L selectin

Summary

Gene Symbol: L selectin
Description: selectin, lymphocyte
Alias: AI528707, CD62L, L-selectin, LECAM-1, Lnhr, Ly-22, Ly-m22, Lyam-1, Lyam1, CD62 antigen-like family member L, L-selectin, LAM-1, LECAM1, leukocyte adhesion molecule 1, leukocyte-endothelial cell adhesion molecule 1, lymph node homing receptor, lymphocyte antigen 22, lymphocyte surface MEL-14 antigen
Species: mouse

Top Publications

  1. ncbi The selectins: vascular adhesion molecules
    T F Tedder
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    FASEB J 9:866-73. 1995
  2. pmc L-selectin from human, but not from mouse neutrophils binds directly to E-selectin
    O Zöllner
    Institute of Cell Biology, ZMBE, University of Munster, Germany
    J Cell Biol 136:707-16. 1997
  3. ncbi Ligation of L-selectin through conserved regions within the lectin domain activates signal transduction pathways and integrin function in human, mouse, and rat leukocytes
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 159:952-63. 1997
  4. ncbi L-selectin-dependent lymphoid occupancy is required to induce alloantigen-specific tolerance
    Yalai Bai
    Carl C Icahn Institute for Gene Therapy and Molecular Medicine and Recanati Miller Transplant Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 168:1579-89. 2002
  5. pmc Lymphocyte homing to bronchus-associated lymphoid tissue (BALT) is mediated by L-selectin/PNAd, alpha4beta1 integrin/VCAM-1, and LFA-1 adhesion pathways
    Baohui Xu
    Dept of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    J Exp Med 197:1255-67. 2003
  6. pmc Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
    Linda V Sinclair
    Department of Cell Biology and Immunology, University of Dundee, Dundee DD1 5EH, UK
    Nat Immunol 9:513-21. 2008
  7. ncbi Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice
    M L Arbones
    Cell Genesys, Incorporated, Foster City, California 94404
    Immunity 1:247-60. 1994
  8. pmc L-selectin shedding regulates leukocyte recruitment
    A Hafezi-Moghadam
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    J Exp Med 193:863-72. 2001
  9. ncbi L-selectin or ICAM-1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivity
    Yuka Shimada
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Immunol 170:4325-34. 2003
  10. ncbi Kruppel-like factor 2 controls T cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor 1 transcription
    Ailin Bai
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, 40 Ames Street, Cambridge, MA 02139, USA
    J Immunol 178:7632-9. 2007

Research Grants

  1. ENDOTHELIAL CELL BIOLOGY IN INFLAMMATION
    Eugene Butcher; Fiscal Year: 2007
  2. Mucosal Lymphocyte Homing in the Head and Neck
    David Pascual; Fiscal Year: 2007
  3. Structure/Functional Characterization of vWF-A1 Domain
    THOMAS DIACOVO; Fiscal Year: 2007
  4. Novel Dendritic Cell Chemoattractant and Receptor
    Eugene Butcher; Fiscal Year: 2009
  5. Mucosal Therapy for Autoimmunity
    David W Pascual; Fiscal Year: 2010
  6. CAM Intervention for Rheumatoid Arthritis
    David Pascual; Fiscal Year: 2007
  7. MUCOSAL IMMUNITY ELICITED BY SALMONELLA VACCINE DELIVERY
    David Pascual; Fiscal Year: 2009
  8. MUCOSAL IMMUNITY ELICITED BY SALMONELLA VACCINE DELIVERY
    David Pascual; Fiscal Year: 2007
  9. MUCOSAL TRANSGENE VACCINATION FOR HIV
    David Pascual; Fiscal Year: 2003
  10. Mucosal Vaccines for Plague
    David Pascual; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications100

  1. ncbi The selectins: vascular adhesion molecules
    T F Tedder
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    FASEB J 9:866-73. 1995
    ..Future studies are focused on how the selectins interact with the increasing array of other adhesion molecules and inflammatory mediators...
  2. pmc L-selectin from human, but not from mouse neutrophils binds directly to E-selectin
    O Zöllner
    Institute of Cell Biology, ZMBE, University of Munster, Germany
    J Cell Biol 136:707-16. 1997
    ..The clear difference between human and mouse L-selectin suggests that E-selectin-binding carbohydrate moieties are attached to different protein scaffolds in different species...
  3. ncbi Ligation of L-selectin through conserved regions within the lectin domain activates signal transduction pathways and integrin function in human, mouse, and rat leukocytes
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 159:952-63. 1997
    ..Signaling through L-selectin may enhance leukocyte-endothelial cell interactions by serving as an activation/priming step during rolling, thereby promoting subsequent firm cell-cell adhesion in the presence of inflammatory mediators...
  4. ncbi L-selectin-dependent lymphoid occupancy is required to induce alloantigen-specific tolerance
    Yalai Bai
    Carl C Icahn Institute for Gene Therapy and Molecular Medicine and Recanati Miller Transplant Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 168:1579-89. 2002
    ..Concurrent administration of anti-L-selectin (CD62L) Ab, which prevents lymph node homing, prevents indefinite allograft survival and tolerance...
  5. pmc Lymphocyte homing to bronchus-associated lymphoid tissue (BALT) is mediated by L-selectin/PNAd, alpha4beta1 integrin/VCAM-1, and LFA-1 adhesion pathways
    Baohui Xu
    Dept of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    J Exp Med 197:1255-67. 2003
    ..This high level of involvement of alpha4beta1 integrin/VCAM-1 is unique among secondary lymphoid tissues, and may help unify lymphocyte migration pathways and immune responses in BALT and other bronchopulmonary tissues...
  6. pmc Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
    Linda V Sinclair
    Department of Cell Biology and Immunology, University of Dundee, Dundee DD1 5EH, UK
    Nat Immunol 9:513-21. 2008
    ..The key lymph node-homing receptors CD62L (L-selectin) and CCR7 were highly expressed on naive T lymphocytes but were downregulated after immune activation...
  7. ncbi Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice
    M L Arbones
    Cell Genesys, Incorporated, Foster City, California 94404
    Immunity 1:247-60. 1994
    ..Thus, L-selectin plays an essential role in leukocyte homing to lymphoid tissues and sites of inflammation...
  8. pmc L-selectin shedding regulates leukocyte recruitment
    A Hafezi-Moghadam
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    J Exp Med 193:863-72. 2001
    ..These observations help to resolve the apparent discrepancy between the minor contribution of L-selectin to rolling and the significant leukocyte recruitment defect in L-selectin knockout mice...
  9. ncbi L-selectin or ICAM-1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivity
    Yuka Shimada
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Immunol 170:4325-34. 2003
    ....
  10. ncbi Kruppel-like factor 2 controls T cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor 1 transcription
    Ailin Bai
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, 40 Ames Street, Cambridge, MA 02139, USA
    J Immunol 178:7632-9. 2007
    ..In this study, we show that in reporter gene assays KLF2 directly activates the promoters of both CD62L and sphingosine-1-phosphate receptor 1 (S1P1), whose expression is critical for T cell egress from the thymus and ..
  11. pmc Impaired primary T cell responses in L-selectin-deficient mice
    J Xu
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Exp Med 183:589-98. 1996
    ..L-selectin does not appear to be rate limiting for the events leading to antigen-driven neutrophil recruitment, since normal DTH responses are obtained at late time points after immunization...
  12. pmc The route of antigen entry determines the requirement for L-selectin during immune responses
    M D Catalina
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235 9072, USA
    J Exp Med 184:2341-51. 1996
    ....
  13. ncbi The LFA-1 adhesion molecule is required for protective immunity during pulmonary Mycobacterium tuberculosis infection
    Shamik Ghosh
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 176:4914-22. 2006
    ..Thus, LFA-1 (CD11a/CD18) plays an essential role in immunity to M. tuberculosis infection...
  14. ncbi Mice lacking two or all three selectins demonstrate overlapping and distinct functions for each selectin
    U Jung
    Department of Biomedical Engineering, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Immunol 162:6755-62. 1999
    ..We conclude that any one of the selectins can support some neutrophil recruitment but eliminating all three selectins significantly impairs neutrophil recruitment...
  15. pmc L- and P-selectins collaborate to support leukocyte rolling in vivo when high-affinity P-selectin-P-selectin glycoprotein ligand-1 interaction is inhibited
    Victoria C Ridger
    Cardiovascular Research Unit, University of Sheffield, Sheffield, UK
    Am J Pathol 166:945-52. 2005
    ..Together these data suggest that leukocytes can continue to roll in the absence of optimal P-selectin/PSGL-1 interaction using an alternative mechanism that involves P-selectin-, L-selectin-, and sLe(x)-bearing ligands...
  16. pmc P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules
    Markus Sperandio
    University of Virginia Health System, Cardiovascular Research Center, MR5 Bldg, Rm 1013, P O Box 801 394, Charlottesville, VA 22908 1394, USA
    J Exp Med 197:1355-63. 2003
    ..L-selectin binding to PSGL-1 initiates tethering events that enable L-selectin-independent leukocyte-endothelial interactions. These findings provide a molecular mechanism for the inflammatory defects seen in L-selectin-deficient mice...
  17. pmc Early establishment of diverse T cell receptor profiles for influenza-specific CD8(+)CD62L(hi) memory T cells
    Katherine Kedzierska
    Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Melbourne, Australia
    Proc Natl Acad Sci U S A 103:9184-9. 2006
    ..indicates that prominent clonotypes bearing "public" or "shared" T cell receptors (TCRs) subset early into CD62L(hi) and CD62L(lo) populations...
  18. doi No detectable endothelial- or leukocyte-derived L-selectin ligand activity on the endothelium in inflamed cremaster muscle venules
    Einar E Eriksson
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Leukoc Biol 84:93-103. 2008
    ..These data demonstrate that expression of L-selectin on leukocytes is insufficient for mediating rolling and efficient recruitment of leukocytes in inflammation...
  19. pmc Importance of primary capture and L-selectin-dependent secondary capture in leukocyte accumulation in inflammation and atherosclerosis in vivo
    E E Eriksson
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Exp Med 194:205-18. 2001
    ..What is more, secondary capture occurs on atherosclerotic lesions, a fact that provides the first evidence for roles of L-selectin in leukocyte accumulation in atherogenesis...
  20. ncbi P-, E-, and L-selectin mediate migration of activated CD8+ T lymphocytes into inflamed skin
    Takako Hirata
    Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Immunol 169:4307-13. 2002
    ..P- and E-selectin-independent migration of Tc1 cells into the inflamed skin was predominantly mediated by L-selectin. These observations indicate that all three selectins can mediate Tc1 cell migration into the inflamed skin...
  21. ncbi Humoral immune responses in L-selectin-deficient mice
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 157:4899-907. 1996
    ....
  22. ncbi Leukocyte entry into sites of inflammation requires overlapping interactions between the L-selectin and ICAM-1 pathways
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 163:2176-86. 1999
    ..Thus, members of the selectin and Ig families function synergistically to mediate optimal leukocyte rolling and entry into tissues, which is essential for the generation of effective inflammatory responses in vivo...
  23. ncbi Intrinsic differences in L-selectin expression levels affect T and B lymphocyte subset-specific recirculation pathways
    M L Tang
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 160:5113-21. 1998
    ..Thus, the differential migration of T and B lymphocyte subsets to lymphoid tissues is regulated in part by subset-specific differences in L-selectin expression levels...
  24. ncbi The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches
    E J Kunkel
    Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville 22908, USA
    J Immunol 161:2449-56. 1998
    ..In situ, beta 7 integrins and L-selectin account for all lymphocyte homing to Peyer's patches, but P-selectin-dependent rolling, as induced by minimal trauma, may support trafficking of effector T lymphocytes to Peyer's patches...
  25. ncbi L-selectin facilitates emigration and extravascular locomotion of leukocytes during acute inflammatory responses in vivo
    M J Hickey
    Immunology Research Group, University of Calgary, Calgary, Alberta, Canada
    J Immunol 165:7164-70. 2000
    ..These findings indicate that L-selectin is important in enabling leukocytes to respond effectively to chemotactic stimuli in inflamed tissues...
  26. ncbi Selectin-independent leukocyte rolling and adhesion in mice deficient in E-, P-, and L-selectin and ICAM-1
    S B Forlow
    Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Am J Physiol Heart Circ Physiol 280:H634-41. 2001
    ..Comparison of our data with mice lacking individual or other combinations of adhesion molecules reveal that elimination of more adhesion molecules further reduces leukocyte recruitment but the effect is less than additive...
  27. ncbi Differential expression of ICAM-1 and LFA-1 versus L-selectin and VCAM-1 in autoimmune insulitis of NOD mice and association with both Th1- and Th2-type infiltrates
    S Martin
    Diabetes Research Institute, Heinrich Heine University, Dusseldorf, Germany
    J Autoimmun 9:637-43. 1996
    ..ICAM-1 and LFA-1 expression is seen prior to L-selectin and VCAM-1. However, adhesion molecule expression during Th1 versus Th2 cell infiltration is very similar, suggesting similar adhesion molecule requirements of the two Th subsets...
  28. ncbi Lyphocyte migration in L-selectin-deficient mice. Altered subset migration and aging of the immune system
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 157:1096-106. 1996
    ..Therefore, L-selectin-dependent pathways of lymphocyte migration are important for the normal migration of both naive and memory lymphocytes...
  29. pmc Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34
    P R Baum
    Department of Gene Expression, Immunex R and D Corporation, Seattle, WA 98101
    EMBO J 13:3992-4001. 1994
    ..In addition, the HTLV-1 regulation of gp34 suggests a possible connection between virally induced pathogenesis and the OX40 system...
  30. pmc Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent
    Elena Galkina
    Department of Biomedical Engineering, University of Virginia, Health Sciences Center, Charlottesville, VA 22908, USA
    J Exp Med 203:1273-82. 2006
    ..Atherosclerosis induces the recruitment of macrophages and dendritic cells that support antigen presentation...
  31. pmc L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites
    T F Tedder
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Exp Med 181:2259-64. 1995
    ..These results demonstrate that L-selectin plays a prominent role in leukocyte homing to nonlymphoid tissues during inflammation and that blocking this process can be beneficial during pathological inflammatory responses...
  32. pmc CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells
    H Nakano
    Department of Medicine and Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 194:1171-8. 2001
    ..These cells also display a strain-specific variation in frequency, being fivefold increased in the LNs of BALB/c relative to C57BL/6 mice. These CD11c(+)CD11b(-)B220(+)Gr-1(+) cells appear to be the murine equivalent of human pDCs...
  33. ncbi The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics
    Levi G Ledgerwood
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Immunol 9:42-53. 2008
    ..Thus, the increased sphingosine 1-phosphate present in inflamed peripheral tissues may induce T cell retention and suppress T cell egress...
  34. ncbi ICAM-1-dependent pathways regulate colonic eosinophilic inflammation
    Elizabeth Forbes
    Allergy and Inflammation Research Group, Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Leukoc Biol 80:330-41. 2006
    ..These studies demonstrate that beta2 -integrin/ICAM-1-dependent pathways are integral to eosinophil recruitment into the colon during GI inflammation associated with colonic injury...
  35. ncbi Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation
    L G Ellies
    Howard Hughes Medical Institute, Division of Cellular and Molecular Medicine, University of California San Diego, La Jolla 92093, USA
    Immunity 9:881-90. 1998
    ..These studies indicate that core 2 oligosaccharide biosynthesis segregates the physiologic roles of selectins and reveal a function for the C2 GlcNAcT in myeloid homeostasis and inflammation...
  36. pmc Optimal selectin-mediated rolling of leukocytes during inflammation in vivo requires intercellular adhesion molecule-1 expression
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 95:7562-7. 1998
    ..Thus, members of the selectin and Ig families function synergistically to mediate optimal leukocyte rolling in vivo, which is essential for the generation of effective inflammatory responses...
  37. ncbi Mouse lymph node homing receptor cDNA clone encodes a glycoprotein revealing tandem interaction domains
    M H Siegelman
    Department of Pathology, Stanford University School of Medicine, CA 94305
    Science 243:1165-72. 1989
    Isolation of a clone encoding the mouse lymph node homing receptor reveals a deduced protein with an unusual protein mosaic architecture, containing a separate carbohydrate-binding (lectin) domain, an epidermal growth factor-like (EGF) ..
  38. doi Monocyte migration to inflamed skin and lymph nodes is differentially controlled by L-selectin and PSGL-1
    Beatriz León
    Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia CSIC, Universidad Autonoma, Madrid, Spain
    Blood 111:3126-30. 2008
    ....
  39. ncbi The mouse lymph node homing receptor is identical with the lymphocyte cell surface marker Ly-22: role of the EGF domain in endothelial binding
    M H Siegelman
    Department of Pathology, Stanford University School of Medicine, California 94305
    Cell 61:611-22. 1990
    The lymph node homing receptor core polypeptide (mLHRc) is composed of a tandem collection of domains: a lectin domain, an epidermal growth factor (EGF) domain, and two repeats common in complement regulatory proteins...
  40. ncbi A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo
    LiLi Tu
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 169:2034-43. 2002
    ..These results suggest that sL-selectin influences lymphocyte migration in vivo and that the increased sL-selectin levels present in certain pathologic conditions may adversely affect leukocyte migration...
  41. ncbi Purification and quantification of L-selectin-reactive GlyCAM-1 from mouse serum
    M S Singer
    Department of Anatomy, University of California, San Francisco 94143 0452, USA
    J Immunol Methods 196:153-61. 1996
    ..This material may now be used to address the biological functions of GlyCAM-1 and to further define its structural features...
  42. ncbi Molecular pathways in bone marrow homing: dominant role of alpha(4)beta(1) over beta(2)-integrins and selectins
    T Papayannopoulou
    Division of Hematology, University of Washington, Seattle 98195 7710, USA
    Blood 98:2403-11. 2001
    ....
  43. ncbi L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient mice
    M L Tang
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 158:5191-9. 1997
    ..These findings delineate an important role for L-selectin in lymphocyte recruitment to cutaneous sites of inflammation...
  44. ncbi Role of primary and secondary capture for leukocyte accumulation in vivo
    E J Kunkel
    Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville 22908, USA
    Circ Res 82:30-8. 1998
    ..Cluster formation appears to be dominated by areas of endothelium with a higher expression of E-selectin, because cluster formation is greatly reduced in E-selectin-deficient mice...
  45. ncbi Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate
    D R Coombe
    Sir William Dunn School of Pathology, University of Oxford, UK
    Blood 84:739-52. 1994
    ..The data suggest that heparan sulfate on the 3T3 cell surface is a ligand for both CD45 and Mac-1, but the two molecules recognize different heparan sulfate structural motifs...
  46. ncbi Gene-targeted mice reveal importance of L-selectin-dependent rolling for neutrophil adhesion
    U Jung
    Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville 22908, USA
    Am J Physiol 274:H1785-91. 1998
    ..We conclude that L-selectin can mediate rolling that results in sufficient leukocyte recruitment to account for the robust inflammatory response seen in E-/P- mice at later times...
  47. ncbi Overlapping roles for L-selectin and P-selectin in antigen-induced immune responses in the microvasculature
    S Kanwar
    Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    J Immunol 162:2709-16. 1999
    ..In conclusion, leukocyte rolling is L-selectin-dependent post-Ag challenge with L-selectin and P-selectin sharing overlapping functions...
  48. ncbi L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine
    Jesus Rivera-Nieves
    Digestive Health Center of Excellence, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Immunol 174:2343-52. 2005
    ..Thus, pathogenic CD4+ T cells not only use the physiologic alpha4beta7/MAdCAM-1 pathway, but alternatively engage alpha4beta1 and L-selectin to recirculate to the chronically inflamed small intestine...
  49. ncbi Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo
    Junko Matsuzaki
    Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, 060 0815, Hokkaido, Sapporo, Japan
    Cell Immunol 224:98-105. 2003
    ..antigen on various subsets of mouse spleen cells, we found that Gr-1 was expressed on memory-type CD8(+)CD44(high)CD62L(high) T cells in addition to granulocytes...
  50. doi Signals regulating L-selectin-dependent leucocyte adhesion and transmigration
    Aleksandar Ivetic
    Membrane Cytoskeleton Signalling Group, Cardiovascular Division, British Heart Foundation, Centre of Research Excellence, King s College London, London SE5 9NU, United Kingdom
    Int J Biochem Cell Biol 45:550-5. 2013
    ....
  51. ncbi Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice
    Yukiyo Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Immunol 179:698-707. 2007
    ..Thus, our findings indicate that ICAM-1 expression contributes to the development of skin fibrosis in TSK/+ mice, especially via ICAM-1 expressed on skin fibroblasts...
  52. ncbi An alternatively spliced Muc10 glycoprotein ligand for putative L-selectin binding during mouse embryonic submandibular gland morphogenesis
    M Melnick
    Laboratory for Developmental Genetics, University of Southern California, 925 W 34th Street, DEN 4266, CA 90089 0641, Los Angeles, USA
    Arch Oral Biol 46:745-57. 2001
    ..As the primary role of L-selectin is to mediate cell adhesion and its ligands are mucin-like glycoproteins, it is suggested that this embryonic low molecular-weight mucin be termed MucCAM...
  53. pmc Transcriptional regulation of mouse L-selectin
    Xitong Dang
    Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1789:146-52. 2009
    ..Silencing the expression of Sp1 by siRNA significantly decreased sell promoter activity in EL4 cells. We conclude that sell transcription is regulated by Mzf1, Klf2, Sp1, Ets1, and Irf1...
  54. doi Requirement of L-selectin for gammadelta T lymphocyte activation and migration during allergic pleurisy: co-relation with eosinophil accumulation
    Maria Fernanda S Costa
    Laboratório de Farmacologia Aplicada, Departamento de Farmacologia Aplicada, Farmanguinhos, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
    Int Immunopharmacol 9:303-12. 2009
    ..Part of these cells expressed CD62L, which increased on gammadelta T cell surfaces obtained from lymph nodes after ovalbumin (OVA) challenge...
  55. pmc Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectins
    Daniela Taverna
    Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 101:763-8. 2004
    ..These results implicate cells of the innate immune system, macrophages or perhaps natural killer cells, in each case dependent on integrins and selectins, in tumor suppression...
  56. doi Identification of novel isoforms of mouse L-selectin with different carboxyl-terminal tails
    Yuko Furukawa
    The 21st Century Center of Excellence Program, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    J Biol Chem 283:12112-9. 2008
    ..These results suggest that alternative splicing is one mechanism for generating functional diversity in L-selectin...
  57. pmc Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells
    Britt E Anderson
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA
    Blood 111:5242-51. 2008
    ..One potential explanation for the inability of T(EM) to cause GVHD is that T(EM) lack CD62L and CCR7, which are instrumental in directing naive T cells (T(N)) to lymph nodes (LN) and Peyer patches (PP), ..
  58. ncbi Absence of L-selectin delays mucosal B cell responses in nonintestinal effector tissues
    Keri L Csencsits
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    J Immunol 169:5649-59. 2002
    ..Yet, these increases in CONALT AFC correlated with restoration of immunity in L-Sel(-/-) nasal passages and reproductive tracts...
  59. ncbi Conservation of IL-6 trans-signaling mechanisms controlling L-selectin adhesion by fever-range thermal stress
    Michelle M Appenheimer
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263 0001, USA
    Eur J Immunol 37:2856-67. 2007
    ....
  60. pmc Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor
    Yann M Kerdiles
    Molecular Biology Section, Division of Biological Sciences, Department of Cellular and Molecular Medicine, University of California, San Diego, California 92093 0377, USA
    Nat Immunol 10:176-84. 2009
    ..These data suggest that Foxo1 regulates the homeostasis and life span of naive T cells by sensing growth factor availability and regulating homing and survival signals...
  61. doi Differentiation of central memory CD8 T cells is independent of CD62L-mediated trafficking to lymph nodes
    Thomas C Wirth
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 182:6195-206. 2009
    b>CD62L (L-selectin) is a key regulator of T cell trafficking, and its surface expression on activated T cells is modulated to control T cell access to lymph nodes after acute infections...
  62. pmc Platelet, not endothelial, P-selectin expression contributes to generation of immunity in cutaneous contact hypersensitivity
    Ralf J Ludwig
    Department of Dermatology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Am J Pathol 176:1339-45. 2010
    ..Our observations indicate that platelet, not endothelial, P-selectin contributes to generation of immunity in DNFB-induced contact hypersensitivity...
  63. ncbi Neonatal infection with a milk-borne virus is independent of beta7 integrin- and L-selectin-expressing lymphocytes
    Jennifer Czarneski
    Department of Microbiology, University of Pennsylvania, Philadelphia, USA
    Eur J Immunol 32:945-56. 2002
    ..These results suggest that adhesion molecules other than beta7 integrin or L-selectin play a role in lymphocyte homing in the gut, peripheral lymph nodes and mammary gland in response to MMTV infection...
  64. pmc Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression
    Laure Guenin-Macé
    Institut Pasteur, Unité de Pathogénomique Mycobactérienne Intégrée, 75015 Paris, France
    Proc Natl Acad Sci U S A 108:12833-8. 2011
    ..Our results identify T-cell homing as a biological process targeted by mycolactone. Moreover, they reveal a mechanism of control of CD62-L expression involving the miRNA let-7b...
  65. ncbi The gene for the ubiquitous octamer-binding protein Oct-1 is on human chromosome 1, region cen-q32, and near Ly-22 and Ltw-4 on mouse chromosome 1
    C L Hsieh
    Howard Hughes Medical Institute, Stanford, California
    Genomics 6:666-72. 1990
    ..There were no recombinants among 26 strains with Ly-22 and 1 recombinant among 24 strains with Ltw-4. The gene symbol is OTF1 for humans and Oct-1 for mouse...
  66. ncbi Up-regulation of leukocyte CXCR4 expression by sulfatide: an L-selectin-dependent pathway on CD4+ T cells
    Pascal Duchesneau
    Division of Thoracic Surgery, The Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Canada
    Eur J Immunol 37:2949-60. 2007
    ..Thus, the response to CXCL12 depends in part on tissue expression of sulfatide and, specifically in CD4(+) T cells, also depends on the surface level of L-selectin...
  67. pmc Neutrophil margination, sequestration, and emigration in the lungs of L-selectin-deficient mice
    N A Doyle
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Clin Invest 99:526-33. 1997
    ..coli-induced pneumonia, and in the accumulation of neutrophils within noncapillary microvessels when induced by either intravascular complement fragments or..
  68. ncbi Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis
    S J Simpson
    Division of Immunology Beth Israel Hospital, Harvard Medical School, Boston, MA 02215, USA
    Eur J Immunol 25:2618-25. 1995
    ..In light of these findings, we propose that infiltrating CD4+, but not CD8+ T cells are central to the inflammation observed in the intestinal mucosa in IL-2null colitis...
  69. ncbi Cloning of a lymphocyte homing receptor reveals a lectin domain
    L A Lasky
    Department of Cardiovascular Research, Genentech, Inc South San Francisco, California 94080
    Cell 56:1045-55. 1989
    ..This result supports a novel mechanism for the distribution of lymphocyte populations to various lymphoid organs...
  70. ncbi Genetic relationships of Mlsa among polymorphic loci on distal mouse chromosome 1
    M F Seldin
    Department of Medicine, Duke University Medical Center, Durham, NC 27710
    J Immunogenet 15:59-66. 1988
    ..The identification of multiple polymorphic loci in the region of Mlsa should allow precise gene localization and assist in efforts to clone this gene...
  71. ncbi CD62L (L-selectin) down-regulation does not affect memory T cell distribution but failure to shed compromises anti-viral immunity
    Hannah Richards
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    J Immunol 180:198-206. 2008
    The down-regulation of CD62L that accompanies T lymphocyte activation is thought to redirect cells away from lymph nodes to sites of infection...
  72. ncbi Characterization of the murine homing receptor gene reveals correspondence between protein domains and coding exons
    D J Dowbenko
    Department of Immunobiology, Genentech, Inc, South San Francisco, California 94080
    Genomics 9:270-7. 1991
    ....
  73. ncbi Genetic linkage analysis in recombinant inbred mice of P40, a putative clone for the high-affinity laminin receptor
    P J Douville
    Centre for Research in Neurosciences, Montreal General Hospital, Quebec, Canada
    Mamm Genome 3:438-46. 1992
    ..These P40 loci comprise part of a multimember gene family that is well dispersed in the mouse genome...
  74. ncbi Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA
    R J Oakey
    Department of Medicine, Duke University Medical Center, Durham, NC 27710
    Hum Mol Genet 1:613-20. 1992
    ..These data support the use of comparative mapping in physical map construction and further suggest the value of using mouse genetics to help define human disease loci...
  75. ncbi Impaired mucosal immunity in L-selectin-deficient mice orally immunized with a Salmonella vaccine vector
    D W Pascual
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    J Immunol 167:407-15. 2001
    ..This evidence shows that L-Sel is important for development of mucosal immunity, and absence of L-Sel is protective against salmonellosis...
  76. pmc Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response
    Nan Zhang
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Immunity 30:458-69. 2009
    ..These results showed that sequential migration from blood to the target tissue and to dLNs is required for Treg cells to differentiate and execute fully their suppressive function...
  77. pmc Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction
    Takayuki Ishii
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Am J Pathol 174:2225-33. 2009
    ..The IgE-mediated cutaneous reverse passive Arthus reaction may serve as an experimental model for cutaneous eosinophilic infiltration in vasculitis as well as in other diseases...
  78. ncbi T lymphocyte rolling and recruitment into peripheral lymph nodes is regulated by a saturable density of L-selectin (CD62L)
    Elena Galkina
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, London, UK
    Eur J Immunol 37:1243-53. 2007
    ....
  79. ncbi Expression of CD44 and L-selectin in the innate immune system is required for severe joint inflammation in the proteoglycan-induced murine model of rheumatoid arthritis
    Bara Sarraj
    Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    J Immunol 177:1932-40. 2006
    ..L-selectin (CD62L) and CD44 are major adhesion molecules on leukocytes that regulate their homing to lymph nodes and entry into ..
  80. pmc L-selectin shedding does not regulate constitutive T cell trafficking but controls the migration pathways of antigen-activated T lymphocytes
    Elena Galkina
    Division of Cellular Immunology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    J Exp Med 198:1323-35. 2003
    ..These results suggest that the ability to shed L-selectin is not required for T cell recirculation and homing to PLNs. However, L-selectin shedding from antigen-activated T cells prevents reentry into PLNs...
  81. pmc Mobilization of stem/progenitor cells by sulfated polysaccharides does not require selectin presence
    E A Sweeney
    Department of Medicine, Division of Hematology, University of Washington, Seattle, WA 98195 7710, USA
    Proc Natl Acad Sci U S A 97:6544-9. 2000
    ..As similarly sulfated compounds were ineffective in vivo, the data also underscore the fact that polysaccharides with similar structures may elicit diverse in vivo effects...
  82. ncbi Pathophysiologic importance of E- and L-selectin for neutrophil-induced liver injury during endotoxemia in mice
    J A Lawson
    Department of Pharmacology, Pharmacia and Upjohn, Inc, Kalamazoo, MI, USA
    Hepatology 32:990-8. 2000
    ..Therefore, we conclude that blocking E-selectin or eliminating this gene may have protected against Gal/ET-induced liver injury in vivo by inhibiting the full activation of neutrophils during the transmigration process...
  83. ncbi Natural killer cells and B lymphocytes in L-selectin and Mac-1/LFA-1 knockout mice: marker-dependent, but not cell lineage-dependent changes in the spleen and bone marrow
    Duncan Lejtenyi
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
    Immunobiology 207:129-35. 2003
    ....
  84. pmc Intercellular adhesion molecule-1 and L-selectin regulate bleomycin-induced lung fibrosis
    Yasuhito Hamaguchi
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    Am J Pathol 161:1607-18. 2002
    ..This suggests that these adhesion molecules are potential therapeutic targets for inhibiting human pulmonary fibrosis...
  85. ncbi Dermal and pulmonary inflammatory disease in E-selectin and P-selectin double-null mice is reduced in triple-selectin-null mice
    R G Collins
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Blood 98:727-35. 2001
    ..The occurrence of skin and pulmonary disease in E/P double-mutant mice but not E/L/P triple-mutant mice suggests that deficiency of L-selectin alters the inflammatory response in E/P mutants. (Blood. 2001;98:727-735)..
  86. ncbi Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells
    Satoshi Fukuyama
    Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    Immunity 17:31-40. 2002
    ....
  87. ncbi L-selectin dimerization enhances tether formation to properly spaced ligand
    Oren Dwir
    Department of Immunology, Weizmann Institute of Science, Rehovot, 76100 Israel
    J Biol Chem 277:21130-9. 2002
    ..This is the first indication that shear stress augments effective selectin ligand density at local contact sites by promoting L-selectin encounter of immobilized ligand...
  88. ncbi Role of selectins in experimental Staphylococcus aureus-induced arthritis
    M Verdrengh
    Department of Rheumatology, University of Goteborg, Sweden
    Eur J Immunol 30:1606-13. 2000
    ..aureus-induced arthritis: on the one hand, blockade of these selectins leads to less severe arthritic lesions in the initial stage of the disease; on the other, delayed recruitment of phagocytes decreases the clearance of bacteria...
  89. ncbi Changes in the expression of many Ets family transcription factors and of potential target genes in normal mammary tissue and tumors
    Christina K Galang
    OncoDevelopmental Biology Program, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 279:11281-92. 2004
    ....
  90. ncbi Expression of L-selectin, but not CD44, is required for early neutrophil extravasation in antigen-induced arthritis
    Sandor Szanto
    Section of Biochemistry and Molecular Biology, Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA
    J Immunol 172:6723-34. 2004
    L (leukocyte)-selectin (CD62L) and CD44 are major adhesion receptors that support the rolling of leukocytes on endothelium, the first step of leukocyte entry into inflamed tissue...
  91. pmc The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells
    Wook Jin Chae
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:9631-6. 2006
    ..Defects are also observed in the expression of adhesion molecules, such as l-selectin (CD62L) and CD103, suggesting an important role of glutamic acid in the migratory behavior of regulatory T cells...
  92. pmc Endogenous xenotropic murine leukemia virus-related sequences map to chromosomal regions encoding mouse lymphocyte antigens
    J C Wejman
    J Virol 50:237-47. 1984
    ..These studies indicate that xenotropic proviral loci are located on many different mouse chromosomes and may be useful markers for molecularly cloning and characterizing regions of the mouse genome important in lymphocyte development...
  93. ncbi Mapping of the gene for high-density lipoprotein binding protein (Hdlbp) to proximal mouse chromosome 1
    R C LeBoeuf
    Department of Medicine, University of Washington, Seattle 98195
    Genomics 23:296-8. 1994
  94. ncbi Endogenous nonecotropic proviruses mapped with oligonucleotide probes from the long terminal repeat region
    W N Frankel
    Jackson Laboratory, Bar Harbor, Maine 04609
    Mamm Genome 5:275-81. 1994
    ..Together with proviruses identified previously with env probes, the LTR probe-reactive elements represent the majority of endogenous murine leukemia proviruses in the mouse genome...
  95. ncbi Cloning of the cDNA for rabbit L-selectin and expression of recombinant protein with a kinase target site to facilitate radiolabeling
    J Qian
    Department of Internal Medicine, University of Michigan, Ann Arbor 48109 0531, USA
    Biochem Biophys Res Commun 225:406-12. 1996
    ..Amino-terminal peptide sequencing of recombinant L-Selectin confirmed that the signal peptide had been removed at the expected site...
  96. ncbi Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses
    Lianchun Wang
    Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California 92093 0687, USA
    Nat Immunol 6:902-10. 2005
    ....
  97. pmc Antigen-sensitized CD4+CD62Llow memory/effector T helper 2 cells can induce airway hyperresponsiveness in an antigen free setting
    Kazuyuki Nakagome
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Respir Res 6:46. 2005
    ..In the present study, we examined this possibility by cell transfer experiment, and then analyzed which cell source was essential for this process...
  98. ncbi The value of gene 'knock-out' for assessing the role of cell adhesion molecules in renal disease
    A McGinty
    Department of Medicine and Therapeutics, Mater Misericordiae Hospital, University College Dublin, Ireland
    Nephrol Dial Transplant 14:27-9. 1999
  99. ncbi Cutting edge: dichotomy of homing receptor dependence by mucosal effector B cells: alpha(E) versus L-selectin
    K L Csencsits
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    J Immunol 167:2441-5. 2001
    ..This study provides evidence for compartmentalization of the common mucosal immune system into "intestinal" vs "nonintestinal" effector sites...
  100. doi L-Selectin-deficient SJL and C57BL/6 mice are not resistant to experimental autoimmune encephalomyelitis
    Chiara Uboldi
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    Eur J Immunol 38:2156-67. 2008
    ..PL mice, may be attributed to background genes rather than L-selectin and to a unique role of L-selectin in EAE pathogenesis in MBP-TCR-transgenic mice...

Research Grants73

  1. ENDOTHELIAL CELL BIOLOGY IN INFLAMMATION
    Eugene Butcher; Fiscal Year: 2007
    ..The proposed studies should expand our understanding of the critical role of the vascular endothelium in regulating lymphocyte trafficking during normal and pathologic immune responses. ..
  2. Mucosal Lymphocyte Homing in the Head and Neck
    David Pascual; Fiscal Year: 2007
    ..n. challenge with CT. From this work, we will learn how routes of immunizations can be used to effectively target vaccines to nonintestinal mucosal sites. ..
  3. Structure/Functional Characterization of vWF-A1 Domain
    THOMAS DIACOVO; Fiscal Year: 2007
    ..Information from these studies may aid in the design of antithrombotics with specific kinetic properties that can compete with the native-ligand pair. ..
  4. Novel Dendritic Cell Chemoattractant and Receptor
    Eugene Butcher; Fiscal Year: 2009
    ..abstract_text> ..
  5. Mucosal Therapy for Autoimmunity
    David W Pascual; Fiscal Year: 2010
    ..Thus, once we are able to establish the ps1 delivery technology, we will move forward to use current models for Sj"gren's Syndrome to test if disease progression can be reduced. ..
  6. CAM Intervention for Rheumatoid Arthritis
    David Pascual; Fiscal Year: 2007
    ..This application is responsive to RFA-AT-06-005: "Mechanisms of Immune Modulation" by addressing the requested research areas in understanding CAMs' mechanisms of action upon the induction and expansion of T cell regulatory populations. ..
  7. MUCOSAL IMMUNITY ELICITED BY SALMONELLA VACCINE DELIVERY
    David Pascual; Fiscal Year: 2009
    ..Thus, from these studies we will learn the specific mechanisms induced by this anti-inflammatory vaccine. ..
  8. MUCOSAL IMMUNITY ELICITED BY SALMONELLA VACCINE DELIVERY
    David Pascual; Fiscal Year: 2007
    ..Thus, from these studies we will learn the specific mechanisms induced by this anti-inflammatory vaccine. ..
  9. MUCOSAL TRANSGENE VACCINATION FOR HIV
    David Pascual; Fiscal Year: 2003
    ..These studies will provide the basis for future development of subunit vaccines to target the NALT for eliciting protective immunity via the common mucosal immune system. ..
  10. Mucosal Vaccines for Plague
    David Pascual; Fiscal Year: 2006
    ..pestis challenge. From these studies, we will produce efficacious vaccines to plague, as well as a supporting vaccine regimen, that will confer protective immunity in the mucosal and systemic immune compartments. ..
  11. TARGETED DNA DELIVERY FOR SALIVARY IGA RESPONSES
    David Pascual; Fiscal Year: 2004
    ..These studies will provide the basis for future development of subunit vaccines to target the NALT for eliciting protective immunity in the oral cavity and SALT. ..
  12. MUCOSAL IMMUNITY ELICITED BY SALMONELLA VACCINE DELIVERY
    David Pascual; Fiscal Year: 2001
    ..abstract_text> ..
  13. A Novel Tolergenic Dendritic Cell: Biology & Therapeutic Potential
    Eugene Butcher; Fiscal Year: 2009
    ..They will test a novel approach using these cells for transplantation immunotherapy, and may lead to new insights and treatments for autoimmune, allergic and other disorders of the immune system. ..
  14. NOD2 and Uveitis
    Holly Rosenzweig; Fiscal Year: 2009
    ..The connection between a single gene and uveitis offers enormous potential to study the pathogenesis of uveitis. ..
  15. GPIb Alpha-VWF-A1 bond kinetics in health and disease
    Thomas G Diacovo; Fiscal Year: 2010
    ....
  16. Intestinal Lymphocyte Trafficking
    Eugene Butcher; Fiscal Year: 2007
    ....
  17. GLOBIN SWITCHING AND ERYTHROID DIFFERENTATION
    Thalia Papayannopoulou; Fiscal Year: 1990
    ..Successful completion of the proposed studies will provide several insights on the control of globin genes during development and differentiation...
  18. STRUCTURAL/FUNCTIONAL CHARACTERIZATION OF VWF-AL DOMAIN
    THOMAS DIACOVO; Fiscal Year: 2003
    ..Mice will be genetically engineered to express green fluorescent protein (GFP) in platelets in order to facilitate these in vivo studies. ..
  19. VASCULAR-MONOCYTE ADHESION MOLECULE IN ATHEROGENESIS
    Eugene Butcher; Fiscal Year: 2002
    ..The proposed studies will elucidate the structure of this novel vascular receptor and its role in monocyte recruitment in atherogenesis. They may lead to new approaches to the regulation of the atherogenic process. ..
  20. CCR9 AND TECK IN INTESTINAL LYMPHOCYTE TRAFFICKING
    Eugene Butcher; Fiscal Year: 2005
    ....
  21. CHEMOATTRACTANT SIGNALING TO LEUKOCYTE INTEGRINS
    Eugene Butcher; Fiscal Year: 2001
    ..These studies should define signaling mechanisms regulating the adhesion of leukocytes and other cells, and may lead to novel therapeutic approaches for the control of neoplastic and inflammatory diseases ..
  22. BIOLOGICAL PROPERTIES AND REGULATION OF STEM CELLS
    Thalia Papayannopoulou; Fiscal Year: 2004
    ....
  23. BIOLOGICAL PROPERTIES AND REGULATION OF STEM CELLS
    Thalia Papayannopoulou; Fiscal Year: 2009
    ..We believe that the proposed studies will enhance our understanding and provide a more comprehensive picture of the influence of <x4 integrins on prenatal and postnatal hematopoiesis. ..
  24. Conference on Leukocyte Trafficking
    Eugene Butcher; Fiscal Year: 2004
    ..abstract_text> ..