Lat

Summary

Gene Symbol: Lat
Description: linker for activation of T cells
Alias: p36-38, pp36, linker for activation of T-cells family member 1, 36 kDa phospho-tyrosine adapter protein, linker protein
Species: mouse
Products:     Lat

Top Publications

  1. Mingueneau M, Roncagalli R, Gregoire C, Kissenpfennig A, Miazek A, Archambaud C, et al. Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor. Immunity. 2009;31:197-208 pubmed publisher
    ..cell antigen receptor (TCR) signaling, mice in which tyrosine 136 of the adaptor linker for activation of T cells (LAT) was constitutively mutated (Lat(Y136F) mice) accumulate CD4(+) T cells that trigger autoimmunity and inflammation...
  2. Sommers C, Menon R, Grinberg A, Zhang W, Samelson L, Love P. Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development. J Exp Med. 2001;194:135-42 pubmed
    The integral membrane adapter protein linker for activation of T cells (LAT) performs a critical function in T cell antigen receptor (TCR) signal transduction by coupling the TCR to downstream signaling pathways...
  3. Wang Y, Kissenpfennig A, Mingueneau M, Richelme S, Perrin P, Chevrier S, et al. Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells. J Immunol. 2008;180:1565-75 pubmed
    Mutant mice where tyrosine 136 of linker for activation of T cells (LAT) was replaced with a phenylalanine (Lat(Y136F) mice) develop a fast-onset lymphoproliferative disorder involving polyclonal CD4 T cells that produce massive amounts ..
  4. Sommers C, Lee J, Steiner K, Gurson J, Depersis C, El Khoury D, et al. Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection. J Exp Med. 2005;201:1125-34 pubmed
    Linker for activation of T cells (LAT) is a scaffolding adaptor protein that is critical for T cell development and function...
  5. Sarratt K, Chen H, Zutter M, Santoro S, Hammer D, Kahn M. GPVI and alpha2beta1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow. Blood. 2005;106:1268-77 pubmed
    ..leukocyte protein of 76 kDa (SLP-76) but not by the transmembrane adaptor linker for activation of T cells (LAT) is critical for platelet adhesion to collagen under flow...
  6. Kortum R, Rouquette Jazdanian A, Miyaji M, Merrill R, Markegard E, Pinski J, et al. A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice. J Immunol. 2013;190:147-58 pubmed publisher
    Mice expressing a germline mutation in the phospholipase C-γ1-binding site of linker for activation of T cells (LAT) show progressive lymphoproliferation and ultimately die at 4-6 mo age...
  7. Miyaji M, Kortum R, Surana R, Li W, Woolard K, Simpson R, et al. Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice. Proc Natl Acad Sci U S A. 2009;106:14502-7 pubmed publisher
    Germline mutation of the linker for activation of T cells (LAT) gene at the phospholipase C-gamma1 (PLC-gamma1)-binding site leads to a fatal lymphoproliferative disease in mice...
  8. Kalia N, Auger J, Atkinson B, Watson S. Critical role of FcR gamma-chain, LAT, PLCgamma2 and thrombin in arteriolar thrombus formation upon mild, laser-induced endothelial injury in vivo. Microcirculation. 2008;15:325-35 pubmed publisher
    The role of collagen receptor complex GPVI-FcR gamma-chain, PLCgamma2 and LAT in laser-induced thrombosis is unclear. Controversy surrounds whether collagen is exposed in this model or whether thrombosis is dependent on thrombin...
  9. Sommers C, Samelson L, Love P. LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways. Bioessays. 2004;26:61-7 pubmed
    ..pathways (PLC-gamma1 activation, Ca2+ influx, PKC activation and Ras/Erk activation) via the adapter protein LAT (Linker for Activation of T cells)...

More Information

Publications87

  1. Sommers C, Park C, Lee J, Feng C, Fuller C, Grinberg A, et al. A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science. 2002;296:2040-3 pubmed
    Mice homozygous for a single tyrosine mutation in LAT (linker for activation of T cells) exhibited an early block in T cell maturation but later developed a polyclonal lymphoproliferative disorder and signs of autoimmune disease...
  2. Aguado E, Richelme S, Nunez Cruz S, Miazek A, Mura A, Richelme M, et al. Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science. 2002;296:2036-40 pubmed
    The transmembrane protein LAT (linker for activation of T cells) couples the T cell receptor (TCR) to downstream signaling effectors. Mice homozygous for a mutation of a single LAT tyrosine residue showed impeded T cell development...
  3. Judd B, Myung P, Obergfell A, Myers E, Cheng A, Watson S, et al. Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling. J Exp Med. 2002;195:705-17 pubmed
    ..Linker for activation of T cells (LAT)-deficient mice exhibit a similar T cell phenotype, but show no signs of hemorrhage...
  4. Geng L, Rudd C. Signalling scaffolds and adaptors in T-cell immunity. Br J Haematol. 2002;116:19-27 pubmed
  5. Zhang W, Sloan Lancaster J, Kitchen J, Trible R, Samelson L. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell. 1998;92:83-92 pubmed
    ..Its function is demonstrated by inhibition of T cell activation following overexpression of a mutant form lacking critical tyrosine residues. Therefore, we propose to name the molecule LAT-linker for activation of T cells.
  6. Saitoh S, Arudchandran R, Manetz T, Zhang W, Sommers C, Love P, et al. LAT is essential for Fc(epsilon)RI-mediated mast cell activation. Immunity. 2000;12:525-35 pubmed
    The linker molecule LAT is a substrate of the tyrosine kinases activated following TCR engagement of T cells. LAT is also expressed in platelets, NK, and mast cells...
  7. Saitoh S, Odom S, Gomez G, Sommers C, Young H, Rivera J, et al. The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation. J Exp Med. 2003;198:831-43 pubmed
    The linker for activation of T cells (LAT) is an adaptor protein critical for Fc epsilon RI-mediated mast cell activation. LAT is a substrate of the tyrosine kinases activated after TCR and Fc epsilon RI engagement...
  8. Nunez Cruz S, Aguado E, Richelme S, Chetaille B, Mura A, Richelme M, et al. LAT regulates gammadelta T cell homeostasis and differentiation. Nat Immunol. 2003;4:999-1008 pubmed
    b>LAT (linker for activation of T cells) is essential for T cell receptor signaling...
  9. Janssen E, Zhu M, Craven B, Zhang W. Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding. J Immunol. 2004;172:6810-9 pubmed
    ..is expressed in various immune cell types and has a similar domain structure as linker for activation of T cells (LAT). In this study we generated a LAB transgenic mouse to compare the functional differences between LAB and LAT...
  10. Zhang W, Sommers C, Burshtyn D, Stebbins C, DeJarnette J, Trible R, et al. Essential role of LAT in T cell development. Immunity. 1999;10:323-32 pubmed
    The linker molecule LAT is a substrate of the tyrosine kinases activated following TCR engagement. Phosphorylated LAT binds many critical signaling molecules...
  11. Zhang W, Trible R, Samelson L. LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity. 1998;9:239-46 pubmed
    The linker molecule LAT is a critical substrate of the tyrosine kinases activated upon TCR engagement. Phosphorylated LAT binds Grb2, PLC-gamma1, and other signaling molecules...
  12. Chiesa S, Mingueneau M, Fuseri N, Malissen B, Raulet D, Malissen M, et al. Multiplicity and plasticity of natural killer cell signaling pathways. Blood. 2006;107:2364-72 pubmed
    ..In T and mast cells, ITAM-dependent signals are integrated by critical scaffolding elements such as LAT (linker for activation of T cells) and NTAL (non-T-cell activation linker)...
  13. Hayes S, Li L, Love P. TCR signal strength influences alphabeta/gammadelta lineage fate. Immunity. 2005;22:583-93 pubmed
    ..These results support a model in which the strength of the TCR signal is a critical determinant in the lineage fate decision. ..
  14. Sullivan S, Zhu M, Bao S, Lewis C, Ou Yang C, Zhang W. The role of LAT-PLC?1 interaction in ?? T cell development and homeostasis. J Immunol. 2014;192:2865-74 pubmed publisher
    b>LAT is a transmembrane adaptor protein that is vital for integrating TCR-mediated signals to modulate T cell development, activation, and proliferation...
  15. Roncagalli R, Mingueneau M, Gregoire C, Langlet C, Malissen B, Malissen M. Lymphoproliferative disorders involving T helper effector cells with defective LAT signalosomes. Semin Immunopathol. 2010;32:117-25 pubmed publisher
    Linker for activation of T cells (LAT) is a membrane adaptor protein that is expressed in T cells and coordinates the assembly of a multiprotein complex-the LAT signalosome-that links the T cell-specific and the ubiquitous components of ..
  16. Li H, Dai M, Zhuang Y. A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome. Immunity. 2004;21:551-60 pubmed
    ..Thus, this study establishes a critical connection between Id3-mediated T cell development and autoimmune diseases. ..
  17. Ou Yang C, Zhu M, Sullivan S, Fuller D, Zhang W. The requirement of linker for activation of T cells in the primary and memory responses of CD8 T cells. J Immunol. 2013;190:2938-47 pubmed publisher
    Linker for activation of T cells (LAT) is a transmembrane adaptor protein that links TCR engagement to downstream signaling events...
  18. Miazek A, Macha K, Łaszkiewicz A, Kissenpfennig A, Malissen B, Kisielow P. Peripheral Thy1+ lymphocytes rearranging TCR-gammadelta genes in LAT-deficient mice. Eur J Immunol. 2009;39:2596-605 pubmed publisher
    Linker for activation of T cells (LAT) is an adaptor molecule indispensable for development of alphabeta and gammadelta T lymphocytes...
  19. Roncagalli R, Hauri S, Fiore F, Liang Y, Chen Z, Sansoni A, et al. Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub. Nat Immunol. 2014;15:384-392 pubmed publisher
    ..the composition and dynamics of multiprotein complexes that formed around the kinase Zap70 and the adaptors Lat and SLP-76. Most of the 112 high-confidence time-resolved protein interactions we observed were previously unknown...
  20. Vivar O, Masi G, Carpier J, Magalhaes J, Galgano D, Pazour G, et al. IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo. Proc Natl Acad Sci U S A. 2016;113:386-91 pubmed publisher
    ..the centrosome were unaffected, T-cell receptor (TCR)-mediated signaling and recruitment of the signaling adaptor LAT (linker for activation of T cells) at the immune synapse were reduced...
  21. Tanimura N, Saitoh S, Kawano S, Kosugi A, Miyake K. Palmitoylation of LAT contributes to its subcellular localization and stability. Biochem Biophys Res Commun. 2006;341:1177-83 pubmed
    ..Without palmitoylation, linker for activation of T cells (LAT), an adaptor molecule mediating T cell receptor signaling, is unable to localize in lipid rafts and to mediate T ..
  22. Kim K, Kim J, Moon J, Lee J, Kwak H, Park Y, et al. The transmembrane adaptor protein, linker for activation of T cells (LAT), regulates RANKL-induced osteoclast differentiation. Mol Cells. 2012;33:401-6 pubmed publisher
    ..Herein we investigate the role of the transmembrane adaptor proteins in RANKL-induced osteoclastogenesis. LAT positively regulates osteoclast differentiation and is up-regulated by RANKL via c-Fos and NFATc1, whereas LAB and ..
  23. Chan E, Teng G, Corbett E, Choudhury K, Bassing C, Schatz D, et al. Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2. Proc Natl Acad Sci U S A. 2013;110:E4628-37 pubmed publisher
    ..Our data suggest that the nuclear periphery suppresses V(D)J recombination, at least in part, by segregating Tcrb alleles from RAG proteins. ..
  24. Freund J, May R, Yang E, Li H, McCullen M, Zhang B, et al. Activating Receptor Signals Drive Receptor Diversity in Developing Natural Killer Cells. PLoS Biol. 2016;14:e1002526 pubmed publisher
  25. Thaker Y, Schneider H, Rudd C. TCR and CD28 activate the transcription factor NF-κB in T-cells via distinct adaptor signaling complexes. Immunol Lett. 2015;163:113-9 pubmed publisher
    ..in the case of anti-CD28, NF-κB activation by anti-CD3 and its cooperation with ADAP was strictly dependent on LAT expression...
  26. Wu Y, Suzuki Inoue K, Satoh K, Asazuma N, Yatomi Y, Berndt M, et al. Role of Fc receptor gamma-chain in platelet glycoprotein Ib-mediated signaling. Blood. 2001;97:3836-45 pubmed
    ..tyrosine phosphorylation of Fc receptor gamma-chain (FcR gamma-chain), Syk, linker for activation of T cells (LAT), and phospholipase C gamma2 (PLCgamma2)...
  27. Volná P, Lebduska P, Dráberová L, Simova S, Heneberg P, Boubelik M, et al. Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL. J Exp Med. 2004;200:1001-13 pubmed
    ..events include tyrosine phosphorylation of two transmembrane adaptor proteins, linker for activation of T cells (LAT) and non-T cell activation linker (NTAL; also called LAB; a product of Wbscr5 gene)...
  28. Fehrenbach K, Lessmann E, Zorn C, Kuhny M, Grochowy G, Krystal G, et al. Steel factor enhances supraoptimal antigen-induced IL-6 production from mast cells via activation of protein kinase C-beta. J Immunol. 2009;182:7897-905 pubmed publisher
    ..g., Erk, p38, and LAT. However, these effects of prestimulation with SF appear not to be due to reduced engagement of the attenuator ..
  29. Archambaud C, Sansoni A, Mingueneau M, Devilard E, Delsol G, Malissen B, et al. STAT6 deletion converts the Th2 inflammatory pathology afflicting Lat(Y136F) mice into a lymphoproliferative disorder involving Th1 and CD8 effector T cells. J Immunol. 2009;182:2680-9 pubmed publisher
    Mutant mice in which tyrosine 136 of linker for activation of T cells (LAT) was replaced with a phenylalanine (Lat(Y136F) mice) develop a lymphoproliferative disorder involving polyclonal CD4 effector T cells that produce massive amounts ..
  30. Shiheido H, Aoyama T, Takahashi H, Hanaoka K, Abe T, Nishida E, et al. Novel CD3-specific antibody induces immunosuppression via impaired phosphorylation of LAT and PLC?1 following T-cell stimulation. Eur J Immunol. 2014;44:1770-80 pubmed publisher
    ..The phosphorylated forms of the signaling proteins PLC-?1 and LAT in Dow2-induced anergic T cells were markedly decreased upon stimulation...
  31. Zhu M, Liu Y, Koonpaew S, Granillo O, Zhang W. Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL. J Exp Med. 2004;200:991-1000 pubmed
    ..LAB is capable of rescuing thymocyte development in LAT-deficient mice. To study the in vivo function of LAB, LAB-deficient mice were generated...
  32. Kortum R, Balagopalan L, Alexander C, Garcia J, Pinski J, Merrill R, et al. The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo. Sci Signal. 2013;6:ra99 pubmed publisher
    ..in addition to its GEF activity, Sos1 acted as a scaffold to nucleate oligomerization of the T cell adaptor protein LAT (linker for activation of T cells) in vivo...
  33. Wang D, Zheng M, Lei L, Ji J, Yao Y, Qiu Y, et al. Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Nat Immunol. 2012;13:560-8 pubmed publisher
    ..Our findings demonstrate that Tespa1 is a component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development. ..
  34. Clarke R, Thiemann S, Refaeli Y, Werlen G, Potter T. A new function for LAT and CD8 during CD8-mediated apoptosis that is independent of TCR signal transduction. Eur J Immunol. 2009;39:1619-31 pubmed publisher
    ..through the TCR that is dependent on the phosphorylation of the adaptor protein, linker for activation of T cells (LAT)...
  35. Laffleur B, Duchez S, Tarte K, Denis Lagache N, Péron S, Carrion C, et al. Self-Restrained B Cells Arise following Membrane IgE Expression. Cell Rep. 2015;: pubmed publisher
    ..Consequently, few cells survive IgE class switching, which might ensure minimal long-term IgE memory upon differentiation into plasma cells. ..
  36. Malissen B, Aguado E, Malissen M. Role of the LAT adaptor in T-cell development and Th2 differentiation. Adv Immunol. 2005;87:1-25 pubmed
    b>LAT (linker for activation of T cells) is an integral membrane adaptor protein that constitutes in T cells a major substrate of the ZAP-70 protein tyrosine kinase...
  37. Cao Y, Li H, Liu H, Zhang M, Hua Z, Ji H, et al. LKB1 regulates TCR-mediated PLC?1 activation and thymocyte positive selection. EMBO J. 2011;30:2083-93 pubmed publisher
    ..LKB1 was directly phosphorylated by Lck at tyrosine residues 36, 261, and 365 and predominately interacted with LAT and PLC?1 following TCR stimulation. Loss of LKB1 led to impaired recruitment of PLC?1 to the LAT signalosome...
  38. Whittaker G, Burshtyn D, Orr S, Quigley L, Hodge D, Pascal V, et al. Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire. Blood. 2008;112:2869-77 pubmed publisher
    The linker for activation of T cells (LAT) and the linker for activation of B cells (LAB/NTAL/LAT2) are integral proteins in receptor coupling to downstream events...
  39. Heidary Arash E, Song K, Song S, Shiban A, Attisano L. Arhgef7 promotes activation of the Hippo pathway core kinase Lats. EMBO J. 2014;33:2997-3011 pubmed publisher
    ..These studies thus define βPix as a key component that links the Hippo kinase cassette to Yap/Taz in response to multiple upstream Hippo pathway activators. ..
  40. Yamasaki S, Ishikawa E, Sakuma M, Kanagawa O, Cheng A, Malissen B, et al. LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival. Mol Cell Biol. 2007;27:4406-15 pubmed
    ..Here, we report that the transmembrane adaptors LAT and NTAL are phosphorylated slowly upon IgE stimulation and that sustained but not transient Erk activation induced ..
  41. Orr S, Roessler S, Quigley L, Chan T, Ford J, O Connor G, et al. Implications for gene therapy-limiting expression of IL-2R gamma c delineate differences in signaling thresholds required for lymphocyte development and maintenance. J Immunol. 2010;185:1393-403 pubmed publisher
    ..Further, our findings suggest that IL-2Rgamma(c) reconstituted T cells may persist more efficiently than NK cells due to compensation for suboptimal IL-2Rgamma(c) signaling by the TCR...
  42. Liu J, Pestina T, Berndt M, Jackson C, Gartner T. Botrocetin/VWF-induced signaling through GPIb-IX-V produces TxA2 in an alphaIIbbeta3- and aggregation-independent manner. Blood. 2005;106:2750-6 pubmed
    ..leukocyte protein 76 (SLP-76), phospholipase Cgamma2 (PLCgamma2), linker for activation of T cells (LAT), or Fc receptor gamma-chain (FcRgamma-chain) were used for these studies...
  43. Whitten C, Swygert S, Butler S, Finco T. Transcription of the LAT gene is regulated by multiple binding sites for Sp1 and Sp3. Gene. 2008;413:58-66 pubmed publisher
    The LAT gene encodes an adaptor molecule that links receptor engagement to critical downstream signaling events...
  44. Su Y, Herzog S, Lotz M, Feldhahn N, MUSCHEN M, Jumaa H. The molecular requirements for LAT-mediated differentiation and the role of LAT in limiting pre-B cell expansion. Eur J Immunol. 2004;34:3614-22 pubmed
    ..Here, we show that, similarly to SLP-65, the adaptor protein LAT (linker for activation of T cells) limits pre-B cell proliferation and reduces the potential of a tumorgenic pre-B ..
  45. Shen S, Chuck M, Zhu M, Fuller D, Yang C, Zhang W. The importance of LAT in the activation, homeostasis, and regulatory function of T cells. J Biol Chem. 2010;285:35393-405 pubmed publisher
    b>LAT (linker for activation of T cells) is a transmembrane adaptor protein that plays an essential role in TCR-mediated signaling and thymocyte development...
  46. Chiang Y, Sommers C, Jordan M, Gu H, Samelson L, Koretzky G, et al. Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice. J Exp Med. 2004;200:25-34 pubmed
  47. Lillemeier B, Mörtelmaier M, Forstner M, Huppa J, Groves J, Davis M. TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation. Nat Immunol. 2010;11:90-6 pubmed publisher
    ..the spatio-temporal dynamics of T cell antigen receptor (TCR) complexes and linker for activation of T cells (Lat), a key adaptor molecule in the TCR signaling pathway, in T cell membranes using high-speed photoactivated ..
  48. Reynolds L, de Bettignies C, Norton T, Beeser A, Chernoff J, Tybulewicz V. Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1. J Biol Chem. 2004;279:18239-46 pubmed
    ..Second, Vav1 is required for recruitment of Sos1 and -2 to the transmembrane adapter protein LAT. Finally, we show that Vav1 is required for TCR-induced LAT phosphorylation, a key event for the activation of both ..
  49. Prinz I, Kursar M, Mittrücker H, Aguado E, Steinhoff U, Kaufmann S, et al. Autistic effector T cells in mice with a point mutation in the LAT adaptor fail to respond to Listeria monocytogenes infection. Int Immunol. 2005;17:951-7 pubmed
    The adaptor protein linker for activation of T cells (LAT) is an important transducer of extracellular T cell stimuli...
  50. Naik E, Dixit V. Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKCβ Kinase Activity. J Immunol. 2016;196:3438-51 pubmed publisher
    ..ZAP70 through TCR-dependent phosphorylation and enhancement of its catalytic activity and association with the LAT signalosome...
  51. Ragab A, Severin S, Gratacap M, Aguado E, Malissen M, Jandrot Perrus M, et al. Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC gamma 2 activation. Blood. 2007;110:2466-74 pubmed
    Linker for activation of T cells (LAT) is an adaptor protein required for organization of the signaling machinery downstream of the platelet collagen receptor, the glycoprotein VI (GPVI)...
  52. Prinz I, Sansoni A, Kissenpfennig A, Ardouin L, Malissen M, Malissen B. Visualization of the earliest steps of gammadelta T cell development in the adult thymus. Nat Immunol. 2006;7:995-1003 pubmed
    ..this checkpoint required the assembly of gammadelta TCR heterodimers on the cell surface and signaling via the Lat adaptor protein...
  53. Hao B, Naik A, Watanabe A, Tanaka H, Chen L, Richards H, et al. An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development. J Exp Med. 2015;212:809-24 pubmed publisher
    ..Our results provide a novel framework for understanding ASE function and demonstrate a novel role for SATB1 as a regulator of Rag locus organization and gene expression in DP thymocytes. ..
  54. García Blesa A, Klossowicz M, López Osuna C, Martínez Florensa M, Malissen B, García Cózar F, et al. The membrane adaptor LAT is proteolytically cleaved following Fas engagement in a tyrosine phosphorylation-dependent fashion. Biochem J. 2013;450:511-21 pubmed publisher
    Engagement of the TCR (T-cell receptor) induces tyrosine phosphorylation of the LAT (linker for the activation of T-cells) adaptor, and thereby it recruits several cytosolic mediators for downstream signalling pathways...
  55. Rivera J. NTAL/LAB and LAT: a balancing act in mast-cell activation and function. Trends Immunol. 2005;26:119-22 pubmed
  56. Dütting S, Vögtle T, Morowski M, Schiessl S, Schäfer C, Watson S, et al. Growth factor receptor-bound protein 2 contributes to (hem)immunoreceptor tyrosine-based activation motif-mediated signaling in platelets. Circ Res. 2014;114:444-453 pubmed publisher
    ..glycoprotein VI-mediated platelet activation because of defective stabilization of the linker of activated T-cell (LAT) signalosome and activation of downstream signaling proteins that resulted in reduced adhesion, aggregation, and ..
  57. O Brien S, Zhu M, Zhang W. The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity. J Immunol. 2015;195:695-705 pubmed publisher
    Linker for activation of T cells (LAT) is a transmembrane adaptor protein that is highly tyrosine phosphorylated upon engagement of the TCR...
  58. Klem J, Verrett P, Kumar V, Schatzle J. 2B4 is constitutively associated with linker for the activation of T cells in glycolipid-enriched microdomains: properties required for 2B4 lytic function. J Immunol. 2002;169:55-62 pubmed
    ..as from primary murine cells, coimmunoprecipitates with the phosphoprotein linker for the activation of T cells (LAT), which is essential for TCR-mediated signaling...
  59. Malbec O, Malissen M, Isnardi I, Lesourne R, Mura A, Fridman W, et al. Linker for activation of T cells integrates positive and negative signaling in mast cells. J Immunol. 2004;173:5086-94 pubmed
    The transmembrane adapter linker for activation of T cells (LAT) is thought to couple immunoreceptors to intracellular signaling pathways...
  60. Moraes L, Barrett N, Jones C, Holbrook L, Spyridon M, Sage T, et al. Platelet endothelial cell adhesion molecule-1 regulates collagen-stimulated platelet function by modulating the association of phosphatidylinositol 3-kinase with Grb-2-associated binding protein-1 and linker for activation of T cells. J Thromb Haemost. 2010;8:2530-41 pubmed publisher
    ..of phosphatidylinositol 3-kinase (PI3K) to phosphorylated tyrosines in the linker for activation of T cells (LAT)...
  61. Trumel C, Plantavid M, Levy Toledano S, Ragab A, Caen J, Aguado E, et al. Platelet aggregation induced by the C-terminal peptide of thrombospondin-1 requires the docking protein LAT but is largely independent of alphaIIb/beta3. J Thromb Haemost. 2003;1:320-9 pubmed
    ..stimulated a rapid tyrosine phosphorylation of a set of proteins, including Syk, linker for activation of T cells (LAT) and phospholipase Cgamma2...
  62. Sommers C, Rouquette Jazdanian A, Robles A, Kortum R, Merrill R, Li W, et al. miRNA signature of mouse helper T cell hyper-proliferation. PLoS ONE. 2013;8:e66709 pubmed publisher
    Helper T cells from a mutant mouse model, LAT Y136F, hyper-proliferate and cause a severe lymphoproliferative disease that kills the mice by six months of age...
  63. May R, Okumura M, Hsu C, Bassiri H, Yang E, Rak G, et al. Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function. Blood. 2013;121:3135-46 pubmed publisher
    ..In addition to the canonical membrane complex formed between SLP-76 and linker for activation of T cells (LAT) family members, a novel LAT family-independent SLP-76-dependent signaling pathway was identified...
  64. Ou Yang C, Zhu M, Fuller D, Sullivan S, Chuck M, Ogden S, et al. Role of LAT in the granule-mediated cytotoxicity of CD8 T cells. Mol Cell Biol. 2012;32:2674-84 pubmed publisher
    Linker for activation of T cells (LAT) is a transmembrane adaptor protein that is essential to bridge T cell receptor (TCR) engagement to downstream signaling events...
  65. Pedraza Alva G, Koulnis M, Charland C, Thornton T, Clements J, Schlissel M, et al. Activation of p38 MAP kinase by DNA double-strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint. EMBO J. 2006;25:763-73 pubmed
    ..We propose that p38 MAP kinase is activated by V(D)J-mediated DSBs and induces a p53-mediated G2/M checkpoint to allow DNA repair and prevent cellular transformation. ..
  66. Helft J, Jacquet A, Joncker N, Grandjean I, Dorothee G, Kissenpfennig A, et al. Antigen-specific T-T interactions regulate CD4 T-cell expansion. Blood. 2008;112:1249-58 pubmed publisher
    ..In this way, CD4 T-cell proliferation is regulated in a functional relationship to the amount of Ag, while allowing naive T cells to generate repertoire variety. ..
  67. Prinz I, Gregoire C, Mollenkopf H, Aguado E, Wang Y, Malissen M, et al. The type 1 cysteinyl leukotriene receptor triggers calcium influx and chemotaxis in mouse alpha beta- and gamma delta effector T cells. J Immunol. 2005;175:713-9 pubmed
    Linker for activation of T cells (LAT) is essential for T cell activation...
  68. Balagopalan L, Barr V, Sommers C, Barda Saad M, Goyal A, Isakowitz M, et al. c-Cbl-mediated regulation of LAT-nucleated signaling complexes. Mol Cell Biol. 2007;27:8622-36 pubmed
    ..Upon receptor activation, the adapters LAT and SLP-76, visualized as chimeric proteins tagged with yellow fluorescent protein, transiently associate with and ..
  69. Zhu M, Koonpaew S, Liu Y, Shen S, Denning T, Dzhagalov I, et al. Negative regulation of T cell activation and autoimmunity by the transmembrane adaptor protein LAB. Immunity. 2006;25:757-68 pubmed
    LAB (linker for activation of B cells), also known as NTAL (non-T cell activation linker), is a LAT (linker for activation of T cells)-like adaptor protein that is expressed in B, NK, and mast cells...
  70. Genton C, Wang Y, Izui S, Malissen B, Delsol G, Fournié G, et al. The Th2 lymphoproliferation developing in LatY136F mutant mice triggers polyclonal B cell activation and systemic autoimmunity. J Immunol. 2006;177:2285-93 pubmed
    b>Lat(Y136F) knock-in mice harbor a point mutation in Tyr(136) of the linker for activation of T cells and show accumulation of Th2 effector cells and IgG1 and IgE hypergammaglobulinemia...
  71. Fuller D, Zhu M, Koonpaew S, Nelson M, Zhang W. The importance of the Erk pathway in the development of linker for activation of T cells-mediated autoimmunity. J Immunol. 2012;189:4005-13 pubmed publisher
    The ability of the transmembrane adaptor protein linker for activation of T cells (LAT) to regulate T cell development, activation, survival, and homeostasis depends upon phosphorylation of its multiple tyrosine residues...
  72. Azar G, Lemaitre F, Robey E, Bousso P. Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes. Proc Natl Acad Sci U S A. 2010;107:3675-80 pubmed publisher
    ..Using two-photon imaging, we tracked the distribution of LAT-EGFP molecules during antigen recognition by activated CD4(+) T cells in lymph nodes...
  73. Wang Y, Horvath O, Hamm Baarke A, Richelme M, Gregoire C, Guinamard R, et al. Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function. Mol Cell Biol. 2005;25:4455-65 pubmed
    NTAL (non-T-cell activation linker, also called LAB) and LAT (linker for activation of T cells) are evolutionarily related transmembrane adaptor proteins that are phosphorylated upon immunoreceptor engagement...
  74. Reeve J, Zou W, Liu Y, Maltzman J, Ross F, Teitelbaum S. SLP-76 couples Syk to the osteoclast cytoskeleton. J Immunol. 2009;183:1804-12 pubmed publisher
    ..Finally, c-Fms-activated Syk also exerts its OC cytoskeleton-organizing effect in a SLP-76/Vav3-dependent manner. ..
  75. Peng X, Cui Z, Gu W, Xu W, Guo X. Low level of LAT-PLC-?1 interaction is associated with Th2 polarized differentiation: a contributing factor to the etiology of asthma. Cell Immunol. 2014;290:131-7 pubmed publisher
    Linker for activation of T cells (LAT) is a key adaptor in the T cell receptor (TCR) signaling pathway...
  76. Bezman N, Baker R, Lenox L, Jordan M, Koretzky G. Cutting edge: rescue of pre-TCR but not mature TCR signaling in mice expressing membrane-targeted SLP-76. J Immunol. 2009;182:5183-7 pubmed publisher
    ..Thus, fixed localization of SLP-76 reveals differential requirements for the subcellular localization of signaling complexes downstream of the pre-TCR vs mature TCR. ..
  77. Capelo L, Beber E, Fonseca T, Gouveia C. The monocarboxylate transporter 8 and L-type amino acid transporters 1 and 2 are expressed in mouse skeletons and in osteoblastic MC3T3-E1 cells. Thyroid. 2009;19:171-80 pubmed publisher
    ..In addition, the pattern of MCT8 expression observed in vivo and in vitro suggests that MCT8 may be important to modulate TH effects on osteoblast differentiation and on bone development and metabolism. ..
  78. Koonpaew S, Shen S, Flowers L, Zhang W. LAT-mediated signaling in CD4+CD25+ regulatory T cell development. J Exp Med. 2006;203:119-29 pubmed
    ..of signaling complexes mediated through the transmembrane adaptor protein, the linker for activation of T cells (LAT). LAT plays an important role in T cell development, activation, and homeostasis...