Gene Symbol: Krt71
Description: keratin 71
Alias: AA589543, Cal4, Krt2-6g, mK6irs, mK6irs1, keratin, type II cytoskeletal 71, CK-6G, CK-71, K6G, K71, caracul, cytokeratin-6G, cytokeratin-71, keratin complex 2, basic, gene 6g, keratin complex 2, gene 6g, keratin-6G, mK6irs1/Krt2-6g, type II inner root sheath-specific keratin-K6irs1, type-II keratin Kb34
Species: mouse
Products:     Krt71

Top Publications

  1. Horton C, Davisson M, Jacobs J, Bernstein G, Retik A, Mandell J. Congenital progressive hydronephrosis in mice: a new recessive mutation. J Urol. 1988;140:1310-5 pubmed
    ..The cph mouse strain provides a reproducible model for analysis of the onset and development of obstructive uropathic conditions in the neonatal period. ..
  2. Shimomura Y, Wajid M, Petukhova L, Kurban M, Christiano A. Autosomal-dominant woolly hair resulting from disruption of keratin 74 (KRT74), a potential determinant of human hair texture. Am J Hum Genet. 2010;86:632-8 pubmed publisher
    ..Furthermore, we sequenced the mouse Krt71-74 genes in the dominant Caracul-like 4 (Cal4) allele, which is characterized by a wavy-coat phenotype and maps to the same region of mouse ..
  3. Poirier C, Yoshiki A, Fujiwara K, Guenet J, Kusakabe M. Hague (Hag). A new mouse hair mutation with an unstable semidominant allele. Genetics. 2002;162:831-40 pubmed
    ..Fourteen genes were mapped to this region; of these, 11 were expressed in the skin (5 epidermic cytokeratin and 6 hard keratin genes), but none were mutated in hague mice. ..
  4. Di Pasquale E, Keegan K, Noebels J. Increased excitability and inward rectification in layer V cortical pyramidal neurons in the epileptic mutant mouse Stargazer. J Neurophysiol. 1997;77:621-31 pubmed
    ..This defect could lower the threshold for aberrant thalamocortical spike wave oscillations in vivo, and may contribute to the mechanism of one form of inherited absence epilepsy...
  5. Hogan M, King L, Sundberg J. Defects of pelage hairs in 20 mouse mutations. J Invest Dermatol. 1995;104:31S-32S pubmed
  6. Masuya H, Inoue M, Wada Y, Shimizu A, Nagano J, Kawai A, et al. Implementation of the modified-SHIRPA protocol for screening of dominant phenotypes in a large-scale ENU mutagenesis program. Mamm Genome. 2005;16:829-37 pubmed
    ..They could hold great potential for the unraveling of the molecular mechanisms of certain phenotypes. ..
  7. Peters T, Sedlmeier R, Bussow H, Runkel F, Lüers G, Korthaus D, et al. Alopecia in a novel mouse model RCO3 is caused by mK6irs1 deficiency. J Invest Dermatol. 2003;121:674-80 pubmed
    ..Recently, mK6irs1 was described as a type II keratin expressed in Henle's and Huxley's layer of the murine inner root sheath...
  8. Blanco S, Kurowski A, Nichols J, Watt F, Benitah S, Frye M. The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate. PLoS Genet. 2011;7:e1002403 pubmed publisher
    ..Our results reveal that post-transcriptional RNA methylation can play a previously unappreciated role in controlling stem cell fate. ..
  9. Kikkawa Y, Oyama A, Ishii R, Miura I, Amano T, Ishii Y, et al. A small deletion hotspot in the type II keratin gene mK6irs1/Krt2-6g on mouse chromosome 15, a candidate for causing the wavy hair of the caracul (Ca) mutation. Genetics. 2003;165:721-33 pubmed
    ..Applying a positional cloning approach, we identified the mK6irs1/Krt2-6g gene as a strong candidate for Ca(Rin) because among five Ca alleles examined mutations always occurred ..

More Information


  1. Wallace M, Mallyon S. Unusual recombination values and the mapping of the lethal miniature in the house mouse. Genet Res. 1972;20:257-62 pubmed
  2. Runkel F, Klaften M, Koch K, Böhnert V, Bussow H, Fuchs H, et al. Morphologic and molecular characterization of two novel Krt71 (Krt2-6g) mutations: Krt71rco12 and Krt71rco13. Mamm Genome. 2006;17:1172-82 pubmed
    ..mutations were mapped to mouse Chromosome 15 and identified as missense point mutations in the first exon of the Krt71 (formerly called Krt2-6g) gene causing alterations of amino acid residue 143 from alanine to glycine (Rco12) and ..
  3. Lane P, Liu H. Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984;75:435-9 pubmed
    ..6 +/- 1.6 units proximal to Ca. Hairy ears, Eh, a semidominant gene also on chr 15 is shown to have a suppressing effect on crossing over in this section of chr 15. ..
  4. Sweet H, Green M. Progressive ankylosis, a new skeletal mutation in the mouse. J Hered. 1981;72:87-93 pubmed
    ..The new mutation is closely linked, with about 4 percent recombination, to underwhite on chr 15. ..
  5. Stieler C, Hollander W. Location of the velvet coat mutant in linkage group VI of the mouse. J Hered. 1972;63:212-4 pubmed
  6. Sidman R, Kinney H, Sweet H. Transmissible spongiform encephalopathy in the gray tremor mutant mouse. Proc Natl Acad Sci U S A. 1985;82:253-7 pubmed
    Gray tremor (gt) is an autosomal recessive mutation in the mouse linked to caracul (Ca) on chromosome 15...
  7. Dai D, Li L, Huebner A, Zeng H, Guevara E, Claypool D, et al. Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia. Cell Death Differ. 2013;20:130-8 pubmed publisher
  8. Kiso M, Tanaka S, Saba R, Matsuda S, Shimizu A, Ohyama M, et al. The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice. Proc Natl Acad Sci U S A. 2009;106:9292-7 pubmed publisher
    ..These results indicate that Sox21 is a master regulator of hair shaft cuticle differentiation and shed light on the possible causes of human hair disorders. ..
  9. Aoki N, Sawada S, Rogers M, Schweizer J, Shimomura Y, Tsujimoto T, et al. A novel type II cytokeratin, mK6irs, is expressed in the Huxley and Henle layers of the mouse inner root sheath. J Invest Dermatol. 2001;116:359-65 pubmed
    ..Taken together the sum of the data analyzed, we have termed this novel cytokeratin mK6irs (mouse gene nomenclature k2-6g) to indicate both its similar mobility with K6 in two-dimensional gels and its ..
  10. Jin C, Chen J, Meng Q, Carreira V, Tam N, Geh E, et al. Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis. Dev Biol. 2013;374:96-107 pubmed publisher
    ..Using LCM and expression array, our studies have uncovered novel molecular signatures of MAP3K1 in embryonic eyelid closure. ..
  11. Beier D, Morton C, Leder A, Wallace R, Leder P. Perinatal lethality (ple): a mutation caused by integration of a transgene into distal mouse chromosome 15. Genomics. 1989;4:498-504 pubmed
    ..15 by in situ analysis and is tightly linked genetically to a cluster of loci that include the mutations caracul (Ca) and microcytic anemia (mk)...
  12. Porter R, Corden L, Lunny D, Smith F, Lane E, McLean W. Keratin K6irs is specific to the inner root sheath of hair follicles in mice and humans. Br J Dermatol. 2001;145:558-68 pubmed
    ..In addition, this keratin represents a new candidate gene for inherited structural hair defects such as loose anagen syndrome. ..
  13. Tanaka S, Miura I, Yoshiki A, Kato Y, Yokoyama H, Shinogi A, et al. Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament. Genomics. 2007;90:703-11 pubmed
    ..analysis revealed abnormal foam-like immunoreactivity with an antibody raised to type II IRS keratin K71 in the IRS of Re/+ mice...
  14. Teicher L, Caspari E. The genetics of blind--a lethal factor in mice. J Hered. 1978;69:86-90 pubmed
    ..Evidence is presented for the presence of X-linked modifiers affecting the penetrance and possible increased viability of Bld in strain DBA. ..
  15. Handa S, Ferguson J, Wallace M, Bulfield G. Characterization and mapping of a viable anaemic mutant in the mouse: a new allele, mkvan, at the microcytic anaemia locus. Genet Res. 1988;51:41-5 pubmed
  16. Dai D, Zhu H, Wlodarczyk B, Zhang L, Li L, Li A, et al. Fuz controls the morphogenesis and differentiation of hair follicles through the formation of primary cilia. J Invest Dermatol. 2011;131:302-10 pubmed publisher
  17. Noebels J, Qiao X, Bronson R, Spencer C, Davisson M. Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures. Epilepsy Res. 1990;7:129-35 pubmed
  18. Davisson M, Roderick T, Akeson E, Hawes N, Sweet H. The hairy ears (Eh) mutation is closely associated with a chromosomal rearrangement in mouse chromosome 15. Genet Res. 1990;56:167-78 pubmed shows tight linkage with several loci occupying the region extending from congenital goiter (cog) distal to caracul (Ca)...