Gene Symbol: Klrc1
Description: killer cell lectin-like receptor subfamily C, member 1
Alias: CD159a, NKG2A, NKG2B, NKG2-A/NKG2-B type II integral membrane protein, Cluster of Differentiation 159a
Species: mouse
Products:     Klrc1

Top Publications

  1. Jänner N, Hahnke K, Mollenkopf H, Steinhoff U, Kaufmann S, Mittrücker H. Restricted expression of C-type lectin-like natural killer receptors by CD8 T cells in the murine small intestine. Immunology. 2008;125:38-47 pubmed publisher
  2. Vance R, Kraft J, Altman J, Jensen P, Raulet D. Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b). J Exp Med. 1998;188:1841-8 pubmed
    ..Here, we report the cloning of mouse NKG2A, and demonstrate it forms an additional and distinct class I receptor, a CD94/NKG2A heterodimer...
  3. Cho J, Kim H, Webster K, Palendira M, Hahm B, Kim K, et al. Calcineurin-dependent negative regulation of CD94/NKG2A expression on naive CD8+ T cells. Blood. 2011;118:116-28 pubmed publisher
    ..lead to expression of immunoregulatory molecules on T cells, including natural killer (NK) receptors, such as CD94/NKG2A on CD8(+) T cells; these receptors restrain CD8(+) responses, thereby preventing T-cell exhaustion in chronic ..
  4. Vance R, Jamieson A, Raulet D. Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells. J Exp Med. 1999;190:1801-12 pubmed
    The heterodimeric CD94/NKG2A receptor, expressed by mouse natural killer (NK) cells, transduces inhibitory signals upon recognition of its ligand, Qa-1(b), a nonclassical major histocompatibility complex class Ib molecule...
  5. Vance R, Jamieson A, Cado D, Raulet D. Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation. Proc Natl Acad Sci U S A. 2002;99:868-73 pubmed
    ..by NK subsets and are expressed in a monoallelic fashion, but little is known about the mechanisms underlying CD94/NKG2A expression. We show here that, like Ly49 genes, mouse Nkg2a is stochastically and monoallelically expressed...
  6. Lu L, Kim H, Werneck M, Cantor H. Regulation of CD8+ regulatory T cells: Interruption of the NKG2A-Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease. Proc Natl Acad Sci U S A. 2008;105:19420-5 pubmed publisher
    ..We generated Qa-1 mutant knock-in mice that impair Qa-1 binding to the T cell receptor (TCR) and CD94/NKG2A receptors...
  7. Zhou J, Matsuoka M, Cantor H, Homer R, Enelow R. Cutting edge: engagement of NKG2A on CD8+ effector T cells limits immunopathology in influenza pneumonia. J Immunol. 2008;180:25-9 pubmed
    ..responsible for this immunopathology, and we have examined the negative regulation of CD8+ TNF production by CD94/NKG2A engagement with its receptor, Qa-1b...
  8. Lu L, Ikizawa K, Hu D, Werneck M, Wucherpfennig K, Cantor H. Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity. 2007;26:593-604 pubmed
    ..histocompatibility complex (MHC) molecule Qa-1-Qdm on activated T cells responsible for adaptive immunity and CD94-NKG2A inhibitory receptors expressed by natural-killer cells by using Qa-1-deficient and Qa-1 knockin mice containing a ..
  9. Lohwasser S, Hande P, Mager D, Takei F. Cloning of murine NKG2A, B and C: second family of C-type lectin receptors on murine NK cells. Eur J Immunol. 1999;29:755-61 pubmed
    ..Here we report the cloning of murine NKG2A, B and C...

More Information


  1. Lassen M, Lukens J, Dolina J, Brown M, Hahn Y. Intrahepatic IL-10 maintains NKG2A+Ly49- liver NK cells in a functionally hyporesponsive state. J Immunol. 2010;184:2693-701 pubmed publisher
    ..significant population of functionally hyporesponsive NK cells that express high levels of the inhibitory receptor NKG2A and lack expression of MHC class I-binding Ly49 receptors...
  2. Silver E, Lau J, Kane K. Molecular cloning of mouse NKG2A and C. Immunogenetics. 1999;49:727-30 pubmed
  3. Lieto L, Maasho K, West D, Borrego F, Coligan J. The human CD94 gene encodes multiple, expressible transcripts including a new partner of NKG2A/B. Genes Immun. 2006;7:36-43 pubmed
    ..The nkg2a gene encodes two isoforms, NKG2A and NKG2B, with the latter lacking the stem region...
  4. Ely K, Matsuoka M, Deberge M, Ruby J, Liu J, Schneider M, et al. Tissue-protective effects of NKG2A in immune-mediated clearance of virus infection. PLoS ONE. 2014;9:e108385 pubmed publisher
    ..The ligand for the inhibitory receptor, NKG2A, is the non-classical MHC-I molecule Qa1(b), which may also serve as a putative restricting element for the T cell ..
  5. Liu J, Liu S, Xia M, Xu S, Wang C, Bao Y, et al. Rhomboid domain-containing protein 3 is a negative regulator of TLR3-triggered natural killer cell activation. Proc Natl Acad Sci U S A. 2013;110:7814-9 pubmed publisher
    ..Our study outlines a mechanism for the negative regulation of NK cell activation and also provides clues for the function of the rhomboid proteins in immunity. ..
  6. van Bergen J, Thompson A, van Pel M, Retière C, Salvatori D, Raulet D, et al. HLA reduces killer cell Ig-like receptor expression level and frequency in a humanized mouse model. J Immunol. 2013;190:2880-5 pubmed publisher
    ..In addition, in the presence of HLA-Cw3, the frequency of NKG2A(+) cells and the surface expression levels of NKG2A were reduced...
  7. Cush S, Flano E. KLRG1+NKG2A+ CD8 T cells mediate protection and participate in memory responses during ?-herpesvirus infection. J Immunol. 2011;186:4051-8 pubmed publisher
    ..75% of ?HV68-specific CD8 T cells coexpress the NK receptors killer cell lectin-like receptor G1 (KLRG1) and NKG2A. In this study, we take advantage of this unique phenotype to analyze the capacity of CD8 T cells expressing or ..
  8. Orr M, Wu J, Fang M, Sigal L, Spee P, Egebjerg T, et al. Development and function of CD94-deficient natural killer cells. PLoS ONE. 2010;5:e15184 pubmed publisher
    The CD94 transmembrane-anchored glycoprotein forms disulfide-bonded heterodimers with the NKG2A subunit to form an inhibitory receptor or with the NKG2C or NKG2E subunits to assemble a receptor complex with activating DAP12 signaling ..
  9. Colmenero P, Zhang A, Qian T, Lu L, Cantor H, Soderstrom K, et al. Qa-1(b)-dependent modulation of dendritic cell and NK cell cross-talk in vivo. J Immunol. 2007;179:4608-15 pubmed
    ..In this study, we analyzed whether the interaction between Qa-1(b) expressed on DC and its CD94/NKG2A receptor on NK cells affects this process...
  10. Ota T, Takeda K, Akiba H, Hayakawa Y, Ogasawara K, Ikarashi Y, et al. IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2. Blood. 2005;106:184-92 pubmed
    ..Here we show that the CD94/NKG2A inhibitory receptor plays a critical role in down-regulating iNKT-cell responses...
  11. Byers A, Andrews N, Lukacher A. CD94/NKG2A expression is associated with proliferative potential of CD8 T cells during persistent polyoma virus infection. J Immunol. 2006;176:6121-9 pubmed
    ..infection, the majority of persistence-phase antiviral CD8 T cells express the inhibitory NK cell receptor CD94/NKG2A. In this study, we asked whether CD94/NKG2A expression is associated with Ag-specific recall of polyoma virus-..
  12. Roda Navarro P, Arce I, Renedo M, Montgomery K, Kucherlapati R, Fernández Ruiz E. Human KLRF1, a novel member of the killer cell lectin-like receptor gene family: molecular characterization, genomic structure, physical mapping to the NK gene complex and expression analysis. Eur J Immunol. 2000;30:568-76 pubmed
    ..The presence of two immunoreceptor tyrosine-based inhibitory-like motifs within the cytoplasmic tail of KLRF1 suggests an inhibitory role in NK cell and monocyte activity. ..
  13. Chaignat E, Yahya Graison E, Henrichsen C, Chrast J, Schutz F, Pradervand S, et al. Copy number variation modifies expression time courses. Genome Res. 2011;21:106-13 pubmed publisher
    ..Thus, modifying the copy number of a gene may potentially alter not only its expression level, but also the timing of its expression. ..
  14. Saether P, Westgaard I, Flornes L, Hoelsbrekken S, Ryan J, Fossum S, et al. Molecular cloning of KLRI1 and KLRI2, a novel pair of lectin-like natural killer-cell receptors with opposing signalling motifs. Immunogenetics. 2005;56:833-9 pubmed
    ..Epitope-tagged expression constructs of rat KLRI1 and rat KLRI2 induced surface expression of a nondisulphide-linked protein of M(r) 36,000/39,000 and M(r) 34,000, respectively. ..
  15. Zeng L, Sullivan L, Vivian J, Walpole N, Harpur C, Rossjohn J, et al. A structural basis for antigen presentation by the MHC class Ib molecule, Qa-1b. J Immunol. 2012;188:302-10 pubmed publisher
    ..Whereas the mode of peptide presentation by its ortholog HLA-E, and subsequent recognition by CD94-NKG2A, is known, the molecular basis of Qa-1(b) function is unclear...
  16. Stevenaert F, Van Beneden K, De Colvenaer V, Franki A, Debacker V, Boterberg T, et al. Ly49 and CD94/NKG2 receptor acquisition by NK cells does not require lymphotoxin-beta receptor expression. Blood. 2005;106:956-62 pubmed
    ..These results indicate that LTbetaR-mediated signals are not required for Ly49 and CD94/NKG2 receptor acquisition. ..
  17. Rapaport A, Schriewer J, Gilfillan S, Hembrador E, Crump R, Plougastel B, et al. The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8⁺ T Cells in Response to a Lethal Poxvirus Infection. Immunity. 2015;43:1112-24 pubmed publisher
    ..Several inhibitory receptors limit the magnitude and duration of these anti-viral responses. NKG2A, which is encoded by Klrc1, is a lectin-like inhibitory receptor that is expressed as a heterodimer with CD94 on ..
  18. Koike J, Wakao H, Ishizuka Y, Sato T, Hamaoki M, Seino K, et al. Bone marrow allograft rejection mediated by a novel murine NK receptor, NKG2I. J Exp Med. 2004;199:137-44 pubmed
    ..NKG2I is a novel activating receptor mediating recognition and rejection of allogeneic target cells. ..
  19. Hall L, Murphy C, Quinlan A, Hurley G, Shanahan F, Nally K, et al. Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptor. Mucosal Immunol. 2013;6:1016-26 pubmed publisher
    ..oxygen species and cytokine production, by direct cell-to-cell contact involving the NK cell-inhibitory receptor NKG2A. Our results indicate an immunoregulatory mechanism of action of NK cells attenuating DSS-induced colitis ..
  20. Zou Z, Zuo D, Yang J, Fan H. The ANXA1 released from intestinal epithelial cells alleviate DSS-induced colitis by improving NKG2A expression of Natural Killer cells. Biochem Biophys Res Commun. 2016;478:213-220 pubmed publisher
    ..In addition, the expression of NKG2A was upregulated when co-cultured with NK cells...