Gene Symbol: Lasp1
Description: LIM and SH3 protein 1
Alias: AA408629, Def-4, LASP-1, MLN 50, SH3P6, Tg(Col1a1-lacZ)1Ngma, LIM and SH3 domain protein 1, Tg(11Col1a1)NG, metastatic lymph node gene 50 protein
Species: mouse
Products:     Lasp1

Top Publications

  1. Keicher C, Gambaryan S, Schulze E, Marcus K, Meyer H, Butt E. Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase. Biochem Biophys Res Commun. 2004;324:308-16 pubmed
    ..Immunoblotting of LASP-1 in various mouse and human tissues detected a similar prominent expression in non-muscle tissue. Altogether, our data suggest so far no functional differences between human and mouse LASP-1. ..
  2. Sparks A, Hoffman N, McConnell S, Fowlkes D, Kay B. Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996;14:741-4 pubmed
    ..The isolation of entire repertoires of modular domain-containing proteins will prove invaluable in genome analysis and in bringing new targets into drug discovery programs. ..
  3. Zhao T, Ren H, Li J, Chen J, Zhang H, Xin W, et al. LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer. Cancer Res. 2015;75:111-9 pubmed publisher
    b>LASP1 is an actin-binding protein associated with actin assembly dynamics in cancer cells. Here, we report that LASP1 is overexpressed in pancreatic ductal adenocarcinoma (PDAC) where it promotes invasion and metastasis...
  4. Hermann Kleiter N, Ghaffari Tabrizi N, Blumer M, Schwarzer C, Mazur M, Artner I. Lasp1 misexpression influences chondrocyte differentiation in the vertebral column. Int J Dev Biol. 2009;53:983-91 pubmed publisher
    ..The insertion site was located between the transcription start sites of the Rpl23 and Lasp1 genes...
  5. Chew C, Chen X, Bollag R, Isales C, Ding K, Zhang H. Targeted disruption of the Lasp-1 gene is linked to increases in histamine-stimulated gastric HCl secretion. Am J Physiol Gastrointest Liver Physiol. 2008;295:G37-G44 pubmed publisher
    Lasp-1 (LIM and SH3 domain protein 1) is a multidomain actin-binding protein that is differentially expressed within epithelial tissues and brain...
  6. Ramsdell C, Thames E, Weston J, Dewey M. Development of a deer mouse whole-genome radiation hybrid panel and comparative mapping of Mus chromosome 11 loci. Mamm Genome. 2006;17:37-48 pubmed
    ..Furthermore, this separate linkage group is likely to reside in a chromosomal region of inversion polymorphism between P. maniculatus and P. polionotus. ..
  7. Zhou Q, Zhao J, Wiedmer T, Sims P. Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1. Blood. 2002;99:4030-8 pubmed
    ..These data provide direct evidence that PLSCR1 functionally contributes to cytokine-regulated cell proliferation and differentiation and suggest it is required for normal myelopoiesis. ..
  8. Schreiber V, Masson R, Linares J, Mattei M, Tomasetto C, Rio M. Chromosomal assignment and expression pattern of the murine Lasp-1 gene. Gene. 1998;207:171-5 pubmed
    ..Northern blot analysis shows that this gene is expressed from 7.5 to 17.5 days post-coitum of mouse embryogenesis and in almost all adult tissues. ..
  9. Kleiter N, Artner I, Gmachl N, Ghaffari Tabrizi N, Kratochwil K. Mutagenic transgene insertion into a region of high gene density and multiple linkage disruptions on mouse chromosome 11. Cytogenet Genome Res. 2002;97:100-5 pubmed
    ..By cDNA selection and sequencing we have found six genes (Lasp1, Rpl23, Mllt6, Pip5k2b, Psmb3, Zfp144), one truncated gene (Mel13), and one pseudogene (Rps15-ps) within this ..

More Information


  1. Samuels A, Klinken S, Ingley E. Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation. Blood. 2009;113:3845-56 pubmed publisher
    ..These results show that Liar is a novel Lyn-interacting molecule that plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation. ..
  2. Gingras M, Kharitidi D, Chénard V, Uetani N, Bouchard M, Tremblay M, et al. Expression analysis and essential role of the putative tyrosine phosphatase His-domain-containing protein tyrosine phosphatase (HD-PTP). Int J Dev Biol. 2009;53:1069-74 pubmed publisher
    ..Our results show that Ptpn23 is expressed early during mouse development and that its expression is maintained in adult tissues, markedly in the epithelial cells of many organs. ..
  3. Hotfilder M, Baxendale S, Cross M, Sablitzky F. Def-2, -3, -6 and -8, novel mouse genes differentially expressed in the haemopoietic system. Br J Haematol. 1999;106:335-44 pubmed
    ..Def-3, which is down-regulated upon differentiation into granulocytes but expressed in progenitor cells and macrophages, defines a novel family of RNA binding proteins. ..
  4. Zhang H, Chen X, Bollag W, Bollag R, Sheehan D, Chew C. Lasp1 gene disruption is linked to enhanced cell migration and tumor formation. Physiol Genomics. 2009;38:372-85 pubmed publisher
    b>Lasp1 is an actin-binding, signaling pathway-regulated phosphoprotein that is overexpressed in several cancers...
  5. Krol A, Roellig D, Dequéant M, Tassy O, Glynn E, Hattem G, et al. Evolutionary plasticity of segmentation clock networks. Development. 2011;138:2783-92 pubmed publisher
    ..However, despite this conserved signaling oscillation, the identity of individual cyclic genes mostly differed between the three species, indicating a surprising evolutionary plasticity of the segmentation networks. ..
  6. Campolo F, Gori M, Favaro R, Nicolis S, Pellegrini M, Botti F, et al. Essential role of Sox2 for the establishment and maintenance of the germ cell line. Stem Cells. 2013;31:1408-21 pubmed publisher
    ..Sox2 also stimulates the expression of Zfp148, which is required for normal development of fetal germ cells, and Rif1, a potential regulator of PGC pluripotency. ..
  7. Li B, Zhuang L, Trueb B. Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1. J Biol Chem. 2004;279:20401-10 pubmed
    ..LIM-nebulette reveals a subcellular distribution at focal adhesions similar to Lasp-1. Thus, LIM-nebulette, Lasp-1, and zyxin may play an important role in the organization of focal adhesions. ..
  8. Lin Y, Park Z, Lin D, Brahmbhatt A, Rio M, Yates J, et al. Regulation of cell migration and survival by focal adhesion targeting of Lasp-1. J Cell Biol. 2004;165:421-32 pubmed
    ..Thus, Lasp-1 is a dynamic focal adhesion protein necessary for cell migration and survival in response to growth factors and ECM proteins. ..
  9. Rachlin A, Otey C. Identification of palladin isoforms and characterization of an isoform-specific interaction between Lasp-1 and palladin. J Cell Sci. 2006;119:995-1004 pubmed
  10. Huang T, Chuang H, Chou W, Chen C, Wang H, Chou S, et al. Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality. Nat Neurosci. 2014;17:240-7 pubmed publisher
    ..Our study suggests that TBR1 is important in the regulation of amygdalar axonal connections and cognition. ..