Klrk1

Summary

Gene Symbol: Klrk1
Description: killer cell lectin-like receptor subfamily K, member 1
Alias: D6H12S2489E, NKG2-D, Nkg2d, NKG2-D type II integral membrane protein, NK cell receptor D, NKG2-D-activating NK receptor, natural killer cell group 2D
Species: mouse
Products:     Klrk1

Top Publications

  1. Vance R, Jamieson A, Raulet D. Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells. J Exp Med. 1999;190:1801-12 pubmed
    ..These findings have implications for understanding NK cells and also raise new possibilities for the role of Qa-1 in immune responses. ..
  2. Waggoner S, Cornberg M, Selin L, Welsh R. Natural killer cells act as rheostats modulating antiviral T cells. Nature. 2011;481:394-8 pubmed publisher
    ..Thus, NK cells can act as rheostats, regulating CD4 T-cell-mediated support for the antiviral CD8 T cells that control viral pathogenesis and persistence...
  3. Raulet D, Gasser S, Gowen B, Deng W, Jung H. Regulation of ligands for the NKG2D activating receptor. Annu Rev Immunol. 2013;31:413-41 pubmed publisher
    b>NKG2D is an activating receptor expressed by all NK cells and subsets of T cells...
  4. Strid J, Sobolev O, Zafirova B, Polic B, Hayday A. The intraepithelial T cell response to NKG2D-ligands links lymphoid stress surveillance to atopy. Science. 2011;334:1293-7 pubmed publisher
    ..can activate the cytolytic potential of neighboring intraepithelial T cells by binding the activating receptor, NKG2D. The systemic implications of this lymphoid stress-surveillance response, however, are unknown...
  5. Hamerman J, Ogasawara K, Lanier L. Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor. J Immunol. 2004;172:2001-5 pubmed
    ..that murine macrophages stimulated with pathogen products known to signal through TLRs express ligands for the NKG2D receptor, found on NK cells, activated CD8(+) T cells and activated macrophages...
  6. Regunathan J, Chen Y, Wang D, Malarkannan S. NKG2D receptor-mediated NK cell function is regulated by inhibitory Ly49 receptors. Blood. 2005;105:233-40 pubmed
    Interaction of the activating ligand H60 with NKG2D receptor constitutes a major stimulatory pathway for natural killer (NK) cells. The influence of inhibitory Ly49 receptors on NKG2D-mediated activation is not clearly understood...
  7. Wolan D, Teyton L, Rudolph M, Villmow B, Bauer S, Busch D, et al. Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A. Nat Immunol. 2001;2:248-54 pubmed
    b>NKG2D, a homodimeric lectin-like receptor, is a unique stimulatory molecule that is found on natural killer cells,T cells and activated macrophages...
  8. Ogasawara K, Hamerman J, Ehrlich L, Bour Jordan H, Santamaria P, Bluestone J, et al. NKG2D blockade prevents autoimmune diabetes in NOD mice. Immunity. 2004;20:757-67 pubmed
    b>NKG2D is an activating receptor on CD8(+) T cells and NK cells that has been implicated in immunity against tumors and microbial pathogens...
  9. Whang M, Guerra N, Raulet D. Costimulation of dendritic epidermal gammadelta T cells by a new NKG2D ligand expressed specifically in the skin. J Immunol. 2009;182:4557-64 pubmed publisher
    ..All DETCs also express the activating NKG2D receptor, but the role of NKG2D in DETC activation remains unclear, as does the identity of NKG2D ligands that are ..

More Information

Publications72

  1. Zompi S, Hamerman J, Ogasawara K, Schweighoffer E, Tybulewicz V, Di Santo J, et al. NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases. Nat Immunol. 2003;4:565-72 pubmed
    In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family protein tyrosine kinases, respectively...
  2. Soderquest K, Walzer T, Zafirova B, Klavinskis L, Polic B, Vivier E, et al. Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses. J Immunol. 2011;186:3304-8 pubmed publisher
    ..we show in this study that NK cells shape CD8(+) T cell fate by killing recently activated CD8(+) T cells in an NKG2D- and perforin-dependent manner...
  3. Takada A, Yoshida S, Kajikawa M, Miyatake Y, Tomaru U, Sakai M, et al. Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D. J Immunol. 2008;180:1678-85 pubmed
    ..as a dominant minor histocompatibility Ag, is an MHC class I-like molecule that serves as a ligand for the NKG2D receptor...
  4. Campbell J, Trossman D, Yokoyama W, Carayannopoulos L. Zoonotic orthopoxviruses encode a high-affinity antagonist of NKG2D. J Exp Med. 2007;204:1311-7 pubmed
    ..discovered an orthopoxvirus protein, itself distantly class I-like, that acts as a competitive antagonist of the NKG2D activating receptor...
  5. Lenac T, Budt M, Arapovic J, Hasan M, Zimmermann A, Simic H, et al. The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60. J Exp Med. 2006;203:1843-50 pubmed
    ..We show that the mouse cytomegalovirus (MCMV) molecule fcr-1 promotes a rapid down-regulation of NKG2D ligands murine UL16-binding protein like transcript (MULT)-1 and H60 from the cell surface...
  6. Zafirova B, Wensveen F, Gulin M, Polic B. Regulation of immune cell function and differentiation by the NKG2D receptor. Cell Mol Life Sci. 2011;68:3519-29 pubmed publisher
    b>NKG2D is one of the most intensively studied immune receptors of the past decade...
  7. Zhang T, Sentman C. Mouse tumor vasculature expresses NKG2D ligands and can be targeted by chimeric NKG2D-modified T cells. J Immunol. 2013;190:2455-63 pubmed publisher
    ..In this study, we show that murine tumor vasculature expresses Rae1, a ligand for a stimulatory NK receptor NKG2D. By genetic modification of T cells with an NKG2D-based chimeric Ag receptor, referred to as chNKG2D in which the ..
  8. Markiewicz M, Carayannopoulos L, Naidenko O, Matsui K, Burack W, Wise E, et al. Costimulation through NKG2D enhances murine CD8+ CTL function: similarities and differences between NKG2D and CD28 costimulation. J Immunol. 2005;175:2825-33 pubmed
    Multiple studies have demonstrated that the NK cell activating receptor NKG2D can function as a costimulatory receptor for both mouse and human CD8+ T cells...
  9. Ho E, Heusel J, Brown M, Matsumoto K, Scalzo A, Yokoyama W. Murine Nkg2d and Cd94 are clustered within the natural killer complex and are expressed independently in natural killer cells. Proc Natl Acad Sci U S A. 1998;95:6320-5 pubmed
    ..Last, we have finely mapped the physical location of the Cd94 (centromeric) and Nkg2d (telomeric) genes between Cd69 and the Ly49 cluster in the NK complex...
  10. Arapovic J, Lenac Rovis T, Reddy A, Krmpotic A, Jonjic S. Promiscuity of MCMV immunoevasin of NKG2D: m138/fcr-1 down-modulates RAE-1epsilon in addition to MULT-1 and H60. Mol Immunol. 2009;47:114-22 pubmed publisher
    ..that inhibit the activation of NK cells by down-regulating the cellular ligands for activating NK cell receptor, NKG2D. MCMV proteins m145, m152 and m155 interfere with the expression of all known NKG2D ligands, MULT-1, RAE-1 family ..
  11. Raulet D. Roles of the NKG2D immunoreceptor and its ligands. Nat Rev Immunol. 2003;3:781-90 pubmed
    ..b>NKG2D is, perhaps, the best characterized receptor that is associated with responses to cellular distress, defined as ..
  12. O Callaghan C, Cerwenka A, Willcox B, Lanier L, Bjorkman P. Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60. Immunity. 2001;15:201-11 pubmed
    b>NKG2D is a potent activating receptor on natural killer cells, T cells, and macrophages. Mouse NKG2D interacts with two cell surface ligands related to class I MHC molecules: RAE1 and H60...
  13. Ogasawara K, Benjamin J, Takaki R, Phillips J, Lanier L. Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts. Nat Immunol. 2005;6:938-45 pubmed
    ..in certain mouse strains expressed retinoic acid early inducible 1 proteins, which are ligands for the activating NKG2D NK cell receptor...
  14. Guerra N, Tan Y, Joncker N, Choy A, Gallardo F, Xiong N, et al. NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy. Immunity. 2008;28:571-80 pubmed publisher
    Ligands for the NKG2D stimulatory receptor are frequently upregulated on tumor lines, rendering them sensitive to natural killer (NK) cells, but the role of NKG2D in tumor surveillance has not been addressed in spontaneous cancer models...
  15. Carayannopoulos L, Naidenko O, Kinder J, Ho E, Fremont D, Yokoyama W. Ligands for murine NKG2D display heterogeneous binding behavior. Eur J Immunol. 2002;32:597-605 pubmed
    b>NKG2D transmits stimulatory signals to natural killer cells and other hematopoietic cells, leading to enhanced proliferation, cytokine secretion and target killing...
  16. Xia M, Guerra N, Sukhova G, Yang K, Miller C, Shi G, et al. Immune activation resulting from NKG2D/ligand interaction promotes atherosclerosis. Circulation. 2011;124:2933-43 pubmed publisher
    ..and organs of humans and mice with hyperglycemia and hyperlipidemia were examined for expression of ligands for NKG2D, a potent immune-activating receptor expressed by several types of immune cells, and the role of NKG2D in ..
  17. Rosen D, Araki M, Hamerman J, Chen T, Yamamura T, Lanier L. A Structural basis for the association of DAP12 with mouse, but not human, NKG2D. J Immunol. 2004;173:2470-8 pubmed
    Prior studies have revealed that alternative mRNA splicing of the mouse NKG2D gene generates receptors that associate with either the DAP10 or DAP12 transmembrane adapter signaling proteins...
  18. Gilfillan S, Ho E, Cella M, Yokoyama W, Colonna M. NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat Immunol. 2002;3:1150-5 pubmed
    b>NKG2D is a receptor on natural killer (NK) cells and cytotoxic T lymphocytes that binds major histocompatibility complex (MHC) class I-like ligands expressed primarily on virally infected and neoplastic cells...
  19. Ho E, Carayannopoulos L, Poursine Laurent J, Kinder J, Plougastel B, Smith H, et al. Costimulation of multiple NK cell activation receptors by NKG2D. J Immunol. 2002;169:3667-75 pubmed
    ..To study the function of NKG2D, a potential NK costimulatory receptor, we have generated two novel hamster mAbs that recognize mouse NKG2D...
  20. Vance R, Tanamachi D, Hanke T, Raulet D. Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells. Eur J Immunol. 1997;27:3236-41 pubmed
    ..Murine homologs of human NKG2 family members have not yet been identified, but we report here the existence of a murine NKG2D-like sequence that also maps to the murine NK complex near CD94 and Ly49 family members.
  21. Zhou R, Wei H, Sun R, Zhang J, Tian Z. NKG2D recognition mediates Toll-like receptor 3 signaling-induced breakdown of epithelial homeostasis in the small intestines of mice. Proc Natl Acad Sci U S A. 2007;104:7512-5 pubmed
    ..stimulation induces intestinal epithelial cells (IECs) to express retinoic acid early inducible-1 (a ligand for NKG2D) and to induce NKG2D expression on CD8alphaalpha intestinal intraepithelial lymphocytes by IL-15 derived from TLR3-..
  22. Horng T, Bezbradica J, Medzhitov R. NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway. Nat Immunol. 2007;8:1345-52 pubmed
    ..of the signaling adaptor DAP10 and ubiquitin efficiently downregulated expression of the activating receptor NKG2D on the surfaces of natural killer cells...
  23. Li P, McDermott G, Strong R. Crystal structures of RAE-1beta and its complex with the activating immunoreceptor NKG2D. Immunity. 2002;16:77-86 pubmed
    ..implicated in playing a role in development, rodent RAE-1 proteins are ligands for the activating immunoreceptor NKG2D, widely expressed on natural killer cells, T cells, and macrophages...
  24. Sheppard S, Triulzi C, Ardolino M, Serna D, Zhang L, Raulet D, et al. Characterization of a novel NKG2D and NKp46 double-mutant mouse reveals subtle variations in the NK cell repertoire. Blood. 2013;121:5025-33 pubmed publisher
    The immunoreceptors NKG2D and NKp46 are known for their capacity to activate natural killer (NK) cell cytotoxicity and secretory responses in the contexts of tumors and infections, yet their roles in NK cell education remain unclear...
  25. Walsh K, Lanier L, Lane T. NKG2D receptor signaling enhances cytolytic activity by virus-specific CD8+ T cells: evidence for a protective role in virus-induced encephalitis. J Virol. 2008;82:3031-44 pubmed
    ..The present study was undertaken to reveal the functional contributions of the activating NKG2D receptor in host defense and disease following JHMV infection...
  26. Ehrlich L, Ogasawara K, Hamerman J, Takaki R, Zingoni A, Allison J, et al. Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cells. J Immunol. 2005;174:1922-31 pubmed
    ..The role of CD28 in costimulating T cell activation is well established. NKG2D, a receptor found on NK cells, CD8+ alphabeta-TCR+ T cells, and gammadelta-TCR+ T cells, has also been implicated ..
  27. Wortham B, Eppert B, Motz G, Flury J, Orozco Levi M, Hoebe K, et al. NKG2D mediates NK cell hyperresponsiveness and influenza-induced pathologies in a mouse model of chronic obstructive pulmonary disease. J Immunol. 2012;188:4468-75 pubmed publisher
    ..NKG2D is a key mediator for CS-stimulated NK cell hyperresponsiveness, because CS-exposed NKG2D-deficient mice (Klrk1(-/-)) did not exhibit enhanced effector functions as assessed by cytokine responsiveness...
  28. Wiemann K, Mittrücker H, Feger U, Welte S, Yokoyama W, Spies T, et al. Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo. J Immunol. 2005;175:720-9 pubmed
    The immunoreceptor NKG2D stimulates activation of cytotoxic lymphocytes upon engagement with MHC class I-related NKG2D ligands of which at least some are expressed inducibly upon exposure to carcinogens, cell stress, or viruses...
  29. Diefenbach A, Tomasello E, Lucas M, Jamieson A, Hsia J, Vivier E, et al. Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat Immunol. 2002;3:1142-9 pubmed
    ..Here, we report that alternative splicing leads to two distinct NKG2D polypeptides that associate differentially with the DAP10 and KARAP (also known as DAP12) signaling subunits...
  30. Coudert J, Held W. The role of the NKG2D receptor for tumor immunity. Semin Cancer Biol. 2006;16:333-43 pubmed
    ..One of these receptor ligand systems, the NKG2D pathway, has received particular attention, and now serves as a paradigm for how the immune system is able to ..
  31. Zafirova B, Mandarić S, Antulov R, Krmpotic A, Jonsson H, Yokoyama W, et al. Altered NK cell development and enhanced NK cell-mediated resistance to mouse cytomegalovirus in NKG2D-deficient mice. Immunity. 2009;31:270-82 pubmed publisher
    b>NKG2D is a potent activating receptor on natural killer (NK) cells and acts as a molecular sensor for stressed cells expressing NKG2D ligands such as infected or tumor-transformed cells...
  32. Girardi M, Oppenheim D, Steele C, Lewis J, Glusac E, Filler R, et al. Regulation of cutaneous malignancy by gammadelta T cells. Science. 2001;294:605-9 pubmed
    ..Each of these is a ligand for NKG2d, a receptor expressed by cytolytic T cells and natural killer (NK) cells...
  33. Diefenbach A, Hsia J, Hsiung M, Raulet D. A novel ligand for the NKG2D receptor activates NK cells and macrophages and induces tumor immunity. Eur J Immunol. 2003;33:381-91 pubmed
    ..mode of immune recognition employed by NK cells is "induced self recognition" exemplified by the NKG2D receptor-ligand system...
  34. Oppenheim D, Roberts S, Clarke S, Filler R, Lewis J, Tigelaar R, et al. Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance. Nat Immunol. 2005;6:928-37 pubmed
    ..MICA (human) and Rae-1 (mouse) may promote tumor surveillance and autoimmunity by engaging the activating receptor NKG2D on natural killer (NK) cells and T cells...
  35. Ogasawara K, Hamerman J, Hsin H, Chikuma S, Bour Jordan H, Chen T, et al. Impairment of NK cell function by NKG2D modulation in NOD mice. Immunity. 2003;18:41-51 pubmed
    ..Here we show impairment in an activating receptor, NKG2D, in NOD NK cells...
  36. Markiewicz M, Wise E, Buchwald Z, Pinto A, Zafirova B, Polic B, et al. RAE1? ligand expressed on pancreatic islets recruits NKG2D receptor-expressing cytotoxic T cells independent of T cell receptor recognition. Immunity. 2012;36:132-41 pubmed publisher
    ..With a transgenic mouse expressing the NKG2D ligand retinoic acid early transcript 1? (RAE1?) in ?-islet cells of the pancreas, we found that RAE1 expression ..
  37. Billadeau D, Upshaw J, Schoon R, Dick C, Leibson P. NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. Nat Immunol. 2003;4:557-64 pubmed
    The immune recognition receptor complex NKG2D-DAP10 on natural killer cells is stimulated by specific ligands carried on virus-infected and malignant cells...
  38. Vivier E, Tomasello E, Paul P. Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition?. Curr Opin Immunol. 2002;14:306-11 pubmed
    b>NKG2D is an activating cell surface receptor expressed on a wide range of immune effector cells including NK cells, NKT cells, gammadelta T cells as well as CD8(+) alphabeta T cells...
  39. Jamieson A, Diefenbach A, McMahon C, Xiong N, Carlyle J, Raulet D. The role of the NKG2D immunoreceptor in immune cell activation and natural killing. Immunity. 2002;17:19-29 pubmed
    ..We generated a monoclonal antibody specific for murine NKG2D in order to investigate its function...
  40. Carayannopoulos L, Naidenko O, Fremont D, Yokoyama W. Cutting edge: murine UL16-binding protein-like transcript 1: a newly described transcript encoding a high-affinity ligand for murine NKG2D. J Immunol. 2002;169:4079-83 pubmed
    Murine NKG2D is known to recognize H60 and five RAE1 variants. The human homologue recognizes both inducible MHC class I chain-related gene and constitutive (UL16-binding protein (ULBP)) ligands...
  41. Smyth M, Swann J, Cretney E, Zerafa N, Yokoyama W, Hayakawa Y. NKG2D function protects the host from tumor initiation. J Exp Med. 2005;202:583-8 pubmed
    The activation NKG2D receptor has been shown to play an important role in the control of experimental tumor growth and metastases expressing ligands for NKG2D; however, a function for this recognition pathway in host protection from de ..
  42. Fang M, Lanier L, Sigal L. A role for NKG2D in NK cell-mediated resistance to poxvirus disease. PLoS Pathog. 2008;4:e30 pubmed publisher
    ..Furthermore, we show that the activating receptor NKG2D is required for optimal NK cell-mediated resistance to disease and lethality...
  43. Jung H, Hsiung B, Pestal K, Procyk E, Raulet D. RAE-1 ligands for the NKG2D receptor are regulated by E2F transcription factors, which control cell cycle entry. J Exp Med. 2012;209:2409-22 pubmed publisher
    The NKG2D stimulatory receptor expressed by natural killer cells and T cell subsets recognizes cell surface ligands that are induced on transformed and infected cells and facilitate immune rejection of tumor cells...
  44. Kavazović I, Lenartic M, Jelencic V, Jurkovic S, Lemmermann N, Jonjic S, et al. NKG2D stimulation of CD8+ T cells during priming promotes their capacity to produce cytokines in response to viral infection in mice. Eur J Immunol. 2017;47:1123-1135 pubmed publisher
    Natural killer group 2 member D (NKG2D) is an activating receptor that is expressed on most cytotoxic cells of the immune system, including NK cells, ??, and CD8+ T cells...
  45. Orozco L, Cokus S, Ghazalpour A, Ingram Drake L, Wang S, Van Nas A, et al. Copy number variation influences gene expression and metabolic traits in mice. Hum Mol Genet. 2009;18:4118-29 pubmed publisher
    ..Our results suggest that CNVs have a significant impact on gene expression and that CNVs may be playing a role in the mechanisms underlying metabolic traits in mice. ..
  46. Lenartic M, Jelencic V, Zafirova B, Ozanic M, Marečić V, Jurkovic S, et al. NKG2D Promotes B1a Cell Development and Protection against Bacterial Infection. J Immunol. 2017;198:1531-1542 pubmed publisher
    ..b>Klrk1-/- B1a cells are also functionally impaired and they fail to provide protection against Francisella ..
  47. Chung J, Markiewicz M, Polić B, Shaw A. Role of NKG2D in obesity-induced adipose tissue inflammation and insulin resistance. PLoS ONE. 2014;9:e110108 pubmed publisher
    ..We have previously shown that interaction between NKG2D (natural-killer group 2, member D) and its ligand Rae-1ε is sufficient to recruit cytotoxic T lymphocytes to ..
  48. Zhang B, Wei H, Zheng X, Zhang J, Sun R, Tian Z. The inhibitory effects of synthetic short peptides, mimicking MICA and targeting at NKG2D receptors, on function of NK cells. Peptides. 2005;26:405-12 pubmed
    b>NKG2D is an activating receptor expressed on most of human NK cells, one of whose ligands is MICA...
  49. Lai C, Zhang Y, Rogers S, Mager D. Creation of the two isoforms of rodent NKG2D was driven by a B1 retrotransposon insertion. Nucleic Acids Res. 2009;37:3032-43 pubmed publisher
    The mouse gene for the natural killer (NK) cell-activating receptor Nkg2d produces two protein isoforms, NKG2D-S and NKG2D-L, which differ by 13 amino acids at the N-terminus and have different signalling capabilities...
  50. Luo Y, Tian W, Cai L, Wang Y, Zhang J, Teng H, et al. Expression profiling reveals a positive regulation by mPer2 on circadian rhythm of cytotoxicity receptors: Ly49C and Nkg2d. Chronobiol Int. 2009;26:1514-44 pubmed publisher
    ..WT) and mPer2 knockout (mPer2(-/-)) mice bone marrow, that is, Dap-10, Ly49C, Ly49I, Rac1, Mapk1, Map2k1, Nkg2d, Shp-1, Pak1, Pik3ca, and Vav1. The mRNA levels of Ly49C (p < 0.001), Ly49I (p = 0.039), and Nkg2d (p = 0...
  51. Galazka G, Jurewicz A, Orlowski W, Stasiolek M, Brosnan C, Raine C, et al. EAE tolerance induction with Hsp70-peptide complexes depends on H60 and NKG2D activity. J Immunol. 2007;179:4503-12 pubmed
    ..Similarly, blocking of the NK cell receptor for H60, NKG2D, also reversed the Hsp70-pc-induced EAE inhibition...
  52. Han Y, Zhang M, Li N, Chen T, Zhang Y, Wan T, et al. KLRL1, a novel killer cell lectinlike receptor, inhibits natural killer cell cytotoxicity. Blood. 2004;104:2858-66 pubmed
    ..Taken together, our results demonstrate that KLRL1 belongs to the KLR family and is a novel inhibitory NK cell receptor. ..
  53. Iannello A, Thompson T, Ardolino M, Lowe S, Raulet D. p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells. J Exp Med. 2013;210:2057-69 pubmed publisher
    ..The elimination of senescent tumor cells is dependent on NKG2D. Interestingly, p53 restoration neither increases ligand expression nor increases the sensitivity to lysis by NK ..
  54. Depatie C, Chalifour A, Pare C, Lee S, Vidal S, Lemieux S. Assessment of Cmv1 candidates by genetic mapping and in vivo antibody depletion of NK cell subsets. Int Immunol. 1999;11:1541-51 pubmed
    ..the candidacy of individual NKC members for the resistance locus, first we followed the co-segregation of Cd94, Nkg2d, and the well-characterized Ly49a, Ly49c and Ly49g genes with respect to Cmv1 in pre-existing panels of ..
  55. Phillips L, Gould E, Babu H, Krams S, Palmer T, Martinez O. Natural killer cell-activating receptor NKG2D mediates innate immune targeting of allogeneic neural progenitor cell grafts. Stem Cells. 2013;31:1829-39 pubmed publisher
    ..allogeneic NPC, and killing is modulated primarily by NK-inhibiting "self" class I MHC and NK-activating NKG2D-ligand expression...
  56. Lam A, Bert N, Ho S, Shen Y, Tang L, Xiong G, et al. RAE1 ligands for the NKG2D receptor are regulated by STING-dependent DNA sensor pathways in lymphoma. Cancer Res. 2014;74:2193-2203 pubmed publisher
    The immunoreceptor NKG2D originally identified in natural killer (NK) cells recognizes ligands that are upregulated on tumor cells...
  57. Zloza A, Kohlhapp F, Lyons G, Schenkel J, Moore T, Lacek A, et al. NKG2D signaling on CD8? T cells represses T-bet and rescues CD4-unhelped CD8? T cell memory recall but not effector responses. Nat Med. 2012;18:422-8 pubmed publisher
    ..Given the co-stimulatory role of natural-killer group 2, member D protein (NKG2D) on CD8(+) T cells, we investigated its ability to rescue these immunologically impotent cells...
  58. Kawakami T, Ito K, Matsuda Y, Noda M, Sakurada A, Hoshikawa Y, et al. Cytotoxicity of Natural Killer Cells Activated Through NKG2D Contributes to the Development of Bronchiolitis Obliterans in a Murine Heterotopic Tracheal Transplant Model. Am J Transplant. 2017;17:2338-2349 pubmed publisher
    ..Furthermore, we found upregulation of NKG2D-ligand in allografts and demonstrated the significance of this using grafts expressing Rae-1, a murine NKG2D-..
  59. Mitra A, Satelli A, Yan J, Xueqing X, Gagea M, Hunter C, et al. IL-30 (IL27p28) attenuates liver fibrosis through inducing NKG2D-rae1 interaction between NKT and activated hepatic stellate cells in mice. Hepatology. 2014;60:2027-39 pubmed publisher
    ..neutralization studies showed that liver NKT cells up-regulate the natural killer group 2, member D (NKG2D) ligand and bind with the NKG2D ligand, retinoic acid early inducible 1 (Rae1), and positively activated HSCs to ..
  60. Marie J, Liggitt D, Rudensky A. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity. 2006;25:441-54 pubmed
    ..Thus, TGF-beta signaling in peripheral T cells is crucial in restraining TCR activation-dependent Th1, cytotoxic, and NK cell-like differentiation program which, when left unchecked, leads to rapidly progressing fatal autoimmunity. ..
  61. Hansen C, Holm T, Krych Ł, Andresen L, Nielsen D, Rune I, et al. Gut microbiota regulates NKG2D ligand expression on intestinal epithelial cells. Eur J Immunol. 2013;43:447-57 pubmed publisher
    ..are one of a few cell types in the body with constitutive surface expression of natural killer group 2 member D (NKG2D) ligands, although the magnitude of ligand expression by IECs varies...
  62. Wortham B, Eppert B, Flury J, Morgado Garcia S, Borchers M. TLR and NKG2D signaling pathways mediate CS-induced pulmonary pathologies. PLoS ONE. 2013;8:e78735 pubmed publisher
    ..Our previous work has shown that the expression of ligands for the cytotoxic lymphocyte activating receptor NKG2D is enhanced in patients with COPD and that the induction of these ligands in a mouse model can replicate COPD ..
  63. Shivakumar P, Sabla G, Whitington P, Chougnet C, Bezerra J. Neonatal NK cells target the mouse duct epithelium via Nkg2d and drive tissue-specific injury in experimental biliary atresia. J Clin Invest. 2009;119:2281-90 pubmed
    ..Rotavirus-primed hepatic NK cells lysed cholangiocytes in a contact- and Nkg2d-dependent fashion...