. 2014;26:307-14 pubmed publisher
  8. Wei L, Simen A, Mane S, Kaffman A. Early life stress inhibits expression of a novel innate immune pathway in the developing hippocampus. Neuropsychopharmacology. 2012;37:567-80 pubmed publisher
    ..Using an unbiased genomic screen, we found that expression of lipopolysaccharide binding protein (LBP), a member of the innate immune system, is dramatically decreased in the hippocampus of pups ..
  9. Hansen G, Rasmussen K, Niels Christiansen L, Danielsen E. Lipopolysaccharide-binding protein: localization in secretory granules of Paneth cells in the mouse small intestine. Histochem Cell Biol. 2009;131:727-32 pubmed publisher
    Lipopolysaccharide (LPS)-binding protein (LBP) is an acute-phase protein involved in the host's response to endotoxin and mainly synthesized and secreted to the blood by the liver...

More Information

Publications38

  1. Wolk K, Witte E, Hoffmann U, Doecke W, Endesfelder S, Asadullah K, et al. IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease. J Immunol. 2007;178:5973-81 pubmed
    ..systemic IL-22 in CD, we then administered IL-22 to healthy mice and found an up-regulation of LPS-binding protein (LBP) blood levels reaching concentrations known to neutralize LPS...
  2. Lehnert M, Uehara T, Bradford B, Lind H, Zhong Z, Brenner D, et al. Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. Am J Physiol Gastrointest Liver Physiol. 2006;291:G456-63 pubmed
    ..Because lipopolysaccharide-binding protein (LBP) enhances cellular responses to endotoxin, our aim was to determine whether LBP contributes to hemorrhage/..
  3. Su G, Gong K, Fan M, Kelley W, Hsieh J, Sun J, et al. Lipopolysaccharide-binding protein modulates acetaminophen-induced liver injury in mice. Hepatology. 2005;41:187-95 pubmed
    ..In this study, we examined the role of lipopolysaccharide-binding protein (LBP), a protein important in mediating cellular response to lipopolysaccharides, by using LBP wild-type and knockout (..
  4. Haudek S, Natmessnig B, Redl H, Schlag G, Hatlen L, Tobias P. Isolation, partial characterization, and concentration in experimental sepsis of baboon lipopolysaccharide-binding protein. J Lab Clin Med. 2000;136:363-70 pubmed
    Lipopolysaccharide-binding protein (LBP) is important for mediating host responses to lipopolysaccharide (LPS). The structure and properties of human, rabbit, and murine LBP have been previously described...
  5. Ulevitch R, Tobias P. Recognition of gram-negative bacteria and endotoxin by the innate immune system. Curr Opin Immunol. 1999;11:19-22 pubmed
  6. Uesugi T, Froh M, Arteel G, Bradford B, Wheeler M, Gabele E, et al. Role of lipopolysaccharide-binding protein in early alcohol-induced liver injury in mice. J Immunol. 2002;168:2963-9 pubmed
    Cellular responses to endotoxins are enhanced markedly by LPS-binding protein (LBP). Furthermore, it has been demonstrated that endotoxins and proinflammatory cytokines such as TNF-alpha participate in early alcohol-induced liver injury...
  7. Weber J, Freyer D, Alexander C, Schröder N, Reiss A, Küster C, et al. Recognition of pneumococcal peptidoglycan: an expanded, pivotal role for LPS binding protein. Immunity. 2003;19:269-79 pubmed
    b>Lipopolysaccharide binding protein (LBP) has a well-established role in LPS-induced immune responses...
  8. Feng Y, Yang Q, Liu Y, Xu J, Qian G, Wang Y. The localization of two mimic epitopes of lipopolysaccharide binding protein and the preparation of their tandem multiple antigen peptide. J Immunol Methods. 2010;362:60-9 pubmed publisher
    To screen and identify two mimic epitopes in the inflammatory site of lipopolysaccharide binding protein (LBP), and to synthesize and purify their corresponding mimic epitope four branched peptide (multiple antigen peptide, MAP)...
  9. Ngure R, Eckersall P, Mungatana N, Mburu J, Jennings F, Burke J, et al. Lipopolysaccharide binding protein in the acute phase response of experimental murine Trypanosoma brucei brucei infection. Res Vet Sci. 2009;86:394-8 pubmed publisher
    Cellular responses to lipopolysaccharide (LPS) are enhanced by LPS-binding protein (LBP). The present study investigated the acute phase response of LBP during Trypanosoma brucei brucei infection in mice...
  10. Strohmeier G, Walsh J, Klings E, Farber H, Cruikshank W, Center D, et al. Lipopolysaccharide binding protein potentiates airway reactivity in a murine model of allergic asthma. J Immunol. 2001;166:2063-70 pubmed
    ..are insufficient to activate alveolar macrophages in the absence of the accessory molecule LPS binding protein (LBP)...
  11. Heinrich J, Bernheiden M, Minigo G, Yang K, Schutt C, Mannel D, et al. The essential role of lipopolysaccharide-binding protein in protection of mice against a peritoneal Salmonella infection involves the rapid induction of an inflammatory response. J Immunol. 2001;167:1624-8 pubmed
    ..For example, LPS-binding protein (LBP) can transfer the LPS of Gram-negative bacteria to CD14 on the surface of macrophages, and this initiates an ..
  12. Echtenacher B, Freudenberg M, Jack R, Mannel D. Differences in innate defense mechanisms in endotoxemia and polymicrobial septic peritonitis. Infect Immun. 2001;69:7271-6 pubmed
    ..gene, which encodes the critical receptor molecule for LPS responses, or mice deficient for LPS binding protein (LBP) or mice sensitized to LPS by Propionibacterium acnes...
  13. Isayama F, Hines I, Kremer M, Milton R, Byrd C, Perry A, et al. LPS signaling enhances hepatic fibrogenesis caused by experimental cholestasis in mice. Am J Physiol Gastrointest Liver Physiol. 2006;290:G1318-28 pubmed
    ..LPS was involved in experimental cholestatic liver fibrosis was tested using mice deficient in LPS-binding protein (LBP(-/-))...
  14. Fierer J, Swancutt M, Heumann D, Golenbock D. The role of lipopolysaccharide binding protein in resistance to Salmonella infections in mice. J Immunol. 2002;168:6396-403 pubmed
    Polymorphonuclear leukocytes (PMN) and LPS-binding protein (LBP) are both components of the innate immune system. LBP is a plasma protein that binds to lipid A and enhances the biological activity of LPS 100- to 1000-fold...
  15. Yang K, Dorner B, Merkel U, Ryffel B, Schütt C, Golenbock D, et al. Neutrophil influx in response to a peritoneal infection with Salmonella is delayed in lipopolysaccharide-binding protein or CD14-deficient mice. J Immunol. 2002;169:4475-80 pubmed
    ..In the case of an i.p. infection with Salmonella typhimurium, survival requires both CD14 and LPS-binding protein (LBP) which, together with Toll-like receptor 4 and myeloid differentiation protein 2, provide a sensitive means to ..
  16. Knapp S, de Vos A, Florquin S, Golenbock D, van der Poll T. Lipopolysaccharide binding protein is an essential component of the innate immune response to Escherichia coli peritonitis in mice. Infect Immun. 2003;71:6747-53 pubmed
    Lipopolysaccharide (LPS) binding protein (LBP) is an acute-phase protein that enhances the responsiveness of immune cells to LPS by virtue of its capacity to transfer LPS to CD14...
  17. Moreno Navarrete J, Escoté X, Ortega F, Camps M, Ricart W, Zorzano A, et al. Lipopolysaccharide binding protein is an adipokine involved in the resilience of the mouse adipocyte to inflammation. Diabetologia. 2015;58:2424-34 pubmed publisher
    Lipopolysaccharide (LPS) binding protein (LBP) is a novel 65 kDa adipokine, linked to adipose tissue (AT) inflammation, obesity and insulin resistance, that inhibits adipocyte differentiation...
  18. Maxwell J, Zhang Y, Brown W, Smith C, Byrne F, Fiorino M, et al. Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation. Immunity. 2015;43:739-50 pubmed publisher
    ..These data show that IL-17A acts on intestinal epithelium to promote barrier function and provide insight into mechanisms underlying exacerbation of Crohn's disease when IL-17A or IL-17RA is inhibited. ..
  19. Sallam T, Ito A, Rong X, Kim J, van Stijn C, Chamberlain B, et al. The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis. J Lipid Res. 2014;55:1120-30 pubmed publisher
    ..Here we characterize a novel LXR target gene, the lipopolysaccharide binding protein (LBP) gene...
  20. Gavaldà Navarro A, Moreno Navarrete J, Quesada López T, Cairó M, Giralt M, Fernández Real J, et al. Lipopolysaccharide-binding protein is a negative regulator of adipose tissue browning in mice and humans. Diabetologia. 2016;59:2208-18 pubmed publisher
    Adipocyte lipopolysaccharide-binding protein (LBP) biosynthesis is associated with obesity-induced adipose tissue dysfunction. Our purpose was to study the role of LBP in regulating the browning of adipose tissue...
  21. Jack R, Fan X, Bernheiden M, Rune G, Ehlers M, Weber A, et al. Lipopolysaccharide-binding protein is required to combat a murine gram-negative bacterial infection. Nature. 1997;389:742-5 pubmed
    ..In vitro, LPS is bound by lipopolysaccharide-binding protein (LBP) and transferred to CD14--the LPS receptor on the macrophage surface--or to high-density lipoprotein (HDL) ..
  22. Lengacher S, Reed D, Heumann D, Jongeneel C. Genomic organization and chromosomal localization of the mouse lipopolysaccharide binding protein gene. Immunogenetics. 1999;49:553-6 pubmed
  23. Minter R, Bi X, Ben Josef G, Wang T, Hu B, Arbabi S, et al. LPS-binding protein mediates LPS-induced liver injury and mortality in the setting of biliary obstruction. Am J Physiol Gastrointest Liver Physiol. 2009;296:G45-54 pubmed publisher
    It is generally accepted that low levels of lipopolysaccharide (LPS)-binding protein (LBP) augment the cell's response to LPS, whereas high levels of LBP have been shown to inhibit cell responses to LPS...
  24. Erridge C, Kennedy S, Spickett C, Webb D. Oxidized phospholipid inhibition of toll-like receptor (TLR) signaling is restricted to TLR2 and TLR4: roles for CD14, LPS-binding protein, and MD2 as targets for specificity of inhibition. J Biol Chem. 2008;283:24748-59 pubmed publisher
    ..as key targets for the specificity of TLR inhibition as supplementation with excess serum or recombinant CD14 or LBP reversed TLR2 inhibition by OxPAPC, whereas serum accessory proteins or expression of membrane CD14 potentiated ..
  25. Knapp S, Florquin S, Golenbock D, van der Poll T. Pulmonary lipopolysaccharide (LPS)-binding protein inhibits the LPS-induced lung inflammation in vivo. J Immunol. 2006;176:3189-95 pubmed
    LPS-binding protein (LBP) facilitates the interaction of the Gram-negative cell wall component LPS with CD14, thereby enhancing the immune response to LPS...
  26. Branger J, Leemans J, Florquin S, Speelman P, Golenbock D, van der Poll T. Lipopolysaccharide binding protein-deficient mice have a normal defense against pulmonary mycobacterial infection. Clin Immunol. 2005;116:174-81 pubmed
    Lipopolysaccharide (LPS) binding protein (LBP) facilitates the transfer of LPS of Gram-negative bacteria to the pattern recognition receptor CD14, resulting in activation of immunocompetent cells...
  27. Fan M, Klein R, Steinstraesser L, Merry A, Nemzek J, Remick D, et al. An essential role for lipopolysaccharide-binding protein in pulmonary innate immune responses. Shock. 2002;18:248-54 pubmed
    Lipopolysaccharide (LPS)-binding protein (LBP) greatly facilitates LPS activation of monocytic cells through the CD14 receptor, triggering activation of innate immune responses...
  28. Levin S, Pevsner Fischer M, Kagan S, Lifshitz H, Weinstock A, Gataulin D, et al. Divergent levels of LBP and TGF?1 in murine MSCs lead to heterogenic response to TLR and proinflammatory cytokine activation. Stem Cell Rev. 2014;10:376-88 pubmed publisher
    ..Marked differences were observed in LPS binding protein (LBP) and transforming growth factor (TGF)?1 expression. These differences correlated with MSC functionality...
  29. Brass D, Savov J, Whitehead G, Maxwell A, Schwartz D. LPS binding protein is important in the airway response to inhaled endotoxin. J Allergy Clin Immunol. 2004;114:586-92 pubmed
    ..Our objective was to determine the importance of LPS binding protein (LBP) in the response to inhaled LPS...