Gene Symbol: Larp7
Description: La ribonucleoprotein domain family, member 7
Alias: C330027G06Rik, D3Wsu161e, la-related protein 7
Kerr S, Taggart M, Lee M, Cooke H. Ott, a mouse X-linked multigene family expressed specifically during meiosis. Hum Mol Genet. 1996;5:1139-48 pubmed
..This work could lead to the identification of a human Ott homologue, which is likely to be X-linked and would provide a candidate locus for some cases of male infertility. ..
Kumada T, Yamanaka Y, Kitano A, Shibata M, Awaya T, Kato T, et al
. Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic reticulum, is required for early embryonic development. Dev Dyn. 2010;239:2233-45 pubmed publisher
..Our findings indicate that Ttyh1 plays an indispensable role during mitosis in early embryogenesis, possibly by maintaining Ca(2+) homeostasis in the ER. ..
Okamura D, Maeda I, Taniguchi H, Tokitake Y, Ikeda M, Ozato K, et al
. Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. Genes Dev. 2012;26:2477-82 pubmed publisher
..These results indicate that CDKI gene-specific control of transcription by 7SK snRNP plays a pivotal role in the maintenance of PGC proliferation. ..
Mizutani T, Ishizaka A, Suzuki Y, Iba H. 7SK small nuclear ribonucleoprotein complex is recruited to the HIV-1 promoter via short viral transcripts. FEBS Lett. 2014;588:1630-6 pubmed publisher
..This report provides insight into how 7SK snRNP complex is recruited to HIV-1 promoter in the absence of Tat. ..
Tian Y, Liu Y, Wang T, Zhou N, Kong J, Chen L, et al
. A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice. Sci Transl Med. 2015;7:279ra38 pubmed publisher
..Our data demonstrate the ability of microRNA-based therapeutic approaches to promote mammalian cardiac repair and regeneration through the transient activation of cardiomyocyte proliferation. ..
Alazami A, Al Owain M, Alzahrani F, Shuaib T, Al Shamrani H, Al Falki Y, et al
. Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism. Hum Mutat. 2012;33:1429-34 pubmed publisher
..for PD involving depletion of 7SK, an abundant cellular noncoding RNA (ncRNA), due to mutation of its chaperone LARP7. We show that 7SK levels are tightly linked to LARP7 expression across cell lines, and that this chaperone is ..
Dai Q, Luan G, Deng L, Lei T, Kang H, Song X, et al
. Primordial dwarfism gene maintains Lin28 expression to safeguard embryonic stem cells from premature differentiation. Cell Rep. 2014;7:735-46 pubmed publisher
..Paradoxically, LARP7 deficiency was previously assumed to be associated with increased cell growth and proliferation via activation of ..