Gene Symbol: Kmt2b
Description: lysine (K)-specific methyltransferase 2B
Alias: 2610014H22Rik, Mll2, Wbp7, mKIAA0304, histone-lysine N-methyltransferase 2B, WBP-7, WW domain binding protein 7, histone-lysine N-methyltransferase MLL4, lysine N-methyltransferase 2B, mixed lineage leukemia 2, myeloid/lymphoid or mixed-lineage leukemia protein 4 homolog, trithorax homolog 2
Species: mouse
Products:     Kmt2b

Top Publications

  1. Hough T, Nolan P, Tsipouri V, Toye A, Gray I, Goldsworthy M, et al. Novel phenotypes identified by plasma biochemical screening in the mouse. Mamm Genome. 2002;13:595-602 pubmed
    ..Our results have validated our biochemical screen, which is applicable to other mutagenesis projects, and we have produced a new set of mutants with defined metabolic phenotypes. ..
  2. Glaser S, Schaft J, Lubitz S, Vintersten K, van der Hoeven F, Tufteland K, et al. Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development. Development. 2006;133:1423-32 pubmed
    ..To look for evidence of gene-specific epigenetic regulation in mammalian development, we examined one of these six, Mll2, using a multipurpose allele in the mouse to ascertain the loss-of-function phenotype...
  3. Kerimoglu C, Agis Balboa R, Kranz A, Stilling R, Bahari Javan S, Benito Garagorri E, et al. Histone-methyltransferase MLL2 (KMT2B) is required for memory formation in mice. J Neurosci. 2013;33:3452-64 pubmed publisher
    ..Here we show that mice lacking the histone-methyltransferase myeloid/lymphoid or mixed-lineage leukemia 2 (mll2/kmt2b) gene in adult forebrain excitatory neurons display impaired hippocampus-dependent memory function...
  4. Bedford M, Chan D, Leder P. FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands. EMBO J. 1997;16:2376-83 pubmed
  5. Dahl J, Jung I, Aanes H, Greggains G, Manaf A, Lerdrup M, et al. Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition. Nature. 2016;537:548-552 pubmed publisher
    ..Our results provide insight into the onset of the developmental program in mouse embryos and demonstrate a role for broad H3K4me3 domains in MZT. ..
  6. Lee J, Wang C, Xu S, Cho Y, Wang L, Feng X, et al. H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation. elife. 2013;2:e01503 pubmed publisher
    ..Together, these findings identify MLL4 as a major mammalian H3K4 mono- and di-methyltransferase essential for enhancer activation during cell differentiation. DOI: ..
  7. Hu D, Garruss A, Gao X, Morgan M, Cook M, Smith E, et al. The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells. Nat Struct Mol Biol. 2013;20:1093-7 pubmed publisher
    ..Here, we identify Mll2 (KMT2b) as the enzyme catalyzing H3K4 trimethylation at bivalentlymarked promoters in embryonic stem cells...
  8. Kim D, Lee J, Lee B, Lee J. ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity. Mol Endocrinol. 2009;23:1556-62 pubmed publisher
    ..Overall, these results suggest that ASCOM-MLL3 and ASCOM-MLL4 play redundant but essential roles in FXR transactivation via their H3K4 trimethylation activity. ..
  9. Austenaa L, Barozzi I, Chronowska A, Termanini A, Ostuni R, Prosperini E, et al. The histone methyltransferase Wbp7 controls macrophage function through GPI glycolipid anchor synthesis. Immunity. 2012;36:572-85 pubmed publisher
    ..By using a genomic approach, we found that in macrophages, MLL4 (also known as Wbp7) was required for the expression of Pigp, an essential component of the GPI-GlcNAc transferase, the enzyme ..

More Information


  1. Wylin T, Baes M, Brees C, Mannaerts G, Fransen M, Van Veldhoven P. Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii. Eur J Biochem. 1998;258:332-8 pubmed
    ..Taken together, the data indicate that HsPMP34 is a peroxisomal membrane protein and is either the human counterpart of CbPMP47 or closely related to it. According to its structure, the protein is most probably involved in transport. ..
  2. Demers C, Chaturvedi C, Ranish J, Juban G, Lai P, Morle F, et al. Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus. Mol Cell. 2007;27:573-84 pubmed
    ..However, it is unclear how MLL complexes are targeted to specific gene loci. Here, we show that the MLL2 complex associates with the hematopoietic activator NF-E2 in erythroid cells and is important for H3K4 ..
  3. Takeda S, Chen D, Westergard T, Fisher J, Rubens J, Sasagawa S, et al. Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression. Genes Dev. 2006;20:2397-409 pubmed
    ..Taspase1 deficiency results in noncleavage (nc) of MLL and MLL2 and homeotic transformations...
  4. Oyama T, Sasagawa S, Takeda S, Hess R, Lieberman P, Cheng E, et al. Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs. Dev Cell. 2013;27:188-200 pubmed publisher
    ..Taspase1 is a protease that cleaves nuclear factors MLL1, MLL2, TFIIA?-?, and ALF?-? (TFIIA?)...
  5. Shao G, Chen J, Zhang L, Huang P, Lu H, Jin J, et al. Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development. In Vitro Cell Dev Biol Anim. 2014;50:603-13 pubmed publisher
    ..Herein, the authors examined the dynamic changes of H3K4me and its key regulators (Ash1l, Ash2l, Kmt2a, Kmt2b, Kmt2c, Setd1a, Setd7, Kdm1a, Kdm1b, Kdm5a, Kdm5b, Kdm5c, and Kdm5d) in mouse oocytes and preimplantation embryos...
  6. Wan X, Liu L, Ding X, Zhou P, Yuan X, Zhou Z, et al. Mll2 controls cardiac lineage differentiation of mouse embryonic stem cells by promoting H3K4me3 deposition at cardiac-specific genes. Stem Cell Rev. 2014;10:643-52 pubmed publisher
    ..Here we show that Mll2, a TrxG member, is required for proliferation but is dispensable for maintaining the pluripotency of mouse ..
  7. Chan D, Bedford M, Leder P. Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. EMBO J. 1996;15:1045-54 pubmed
    ..Our results suggest that these novel protein interaction domains can perform functions similar to those of SH3 domains and, thus, might regulate SH3 interactions with target proteins through competitive binding. ..
  8. Chen Y, Anastassiadis K, Kranz A, Stewart A, Arndt K, Waskow C, et al. MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia. Cancer Cell. 2017;31:755-770.e6 pubmed publisher
    ..Potential redundancy was addressed by co-deleting the closest paralog, Mll2. Surprisingly, Mll2 deletion alone had a significant impact on survival of MLL-AF9-transformed cells, and ..
  9. Kerimoglu C, Sakib M, Jain G, Benito E, Burkhardt S, Capece V, et al. KMT2A and KMT2B Mediate Memory Function by Affecting Distinct Genomic Regions. Cell Rep. 2017;20:538-548 pubmed publisher
    Kmt2a and Kmt2b are H3K4 methyltransferases of the Set1/Trithorax class. We have recently shown the importance of Kmt2b for learning and memory. Here, we report that Kmt2a is also important in memory formation...
  10. Andreu Vieyra C, Chen R, Agno J, Glaser S, Anastassiadis K, Stewart A, et al. MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing. PLoS Biol. 2010;8: pubmed publisher
    ..Here we show that the histone 3 lysine 4 (H3K4) methyltransferase, MLL2, controls most of the promoter-specific chromatin modification, H3K4me3, during oogenesis and early development...
  11. Ladopoulos V, Hofemeister H, Hoogenkamp M, Riggs A, Stewart A, Bonifer C. The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter. Mol Cell Biol. 2013;33:1383-93 pubmed publisher
    b>KMT2B (MLL2/WBP7) is a member of the MLL subfamily of H3K4-specific histone lysine methyltransferases (KMT2) and is vital for normal embryonic development in the mouse...
  12. Goldsworthy M, Absalom N, Schröter D, Matthews H, Bogani D, Moir L, et al. Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice. PLoS ONE. 2013;8:e61870 pubmed publisher
    ..Here we show that haplo-insufficiency of the histone methyltransferase myeloid-lineage leukemia (Mll2/Wbp7) gene causes type 2 diabetes in the mouse...
  13. Jakovcevski M, Ruan H, Shen E, Dincer A, Javidfar B, Ma Q, et al. Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory. J Neurosci. 2015;35:5097-108 pubmed publisher
    ..In contrast, only mild behavioral phenotypes were observed after ablation of the Mll1 ortholog Kmt2b/Mll2 in PFC...