Lama2

Summary

Gene Symbol: Lama2
Description: laminin, alpha 2
Alias: 5830440B04, mKIAA4087, mer, merosin, laminin subunit alpha-2, dystrophia muscularis, laminin M chain, laminin-12 subunit alpha, laminin-2 subunit alpha, laminin-4 subunit alpha, merosin heavy chain
Species: mouse

Top Publications

  1. ncbi Structure of laminin variants. The 300-kDa chains of murine and bovine heart laminin are related to the human placenta merosin heavy chain and replace the a chain in some laminin variants
    M Paulsson
    M E Müller Institute for Biomechanics, University of Bern, Switzerland
    J Biol Chem 266:17545-51. 1991
  2. pmc Tissue distribution of the dystrophin-related gene product and expression in the mdx and dy mouse
    D R Love
    Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Proc Natl Acad Sci U S A 88:3243-7. 1991
  3. ncbi Muscular dystrophies: diseases of the dystrophin-glycoprotein complex
    R Worton
    Department of Genetics, Hospital for Sick Children, Toronto, Canada
    Science 270:755-6. 1995
  4. ncbi Identification of a novel mutant transcript of laminin alpha 2 chain gene responsible for muscular dystrophy and dysmyelination in dy2J mice
    Y Sunada
    Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City 52242, USA
    Hum Mol Genet 4:1055-61. 1995
  5. ncbi Cloning and expression of laminin alpha 2 chain (M-chain) in the mouse
    S M Bernier
    Laboratory of Development of Biology, National Institute of Dental Research, Bethesda, Maryland, USA
    Matrix Biol 14:447-55. 1995
  6. ncbi Murine muscular dystrophy caused by a mutation in the laminin alpha 2 (Lama2) gene
    H Xu
    La Jolla Cancer Research Foundation, California 92037
    Nat Genet 8:297-302. 1994
  7. ncbi Developmental expression and cellular origin of the laminin alpha2, alpha4, and alpha5 chains in the intestine
    O Lefebvre
    INSERM U 381, 3 avenue Moliere, Strasbourg, 67200, France
    Dev Biol 210:135-50. 1999
  8. ncbi Activation of caspase-3 apoptotic pathways in skeletal muscle fibers in laminin alpha2-deficient mice
    T Mukasa
    National Institute of Neuroscience, NCNP, Tokyo, Kodaira, 187 8502, Japan
    Biochem Biophys Res Commun 260:139-42. 1999
  9. ncbi The laminin alpha2-chain short arm mediates cell adhesion through both the alpha1beta1 and alpha2beta1 integrins
    H Colognato
    Department of Pathology, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 272:29330-6. 1997
  10. ncbi Atypical axon-Schwann cell relationships in the common peroneal nerve of the dystrophic mouse: an ultrastructural study
    E Jaros
    Neuropathol Appl Neurobiol 5:133-47. 1979

Research Grants

Scientific Experts

Detail Information

Publications109 found, 100 shown here

  1. ncbi Structure of laminin variants. The 300-kDa chains of murine and bovine heart laminin are related to the human placenta merosin heavy chain and replace the a chain in some laminin variants
    M Paulsson
    M E Müller Institute for Biomechanics, University of Bern, Switzerland
    J Biol Chem 266:17545-51. 1991
    ..Further, heart laminins were compared with merosin, a laminin-like protein isolated from human placenta (Ehrig, K., Leivo, I., Argraves, W. S., Ruoslahti, E...
  2. pmc Tissue distribution of the dystrophin-related gene product and expression in the mdx and dy mouse
    D R Love
    Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Proc Natl Acad Sci U S A 88:3243-7. 1991
    ..Unlike the dystrophin gene, the DMDL gene transcript is not differentially spliced at the 3' end in either fetal muscle or brain...
  3. ncbi Muscular dystrophies: diseases of the dystrophin-glycoprotein complex
    R Worton
    Department of Genetics, Hospital for Sick Children, Toronto, Canada
    Science 270:755-6. 1995
  4. ncbi Identification of a novel mutant transcript of laminin alpha 2 chain gene responsible for muscular dystrophy and dysmyelination in dy2J mice
    Y Sunada
    Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City 52242, USA
    Hum Mol Genet 4:1055-61. 1995
    Murine dystrophia muscularis-2J (dy2J) is an autosomal recessive disorder characterized by muscular dystrophy and dysmyelination of peripheral nerve...
  5. ncbi Cloning and expression of laminin alpha 2 chain (M-chain) in the mouse
    S M Bernier
    Laboratory of Development of Biology, National Institute of Dental Research, Bethesda, Maryland, USA
    Matrix Biol 14:447-55. 1995
    ....
  6. ncbi Murine muscular dystrophy caused by a mutation in the laminin alpha 2 (Lama2) gene
    H Xu
    La Jolla Cancer Research Foundation, California 92037
    Nat Genet 8:297-302. 1994
    ..One mRNA is translated into an alpha 2 polypeptide with a deletion in domain VI. The truncated protein apparently lacks important qualities of the wild type protein and is unable to provide sufficient muscle stability...
  7. ncbi Developmental expression and cellular origin of the laminin alpha2, alpha4, and alpha5 chains in the intestine
    O Lefebvre
    INSERM U 381, 3 avenue Moliere, Strasbourg, 67200, France
    Dev Biol 210:135-50. 1999
    ....
  8. ncbi Activation of caspase-3 apoptotic pathways in skeletal muscle fibers in laminin alpha2-deficient mice
    T Mukasa
    National Institute of Neuroscience, NCNP, Tokyo, Kodaira, 187 8502, Japan
    Biochem Biophys Res Commun 260:139-42. 1999
    dy/dy mice, which carry an unidentified mutation in the Lama2 gene, show dystrophic pathologies similar to those of human congenital muscular dystrophy. Laminin alpha2 deficiency induces apoptosis with DNA fragmentation...
  9. ncbi The laminin alpha2-chain short arm mediates cell adhesion through both the alpha1beta1 and alpha2beta1 integrins
    H Colognato
    Department of Pathology, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 272:29330-6. 1997
    ....
  10. ncbi Atypical axon-Schwann cell relationships in the common peroneal nerve of the dystrophic mouse: an ultrastructural study
    E Jaros
    Neuropathol Appl Neurobiol 5:133-47. 1979
    ..They provide an experimental model for the investigation of factors involved in the origin and maintenance of the structural organization of peripheral nerve...
  11. pmc Dystrophin-associated proteins are greatly reduced in skeletal muscle from mdx mice
    K Ohlendieck
    Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City 52242
    J Cell Biol 115:1685-94. 1991
    ....
  12. ncbi Muscle fiber growth and necrosis in dystrophic muscles: a comparative study between dy and mdx mice
    M Woo
    Division of Ultrastructural Research, National Institute of Neuroscience, NCNP, Tokyo, Japan
    J Neurol Sci 82:111-22. 1987
    ..The difference in clinical symptoms between dy and mdx mice may result from differences in their regenerative response to necrosis...
  13. ncbi Mutations in the laminin alpha 2-chain gene (LAMA2) cause merosin-deficient congenital muscular dystrophy
    A Helbling-Leclerc
    INSERM U153, Hopital de la Pitie Salpetriere, Paris, France
    Nat Genet 11:216-8. 1995
    ..we have demonstrated an absence of one of the components of the extracellular matrix around muscle fibres, the merosin M chain, now referred to as the alpha 2 chain of laminin-2 (ref.3)...
  14. ncbi Morphological changes of neuromuscular junctions in the dystrophic (dy) mouse: a scanning and transmission electron microscopic study
    J Desaki
    Department of Anatomy, Ehime University School of Medicine, Japan
    J Electron Microsc (Tokyo) 44:59-65. 1995
    ..This might help the nerve endings compensate for the functional deterioration of dystrophic muscle fibers...
  15. pmc Defective muscle basement membrane and lack of M-laminin in the dystrophic dy/dy mouse
    H Xu
    Cancer Research Center, La Jolla Cancer Research Foundation, CA 92037
    Proc Natl Acad Sci U S A 91:5572-6. 1994
    ..The dy mouse may provide a model for autosomal muscular dystrophies in humans and facilitate studies of functions of M-laminin...
  16. ncbi Laminin alpha 2 is a component of brain capillary basement membrane: reduced expression in dystrophic dy mice
    M Jucker
    Molecular Neurobiology Unit, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Neuroscience 71:1153-61. 1996
    ..This observation might be explained by the fact that the cerebral capillary basement membrane expresses both alpha chains and therefore exhibits structural redundancy...
  17. ncbi Expression of laminin isoforms in mouse myogenic cells in vitro and in vivo
    F Schuler
    Institute for Experimental Medicine, University of Edangen Nuremberg, Germany
    J Cell Sci 108:3795-805. 1995
    The expression of laminin-1 (previously EHS laminin) and laminin-2 (previously merosin) isoforms by myogenic cells was examined in vitro and in vivo...
  18. pmc The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform
    J H Miner
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 137:685-701. 1997
    ..Together, these results reveal remarkable diversity in BL composition and complexity in BL development...
  19. ncbi Laminin alpha2 chain-null mutant mice by targeted disruption of the Lama2 gene: a new model of merosin (laminin 2)-deficient congenital muscular dystrophy
    Y Miyagoe
    Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    FEBS Lett 415:33-9. 1997
    ..In degenerating muscles, considerable amounts of TUNEL positive nuclei were detected as well as DNA laddering, suggesting increased apoptotic cell death was involved in the process of muscle fiber degeneration...
  20. pmc Animal models for muscular dystrophy show different patterns of sarcolemmal disruption
    V Straub
    Department of, Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Cell Biol 139:375-85. 1997
    ..We furthermore assessed Evans blue incorporation in skeletal muscle of the dystrophia muscularis (dy/dy) mouse and its milder allelic variant, the dy2J/dy2J mouse, animal models for congenital muscular ..
  21. pmc Distribution and function of laminins in the neuromuscular system of developing, adult, and mutant mice
    B L Patton
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 139:1507-21. 1997
    ..The ability of laminin 11 to serve as a stop signal for growing axons explains, in part, axonal behaviors observed at developing and regenerating synapses in vivo...
  22. ncbi Disruption of the lama2 gene in embryonic stem cells: laminin alpha 2 is necessary for sustenance of mature muscle cells
    W Kuang
    Department of Developmental Biology, Wenner Gren Institute, Stockholm University, Sweden
    Exp Cell Res 241:117-25. 1998
    Mutations in the gene coding for the alpha 2 chain of laminin-2 and -4 (merosin) cause a severe form of congenital muscular dystrophy in humans and mice...
  23. pmc Merosin-deficient congenital muscular dystrophy. Partial genetic correction in two mouse models
    W Kuang
    The Burnham Institute, La Jolla Cancer Research Center, La Jolla, California 92037, USA
    J Clin Invest 102:844-52. 1998
    Humans and mice with deficiency of the alpha2 subunit of the basement membrane protein laminin-2/merosin suffer from merosin-deficient congenital muscular dystrophy (MCMD)...
  24. pmc Roles for laminin in embryogenesis: exencephaly, syndactyly, and placentopathy in mice lacking the laminin alpha5 chain
    J H Miner
    Department of Medicine, Renal Division, St Louis, Missouri, USA
    J Cell Biol 143:1713-23. 1998
    ..Other laminin alpha chains accumulate in these BLs, but this compensation is apparently functionally inadequate. Our results identify new roles for laminins and BLs in diverse developmental processes...
  25. ncbi Expression of laminin alpha1, alpha2, alpha4, and alpha5 chains, fibronectin, and tenascin-C in skeletal muscle of dystrophic 129ReJ dy/dy mice
    B Ringelmann
    Institute for Experimental Medicine, University of Erlangen Nürnburg, Schwabachanlage 10, Erlangen, Germany
    Exp Cell Res 246:165-82. 1999
    The dy/dy mouse is an animal model for human merosin-negative congenital muscular dystrophy (CMD), which has been reported to have reduced or no expression of the basement membrane protein laminin alpha2...
  26. pmc Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins
    J F Talts
    Max Planck Institut fur Biochemie, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    EMBO J 18:863-70. 1999
    ..This demonstrated similar binding repertoires for the LG modules of three basement membrane proteins involved in cell-matrix interactions and supramolecular assembly...
  27. ncbi The laminin alpha2 expressed by dystrophic dy(2J) mice is defective in its ability to form polymers
    H Colognato
    Department of Pathology, Robert Wood Johnson Medical School, Piscataway, 08854, USA
    Curr Biol 9:1327-30. 1999
    Mutations in LAMA2 cause severe congenital muscular dystrophy accompanied by nervous system defects [1]...
  28. ncbi Activation of the lama2 gene in muscle regeneration: abortive regeneration in laminin alpha2-deficiency
    W Kuang
    The Burnham Institute, La Jolla Cancer Research Center, California 92037, USA
    Lab Invest 79:1601-13. 1999
    Mutations in laminin alpha2, a subunit of the basement membrane protein laminin-2/merosin, cause merosin-deficient congenital muscular dystrophy...
  29. ncbi The crystal structure of a laminin G-like module reveals the molecular basis of alpha-dystroglycan binding to laminins, perlecan, and agrin
    E Hohenester
    Biophysics Section, Blackett Laboratory, Imperial College, London, United Kingdom
    Mol Cell 4:783-92. 1999
    ..A calcium-coordinated sulfate ion is suggested to mimic the binding of anionic oligosaccharides. The structure demonstrates a conserved function of the LG module in calcium-dependent lectin-like alpha-DG binding...
  30. ncbi Merosin and congenital muscular dystrophy
    Y Miyagoe-Suzuki
    Department of Molecular Genetics, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    Microsc Res Tech 48:181-91. 2000
    b>Merosin (also called as Laminin-2) is an isoform of laminin comprised of the alpha2, beta1 and gamma1 chains...
  31. ncbi Laminin alpha4 and integrin alpha6 are upregulated in regenerating dy/dy skeletal muscle: comparative expression of laminin and integrin isoforms in muscles regenerating after crush injury
    L M Sorokin
    Interdisciplinary Center for Clinical Research IZKF, University of Erlangen Nuremberg, Germany
    Exp Cell Res 256:500-14. 2000
    ....
  32. ncbi Properly formed but improperly localized synaptic specializations in the absence of laminin alpha4
    B L Patton
    Department of Anatomy and Neurobiology, Washington University Medical Center, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Neurosci 4:597-604. 2001
    ..Thus, formation and localization of synaptic specializations are regulated separately, and alpha4beta2gamma1 (called laminin-9) is critical in the latter process...
  33. pmc Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis
    M Sixt
    Interdisciplinary Center for Clinical Research IZKF, Nikolaus Fiebiger Center, University of Erlangen Nuremberg, Glückstr 6, 91054 Erlangen, Germany
    J Cell Biol 153:933-46. 2001
    ....
  34. ncbi An agrin minigene rescues dystrophic symptoms in a mouse model for congenital muscular dystrophy
    J Moll
    Department of Pharmacology Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Nature 413:302-7. 2001
    ..Most cases of congenital muscular dystrophy are caused by mutations in LAMA2, the gene encoding the alpha2 chain of the main laminin isoforms expressed by muscle fibres...
  35. ncbi Laminin alpha2 deficiency and muscular dystrophy; genotype-phenotype correlation in mutant mice
    L T Guo
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuromuscul Disord 13:207-15. 2003
    ..These data may thus be of significance for attempts to treat congenital muscular dystrophy in human patients...
  36. ncbi Expression of laminin receptors in schwann cell differentiation: evidence for distinct roles
    Stefano C Previtali
    Neuropathology Unit, Department of Neuroscience and DIBIT, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Neurosci 23:5520-30. 2003
    ..These data suggest that the action of laminin is mediated by beta1 integrins during axonal sorting and by dystroglycan, alpha6beta1, and alpha6beta4 integrins during myelination...
  37. pmc Laminin gamma1 is critical for Schwann cell differentiation, axon myelination, and regeneration in the peripheral nerve
    Zu Lin Chen
    Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY 10021, USA
    J Cell Biol 163:889-99. 2003
    ..In mutant mice, after sciatic nerve crush, the axons showed impaired regeneration. These experiments demonstrate that laminin is an essential component for axon myelination and regeneration in the PNS...
  38. ncbi Loss of basement membrane, receptor and cytoskeletal lattices in a laminin-deficient muscular dystrophy
    Peter D Yurchenco
    Department of Pathology and Laboratory Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    J Cell Sci 117:735-42. 2004
    ....
  39. ncbi EDL and soleus muscles of the C57BL6J/dy2j laminin-alpha 2-deficient dystrophic mouse are not vulnerable to eccentric contractions
    Stewart I Head
    School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Exp Physiol 89:531-9. 2004
    ..We used the C57BL6J/dy(2j), dystrophia muscularis, dystrophic mouse, in which the laminin-alpha(2) component of the dystrophin-associated complex is mutated,..
  40. ncbi Laminin alpha1 chain reduces muscular dystrophy in laminin alpha2 chain deficient mice
    Kinga Gawlik
    Department of Cell and Molecular Biology, Section of Cell and Developmental Biology, University of Lund, Sweden
    Hum Mol Genet 13:1775-84. 2004
    ..Correction of LNalpha2 chain deficiency by LNalpha1 chain may serve as a paradigm for gene therapy of CMD in patients...
  41. pmc Inhibition of apoptosis improves outcome in a model of congenital muscular dystrophy
    Mahasweta Girgenrath
    Neuromuscular Biology and Disease Group, Boston Biomedical Research Institute, Watertown, Massachusetts 02478, USA
    J Clin Invest 114:1635-9. 2004
    ..significance of apoptosis in CMD1A pathogenesis, we determined whether pathogenesis in laminin-alpha2-deficient (Lama2(-/-)) mice could be ameliorated by inhibiting apoptosis through either (a) inactivation of the proapoptosis ..
  42. pmc Coordinate control of axon defasciculation and myelination by laminin-2 and -8
    Dongren Yang
    Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, OR 97239, USA
    J Cell Biol 168:655-66. 2005
    ..Purified Ln-2 and -8 directly enhanced in vitro Schwann cell proliferation in collaboration with autocrine factors, suggesting Lns control the onset of myelination by modulating responses to mitogens in vivo...
  43. ncbi Muscle-specific BCL2 expression ameliorates muscle disease in laminin {alpha}2-deficient, but not in dystrophin-deficient, mice
    Janice A Dominov
    Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA
    Hum Mol Genet 14:1029-40. 2005
    ..progression, we have determined whether pathogenesis in dystrophin-deficient (mdx) and laminin alpha2-deficient (Lama2-null) mice is ameliorated by overexpression of the anti-apoptosis protein BCL2 in diseased muscles...
  44. ncbi Overexpression of mini-agrin in skeletal muscle increases muscle integrity and regenerative capacity in laminin-alpha2-deficient mice
    C Florian Bentzinger
    Biozentrum, University of Basel, Basel, Switzerland
    FASEB J 19:934-42. 2005
    Mutations in the gene encoding the alpha2 subunit of laminins cause the severe "merosin-deficient congenital muscular dystrophy" (MDC1A)...
  45. pmc Amelioration of laminin-alpha2-deficient congenital muscular dystrophy by somatic gene transfer of miniagrin
    Chunping Qiao
    Department of Orthopedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 102:11999-2004. 2005
    ..Thus, our study demonstrated the efficacy of somatic gene therapy in a mouse model of CMD...
  46. pmc Laminin {alpha}1 chain corrects male infertility caused by absence of laminin {alpha}2 chain
    Mattias Häger
    Department of Experimental Medical Science, Division for Cell and Matrix Biology, University of Lund, Lund, Sweden
    Am J Pathol 167:823-33. 2005
    ..We thus provide genetic data that laminin alpha chains are essential for normal testicular function in vivo...
  47. ncbi Laminin alpha1 chain mediated reduction of laminin alpha2 chain deficient muscular dystrophy involves integrin alpha7beta1 and dystroglycan
    Kinga I Gawlik
    Department of Experimental Medical Science, Division for Cell and Matrix Biology, University of Lund, BMC B12 221 84 Lund, Sweden
    FEBS Lett 580:1759-65. 2006
    ..We suggest that LNalpha1 chain in part ameliorates the development of LNalpha2 chain deficient muscular dystrophy by retaining the binding sites for integrin alpha7Bbeta1D and alpha-dystroglycan, respectively...
  48. ncbi Laminin alpha1 chain improves laminin alpha2 chain deficient peripheral neuropathy
    Kinga I Gawlik
    Muscle Biology Unit, Division for Cell and Matrix Biology, Department of Experimental Medical Science, University of Lund, Sweden
    Hum Mol Genet 15:2690-700. 2006
    ..In summary, we postulate that laminin alpha1 chain is an excellent substitute for laminin alpha2 chain in multiple tissues and suggest that treatment with laminin alpha1 chain may be beneficial for MDC1A in humans...
  49. pmc Linker molecules between laminins and dystroglycan ameliorate laminin-alpha2-deficient muscular dystrophy at all disease stages
    Sarina Meinen
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Cell Biol 176:979-93. 2007
    ....
  50. ncbi Patterns of laminins and integrins in the embryonic ventricular zone of the CNS
    Justin D Lathia
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Comp Neurol 505:630-43. 2007
    ....
  51. pmc Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions
    Francesco J Conti
    The Scripps Research Institute, Department of Cell Biology and Institute of Childhood and Neglected Diseases, La Jolla, CA 92037, USA
    Development 136:3597-606. 2009
    ..We conclude that talin 1 and 2 are crucial for skeletal muscle development, where they regulate myoblast fusion, sarcomere assembly and the maintenance of MTJs...
  52. doi Identification of biologically active sequences in the laminin alpha2 chain G domain
    Shunsuke Urushibata
    Laboratory of Clinical Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192 0392, Japan
    Arch Biochem Biophys 497:43-54. 2010
    ..These active peptides are useful for evaluating the molecular mechanisms of laminin-receptor interactions...
  53. pmc Proinflammatory signals and the loss of lymphatic vessel hyaluronan receptor-1 (LYVE-1) in the early pathogenesis of laminin alpha2-deficient skeletal muscle
    Katherine E Wardrop
    Boston Biomedical Research Institute, Watertown, Massachusetts 02472, USA
    J Histochem Cytochem 59:167-79. 2011
    ..characterized by early-onset muscle weakness and degeneration, is caused by insufficient levels of laminin α2 (LAMA2) in the basal lamina surrounding muscle fibers and other cells...
  54. ncbi Aberrant PNS development in dystrophic mice
    H J Weinberg
    Brain Res 88:532-7. 1975
  55. ncbi Abnormalities of peripheral nerves in murine muscular dystrophy
    W G Bradley
    J Neurol Sci 18:227-47. 1973
  56. pmc Human laminin M chain (merosin): complete primary structure, chromosomal assignment, and expression of the M and A chain in human fetal tissues
    R Vuolteenaho
    Biocenter, University of Oulu, Finland
    J Cell Biol 124:381-94. 1994
    The primary structure of the human laminin M chain was determined from cDNA clones isolated from human placental libraries...
  57. ncbi Peripheral nerve involvement in merosin-deficient congenital muscular dystrophy and dy mouse
    K Matsumura
    Department of Neurology and Neuroscience, Teikyo University School of Medicine, Tokyo, Japan
    Neuromuscul Disord 7:7-12. 1997
    b>Merosin, also called laminin-2, is an isoform of laminin comprised of the alpha 2, beta 1 and gamma 1 chains...
  58. ncbi Differential expression of five laminin alpha (1-5) chains in developing and adult mouse kidney
    L M Sorokin
    Institute for Experimental Medicine, Connective Tissue Research, University of Erlangen Nurnberg, Erlangen, Germany
    Dev Dyn 210:446-62. 1997
    ..Thus, the identity of the alpha chains of many embryonic kidney blood vessels and several basement membranes in the inner medulla in the developing and adult kidney remain unclear...
  59. ncbi Neuromuscular transmission in dystrophic mice
    S Carbonetto
    J Neurophysiol 40:836-43. 1977
    ..6. Neuromuscular transmission in dystrophic mice was found functionally normal and unrelated to the degenerative state of the muscle...
  60. ncbi Genetically determined defect of Schwann cell basement membrane in dystrophic mouse
    R E Madrid
    Nature 257:319-21. 1975
  61. pmc Merosin, a tissue-specific basement membrane protein, is a laminin-like protein
    K Ehrig
    La Jolla Cancer Research Foundation, CA 92037
    Proc Natl Acad Sci U S A 87:3264-8. 1990
    b>Merosin is a basement membrane-associated protein found in placenta, striated muscle, and peripheral nerve. A 3.6-kilobase merosin cDNA clone was isolated from a placental cDNA expression library. The clone contained a 3...
  62. ncbi Mouse heart laminin. Purification of the native protein and structural comparison with Engelbreth-Holm-Swarm tumor laminin
    M Paulsson
    Department of Biophysical Chemistry, University of Basel, Switzerland
    J Biol Chem 264:18726-32. 1989
    ..The Mr 600,000 component contains epitopes shared with both EHS tumor laminin and the Mr 300,000 polypeptide and possibly represents a covalently cross-linked complex of an A or B chain with the Mr 300,000 chain...
  63. ncbi Evidence on hypomyelination of central nervous system in murine muscular dystrophy
    S Tsuji
    J Neurol Sci 68:175-84. 1985
    ..The reduced myelin CEHase activity in dystrophic mice suggests that impairment of hydrolysis of steryl esters may be important in the development of hypomyelination of the CNS...
  64. ncbi Ongoing block of Schwann cell differentiation and deployment in dystrophic mouse spinal roots
    C S Perkins
    Brain Res 227:213-20. 1981
    ..Thus, this study demonstrates that the 'uncommitted' cells of dystrophic spinal roots are undifferentiated Schwann cells whose differentiation in the intact spinal roots is continuously prevented by some unknown mechanism...
  65. ncbi Expression of laminin chains during myogenic differentiation
    T G Kroll
    Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor 48109
    J Biol Chem 269:9270-7. 1994
    ..The results demonstrate that expression of the Ae and Ac3h laminin chains is associated with expression of MyoD and the mammalian myogenic differentiation program...
  66. ncbi Deficiency of merosin in dystrophic dy mice and genetic linkage of laminin M chain gene to dy locus
    Y Sunada
    Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City 52242
    J Biol Chem 269:13729-32. 1994
    ..We have also mapped the mouse M chain gene, Lamm, to the same region of mouse chromosome 10 to which the dystrophia muscularis (dy) locus has been mapped...
  67. ncbi Distribution of the ten known laminin chains in the pathways and targets of developing sensory axons
    S I Lentz
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 378:547-61. 1997
    ..g., gamma 1), continue to be expressed by Schwann cells into adulthood. In contrast to peripheral nerves and ganglia, laminin chains are expressed at low levels, if at all, in the developing spinal cord gray matter...
  68. ncbi Laminin 2 attachment selects myofibroblasts from fetal mouse lung
    G Flores-Delgado
    Department of Pediatric Surgery, Children s Hospital Los Angeles Research Institute, University of Southern California Schools of Dentistry and Medicine, Los Angeles, CA 90033, USA
    Am J Physiol 275:L622-30. 1998
    ..These findings lead us to speculate that LN2 may play a key role in the cell biology of myofibroblasts during lung development...
  69. ncbi Complement 3 deficiency and oral prednisolone improve strength and prolong survival of laminin alpha2-deficient mice
    Anne M Connolly
    Department of Neurology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    J Neuroimmunol 127:80-7. 2002
    ..Because complement activity may be modified pharmacologically, this work may have implications for treatment of children with congenital muscular dystrophy secondary to laminin alpha2 deficiency...
  70. pmc beta1 integrin maintains integrity of the embryonic neocortical stem cell niche
    Karine Loulier
    Center for Neuroscience, Children s National Medical Center, Washington, D C, United States of America
    PLoS Biol 7:e1000176. 2009
    ....
  71. pmc Regeneration of muscles transplanted between normal and dystrophic mice: a quantitative study of early transplants
    J S Neerunjun
    J Anat 124:459-67. 1977
  72. ncbi Conduction of nervous impulses in spinal roots and peripheral nerves of dystrophic mice
    M Rasminsky
    Brain Res 143:71-85. 1978
    ..Internodal lengths were somewhat decreased in the dystrophic peripheral nerves but there was no significant difference in maximum fiber diameters, myelin thickness or nodal morphology between dystrophic and normal nerves...
  73. ncbi Naked axons in myodystrophic mice
    H B Rayburn
    Brain Res 146:380-4. 1978
  74. ncbi Comparison of dy and dy2J, two alleles expressing forms of muscular dystrophy in the mouse
    A D MacPike
    Proc Soc Exp Biol Med 151:670-2. 1976
    ..The dy dystrophy appears the same histologically on either the C57BL/6J or original 129/ReJ and 129B6F backgrounds...
  75. ncbi Differential effects of two alleles of the dy locus on the pituitary-testicular axis of mice
    A G Amador
    Department of Obstetrics and Gynecology, SIU School of Medicine, Springfield 62794 9230
    Rev Esp Fisiol 48:157-66. 1992
    ....
  76. ncbi Reduced level of epidermal growth factor in the skeletal muscle of mice with muscular dystrophy
    M Hiramatsu
    Department of Dental Pharmacology, Meikai University School of Dentistry, Saitama, Japan
    Horm Metab Res 24:138-9. 1992
  77. ncbi A survey of neurological mutant mice. II. Lipid composition of myelinated tissue in possible myelin mutants
    A L Ganser
    Department of Neuroscience, Children s Hospital, Boston, Mass
    Dev Neurosci 10:123-40. 1988
    ..abstract truncated at 400 words)..
  78. ncbi Increased expression of cofilin in dystrophic chicken and mouse skeletal muscles
    K Hayakawa
    Department of Biology, Chiba University
    J Biochem 114:582-7. 1993
    ..We suggest that cofilin is involved in disassembly or reorganization of actin in the dystrophic muscle...
  79. ncbi Expression of merosin in the thymus and its interaction with thymocytes
    A C Chang
    Biological Resources Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 151:1789-801. 1993
    b>Merosin is a 700 kDa multichain protein that has several properties in common with laminin, one of the major extracellular matrix proteins present in basement membranes...
  80. pmc Partial laminin alpha2 chain restoration in alpha2 chain-deficient dy/dy mouse by primary muscle cell culture transplantation
    J T Vilquin
    Centre de Recherche en Neurobiologie de l Université Laval, Hopital de l Enfant Jesus, Quebec, Canada
    J Cell Biol 133:185-97. 1996
    ..chain (LAMA2), however, is absent from muscles of some congenital muscular dystrophy patients and the dystrophia muscularis (dy/dy) mouse model...
  81. ncbi Cloning and expression analyses of mouse dystroglycan gene: specific expression in maternal decidua at the peri-implantation stage
    S Yotsumoto
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48202, USA
    Hum Mol Genet 5:1259-67. 1996
    ....
  82. ncbi Distinct alpha 7A beta 1 and alpha 7B beta 1 integrin expression patterns during mouse development: alpha 7A is restricted to skeletal muscle but alpha 7B is expressed in striated muscle, vasculature, and nervous system
    T Velling
    Department of Animal Physiology, Uppsala University, Sweden
    Dev Dyn 207:355-71. 1996
    ..We conclude that the alpha 7A and alpha 7B integrin variants are expressed in a developmentally regulated, tissue-specific pattern suggesting different functions for the two splice forms...
  83. ncbi Dystroglycan is essential for early embryonic development: disruption of Reichert's membrane in Dag1-null mice
    R A Williamson
    Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
    Hum Mol Genet 6:831-41. 1997
    ..Furthermore, these results suggest that disruption of basement membrane organization might be a common feature of muscular dystrophies linked to the DGC...
  84. ncbi The effects of muscular dystrophy on craniofacial growth in mice: a study of heterochrony and ontogenetic allometry
    P S Lightfoot
    Department of Biological Sciences, University of Cincinnati, Ohio 45221 0006, USA
    J Morphol 235:1-16. 1998
    ..The severely dystrophic mice have flatter, more elongate skulls and mandibles than those of the other two genotypes, concurrent with an absence of muscular forces to stimulate growth in a superior-inferior direction...
  85. ncbi Distribution of dystroglycan in normal adult mouse tissues
    M Durbeej
    Department of Animal Physiology, Uppsala University, Uppsala, Sweden
    J Histochem Cytochem 46:449-57. 1998
    ..We suggest that dystroglycan is involved in linking basement membranes to epithelial and muscle cells. Dystroglycan may be important for the maintenance of tissue integrity...
  86. ncbi epicardin: A novel basic helix-loop-helix transcription factor gene expressed in epicardium, branchial arch myoblasts, and mesenchyme of developing lung, gut, kidney, and gonads
    L Robb
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    Dev Dyn 213:105-13. 1998
    ....
  87. ncbi Essential role of alpha 6 integrins in cortical and retinal lamination
    E Georges-Labouesse
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, C U de Strasbourg, France
    Curr Biol 8:983-6. 1998
    ..These observations are particularly significant given the recent report that human patients suffering from epidermolysis bullosa can carry mutations in ITGA6, the gene encoding the alpha 6 integrin chain [8,9]...
  88. ncbi Basal lamina molecules are concentrated in myogenic regions of the mouse limb bud
    E W Godfrey
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee 53225, USA
    Anat Embryol (Berl) 198:481-6. 1998
    ..These results suggest that basal lamina components play an important stimulatory role in early stages of skeletal muscle differentiation in the developing mouse limb bud...
  89. ncbi Laminin-1 promotes differentiation of fetal mouse pancreatic beta-cells
    F X Jiang
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, The Royal Melbourne Hospital, Parkville, Victoria, Australia
    Diabetes 48:722-30. 1999
    ..Laminin-1 was shown to be expressed in the epithelial basement membrane of the 13.5- to 17.5-day fetal pancreas. These findings provide the first evidence of a role for laminin-1 to promote differentiation of pancreatic beta-cells...
  90. ncbi Increased butyrylcholinesterase levels in microsomal membranes of dystrophic Lama2dy mouse muscle
    M T Moral-Naranjo
    Departamento de Bioquimica y Biologia Molecular A, Universidad de Murcia, Espinardo, Murcia, Spain
    J Neurochem 73:1138-44. 1999
    ..in vesicles rich in sarcoplasmic reticulum from normal (NMV) and dystrophic (DMV) muscle were analyzed, using merosin-deficient dystrophic mice. BuChE activity in DMV was two- to threefold that in NMV...
  91. ncbi Myoblast transplantations lead to the expression of the laminin alpha 2 chain in normal and dystrophic (dy/dy) mouse muscles
    J T Vilquin
    Unité de Médecine Génétique et Moléculaire, Centre hospitalier de l Universite Laval, Quebec, Canada
    Gene Ther 6:792-800. 1999
    ..Myoblasts are, therefore, attractive tools for further exploration of gene complementation strategies in the animal models of congenital muscular dystrophy...
  92. ncbi Assignment of laminin alpha 2-chain gene (Lama2) to mouse chromosome 10A4-B1 by fluorescence in situ hybridization
    R Sallinen
    The Laboratory Department of Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    Cytogenet Cell Genet 87:195-6. 1999
  93. ncbi Caveolin-3 deficiency causes muscle degeneration in mice
    Y Hagiwara
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8502, Japan
    Hum Mol Genet 9:3047-54. 2000
    ..No apparent muscle degeneration was observed in heterozygous mutant mice, indicating that pathological changes caused by caveolin-3 gene disruption were inherited through the recessive form of genetic transmission...
  94. ncbi Laminin alpha5 chain is required for intestinal smooth muscle development
    Anne Laure Bolcato-Bellemin
    INSERM U381, Ontogenese et Pathologie du Systeme Digestif, Avenue Moliere, Strasbourg, France
    Dev Biol 260:376-90. 2003
    ....
  95. ncbi Laminin alpha2 is essential for odontoblast differentiation regulating dentin sialoprotein expression
    Kenji Yuasa
    Division of Pediatric Dentistry, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    J Biol Chem 279:10286-92. 2004
    ..We analyzed the role of laminin alpha2 in tooth development by using targeted mice with a disrupted lama2 gene...
  96. pmc Beta1-integrins are critical for cerebellar granule cell precursor proliferation
    Sandra Blaess
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 24:3402-12. 2004
    ....
  97. ncbi Integrin repertoire on myogenic cells changes during the course of primary myogenesis in the mouse
    Ana Sofia Cachaço
    Departamento de Biologia Animal, Centro de Biologia Ambiental, Faculdade de Ciencias, Universidade de Lisboa, Lisboa, Portugal
    Dev Dyn 232:1069-78. 2005
    ..Thus, myogenic cells change their integrin expression pattern during the course of primary myogenesis in the mouse, suggesting different roles for fibronectin- and laminin-containing matrices in this process...
  98. ncbi Dystrophic mice show age related muscle fibre and myelinated axon losses
    A Montgomery
    Department of Zoology, University of Toronto, Ontario, Canada
    Nature 267:167-9. 1977
    ..Although these losses began after a demonstrable loss of myelinated axons had occurred, it is not possible to say if the loss of muscle fibres was a result of the loss of nerve fibres...
  99. ncbi Severe muscular dystrophy in mice that lack dystrophin and alpha7 integrin
    Jachinta E Rooney
    Department of Pharmacology, University of Nevada, Reno, 89557, USA
    J Cell Sci 119:2185-95. 2006
    ..These results point to complementary roles for dystrophin and alpha7beta1 integrin in maintaining the functional integrity of skeletal muscle...
  100. ncbi Beta1 integrins control the formation of cell chains in the adult rostral migratory stream
    Richard Belvindrah
    The Scripps Research Institute, Department of Cell Biology, Institute for Childhood and Neglected Disease, La Jolla, California 92037, USA
    J Neurosci 27:2704-17. 2007
    ..In addition, we provide evidence that beta1 class integrins are required for the maintenance of the glial tubes and that defects in the glial tubes lead to the ectopic migration of neuroblasts into the surrounding tissue...
  101. ncbi Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box M1 transcription factor
    Sneha Ramakrishna
    Department of Medicine, University of Chicago, Chicago, Illinois
    Dev Dyn 236:1000-13. 2007
    ..Foxm1 regulates expression of genes essential for the proliferation of cardiomyocytes during heart development...

Research Grants11

  1. 2006 Gordon Research Conference on Basement Membranes
    JEFFREY MINER; Fiscal Year: 2006
    ..Studies on the genetic analyses of basement membrane functions and the generation of animal models of human basement membrane disorders will be presented. [unreadable] [unreadable] [unreadable] [unreadable]..
  2. Laminin-Induced Membrane Complexes in Muscle and Nerve
    Peter Yurchenco; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  3. Apoptosis in Laminin alpha2-Deficient Muscle Pathology
    JANICE DOMINOV; Fiscal Year: 2009
    Congenital muscular dystrophy is often caused by deficiency in laminin a2 (merosin) expression in the basement membrane surrounding muscle fibers...
  4. COLLAGEN IV CHAINS IN KIDNEY DEVELOPMENT AND FUNCTION
    JEFFREY MINER; Fiscal Year: 2002
    ..The results obtained under the auspices of this proposal will have important implication for the pathogenesis of Alport syndrome in man and for approaches current under development that will use gene therapy to treat the human disease. ..
  5. Enhancement of Myoblast Chemotactic Migration
    JANICE DOMINOV; Fiscal Year: 2003
    ....
  6. LAMININS AND NEUROMUSCULAR SYNAPSE FORMATION
    Bruce Patton; Fiscal Year: 2004
    ..These studies will provide insight into the mechanisms by which neuronal targets foster and control the pattern of innervation they receive, and these insights will advance methods of treating neuromuscular disorders and injuries. ..
  7. Transmitter Repletion: Key to Phrenic-Diaphragm Function
    Erik van Lunteren; Fiscal Year: 2005
    ..These studies may lead to novel therapeutic approaches to respiratory muscle impairment and resulting hypercapnic respiratory failure for conditions which produce neuromuscular junction dysfunction. ..
  8. Mechanisms of Cell/Matrix Interactions in the Kidney
    JEFFREY MINER; Fiscal Year: 2006
    ..Together, the results of these studies will lead to a more complete understanding of cell-matrix interactions in the kidney and could reveal new avenues for diagnosis and treatment of human kidney disease. ..
  9. Laminin Alpha5 and Polycystic Kidney Disease
    JEFFREY MINER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. 2008 Basement Membranes Gordon Research Conference
    JEFFREY MINER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  11. ASSEMBLY AND FUNCTION OF BASEMENT MEMBRANE PROTEINS
    JEFFREY MINER; Fiscal Year: 2008
    ..The results of these studies will lead to new information regarding the assembly and function of laminins in the in vivo setting. ..