Klf4

Summary

Gene Symbol: Klf4
Description: Kruppel-like factor 4 (gut)
Alias: EZF, Gklf, Zie, Krueppel-like factor 4, Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF), epithelial zinc finger protein EZF, gut-enriched krueppel-like factor
Species: mouse
Products:     Klf4

Top Publications

  1. Han D, Tapia N, Joo J, Greber B, Arauzo Bravo M, Bernemann C, et al. Epiblast stem cell subpopulations represent mouse embryos of distinct pregastrulation stages. Cell. 2010;143:617-27 pubmed publisher
    ..Our findings suggest that the rare ability of EpiSCs to contribute to chimeras is due to the presence of the minor EpiSC fraction representing the early epiblast. ..
  2. Yoon H, Yang V. Requirement of Krüppel-like factor 4 in preventing entry into mitosis following DNA damage. J Biol Chem. 2004;279:5035-41 pubmed
    Previous studies indicate that Krüppel-like factor 4 (KLF4 or GKLF) controls the G1/S cell cycle checkpoint upon DNA damage...
  3. Moore D, Blackmore M, Hu Y, Kaestner K, Bixby J, Lemmon V, et al. KLF family members regulate intrinsic axon regeneration ability. Science. 2009;326:298-301 pubmed publisher
    ..screening genes developmentally regulated in retinal ganglion cells (RGCs), we identified Krüppel-like factor-4 (KLF4) as a transcriptional repressor of axon growth in RGCs and other CNS neurons...
  4. Swamynathan S, Katz J, Kaestner K, Ashery Padan R, Crawford M, Piatigorsky J. Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells. Mol Cell Biol. 2007;27:182-94 pubmed
    The Krüppel-like transcription factor KLF4 is among the most highly expressed transcription factors in the mouse cornea (B. Norman, J. Davis, and J. Piatigorsky, Investig. Ophthalmol. Vis. Sci. 45:429-440, 2004)...
  5. Schuetz A, Nana D, Rose C, Zocher G, Milanovic M, Koenigsmann J, et al. The structure of the Klf4 DNA-binding domain links to self-renewal and macrophage differentiation. Cell Mol Life Sci. 2011;68:3121-31 pubmed publisher
    Krueppel-like factor 4 (Klf4) belongs to the Sp/Klf family of zinc-finger transcription factors and is indispensable for terminal maturation of epithelial tissues...
  6. Feinberg M, Wara A, Cao Z, Lebedeva M, Rosenbauer F, Iwasaki H, et al. The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation. EMBO J. 2007;26:4138-48 pubmed
    ..Here we show that KLF4/GKLF is expressed in a monocyte-restricted and stage-specific pattern during myelopoiesis and functions to promote ..
  7. Ehlermann J, Pfisterer P, Schorle H. Dynamic expression of Krüppel-like factor 4 (Klf4), a target of transcription factor AP-2alpha during murine mid-embryogenesis. Anat Rec A Discov Mol Cell Evol Biol. 2003;273:677-80 pubmed
    Krüppel-like factor 4 (Klf4) belongs to the family of transcription factors that are thought to be involved in the regulation of epithelial and germ cell differentiation, based on their expression in postproliferative cells of the skin, ..
  8. Chen X, Whitney E, Gao S, Yang V. Transcriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation. J Mol Biol. 2003;326:665-77 pubmed
    Krüppel-like factor 4 (KLF4) is an epithelially enriched, zinc finger-containing transcription factor, the expression of which is associated with growth arrest...
  9. Cowan C, Kohler E, Dugan T, Mirza M, Malik A, Wary K. Kruppel-like factor-4 transcriptionally regulates VE-cadherin expression and endothelial barrier function. Circ Res. 2010;107:959-66 pubmed publisher
    ..may have an important role in mediating the expression of VE-cadherin and AJ integrity, we studied the function of KLF4 in regulating VE-cadherin expression and the control of endothelial barrier function...

More Information

Publications63

  1. Wei Z, Yang Y, Zhang P, Andrianakos R, Hasegawa K, Lyu J, et al. Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Stem Cells. 2009;27:2969-78 pubmed publisher
    ..Oct4, Sox2, and Klf4, factors that share many target genes in embryonic stem (ES) cells, are critical components in various ..
  2. Alder J, Georgantas R, Hildreth R, Kaplan I, Morisot S, Yu X, et al. Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo. J Immunol. 2008;180:5645-52 pubmed
    ..We demonstrate in this study that hematopoietic cells from KLF4(-/-) fetal livers (FL) contained normal numbers of functional hematopoietic progenitor cells, were radioprotective, ..
  3. Shao J, Yang V, Sheng H. Prostaglandin E2 and Krüppel-like transcription factors synergistically induce the expression of decay-accelerating factor in intestinal epithelial cells. Immunology. 2008;125:397-407 pubmed publisher
    ..Overexpression of KLF4 and KLF5 robustly induced transcriptional activity of the DAF promoter...
  4. Ton That H, Kaestner K, Shields J, Mahatanankoon C, Yang V. Expression of the gut-enriched Krüppel-like factor gene during development and intestinal tumorigenesis. FEBS Lett. 1997;419:239-43 pubmed
    We examined the expression of GKLF (gut-enriched Krüppel-like factor), a recently identified zinc finger-containing transcription factor, in mice during development using the ribonuclease protection assay...
  5. Katz J, Perreault N, Goldstein B, Actman L, McNally S, Silberg D, et al. Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach. Gastroenterology. 2005;128:935-45 pubmed
    The epithelial zinc-finger transcription factor Klf4 (formerly GKLF) regulates cellular proliferation and differentiation in vitro. Klf4 null mice die by postnatal day 1 and show changes in epithelial differentiation of skin and colon...
  6. Ghaleb A, McConnell B, Nandan M, Katz J, Kaestner K, Yang V. Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Res. 2007;67:7147-54 pubmed
    The zinc finger transcription factor Krüppel-like factor 4 (KLF4) is frequently down-regulated in colorectal cancer...
  7. Ghaleb A, McConnell B, Kaestner K, Yang V. Altered intestinal epithelial homeostasis in mice with intestine-specific deletion of the Krüppel-like factor 4 gene. Dev Biol. 2011;349:310-20 pubmed publisher
    The zinc finger transcription factor, Krüppel-like factor 4 (KLF4), is expressed in the post-mitotic, differentiated epithelial cells lining the intestinal tract and exhibits a tumor suppressive effect on intestinal tumorigenesis...
  8. Feinberg M, Cao Z, Wara A, Lebedeva M, SenBanerjee S, Jain M. Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages. J Biol Chem. 2005;280:38247-58 pubmed
    ..Herein, we identify Kruppel-like factor 4 (KLF4) as being markedly induced in response to IFN-gamma, LPS, or tumor necrosis factor-alpha and decreased by TGF-beta1 ..
  9. Garrett Sinha L, Eberspaecher H, Seldin M, de Crombrugghe B. A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. J Biol Chem. 1996;271:31384-90 pubmed
    ..The chromosomal location of the gene was mapped using mouse interspecific backcrosses and was shown to localize to mouse chromosome 4 and to cosegregate with the thioredoxin gene. ..
  10. Yamada T, Park C, Mamonkin M, Lacorazza H. Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Krüppel-like factors KLF4 and KLF2. Nat Immunol. 2009;10:618-26 pubmed publisher
    ..Here we demonstrate that the transcription factor ELF4 directly activated the tumor suppressor KLF4 'downstream' of T cell antigen receptor signaling to induce cell cycle arrest in naive CD8(+) T cells...
  11. Wang C, Han M, Zhao X, Wen J. Kruppel-like factor 4 is required for the expression of vascular smooth muscle cell differentiation marker genes induced by all-trans retinoic acid. J Biochem. 2008;144:313-21 pubmed publisher
    Krüppel-like factor 4 (KLF4) is involved in phenotypic modulation of vascular smooth muscle cells (VSMCs). All-trans retinoic acid (ATRA) inhibits VSMC proliferation and induces VSMC differentiation...
  12. Han D, Greber B, Wu G, Tapia N, Arauzo Bravo M, Ko K, et al. Direct reprogramming of fibroblasts into epiblast stem cells. Nat Cell Biol. 2011;13:66-71 pubmed publisher
    ..Introduction of the four transcription factors Oct4, Sox2, Klf4 and c-Myc into somatic cells has been shown to generate induced pluripotent stem cells (iPSCs) that are very ..
  13. Li Y, McClintick J, Zhong L, Edenberg H, Yoder M, Chan R. Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4. Blood. 2005;105:635-7 pubmed
    ..of 2 significantly up-regulated genes, suppressor of cytokine signaling-3 (SOCS-3) and Kruppel-like factor 4 (Klf4), was verified using Northern blotting...
  14. Dang D, Bachman K, Mahatan C, Dang L, Giardiello F, Yang V. Decreased expression of the gut-enriched Krüppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients. FEBS Lett. 2000;476:203-7 pubmed
    Gut-enriched Krüppel-like factor (GKLF) is a zinc finger-containing transcription factor, the expression of which is associated with growth arrest...
  15. Mahatan C, Kaestner K, Geiman D, Yang V. Characterization of the structure and regulation of the murine gene encoding gut-enriched Krüppel-like factor (Krüppel-like factor 4). Nucleic Acids Res. 1999;27:4562-9 pubmed
    Gut-enriched Krüppel-like factor (GKLF, KLF4) is an epithelial-specific transcription factor whose expression is associated with growth arrest...
  16. Hagos E, Ghaleb A, Dalton W, Bialkowska A, Yang V. Mouse embryonic fibroblasts null for the Krüppel-like factor 4 gene are genetically unstable. Oncogene. 2009;28:1197-205 pubmed publisher
    Krüppel-like factor 4 (KLF4) is a zinc-finger transcription factor with tumor suppressive activity in colorectal cancer...
  17. Yoon H, Ghaleb A, Nandan M, Hisamuddin I, Dalton W, Yang V. Krüppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage. Oncogene. 2005;24:4017-25 pubmed
    ..Here, we present evidence for the involvement of the mammalian Krüppel-like transcription factor, KLF4, in preventing centrosome amplification following DNA damage caused by gamma-irradiation...
  18. Ghaleb A, Aggarwal G, Bialkowska A, Nandan M, Yang V. Notch inhibits expression of the Krüppel-like factor 4 tumor suppressor in the intestinal epithelium. Mol Cancer Res. 2008;6:1920-7 pubmed publisher
    The zinc finger-containing transcription factor, Krüppel-like factor 4 (KLF4), inhibits cell proliferation...
  19. Zhou G, Hamik A, Nayak L, Tian H, Shi H, Lu Y, et al. Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice. J Clin Invest. 2012;122:4727-31 pubmed publisher
    ..Here, we show that endothelial KLF4 is an essential determinant of atherogenesis and thrombosis...
  20. Segre J, Bauer C, Fuchs E. Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat Genet. 1999;22:356-60 pubmed
    ..We show here that Kruppel-like factor 4 (Klf4, encoded by the gene Klf4), highly expressed in the differentiating layers of epidermis, is both vital to and ..
  21. Evans P, Chen X, Zhang W, Liu C. KLF4 interacts with beta-catenin/TCF4 and blocks p300/CBP recruitment by beta-catenin. Mol Cell Biol. 2010;30:372-81 pubmed publisher
    ..Our laboratory recently found that KLF4, a transcription factor highly expressed in the adult intestine and critical for intestinal differentiation, ..
  22. Hamik A, Lin Z, Kumar A, Balcells M, Sinha S, Katz J, et al. Kruppel-like factor 4 regulates endothelial inflammation. J Biol Chem. 2007;282:13769-79 pubmed
    ..These data implicate Kruppel-like factor 4 as a novel regulator of endothelial activation in response to pro-inflammatory stimuli. ..
  23. Pellegrinet L, Rodilla V, Liu Z, Chen S, Koch U, Espinosa L, et al. Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology. 2011;140:1230-1240.e1-7 pubmed publisher
    ..Furthermore, we investigated whether the induction of goblet cell differentiation that results from loss of Notch requires the transcription factor Krüppel-like factor 4 (Klf4).
  24. Yoon H, Chen X, Yang V. Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage. J Biol Chem. 2003;278:2101-5 pubmed
    ..Previous studies indicate that the Krüppel-like factor 4 (KLF4) gene is activated following DNA damage and that such activation depends on p53...
  25. Yoshida T, Gan Q, Franke A, Ho R, Zhang J, Chen Y, et al. Smooth and cardiac muscle-selective knock-out of Kruppel-like factor 4 causes postnatal death and growth retardation. J Biol Chem. 2010;285:21175-84 pubmed publisher
    Krüppel-like factor 4 (Klf4) is a transcription factor involved in differentiation and proliferation in multiple tissues...
  26. Liao X, Sharma N, Kapadia F, Zhou G, Lu Y, Hong H, et al. Krüppel-like factor 4 regulates macrophage polarization. J Clin Invest. 2011;121:2736-49 pubmed publisher
    ..Here we report our studies that identify Krüppel-like factor 4 (KLF4) as a critical regulator of macrophage polarization...
  27. Qin S, Zhang C. Role of Kruppel-like factor 4 in neurogenesis and radial neuronal migration in the developing cerebral cortex. Mol Cell Biol. 2012;32:4297-305 pubmed publisher
    ..Krüppel-like factor 4 (KLF4) is expressed in neural stem cells and controls axonal regeneration...
  28. Sharma N, Lu Y, Zhou G, Liao X, Kapil P, Anand P, et al. Myeloid Krüppel-like factor 4 deficiency augments atherogenesis in ApoE-/- mice--brief report. Arterioscler Thromb Vasc Biol. 2012;32:2836-8 pubmed publisher
    To investigate the role of Krüppel-like factor 4 (KLF4), an essential transcriptional regulator of macrophage polarization (M1/M2), in the pathogenesis of atherosclerosis...
  29. Yusuf I, Kharas M, Chen J, Peralta R, Maruniak A, Sareen P, et al. KLF4 is a FOXO target gene that suppresses B cell proliferation. Int Immunol. 2008;20:671-81 pubmed publisher
    ..However, the transcription factors that regulate B cell quiescence are not known. KLF4 is a candidate tumor suppressor gene in B lymphocytes, and thus a likely candidate for regulating B cell ..
  30. Liu J, Liu Y, Zhang H, Chen G, Wang K, Xiao X. KLF4 promotes the expression, translocation, and releas eof HMGB1 in RAW264.7 macrophages in response to LPS. Shock. 2008;30:260-6 pubmed publisher
    Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor with diverse regulatory functions in cell growth, proliferation, differentiation, and embryogenesis...
  31. Ghaleb A, Katz J, Kaestner K, Du J, Yang V. Krüppel-like factor 4 exhibits antiapoptotic activity following gamma-radiation-induced DNA damage. Oncogene. 2007;26:2365-73 pubmed
    ..The zinc-finger-containing transcription factor, Krüppel-like factor 4 (KLF4), is a crucial mediator for the checkpoint functions of p53 after gamma-irradiation and does so by inhibiting the ..
  32. Rowland B, Bernards R, Peeper D. The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Nat Cell Biol. 2005;7:1074-82 pubmed
    b>KLF4 (GKLF/EZF) encodes a transcription factor that is associated with both tumour suppression and oncogenesis. We describe the identification of KLF4 in a functional genomic screen for genes that bypass RAS(V12)-induced senescence...
  33. Zhang W, Geiman D, Shields J, Dang D, Mahatan C, Kaestner K, et al. The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter. J Biol Chem. 2000;275:18391-8 pubmed
    ..We show that the gene encoding the gut-enriched Krüppel-like factor (GKLF, KLF4) is concurrently induced with p21(WAF1/Cip1) during serum deprivation and DNA damage elicited by methyl ..
  34. Shields J, Yang V. Identification of the DNA sequence that interacts with the gut-enriched Krüppel-like factor. Nucleic Acids Res. 1998;26:796-802 pubmed
    The gut-enriched Krüppel-like factor (GKLF) is a recently identified eukaryotic transcription factor that contains three C2H2zinc fingers...
  35. Jiang J, Chan Y, Loh Y, Cai J, Tong G, Lim C, et al. A core Klf circuitry regulates self-renewal of embryonic stem cells. Nat Cell Biol. 2008;10:353-60 pubmed publisher
    ..differentiated state of somatic cells back to a pluripotent state with a combination of four transcription factors: Klf4 is one of the reprogramming factors required, in conjunction with Oct4, Sox2 and c-Myc...
  36. Michikami I, Fukushi T, Tanaka M, Egusa H, Maeda Y, Ooshima T, et al. Krüppel-like factor 4 regulates membranous and endochondral ossification. Exp Cell Res. 2012;318:311-25 pubmed publisher
    Krüppel-like factor 4 (KLF4/GKLF/EZF) is a zinc finger type of transcription factor highly expressed in the skin, intestine, testis, lung and bone...
  37. Ghaleb A, Nandan M, Chanchevalap S, Dalton W, Hisamuddin I, Yang V. Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation. Cell Res. 2005;15:92-6 pubmed
    ..b>KLF4 and KLF5 are two closely related members of the KLF family that have a similar tissue distribution in embryos and ..
  38. Katz J, Perreault N, Goldstein B, Lee C, Labosky P, Yang V, et al. The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development. 2002;129:2619-28 pubmed
    Klf4 (formerly GKLF) is a zinc-finger transcription factor expressed in the epithelia of the skin, lungs, gastrointestinal tract and several other organs...
  39. Yoshida T, Kaestner K, Owens G. Conditional deletion of Krüppel-like factor 4 delays downregulation of smooth muscle cell differentiation markers but accelerates neointimal formation following vascular injury. Circ Res. 2008;102:1548-57 pubmed publisher
    ..We previously showed that Krüppel-like factor 4 (Klf4) suppressed SMC differentiation markers in cultured SMCs...
  40. Yet S, McA Nulty M, Folta S, Yen H, Yoshizumi M, Hsieh C, et al. Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. J Biol Chem. 1998;273:1026-31 pubmed
    ..Sequence analysis indicated that our clone, hEZF, is the human homologue of the recently reported mouse EZF and GKLF. hEZF is a single-copy gene that maps to chromosome 9q31...
  41. Zhang W, Shields J, Sogawa K, Fujii Kuriyama Y, Yang V. The gut-enriched Krüppel-like factor suppresses the activity of the CYP1A1 promoter in an Sp1-dependent fashion. J Biol Chem. 1998;273:17917-25 pubmed
    The gut-enriched Krüppel-like factor (GKLF) is a newly identified zinc finger-containing transcription factor...
  42. Yu T, Chen X, Zhang W, Li J, Xu R, Wang T, et al. Krüppel-like factor 4 regulates intestinal epithelial cell morphology and polarity. PLoS ONE. 2012;7:e32492 pubmed publisher
    Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor that plays a vital role in regulating cell lineage differentiation during development and maintaining epithelial homeostasis in the intestine...
  43. Panigada M, Porcellini S, Sutti F, Doneda L, Pozzoli O, Consalez G, et al. GKLF in thymus epithelium as a developmentally regulated element of thymocyte-stroma cross-talk. Mech Dev. 1999;81:103-13 pubmed
    Gut-enriched Krüppel-like factor (GKLF) is a transcriptional regulator expressed in differentiated epithelia...
  44. Nakatake Y, Fukui N, Iwamatsu Y, Masui S, Takahashi K, Yagi R, et al. Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells. Mol Cell Biol. 2006;26:7772-82 pubmed
    ..By functional screening of ES-specific transcription factors, we found that Krüppel-like factor 4 (Klf4) cooperates with Oct3/4 and Sox2 to activate Lefty1 expression, and that Klf4 acts as a mediating factor that ..
  45. McConnell B, Ghaleb A, Nandan M, Yang V. The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology. Bioessays. 2007;29:549-57 pubmed
    ..b>KLF4 and KLF5 are two closely related members of this family and are both highly expressed in epithelial tissues...
  46. Zhang P, Andrianakos R, Yang Y, Liu C, Lu W. Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression. J Biol Chem. 2010;285:9180-9 pubmed publisher
    Transcription factor Kruppel-like factor 4 (Klf4) is essential for somatic cell reprogramming. In addition, Klf4 seems to play a redundant role along with other Klf family proteins in embryonic stem (ES) cell self-renewal...
  47. Nishiyama A, Xin L, Sharov A, Thomas M, Mowrer G, Meyers E, et al. Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell. 2009;5:420-33 pubmed publisher
    ..Of the 50 TFs, Cdx2 provoked the most extensive transcriptome perturbation in ESCs, followed by Esx1, Sox9, Tcf3, Klf4, and Gata3. ChIP-Seq revealed that CDX2 binds to promoters of upregulated target genes...
  48. Yori J, Seachrist D, Johnson E, Lozada K, Abdul Karim F, Chodosh L, et al. Krüppel-like factor 4 inhibits tumorigenic progression and metastasis in a mouse model of breast cancer. Neoplasia. 2011;13:601-10 pubmed
    Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor that functions as an oncogene or tumor suppressor in a highly tissue-specific cell-dependent manner...
  49. Folmes C, Nelson T, Martinez Fernandez A, Arrell D, Lindor J, Dzeja P, et al. Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming. Cell Metab. 2011;14:264-71 pubmed publisher
    ..Thus, the energetic infrastructure of somatic cells transitions into a required glycolytic metabotype to fuel induction of pluripotency. ..
  50. Qin S, Liu M, Niu W, Zhang C. Dysregulation of Kruppel-like factor 4 during brain development leads to hydrocephalus in mice. Proc Natl Acad Sci U S A. 2011;108:21117-21 pubmed publisher
    Kruppel-like factor 4 (KLF4) is involved in self-renewal of embryonic stem cells and reprogramming of somatic cells to pluripotency. However, its role in lineage-committed stem cells remains largely unknown...
  51. Shields J, Christy R, Yang V. Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest. J Biol Chem. 1996;271:20009-17 pubmed
    A cDNA clone, named gut-enriched Krüppel-like factor (GKLF), was isolated from an NIH 3T3 library using a probe encoding the zinc finger region of the immediate-early transcription factor zif/268...
  52. Zheng H, Pritchard D, Yang X, Bennett E, Liu G, Liu C, et al. KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol. 2009;296:G490-8 pubmed publisher
    ..The aim of this study was to examine whether Notch represses KLF4 expression to regulate goblet cell differentiation...
  53. Ghorpade D, Holla S, Sinha A, Alagesan S, Balaji K. Nitric oxide and KLF4 protein epigenetically modify class II transactivator to repress major histocompatibility complex II expression during Mycobacterium bovis bacillus Calmette-Guerin infection. J Biol Chem. 2013;288:20592-606 pubmed publisher
    ..NO responsive recruitment of a bifunctional transcription factor, KLF4, to the promoter of CIITA during M...
  54. Abrigo M, Alvarez R, Paparella M, Calb D, Bal de Kier Joffe E, Gutkind J, et al. Impairing squamous differentiation by Klf4 deletion is sufficient to initiate tongue carcinoma development upon K-Ras activation in mice. Carcinogenesis. 2014;35:662-9 pubmed publisher
    ..Among these, Kr?ppel-like factor 4 (Klf4) suppresses cell proliferation and promotes differentiation and thus helps to maintain epithelial homeostasis...