Gene Symbol: Lamc3
Description: laminin gamma 3
Alias: 1110064A23Rik, AI562206, AW240805, laminin subunit gamma-3, laminin-12 subunit gamma, laminin-14 subunit gamma, laminin-15 subunit gamma
Species: mouse
Products:     Lamc3

Top Publications

  1. Denes V, Witkovsky P, Koch M, Hunter D, Pinzon Duarte G, Brunken W. Laminin deficits induce alterations in the development of dopaminergic neurons in the mouse retina. Vis Neurosci. 2007;24:549-62 pubmed
    ..We postulate that laminin-dependent developmental signals are conveyed to TH amacrine neurons through intermediate cell types, perhaps the Müller glial cell and/or the retinal ganglion cell. ..
  2. Pinzon Duarte G, Daly G, Li Y, Koch M, Brunken W. Defective formation of the inner limiting membrane in laminin beta2- and gamma3-null mice produces retinal dysplasia. Invest Ophthalmol Vis Sci. 2010;51:1773-82 pubmed publisher
    ..These data also suggest that attachment of the MC to the ILM provides important polarity cues to the MC and for postnatal retinal histogenesis...
  3. Gersdorff N, Muller M, Otto S, Poschadel R, Hübner S, Miosge N. Basement membrane composition in the early mouse embryo day 7. Dev Dyn. 2005;233:1140-8 pubmed
    ..In conclusion, laminin-1 might be the only laminin isoform in the early mouse embryo that, together with the other main BM components, nidogens, collagen type IV, and perlecan, is synthesized by all three germ layers. ..
  4. Schneiders F, Maertens B, Böse K, Li Y, Brunken W, Paulsson M, et al. Binding of netrin-4 to laminin short arms regulates basement membrane assembly. J Biol Chem. 2007;282:23750-8 pubmed
    ..When added to explant cultures, netrin-4 retards salivary gland branching morphogenesis. ..
  5. Iivanainen A, Morita T, Tryggvason K. Molecular cloning and tissue-specific expression of a novel murine laminin gamma3 chain. J Biol Chem. 1999;274:14107-11 pubmed
  6. Pietilä I, Prunskaite Hyyryläinen R, Kaisto S, Tika E, van Eerde A, Salo A, et al. Wnt5a Deficiency Leads to Anomalies in Ureteric Tree Development, Tubular Epithelial Cell Organization and Basement Membrane Integrity Pointing to a Role in Kidney Collecting Duct Patterning. PLoS ONE. 2016;11:e0147171 pubmed publisher
    ..Together Wnt5a has a novel function in kidney organogenesis by contributing to patterning of UB derived collecting duct development contributing putatively to congenital disease. ..
  7. Radmanesh F, Caglayan A, Silhavy J, Yilmaz C, Cantagrel V, Omar T, et al. Mutations in LAMB1 cause cobblestone brain malformation without muscular or ocular abnormalities. Am J Hum Genet. 2013;92:468-74 pubmed publisher
    ..LAMB1 is localized to the pial basement membrane, suggesting that defective connection between radial glial cells and the pial surface mediated by LAMB1 leads to this malformation. ..
  8. Yang D, McKee K, Chen Z, Mernaugh G, Strickland S, Zent R, et al. Renal collecting system growth and function depend upon embryonic ?1 laminin expression. Development. 2011;138:4535-44 pubmed publisher
  9. Barak T, Kwan K, Louvi A, Demirbilek V, Saygi S, Tuysuz B, et al. Recessive LAMC3 mutations cause malformations of occipital cortical development. Nat Genet. 2011;43:590-4 pubmed publisher
    ..By using whole-exome sequencing, we initially identified a homozygous 2-bp deletion in LAMC3, the laminin ?3 gene, leading to an immediate premature termination codon...

More Information


  1. Hirrlinger P, Pannicke T, Winkler U, Claudepierre T, Varshney S, Schulze C, et al. Genetic deletion of laminin isoforms ?2 and ?3 induces a reduction in Kir4.1 and aquaporin-4 expression and function in the retina. PLoS ONE. 2011;6:e16106 pubmed publisher
    ..These findings demonstrate a strong impact of laminin ?2 and ?3 subunits on the expression and function of both aquaporin-4 and Kir4.1, two important membrane proteins in Müller cells. ..
  2. Gersdorff N, Kohfeldt E, Sasaki T, Timpl R, Miosge N. Laminin gamma3 chain binds to nidogen and is located in murine basement membranes. J Biol Chem. 2005;280:22146-53 pubmed
    ..Ultrastructural immunogold staining localized the gamma3 chain to basement membranes of these tissues. ..
  3. McKee K, Yang D, Patel R, Chen Z, Strickland S, Takagi J, et al. Schwann cell myelination requires integration of laminin activities. J Cell Sci. 2012;125:4609-19 pubmed publisher
  4. Klaffky E, Williams R, Yao C, Ziober B, Kramer R, Sutherland A. Trophoblast-specific expression and function of the integrin alpha 7 subunit in the peri-implantation mouse embryo. Dev Biol. 2001;239:161-75 pubmed
    ..These interactions are not only important for trophoblast adhesion and spreading but may also play a role in regulating trophectoderm proliferation and differentiation. ..
  5. Gnanaguru G, Bachay G, Biswas S, Pinzon Duarte G, Hunter D, Brunken W. Laminins containing the ?2 and ?3 chains regulate astrocyte migration and angiogenesis in the retina. Development. 2013;140:2050-60 pubmed publisher
  6. Koch M, Olson P, Albus A, Jin W, Hunter D, Brunken W, et al. Characterization and expression of the laminin gamma3 chain: a novel, non-basement membrane-associated, laminin chain. J Cell Biol. 1999;145:605-18 pubmed
    ..We have cloned gene encoding this chain, LAMC3, which maps to chromosome 9 at q31-34...
  7. Copp A, Carvalho R, Wallace A, Sorokin L, Sasaki T, Greene N, et al. Regional differences in the expression of laminin isoforms during mouse neural tube development. Matrix Biol. 2011;30:301-9 pubmed publisher
    ..This information paves the way towards a mechanistic analysis of basement membrane laminin function during early neural tube development in mammals. ..
  8. Mokkapati S, Fleger Weckmann A, Bechtel M, Koch M, Breitkreutz D, Mayer U, et al. Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain. J Biol Chem. 2011;286:1911-8 pubmed publisher
  9. Li Y, Radner S, French M, Pinzon Duarte G, Daly G, Burgeson R, et al. The ?3 chain of laminin is widely but differentially expressed in murine basement membranes: expression and functional studies. Matrix Biol. 2012;31:120-34 pubmed publisher
    ..These data support the suggestion that the ?3 chain is deposited in BMs and contributes some unique properties to their function, particularly in the nervous system...
  10. Lopez Escobar B, De Felipe B, Sánchez Alcázar J, Sasaki T, Copp A, Ybot Gonzalez P. Laminin and integrin expression in the ventral ectodermal ridge of the mouse embryo: implications for regulation of BMP signalling. Dev Dyn. 2012;241:1808-15 pubmed publisher
    ..Laminin532 could interact with α6-containing integrin to direct differentiation of the specialised VER cells from surface ectoderm. ..
  11. Ramos R, Siu N, Brunken W, Yee K, Gabel L, Van Dine S, et al. Cellular and axonal constituents of neocortical molecular layer heterotopia. Dev Neurosci. 2014;36:477-89 pubmed publisher
    ..Finally, we document intracortical projections to/from heterotopia. These data are relevant toward understanding how heterotopia affect brain function in diverse neurodevelopmental disorders. ..