Ksr1

Summary

Gene Symbol: Ksr1
Description: kinase suppressor of ras 1
Alias: AW492498, B-KSR1, D11Bhm183e, D11Bhm184e, Ksr, RSU2, mKSR1, kinase suppressor of Ras 1, protein Hb
Species: mouse
Products:     Ksr1

Top Publications

  1. Kortum R, Lewis R. The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells. Mol Cell Biol. 2004;24:4407-16 pubmed
    ..Here we demonstrate that the molecular scaffold KSR1 regulates the intensity and duration of ERK activation to modulate a cell's proliferative and oncogenic potential...
  2. Giurisato E, Lin J, Harding A, Cerutti E, Cella M, Lewis R, et al. The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse. Mol Cell Biol. 2009;29:1554-64 pubmed publisher
    b>KSR1 is a mitogen-activated protein (MAP) kinase scaffold that enhances the activation of the MAP kinase extracellular signal-regulated kinase (ERK). The function of KSR1 in NK cell function is not known...
  3. Ory S, Zhou M, Conrads T, Veenstra T, Morrison D. Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites. Curr Biol. 2003;13:1356-64 pubmed
    ..Although recruitment of KSR1 from the cytosol to the plasma membrane is required for its scaffolding function, the precise mechanism(s) ..
  4. Costanzo Garvey D, Pfluger P, Dougherty M, Stock J, Boehm M, Chaika O, et al. KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity. Cell Metab. 2009;10:366-78 pubmed publisher
    Kinase suppressors of Ras 1 and 2 (KSR1 and KSR2) function as molecular scaffolds to potently regulate the MAP kinases ERK1/2 and affect multiple cell fates. Here we show that KSR2 interacts with and modulates the activity of AMPK...
  5. Shalin S, Hernandez C, Dougherty M, Morrison D, Sweatt J. Kinase suppressor of Ras1 compartmentalizes hippocampal signal transduction and subserves synaptic plasticity and memory formation. Neuron. 2006;50:765-79 pubmed
    ..We report that kinase suppressor of Ras (KSR1) functions biochemically in the hippocampus to scaffold the components of the ERK cascade, specifically regulating ..
  6. McKay M, Ritt D, Morrison D. RAF inhibitor-induced KSR1/B-RAF binding and its effects on ERK cascade signaling. Curr Biol. 2011;21:563-8 pubmed publisher
    ..In this study, we find that most RAF inhibitors also induce the binding of KSR1 to wild-type and oncogenic B-RAF proteins, including V600E B-RAF, but promote little complex formation between KSR1 ..
  7. Llobet D, Eritja N, Domingo M, Bergada L, Mirantes C, Santacana M, et al. KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels. Am J Pathol. 2011;178:1529-43 pubmed publisher
    ..b>Kinase suppressor of Ras 1 (KSR1) can interact with various kinases of the Raf/MEK/extracellular signal-regulated kinase pathway to ..
  8. Fernandez M, Henry M, Lewis R. Kinase suppressor of Ras 2 (KSR2) regulates tumor cell transformation via AMPK. Mol Cell Biol. 2012;32:3718-31 pubmed publisher
    b>Kinase suppressor of Ras 1 (KSR1) and KSR2 are scaffolds that promote extracellular signal-regulated kinase (ERK) signaling but have dramatically different physiological functions...
  9. Kortum R, Costanzo D, Haferbier J, Schreiner S, Razidlo G, Wu M, et al. The molecular scaffold kinase suppressor of Ras 1 (KSR1) regulates adipogenesis. Mol Cell Biol. 2005;25:7592-604 pubmed
    ..Here, we titrate expression of the molecular scaffold kinase suppressor of Ras 1 (KSR1) to regulate signaling through the Raf/MEK/ERK/p90 ribosomal S6 kinase (RSK) kinase cascade and ..

More Information

Publications64

  1. Nguyen A, Burack W, Stock J, Kortum R, Chaika O, Afkarian M, et al. Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol Cell Biol. 2002;22:3035-45 pubmed
    ..analyze a potential scaffold of the Ras/mitogen-activated protein kinase (MAPK) pathway, kinase suppressor of Ras (KSR), by generating KSR-deficient mice...
  2. Gramling M, Eischen C. Suppression of Ras/Mapk pathway signaling inhibits Myc-induced lymphomagenesis. Cell Death Differ. 2012;19:1220-7 pubmed publisher
    ..Deletion of the scaffold protein kinase suppressor of Ras 1 (Ksr1) attenuated signaling through the Ras/Mapk pathway, including activation following Myc induction...
  3. Lozano J, Xing R, Cai Z, Jensen H, Trempus C, Mark W, et al. Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice. Cancer Res. 2003;63:4232-8 pubmed
    ..The precise signaling mechanism of mammalian KSR1 and its role in Ras-mediated transformation, however, remain uncertain...
  4. Razidlo G, Kortum R, Haferbier J, Lewis R. Phosphorylation regulates KSR1 stability, ERK activation, and cell proliferation. J Biol Chem. 2004;279:47808-14 pubmed
    ..Phosphorylation of KSR1, particularly at Ser(392), is a critical regulator of KSR1 subcellular localization and ERK activation...
  5. Kortum R, Johnson H, Costanzo D, Volle D, Razidlo G, Fusello A, et al. The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence. Mol Cell Biol. 2006;26:2202-14 pubmed
    ..We show that Kinase Suppressor of Ras 1 (KSR1), a molecular scaffold for the Raf/MEK/ERK cascade, is necessary for RasV12-induced senescence, ..
  6. Muller J, Ory S, Copeland T, Piwnica Worms H, Morrison D. C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. Mol Cell. 2001;8:983-93 pubmed
    ..Here we show that KSR1 translocates from the cytoplasm to the cell surface in response to growth factor treatment and that this process is ..
  7. Yu W, Fantl W, Harrowe G, Williams L. Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK. Curr Biol. 1998;8:56-64 pubmed
    Genetic screens in Drosophila melanogaster and Caenorhabditis elegans identified the kinase suppressor of Ras, Ksr, as a new component in the Ras intracellular signaling pathway...
  8. Razidlo G, Johnson H, Stoeger S, Cowan K, Bessho T, Lewis R. KSR1 is required for cell cycle reinitiation following DNA damage. J Biol Chem. 2009;284:6705-15 pubmed publisher
    KSR1 (kinase suppressor of Ras 1) is a molecular scaffold and positive regulator of the Raf/MEK/ERK phosphorylation cascade. KSR1 is required for maximal ERK activation induced by growth factors and by some cytotoxic agents...
  9. McKay M, Ritt D, Morrison D. Signaling dynamics of the KSR1 scaffold complex. Proc Natl Acad Sci U S A. 2009;106:11022-7 pubmed publisher
    Scaffold proteins contribute to the spatiotemporal control of MAPK signaling and KSR1 is an ERK cascade scaffold that localizes to the plasma membrane in response to growth factor treatment...
  10. Smith F, Langeberg L, Cellurale C, Pawson T, Morrison D, Davis R, et al. AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nat Cell Biol. 2010;12:1242-9 pubmed publisher
    ..We demonstrate that the A-kinase-anchoring protein AKAP-Lbc and the scaffolding protein kinase suppressor of Ras (KSR-1) form the core of a signalling network that efficiently relay signals from RAF, through MEK, and on to ERK1/2...
  11. Dougherty M, Ritt D, Zhou M, Specht S, Monson D, Veenstra T, et al. KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals. Mol Cell. 2009;34:652-62 pubmed publisher
    ..Using a proteomics approach to compare the binding partners of the two mammalian KSR scaffolds, we find that both KSR1 and KSR2 interact with the kinase components of the ERK cascade and have a common function in promoting RTK-..
  12. Fernández I, Pérez Rivas L, Blanco S, Castillo Dominguez A, Lozano J, Lazo P. VRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signaling. Cell Mol Life Sci. 2012;69:3881-93 pubmed publisher
    ..The scaffold KSR1 protein interacts with MAPK forming a complex that conveys a differential signaling in response to growth factors...
  13. Muller J, Cacace A, Lyons W, McGill C, Morrison D. Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling. Mol Cell Biol. 2000;20:5529-39 pubmed
    ..Here, we report the identification of B-KSR1, a novel splice variant of murine KSR1 that is highly expressed in brain-derived tissues...
  14. Kortum R, Fernandez M, Costanzo Garvey D, Johnson H, Fisher K, Volle D, et al. Caveolin-1 is required for kinase suppressor of Ras 1 (KSR1)-mediated extracellular signal-regulated kinase 1/2 activation, H-RasV12-induced senescence, and transformation. Mol Cell Biol. 2014;34:3461-72 pubmed publisher
    The molecular scaffold kinase suppressor of Ras 1 (KSR1) regulates the activation of the Raf/MEK/extracellular signal-regulated kinase (ERK) signal transduction pathway...
  15. Roring M, Herr R, Fiala G, Heilmann K, Braun S, Eisenhardt A, et al. Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling. EMBO J. 2012;31:2629-47 pubmed publisher
    ..Our data further implicate the Raf DIF as a potential target against Ras-driven Raf-mediated (paradoxical) ERK activation. ..
  16. Laurent M, Ramirez D, Alberola Ila J. Kinase suppressor of Ras couples Ras to the ERK cascade during T cell development. J Immunol. 2004;173:986-92 pubmed
    ..Recently, the scaffolding molecule kinase suppressor of Ras (KSR) was isolated in genetic screens as a modifier of Ras signaling, although its contribution to regulating Ras-..
  17. Shen C, Yuan P, Perez Lorenzo R, Zhang Y, Lee S, Ou Y, et al. Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation. Mol Cell. 2013;52:161-72 pubmed publisher
    ..This phosphorylation promotes the association of BRAF with 14-3-3 proteins and disrupts its interaction with the KSR1 scaffolding protein, leading to attenuation of the MEK-ERK signaling...
  18. McKay M, Morrison D. Caspase-dependent cleavage disrupts the ERK cascade scaffolding function of KSR1. J Biol Chem. 2007;282:26225-34 pubmed
    b>Kinase suppressor of Ras 1 (KSR1) is a protein scaffold that facilitates ERK cascade activation at the plasma membrane, a critical step in the signal transduction process that allows cells to respond to survival, proliferative, and ..
  19. Jung H, Seong H, Ha H. NM23-H1 tumor suppressor and its interacting partner STRAP activate p53 function. J Biol Chem. 2007;282:35293-307 pubmed
    ..These results suggest that NM23-H1 and its interacting partner STRAP physically interact with p53 and positively regulate its functions, including p53-induced apoptosis and cell cycle arrest. ..
  20. Filbert E, Le Borgne M, Lin J, Heuser J, Shaw A. Stathmin regulates microtubule dynamics and microtubule organizing center polarization in activated T cells. J Immunol. 2012;188:5421-7 pubmed publisher
    ..These data implicate stathmin as a regulator of the microtubule network during T cell activation. ..
  21. Quiel A, Jürgen B, Greinacher A, Lassen S, Wörl R, Witt S, et al. Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip. Biosens Bioelectron. 2012;36:207-11 pubmed publisher
    ..With this electrical chip assay it is possible to detect antibodies against HPA-1a, HPA-5b and HLA with high sensitivity and specificity in less than half the duration of the MAIPA protocol with similar intra- and interassay variance. ..
  22. Le Borgne M, Filbert E, Shaw A. Kinase suppressor of Ras 1 is not required for the generation of regulatory and memory T cells. PLoS ONE. 2013;8:e57137 pubmed publisher
    ..Absence of kinase suppressor of Ras 1 (KSR1), a scaffold protein of the ERK signaling pathway, or inhibition of ERK resulted in decreased ..
  23. Filbert E, Nguyen A, Markiewicz M, Fowlkes B, Huang Y, Shaw A. Kinase suppressor of Ras 1 is required for full ERK activation in thymocytes but not for thymocyte selection. Eur J Immunol. 2010;40:3226-34 pubmed publisher
    The scaffold protein kinase suppressor of Ras 1 (KSR1) is critical for efficient activation of ERK in a number of cell types. Consistent with this, we observed a defect in ERK activation in thymocytes that lack KSR1...
  24. Cullis J, Meiri D, Sandi M, Radulovich N, Kent O, Medrano M, et al. The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1. Cancer Cell. 2014;25:181-95 pubmed publisher
    Cellular transformation by oncogenic RAS engages the MAPK pathway under strict regulation by the scaffold protein KSR-1...
  25. Rinaldi L, Delle Donne R, Sepe M, Porpora M, Garbi C, Chiuso F, et al. praja2 regulates KSR1 stability and mitogenic signaling. Cell Death Dis. 2016;7:e2230 pubmed publisher
    The kinase suppressor of Ras 1 (KSR1) has a fundamental role in mitogenic signaling by scaffolding components of the Ras/MAP kinase pathway...
  26. Takahashi M, Li Y, Dillon T, Stork P. Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP. J Biol Chem. 2017;292:1449-1461 pubmed publisher
    ..create potential binding sites for the adaptor protein 14-3-3 that links Rap1 to the scaffold protein KSR. These results suggest that Rap1 activation of ERKs requires PKA phosphorylation and KSR binding...
  27. Casar B, Arozarena I, Sanz Moreno V, Pinto A, Agudo Ibáñez L, Marais R, et al. Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins. Mol Cell Biol. 2009;29:1338-53 pubmed publisher
    ..As such, we show that for cPLA(2) activation, ERK1/2 activated at lipid rafts interact with KSR1, whereas ERK1/2 activated at the endoplasmic reticulum utilize Sef-1...
  28. Yan F, John S, Wilson G, Jones D, Washington M, Polk D. Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation. J Clin Invest. 2004;114:1272-80 pubmed
    ..In vitro studies suggest that kinase suppressor of Ras-1 (KSR1) is an essential regulatory kinase for TNF-stimulated survival pathways in intestinal epithelial cell lines...
  29. Hartsough M, Morrison D, Salerno M, Palmieri D, Ouatas T, Mair M, et al. Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway. J Biol Chem. 2002;277:32389-99 pubmed
    ..previously reported to be c-Raf; we now report that CTR1 also exhibits homology to the kinase suppressor of Ras (KSR), a scaffold protein for the mitogen-activated protein kinase (MAPK) cascade...
  30. Zhou M, Horita D, Waugh D, Byrd R, Morrison D. Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of Ras (KSR). J Mol Biol. 2002;315:435-46 pubmed
    ..proteins contain a conserved cysteine-rich C1 domain, and studies have implicated this domain in the regulation of KSR1 subcellular localization and function...
  31. Xing H, Kornfeld K, Muslin A. The protein kinase KSR interacts with 14-3-3 protein and Raf. Curr Biol. 1997;7:294-300 pubmed
    b>KSR (kinase suppressor of Ras) is a recently identified putative protein kinase that positively mediates the Ras signaling pathway in the invertebrates Caenorhabditis elegans and Drosophila melanogaster...
  32. Fusello A, Mandik Nayak L, Shih F, Lewis R, Allen P, Shaw A. The MAPK scaffold kinase suppressor of Ras is involved in ERK activation by stress and proinflammatory cytokines and induction of arthritis. J Immunol. 2006;177:6152-8 pubmed
    ..scaffold kinase suppressor of Ras (KSR)1 is required for efficient Erk activation by mitogenic stimuli, the role of KSR1 in ERK activation by inflammatory and stress stimuli is unknown...
  33. Ritt D, Zhou M, Conrads T, Veenstra T, Copeland T, Morrison D. CK2 Is a component of the KSR1 scaffold complex that contributes to Raf kinase activation. Curr Biol. 2007;17:179-84 pubmed
    ..In this report, we identify the heterotetrameric protein kinase, casein kinase 2 (CK2), as a new KSR1-binding partner...
  34. Goettel J, Liang D, Hilliard V, Edelblum K, Broadus M, Gould K, et al. KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1. Exp Cell Res. 2011;317:452-63 pubmed publisher
    ..Kinase suppressor of Ras-1 (KSR1) binds each of the three ERK cascade components to facilitate pathway activation...
  35. Goettel J, Scott Algood H, Olivares Villagómez D, Washington M, Chaturvedi R, Wilson K, et al. KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-? production. Gastroenterology. 2011;140:265-74 pubmed publisher
    ..b>Kinase suppressor of Ras 1 (KSR1) is involved in tumor necrosis factor-mediated colon epithelial cell survival, yet its role in ..
  36. Salerno M, Palmieri D, Bouadis A, Halverson D, Steeg P. Nm23-H1 metastasis suppressor expression level influences the binding properties, stability, and function of the kinase suppressor of Ras1 (KSR1) Erk scaffold in breast carcinoma cells. Mol Cell Biol. 2005;25:1379-88 pubmed
    ..We previously reported that the Kinase Suppressor of Ras1 (KSR1) scaffold protein for the Erk mitogen-activated protein kinase pathway coimmunoprecipitated the metastasis ..
  37. Canal F, Palygin O, Pankratov Y, Corrêa S, Muller J. Compartmentalization of the MAPK scaffold protein KSR1 modulates synaptic plasticity in hippocampal neurons. FASEB J. 2011;25:2362-72 pubmed publisher
    ..Here, we show that the MAPK scaffold protein kinase suppressor of Ras 1 (KSR1) is directly phosphorylated by the downstream kinase ERK1/2...
  38. Koveal D, Schuh Nuhfer N, Ritt D, Page R, Morrison D, Peti W. A CC-SAM, for coiled coil-sterile ? motif, domain targets the scaffold KSR-1 to specific sites in the plasma membrane. Sci Signal. 2012;5:ra94 pubmed publisher
    Kinase suppressor of Ras-1 (KSR-1) is an essential scaffolding protein that coordinates the assembly of the mitogen-activated protein kinase (MAPK) module, consisting of the MAPK kinase kinase Raf, the MAPK kinase MEK (mitogen-activated ..
  39. Nehls M, Lüno K, Schorpp M, Pfeifer D, Krause S, Matysiak Scholze U, et al. YAC/P1 contigs defining the location of 56 microsatellite markers and several genes across a 3.4-cM interval on mouse chromosome 11. Mamm Genome. 1995;6:321-31 pubmed
    ..In the cryb1/Nf1 interval of the central contig, several new genes have been identified by exon trapping and precisely localized with respect to known STS markers. ..
  40. Li X, Gulbins E, Zhang Y. Role of kinase suppressor of ras-1 in lipopolysaccharide-induced acute lung injury. Cell Physiol Biochem. 2012;30:905-14 pubmed publisher
    Kinase suppressor of ras-1 (Ksr1) has been recently shown to be a central signaling molecule in the host response to Pseudomonas aeruginosa infections in the lung...
  41. Chen C, Fan J, Chuang N. Effects of prenyl pyrophosphates on the binding of S-Ras proteins with KSR. J Exp Zool. 2002;293:551-60 pubmed
    ..2001. J. Exp. Zool. 289:441-448). On a Western blot, the kinase suppressor of Ras (KSR) in the membrane fraction was expressed at slightly reduced level as compared to that of the untransformed cells...
  42. Denouel Galy A, Douville E, Warne P, Papin C, Laugier D, Calothy G, et al. Murine Ksr interacts with MEK and inhibits Ras-induced transformation. Curr Biol. 1998;8:46-55 pubmed
    b>Ksr (kinase supressor of Ras) was identified as a regulator of the Ras-MAP kinase (mitogen-activated protein kinase) pathway by genetic screens in Drosophila and Caenorhabditis elegans...
  43. Sibilski C, Mueller T, Kollipara L, Zahedi R, Rapp U, Rudel T, et al. Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase. J Biol Chem. 2013;288:35237-52 pubmed publisher
    ..b>KSR1 functions as an essential scaffold that binds the individual components of the cascade and coordinates their ..
  44. Therrien M, Chang H, Solomon N, Karim F, Wassarman D, Rubin G. KSR, a novel protein kinase required for RAS signal transduction. Cell. 1995;83:879-88 pubmed
    ..The other encodes a protein kinase that we have named kinase suppressor of ras (ksr). By genetic criteria, we show that KSR functions in multiple receptor tyrosine kinase pathways...
  45. Roy F, Therrien M. MAP kinase module: the Ksr connection. Curr Biol. 2002;12:R325-7 pubmed
    b>Ksr has been genetically defined as a component of the Ras/MAP kinase pathway, but its role has been unclear...
  46. Giblett S, Lloyd D, Light Y, Marais R, Pritchard C. Expression of kinase suppressor of Ras in the normal adult and embryonic mouse. Cell Growth Differ. 2002;13:307-13 pubmed
    Recent studies indicate that kinase suppressor of Ras (KSR)is a scaffold protein for the Ras/Raf/MEK/ERK signaling cascade in mammals...
  47. Matheny S, Chen C, Kortum R, Razidlo G, Lewis R, White M. Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP. Nature. 2004;427:256-60 pubmed
    ..activation by limiting functional assembly of the core enzymatic components through the inactivation of KSR, a scaffold/adaptor protein that couples activated Raf to its substrate MEK...
  48. Klutho P, Costanzo Garvey D, Lewis R. Regulation of glucose homeostasis by KSR1 and MARK2. PLoS ONE. 2011;6:e29304 pubmed publisher
    ..b>KSR1 is a molecular scaffold of the Raf/MEK/ERK MAP kinase cascade that regulates the intensity and duration of ERK ..
  49. Zhang Y, Li X, Carpinteiro A, Goettel J, Soddemann M, Gulbins E. Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections. Nat Med. 2011;17:341-6 pubmed publisher
    ..Here we show that kinase suppressor of Ras-1 (Ksr1)-deficient mice are highly susceptible to pulmonary P...
  50. Stewart S, Sundaram M, Zhang Y, Lee J, Han M, Guan K. Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. Mol Cell Biol. 1999;19:5523-34 pubmed
    Genetic screens for modifiers of activated Ras phenotypes have identified a novel protein, kinase suppressor of Ras (KSR), which shares significant sequence homology with Raf family protein kinases...
  51. Chen M, Burgin S, Staser K, He Y, Li X, Robinson M, et al. Kinase suppressor of Ras (KSR1) modulates multiple kit-ligand-dependent mast cell functions. Exp Hematol. 2011;39:969-76 pubmed publisher
    ..The kinase suppressor of Ras (KSR1) protein is known to function as a molecular scaffold and coordinates the organization of Raf/Mek/Erk in response ..
  52. Baljuls A, Dobrzynski M, Rauch J, Rauch N, Kolch W. Stabilization of C-RAF:KSR1 complex by DiRas3 reduces availability of C-RAF for dimerization with B-RAF. Cell Signal. 2016;28:1451-62 pubmed publisher
    ..Here we show that DiRas3 binds to KSR1 independently of its interaction with activated Ras and RAF...
  53. Chen C, Lewis R, White M. IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds. J Biol Chem. 2008;283:12789-96 pubmed publisher
    ..of autodegradation and can modulate signal/response thresholds by directly limiting the assembly of functional KSR1-dependent Raf.MEK complexes...
  54. Janssen R, Kim P, Mier J, Morrison D. Overexpression of kinase suppressor of Ras upregulates the high-molecular-weight tropomyosin isoforms in ras-transformed NIH 3T3 fibroblasts. Mol Cell Biol. 2003;23:1786-97 pubmed
    ..Here, we report that overexpression of wild-type KSR1 in ras-transformed fibroblasts restores TM expression and induces cell flattening and stress fiber formation...
  55. Yan F, John S, Polk D. Kinase suppressor of Ras determines survival of intestinal epithelial cells exposed to tumor necrosis factor. Cancer Res. 2001;61:8668-75 pubmed
    ..Our laboratory reported that kinase suppressor of Ras (KSR) regulates TNF activation of the Raf/mitogen-activated protein (MAP) kinase/extracellular signal-regulated kinase (..