Klrg1

Summary

Gene Symbol: Klrg1
Description: killer cell lectin-like receptor subfamily G, member 1
Alias: 2F1-Ag, MAFA, MAFA-L, killer cell lectin-like receptor subfamily G member 1, mast cell function-associated antigen 2F1
Species: mouse
Products:     Klrg1

Top Publications

  1. Corral L, Hanke T, Vance R, Cado D, Raulet D. NK cell expression of the killer cell lectin-like receptor G1 (KLRG1), the mouse homolog of MAFA, is modulated by MHC class I molecules. Eur J Immunol. 2000;30:920-30 pubmed
    ..mAb, 2F1, we characterize a mouse natural killer (NK) cell antigen termed 'killer cell lectin-like receptor G1' (KLRG1; formerly mouse MAFA or 2F1-Ag)...
  2. Robbins S, Nguyen K, Takahashi N, Mikayama T, Biron C, Brossay L. Cutting edge: inhibitory functions of the killer cell lectin-like receptor G1 molecule during the activation of mouse NK cells. J Immunol. 2002;168:2585-9 pubmed
    The killer cell lectin-like receptor G1 (KLRG1) is the mouse homolog of the rat mast cell function-associated Ag and contains an immunoreceptor tyrosine-based inhibitory motif in its cytoplasmic domain...
  3. Robbins S, Tessmer M, Mikayama T, Brossay L. Expansion and contraction of the NK cell compartment in response to murine cytomegalovirus infection. J Immunol. 2004;173:259-66 pubmed
    ..These findings illustrate the plasticity of the NK cell compartment in response to pathogens and underscore the homeostatic maintenance of the resting peripheral NK cell pool. ..
  4. Blaser C, Kaufmann M, Pircher H. Virus-activated CD8 T cells and lymphokine-activated NK cells express the mast cell function-associated antigen, an inhibitory C-type lectin. J Immunol. 1998;161:6451-4 pubmed
    The mast cell function-associated Ag (MAFA) is an inhibitory C-type lectin that was originally identified on the cell surface of a rat mucosal mast cell line, RBL-2H3...
  5. Hanke T, Corral L, Vance R, Raulet D. 2F1 antigen, the mouse homolog of the rat "mast cell function-associated antigen", is a lectin-like type II transmembrane receptor expressed by natural killer cells. Eur J Immunol. 1998;28:4409-17 pubmed
    ..mAb specific for mouse NK cells, 2F1, recognizes the mouse homolog of the mast cell function-associated antigen (MAFA), an inhibitory lectin-like transmembrane receptor expressed on rat mast cells...
  6. Mathieu C, Beltra J, Charpentier T, Bourbonnais S, Di Santo J, Lamarre A, et al. IL-2 and IL-15 regulate CD8+ memory T-cell differentiation but are dispensable for protective recall responses. Eur J Immunol. 2015;45:3324-38 pubmed publisher
    ..Globally, these results indicate that lack of IL-2 and IL-15 signaling modulates the CD8(+) T-cell differentiation program but does not impede adequate effector functions. ..
  7. Göthert J, Eisele L, Klein Hitpass L, Weber S, Zesewitz M, Sellmann L, et al. Expanded CD8+ T cells of murine and human CLL are driven into a senescent KLRG1+ effector memory phenotype. Cancer Immunol Immunother. 2013;62:1697-1709 pubmed
    ..and also mouse CLL (E?-TCL1 model) were due to an expansion of the inhibitory killer cell lectin-like receptor G1 (KLRG1) expressing cellular subset...
  8. Gründemann C, Bauer M, Schweier O, von Oppen N, Lässing U, Saudan P, et al. Cutting edge: identification of E-cadherin as a ligand for the murine killer cell lectin-like receptor G1. J Immunol. 2006;176:1311-5 pubmed
    The killer cell lectin-like receptor G1 (KLRG1) is expressed by NK cells and by T cells...
  9. Bouchentouf M, Forner K, Cuerquis J, Michaud V, Zheng J, Paradis P, et al. Induction of cardiac angiogenesis requires killer cell lectin-like receptor 1 and ?4?7 integrin expression by NK cells. J Immunol. 2010;185:7014-25 pubmed publisher
    ..These data define a potential role of activated NK cells in cardiac angiogenesis and open new perspectives for the treatment of ischemic diseases. ..

More Information

Publications42

  1. Huang W, Kachapati K, Adams D, Wu Y, Leung P, Yang G, et al. Murine autoimmune cholangitis requires two hits: cytotoxic KLRG1(+) CD8 effector cells and defective T regulatory cells. J Autoimmun. 2014;50:123-34 pubmed publisher
    ..Herein we report significantly increased numbers of hepatic dnTGF?RII terminally differentiated (KLRG1(+)) CD8 T cells, a CD8 subset previously shown to be enriched in antigen specific cells during hepatic immune ..
  2. Nakamura S, Kuroki K, Ohki I, Sasaki K, Kajikawa M, Maruyama T, et al. Molecular basis for E-cadherin recognition by killer cell lectin-like receptor G1 (KLRG1). J Biol Chem. 2009;284:27327-35 pubmed publisher
    The killer cell lectin-like receptor G1, KLRG1, is a cell surface receptor expressed on subsets of natural killer (NK) cells and T cells...
  3. Cyktor J, Carruthers B, Stromberg P, Flano E, Pircher H, Turner J. Killer cell lectin-like receptor G1 deficiency significantly enhances survival after Mycobacterium tuberculosis infection. Infect Immun. 2013;81:1090-9 pubmed publisher
    ..We examined the requirement of the T cell differentiation marker killer cell lectin-like receptor G1 (KLRG1) during M. tuberculosis infection using mice deficient in KLRG1...
  4. Ye F, Turner J, Flano E. Contribution of pulmonary KLRG1(high) and KLRG1(low) CD8 T cells to effector and memory responses during influenza virus infection. J Immunol. 2012;189:5206-11 pubmed publisher
    ..response to influenza virus infection lung CD8 T cell subsets expressing killer cell lectin-like receptor G1 (KLRG1)(high) or KLRG1(low) had similar effector functions and immediate recall efficacy...
  5. Thimme R, Appay V, Koschella M, Panther E, Roth E, Hislop A, et al. Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation. J Virol. 2005;79:12112-6 pubmed
    The killer cell lectin-like receptor G1 (KLRG1) is a natural killer cell receptor expressed by T cells that exhibit impaired proliferative capacity. Here, we determined the KLRG1 expression by virus-specific T cells...
  6. Shimizu K, Sato Y, Shinga J, Watanabe T, Endo T, Asakura M, et al. KLRG+ invariant natural killer T cells are long-lived effectors. Proc Natl Acad Sci U S A. 2014;111:12474-9 pubmed publisher
    ..Further analyses showed that the KLRG1(+) (Killer cell lectin-like receptor subfamily G, member 1-positive) iNKT cells coexpressing CD49d and granzyme A ..
  7. Rosshart S, Hofmann M, Schweier O, Pfaff A, Yoshimoto K, Takeuchi T, et al. Interaction of KLRG1 with E-cadherin: new functional and structural insights. Eur J Immunol. 2008;38:3354-64 pubmed publisher
    The killer cell lectin-like receptor G1 (KLRG1) is an inhibitory receptor expressed by memory T cells and NK cells in man and mice...
  8. Gründemann C, Schwartzkopff S, Koschella M, Schweier O, Peters C, Voehringer D, et al. The NK receptor KLRG1 is dispensable for virus-induced NK and CD8+ T-cell differentiation and function in vivo. Eur J Immunol. 2010;40:1303-14 pubmed publisher
    The killer cell lectin-like receptor G1 (KLRG1) is expressed by NK and T-cell subsets and recognizes members of the classical cadherin family...
  9. Lin S, Kisseleva T, Brenner D, Duffield J. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol. 2008;173:1617-27 pubmed publisher
    ..Therefore, our results serve to refocus fibrosis research to injury of the vasculature rather than injury to the epithelium. ..
  10. Schwartzkopff S, Woyciechowski S, Aichele U, Flecken T, Zhang N, Thimme R, et al. TGF-β downregulates KLRG1 expression in mouse and human CD8(+) T cells. Eur J Immunol. 2015;45:2212-7 pubmed publisher
    The inhibitory receptor killer cell lectin-like receptor G1 (KLRG1) and the integrin αE (CD103) are expressed by CD8(+) T cells and both are specific for E-cadherin...
  11. Tessmer M, Fugere C, Stevenaert F, Naidenko O, Chong H, Leclercq G, et al. KLRG1 binds cadherins and preferentially associates with SHIP-1. Int Immunol. 2007;19:391-400 pubmed
    The killer cell lectin-like receptor G1 (KLRG1) is a unique inhibitory receptor expressed on a phenotypically mature subset of resting NK cells as well as subsets of T cells in naive mice...
  12. Wilson D, Matthews S, Yap G. IL-12 signaling drives CD8+ T cell IFN-gamma production and differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii Infection. J Immunol. 2008;180:5935-45 pubmed
    ..of effector molecules and the cell surface activation markers CD62L and killer cell lectin-like receptor G1 (KLRG1)...
  13. Vesper A, Raetzman L, Camper S. Role of prophet of Pit1 (PROP1) in gonadotrope differentiation and puberty. Endocrinology. 2006;147:1654-63 pubmed
    ..Microarray analysis identified the inhibitory transmembrane receptor gene Klrg1 and the protease gene Prss28 as candidates for involvement in this process...
  14. Mackay L, Rahimpour A, Ma J, Collins N, Stock A, Hafon M, et al. The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin. Nat Immunol. 2013;14:1294-301 pubmed publisher
    ..in the skin from epithelium-infiltrating precursor cells that lacked expression of the effector-cell marker KLRG1. A combination of entry into the epithelium plus local signaling by interleukin 15 (IL-15) and transforming growth ..
  15. Banh C, Fugere C, Brossay L. Immunoregulatory functions of KLRG1 cadherin interactions are dependent on forward and reverse signaling. Blood. 2009;114:5299-306 pubmed publisher
    b>KLRG1 is an inhibitory receptor expressed on a subset of mature T and NK cells. Recently, E-, N-, and R-cadherin have been identified as ligands for KLRG1...
  16. Curran M, Kim M, Montalvo W, Al Shamkhani A, Allison J. Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production. PLoS ONE. 2011;6:e19499 pubmed publisher
    ..75% of CD8+ and 45% of CD4+ effector T-cells in the tumor to express the killer cell lectin-like receptor G1 (KLRG1). Tumors treated with combination antibody therapy showed 1...
  17. Huntington N, Tabarias H, Fairfax K, Brady J, Hayakawa Y, Degli Esposti M, et al. NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation. J Immunol. 2007;178:4764-70 pubmed
    ..A subset of NK cells express the inhibitory killer cell lectin-like receptor G1 (KLRG1)...
  18. Steinle A. Transferrin' activation: bonding with transferrin receptors tunes KLRG1 function. Eur J Immunol. 2014;44:1600-3 pubmed publisher
    The inhibitory C-type lectin-like immunoreceptor KLRG1 enables mature NK cells and differentiated T cells to sense cadherin-expressing cells by ligating "classical" cadherins...
  19. Meinicke H, Bremser A, Brack M, Akeus P, Pearson C, Bullers S, et al. Tumour-associated changes in intestinal epithelial cells cause local accumulation of KLRG1+ GATA3+ regulatory T cells in mice. Immunology. 2017;152:74-88 pubmed publisher
    ..and tumour progression, promotes the accumulation of intestinal Treg cells by the specific accumulation of the KLRG1+ GATA3+ Treg subset...
  20. Knell J, Best J, Lind N, Yang E, D Cruz L, Goldrath A. Id2 influences differentiation of killer cell lectin-like receptor G1(hi) short-lived CD8+ effector T cells. J Immunol. 2013;190:1501-9 pubmed publisher
    ..T cells lacking Id2 did not generate a robust terminally differentiated killer cell lectin-like receptor G1 (KLRG1)(hi) effector population, but displayed a cell-surface phenotype and cytokine profile consistent with memory ..
  21. Ito M, Maruyama T, Saito N, Koganei S, Yamamoto K, Matsumoto N. Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity. J Exp Med. 2006;203:289-95 pubmed
    Killer cell lectin-like receptor G1 (KLRG1) is an inhibitory receptor expressed on subsets of natural killer (NK) cells and T cells, for which no endogenous ligands are known...
  22. Robbins S, Terrizzi S, Sydora B, Mikayama T, Brossay L. Differential regulation of killer cell lectin-like receptor G1 expression on T cells. J Immunol. 2003;170:5876-85 pubmed
    The killer cell lectin-like receptor G1 (KLRG1) is the mouse homologue of the rat mast cell function-associated Ag and contains a tyrosine-based inhibitory motif in its cytoplasmic domain...
  23. Montufar Solis D, Williams A, Vigneswaran N, Klein J. Involvement of Ly6C, 4-1BB, and KLRG1 in the activation of lamina propria lymphocytes in the small intestine of sanroque mice. Biochem Biophys Res Commun. 2017;483:590-595 pubmed publisher
    ..sanroque small intestinal LPLs, and we show that both of those subsets, in conjunction with cells expressing the KLRG1 T cell activation molecule, are sources of IL-17A, IFN-?, and TNF?...
  24. Voehringer D, Kaufmann M, Pircher H. Genomic structure, alternative splicing, and physical mapping of the killer cell lectin-like receptor G1 gene (KLRG1), the mouse homologue of MAFA. Immunogenetics. 2001;52:206-11 pubmed
    The mouse killer cell lectin-like receptor G1 (KLRG1), the mouse homologue of the mast cell function-associated antigen (MAFA), is an inhibitory C-type lectin expressed on natural killer (NK) cells and activated CD8 T cells...
  25. Jänner N, Hahnke K, Mollenkopf H, Steinhoff U, Kaufmann S, Mittrücker H. Restricted expression of C-type lectin-like natural killer receptors by CD8 T cells in the murine small intestine. Immunology. 2008;125:38-47 pubmed publisher
  26. Cush S, Flano E. KLRG1+NKG2A+ CD8 T cells mediate protection and participate in memory responses during ?-herpesvirus infection. J Immunol. 2011;186:4051-8 pubmed publisher
    ..persistence, ?75% of ?HV68-specific CD8 T cells coexpress the NK receptors killer cell lectin-like receptor G1 (KLRG1) and NKG2A...
  27. Cheng G, Yuan X, Tsai M, Podack E, Yu A, Malek T. IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells. J Immunol. 2012;189:1780-91 pubmed publisher
    ..Recently, a small fraction of peripheral Tregs has been shown to express Klrg1, but it remains unclear as to what extent Klrg1 defines a unique Treg subset...
  28. Schweier O, Hofmann M, Pircher H. KLRG1 activity is regulated by association with the transferrin receptor. Eur J Immunol. 2014;44:1851-6 pubmed publisher
    The killer cell lectin-like receptor G1 (KLRG1) is a cadherin-binding inhibitory receptor expressed by NK cells and differentiated T cells...
  29. Tauro S, Nguyen P, Li B, Geiger T. Diversification and senescence of Foxp3+ regulatory T cells during experimental autoimmune encephalomyelitis. Eur J Immunol. 2013;43:1195-207 pubmed publisher
    ..We observed a marked elevation in KLRG1(+) (where KLRG1 stands for killer cell lectin-like receptor G1) CNS-infiltrating Treg cells in experimental ..
  30. Kataoka K, Shioda S, Ando K, Sakagami K, Handa H, Yasuda K. Differentially expressed Maf family transcription factors, c-Maf and MafA, activate glucagon and insulin gene expression in pancreatic islet alpha- and beta-cells. J Mol Endocrinol. 2004;32:9-20 pubmed
    A basic-leucine zipper transcription factor, MafA, was recently identified as one of the most important transactivators of insulin gene expression...
  31. Meinicke H, Bremser A, Brack M, Schrenk K, Pircher H, Izcue A. KLRG1 impairs regulatory T-cell competitive fitness in the gut. Immunology. 2017;152:65-73 pubmed publisher
    ..The cadherin-binding inhibitory receptor killer cell lectin-like receptor G1 (KLRG1) is expressed by a subpopulation of Treg cells with GATA3+ effector phenotype...
  32. Andrews T, Whittle B, Field M, Balakishnan B, Zhang Y, Shao Y, et al. Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models. Open Biol. 2012;2:120061 pubmed publisher
    ..This approach transforms genetic screens in mice, establishes a general strategy for analysing rare DNA variants and opens up a large new source for experimental models of human disease. ..
  33. Hofmann M, Schweier O, Pircher H. Different inhibitory capacities of human and mouse KLRG1 are linked to distinct disulfide-mediated oligomerizations. Eur J Immunol. 2012;42:2484-90 pubmed publisher
    The killer cell lectin-like receptor G1 (KLRG1) is a cadherin-binding inhibitory receptor expressed by NK and T cells in humans and mice...