Gene Symbol: Kmt2e
Description: lysine (K)-specific methyltransferase 2E
Alias: 1810033J14Rik, 9530077A04Rik, D230038D11Rik, Mll5, NKp44L, inactive histone-lysine N-methyltransferase 2E, histone-lysine N-methyltransferase 2E, histone-lysine N-methyltransferase MLL5, inactive lysine N-methyltransferase 2E, lysine N-methyltransferase 2E, myeloid/lymphoid or mixed-lineage leukemia 5, myeloid/lymphoid or mixed-lineage leukemia protein 5 homolog
Sebastian S, Sreenivas P, Sambasivan R, Cheedipudi S, Kandalla P, Pavlath G, et al
. MLL5, a trithorax homolog, indirectly regulates H3K4 methylation, represses cyclin A2 expression, and promotes myogenic differentiation. Proc Natl Acad Sci U S A. 2009;106:4719-24 pubmed publisher
..in conditional quiescence by analyzing the function of a predicted chromatin regulator mixed lineage leukemia 5 (MLL5) in a culture model of reversible arrest...
Zhang Y, Wong J, Klinger M, Tran M, Shannon K, Killeen N. MLL5 contributes to hematopoietic stem cell fitness and homeostasis. Blood. 2009;113:1455-63 pubmed publisher
b>MLL5 is a novel trithorax group gene and a candidate tumor suppressor gene located within a 2.5-Mb interval of chromosome band 7q22 that frequently is deleted in human myeloid malignancy...
Heuser M, Yap D, Leung M, de Algara T, Tafech A, McKinney S, et al
. Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation. Blood. 2009;113:1432-43 pubmed publisher
b>MLL5 is a divergent member of the Drosophila Trithorax-related (SET) domain and plant homeodomain (PHD) domain-containing chromatin regulators that are involved in the regulation of transcriptional "memory" during ..
Madan V, Madan B, Brykczynska U, Zilbermann F, Hogeveen K, Dohner K, et al
. Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5. Blood. 2009;113:1444-54 pubmed publisher
The human Mixed-Lineage-Leukemia-5 (MLL5) gene is located in a genomic region frequently deleted in patients with myeloid malignancies and encodes a widely expressed nuclear protein most closely related to MLL1, a Trithorax ..
Dahl J, Jung I, Aanes H, Greggains G, Manaf A, Lerdrup M, et al
. Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition. Nature. 2016;537:548-552 pubmed publisher
..Our results provide insight into the onset of the developmental program in mouse embryos and demonstrate a role for broad H3K4me3 domains in MZT. ..
Waskow C, Madan V, Bartels S, Costa C, Blasig R, Rodewald H. Hematopoietic stem cell transplantation without irradiation. Nat Methods. 2009;6:267-9 pubmed publisher
Cheng F, Liu J, Teh C, Chong S, Korzh V, Jiang Y, et al
. Camptothecin-induced downregulation of MLL5 contributes to the activation of tumor suppressor p53. Oncogene. 2011;30:3599-611 pubmed publisher
Mixed lineage leukemia 5 (MLL5) has been implicated in multiple aspects of cell physiology, such as hematopoiesis, cell cycle control and chromatin regulatory network...
Yap D, Walker D, Prentice L, McKinney S, Turashvili G, Mooslehner Allen K, et al
. Mll5 is required for normal spermatogenesis. PLoS ONE. 2011;6:e27127 pubmed publisher
b>Mll5 is currently a member of the Mll family of SET domain histone methyltransferase proteins but studies have also showed that it could be part of the SET3 branch of proteins...
Tasdogan A, Kumar S, Allies G, Bausinger J, Beckel F, Hofemeister H, et al
. DNA Damage-Induced HSPC Malfunction Depends on ROS Accumulation Downstream of IFN-1 Signaling and Bid Mobilization. Cell Stem Cell. 2016;19:752-767 pubmed publisher
..Using Mixed-Lineage-Leukemia-5 (Mll5)-deficient mice as prototypical examples, we have identified a mechanistic pathway linking DNA damage and HSPC ..