Klf2

Summary

Gene Symbol: Klf2
Description: Kruppel-like factor 2 (lung)
Alias: Lklf, Krueppel-like factor 2, lung krueppel-like factor
Species: mouse
Products:     Klf2

Top Publications

  1. Lin Z, Natesan V, Shi H, Dong F, Kawanami D, Mahabeleshwar G, et al. Kruppel-like factor 2 regulates endothelial barrier function. Arterioscler Thromb Vasc Biol. 2010;30:1952-9 pubmed publisher
    ..Accumulating evidence implicates the Kruppel-like factor 2 (KLF2) as a key regulator of endothelial function. However, its role in vascular barrier function is unknown...
  2. Bai A, Hu H, Yeung M, Chen J. Kruppel-like factor 2 controls T cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor 1 transcription. J Immunol. 2007;178:7632-9 pubmed
    Krüppel-like factor 2 (KLF2) is a member of zinc-finger transcription factors...
  3. Atkins G, Wang Y, Mahabeleshwar G, Shi H, Gao H, Kawanami D, et al. Hemizygous deficiency of Krüppel-like factor 2 augments experimental atherosclerosis. Circ Res. 2008;103:690-3 pubmed publisher
    ..Although the composite effects of KLF2 in these 2 cell types predict that it likely inhibits vascular inflammation, the role of KLF2 in this process in ..
  4. Chiplunkar A, Lung T, Alhashem Y, Koppenhaver B, Salloum F, Kukreja R, et al. Krüppel-like factor 2 is required for normal mouse cardiac development. PLoS ONE. 2013;8:e54891 pubmed publisher
    Krüppel-like factor 2 (KLF2) is expressed in endothelial cells in the developing heart, particularly in areas of high shear stress, such as the atrioventricular (AV) canal...
  5. Lingrel J, Pilcher Roberts R, Basford J, Manoharan P, Neumann J, Konaniah E, et al. Myeloid-specific Krüppel-like factor 2 inactivation increases macrophage and neutrophil adhesion and promotes atherosclerosis. Circ Res. 2012;110:1294-302 pubmed publisher
    Hemizygous deficiency of the transcription factor Krüppel-like factor 2 (KLF2) has been shown previously to augment atherosclerosis in hypercholesterolemic mice...
  6. Kuo C, Veselits M, Leiden J. LKLF: A transcriptional regulator of single-positive T cell quiescence and survival. Science. 1997;277:1986-90 pubmed
    ..Here it was found that the expression of a Kruppel-like zinc finger transcription factor, lung Kruppel-like factor (LKLF), is developmentally induced during the maturation of SP quiescent T cells and rapidly extinguished after SP T cell ..
  7. Alhashem Y, Vinjamur D, Basu M, Klingmuller U, Gaensler K, Lloyd J. Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding. J Biol Chem. 2011;286:24819-27 pubmed publisher
    ..KLF1 (erythroid Krüppel-like factor) plays essential roles in embryonic and adult erythropoiesis. KLF2 is a positive regulator of the mouse and human embryonic ?-globin genes...
  8. Weinreich M, Jameson S, Hogquist K. Postselection thymocyte maturation and emigration are independent of IL-7 and ERK5. J Immunol. 2011;186:1343-7 pubmed publisher
    The transcription factor Krüppel-like factor 2 (KLF2) controls the emigration of conventional T cells from the thymus through its regulation of the cell surface receptor S1P1...
  9. Takada K, Wang X, Hart G, Odumade O, Weinreich M, Hogquist K, et al. Kruppel-like factor 2 is required for trafficking but not quiescence in postactivated T cells. J Immunol. 2011;186:775-83 pubmed publisher
    The transcription factor Kruppel-like factor 2 (KLF2) was proposed to regulate genes involved in cell cycle entry and T cell trafficking; however, the physiological role of its expression in postactivated T cells is not well defined...

More Information

Publications81

  1. Han D, Tapia N, Joo J, Greber B, Arauzo Bravo M, Bernemann C, et al. Epiblast stem cell subpopulations represent mouse embryos of distinct pregastrulation stages. Cell. 2010;143:617-27 pubmed publisher
    ..Our findings suggest that the rare ability of EpiSCs to contribute to chimeras is due to the presence of the minor EpiSC fraction representing the early epiblast. ..
  2. Hall J, Guo G, Wray J, Eyres I, Nichols J, Grotewold L, et al. Oct4 and LIF/Stat3 additively induce Krüppel factors to sustain embryonic stem cell self-renewal. Cell Stem Cell. 2009;5:597-609 pubmed publisher
    ..Oct4 primarily induces Klf2 while LIF/Stat3 selectively enhances Klf4 expression...
  3. Bista P, Mele D, Baez D, Huber B. Lymphocyte quiescence factor Dpp2 is transcriptionally activated by KLF2 and TOB1. Mol Immunol. 2008;45:3618-23 pubmed publisher
    ..Since lung Kruppel-like factor (KLF2), a transcription factor, and TOB1, a transcriptional co-activator, have been shown to be important in maintaining ..
  4. Sebzda E, Zou Z, Lee J, Wang T, Kahn M. Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns. Nat Immunol. 2008;9:292-300 pubmed publisher
    ..Here we identify Krupple-like factor 2 (KLF2) as a key transcriptional factor needed to prevent naive T cells from expressing inflammatory chemokine receptors ..
  5. Carlson C, Endrizzi B, Wu J, Ding X, Weinreich M, Walsh E, et al. Kruppel-like factor 2 regulates thymocyte and T-cell migration. Nature. 2006;442:299-302 pubmed
    ..Kruppel-like factor (KLF) 2 (also known as LKLF) leads to a massive loss of the peripheral T-cell pool, suggesting KLF2 regulates T-cell quiescence and survival. Here we show, however, that KLF2 is essential for T-cell trafficking...
  6. Wani M, Means R, Lingrel J. Loss of LKLF function results in embryonic lethality in mice. Transgenic Res. 1998;7:229-38 pubmed
    Lung Kruppel-like factor (LKLF) is a member of the Kruppel-like family of zinc finger transcription factors and is closely related to erythroid kruppel-like factor (EKLF), which is necessary for beta-globin gene expression...
  7. Wani M, Wert S, Lingrel J. Lung Kruppel-like factor, a zinc finger transcription factor, is essential for normal lung development. J Biol Chem. 1999;274:21180-5 pubmed
    Lung Kruppel-like factor (LKLF) is a member of the Kruppel-like factor family of transcription factors and is highly expressed in lung with limited distribution in other tissues...
  8. Hoek K, Gordy L, Collins P, Parekh V, Aune T, Joyce S, et al. Follicular B cell trafficking within the spleen actively restricts humoral immune responses. Immunity. 2010;33:254-65 pubmed publisher
    ..that B cell sequestration requires lineage-specific regulation of migratory receptors by the transcription factor Klf2. Moreover, using gene-targeted mice we show that altered splenic B cell migration confers a significant in vivo ..
  9. Kuo C, Veselits M, Barton K, Lu M, Clendenin C, Leiden J. The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis. Genes Dev. 1997;11:2996-3006 pubmed
    ..In this paper, we examine the role of the zinc finger transcription factor LKLF in murine blood vessel morphogenesis and homeostasis...
  10. Shi H, Sheng B, Zhang F, Wu C, Zhang R, Zhu J, et al. Kruppel-like factor 2 protects against ischemic stroke by regulating endothelial blood brain barrier function. Am J Physiol Heart Circ Physiol. 2013;304:H796-805 pubmed publisher
    ..Kruppel-like factor 2 (KLF2) is regulated by flow, is highly expressed in vascular endothelial cells (ECs), and serves as a key molecular ..
  11. Hart G, Wang X, Hogquist K, Jameson S. Krüppel-like factor 2 (KLF2) regulates B-cell reactivity, subset differentiation, and trafficking molecule expression. Proc Natl Acad Sci U S A. 2011;108:716-21 pubmed publisher
    The transcription factor Krüppel-like factor 2 (KLF2) is critical for normal trafficking of T lymphocytes, but its role in B cells is unclear...
  12. Wu J, Lingrel J. Krüppel-like factor 2, a novel immediate-early transcriptional factor, regulates IL-2 expression in T lymphocyte activation. J Immunol. 2005;175:3060-6 pubmed
    ..Previous studies have found that expression of Krüppel-like factor 2 (KLF2), a zinc finger transcription factor, is extinguished after T cell activation...
  13. Odumade O, Weinreich M, Jameson S, Hogquist K. Krüppel-like factor 2 regulates trafficking and homeostasis of gammadelta T cells. J Immunol. 2010;184:6060-6 pubmed publisher
    ..Both of these genes are regulated by the transcription factor Krüppel-like factor 2 (KLF2) in conventional alphabeta T cells. It is unclear if gammadelta T cells use similar mechanisms...
  14. Weinreich M, Takada K, Skon C, Reiner S, Jameson S, Hogquist K. KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity. 2009;31:122-30 pubmed publisher
    The transcription factor KLF2 regulates T cell trafficking by promoting expression of the lipid-binding receptor S1P(1) and the selectin CD62L. Recently, it was proposed that KLF2 also represses the expression of chemokine receptors...
  15. Wu J, Bohanan C, Neumann J, Lingrel J. KLF2 transcription factor modulates blood vessel maturation through smooth muscle cell migration. J Biol Chem. 2008;283:3942-50 pubmed
    ..b>KLF2(-/-) embryos fail to develop beyond 13.5 days because of a lack of blood vessel stabilization...
  16. Jiang J, Chan Y, Loh Y, Cai J, Tong G, Lim C, et al. A core Klf circuitry regulates self-renewal of embryonic stem cells. Nat Cell Biol. 2008;10:353-60 pubmed publisher
    ..Here, we show that Krüppel-like factors are required for the self-renewal of ES cells. Simultaneous depletion of Klf2, Klf4 and Klf5 lead to ES cell differentiation...
  17. Lee J, Yu Q, Shin J, Sebzda E, Bertozzi C, Chen M, et al. Klf2 is an essential regulator of vascular hemodynamic forces in vivo. Dev Cell. 2006;11:845-57 pubmed
    ..The transcription factor KLF2 is activated by fluid shear stress in cultured endothelial cells, where it regulates a large number of vasoactive ..
  18. Basu P, Lung T, Lemsaddek W, Sargent T, Williams D, Basu M, et al. EKLF and KLF2 have compensatory roles in embryonic beta-globin gene expression and primitive erythropoiesis. Blood. 2007;110:3417-25 pubmed
    ..b>KLF2 is required for normal embryonic Ey- and betah1-, but not adult betaglobin, gene expression in mice...
  19. Winkelmann R, Sandrock L, Porstner M, Roth E, Mathews M, Hobeika E, et al. B cell homeostasis and plasma cell homing controlled by Krüppel-like factor 2. Proc Natl Acad Sci U S A. 2011;108:710-5 pubmed publisher
    Krüppel-like factor 2 (KLF2) controls T lymphocyte egress from lymphoid organs by regulating sphingosin-1 phosphate receptor 1 (S1Pr1). Here we show that this is not the case for B cells...
  20. Schrick J, Hughes M, Anderson K, Croyle M, Lingrel J. Characterization of the lung Krüppel-like transcription factor gene and upstream regulatory elements. Gene. 1999;236:185-95 pubmed
    We previously described the isolation and characterization of the cDNA for lung Krüppel-like factor (LKLF), a zinc finger transcription factor that is predominately expressed in the lung of adult mice...
  21. Conkright M, Wani M, Lingrel J. Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase. J Biol Chem. 2001;276:29299-306 pubmed
    Lung Krüppel-like factor (LKLF/Krüppel-like factor 2), a member of the Krüppel-like factor family of transcription factors, is expressed predominantly in the lungs, with low levels of expression in other organs such as heart, spleen, ..
  22. Sohn S, Li D, Lee L, Winoto A. Transcriptional regulation of tissue-specific genes by the ERK5 mitogen-activated protein kinase. Mol Cell Biol. 2005;25:8553-66 pubmed
    ..revealed several potential ERK5 target genes, including a proapoptotic gene bnip3, known angiogenic genes flt1 and lklf (lung Krüppel-like factor), and genes that regulate cardiovascular development...
  23. Kang Y, Kim J, Anderson J, Wu J, Gleim S, Kundu R, et al. Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development. Circ Res. 2013;113:22-31 pubmed publisher
    ..Our results demonstrate a novel role for apelin-APJ signaling as a potent regulator of endothelial MEF2 function in the developing cardiovascular system. ..
  24. Renz M, Otten C, Faurobert E, Rudolph F, Zhu Y, Boulday G, et al. Regulation of β1 integrin-Klf2-mediated angiogenesis by CCM proteins. Dev Cell. 2015;32:181-90 pubmed publisher
    ..Here we report that the upregulation of klf2 mRNA causes enhanced egfl7 expression and angiogenesis signaling, which underlies cardiovascular defects associated ..
  25. Zhou Z, Tang A, Wong W, Bamezai S, Goddard L, Shenkar R, et al. Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling. Nature. 2016;532:122-6 pubmed publisher
    ..Using a neonatal mouse model of CCM disease, we show that expression of the MEKK3 target genes Klf2 and Klf4, as well as Rho and ADAMTS protease activity, are increased in the endothelial cells of early CCM lesions...
  26. Preston G, Feijoo Carnero C, Schurch N, Cowling V, Cantrell D. The impact of KLF2 modulation on the transcriptional program and function of CD8 T cells. PLoS ONE. 2013;8:e77537 pubmed publisher
    Krüppel-like factor 2 (KLF2) is a transcription factor that is highly expressed in quiescent T lymphocytes and downregulated in effector T cells...
  27. Das M, Lu J, Joseph M, Aggarwal R, Kanji S, McMichael B, et al. Kruppel-like factor 2 (KLF2) regulates monocyte differentiation and functions in mBSA and IL-1?-induced arthritis. Curr Mol Med. 2012;12:113-25 pubmed
    Kruppel-like factor 2 (KLF2) plays an important role in the regulation of a variety of immune cells, including monocytes. We have previously shown that KLF2 inhibits proinflammatory activation of monocytes...
  28. Hart G, Peery S, Hamilton S, Jameson S. Cutting edge: Kr?ppel-like factor 2 is required for phenotypic maintenance but not development of B1 B cells. J Immunol. 2012;189:3293-7 pubmed
    ..Conditional B cell KLF2 knockout mice have increased numbers of marginal zone B cells and decreased numbers of B1 phenoytpe cells...
  29. Skon C, Lee J, Anderson K, Masopust D, Hogquist K, Jameson S. Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells. Nat Immunol. 2013;14:1285-93 pubmed publisher
    ..We found that CD8(+) T(RM) cells lacked expression of the transcription factor KLF2 and its target gene S1pr1 (which encodes S1P1, a receptor for sphingosine 1-phosphate)...
  30. Turner J, Crossley M. Mammalian Krüppel-like transcription factors: more than just a pretty finger. Trends Biochem Sci. 1999;24:236-40 pubmed
    ..Analysis of these differences is illuminating specific mechanisms by which transcription is regulated. ..
  31. Liang H, Coles A, Zhu Z, Zayas J, Jurecic R, Kang J, et al. Noncanonical Wnt signaling promotes apoptosis in thymocyte development. J Exp Med. 2007;204:3077-84 pubmed
    ..These results indicate that Wnt5a induction of the noncanonical Wnt-Ca(2+) pathway alters canonical Wnt signaling and is critical for normal T cell development. ..
  32. Alberts Grill N, Engelbertsen D, Bu D, Foks A, Grabie N, Herter J, et al. Dendritic Cell KLF2 Expression Regulates T Cell Activation and Proatherogenic Immune Responses. J Immunol. 2016;197:4651-4662 pubmed
    ..studies have shown an important anti-inflammatory role for the transcription factor Krüppel-like factor 2 (KLF2) in regulating activation of various cell types that participate in atherosclerotic lesion development, including ..
  33. Zhong F, Chen H, Wei C, Zhang W, Li Z, Jain M, et al. Reduced Krüppel-like factor 2 expression may aggravate the endothelial injury of diabetic nephropathy. Kidney Int. 2015;87:382-95 pubmed publisher
    Krüppel-like factor 2 (KLF2), a shear stress-inducible transcription factor, has endoprotective effects. In streptozotocin-induced diabetic rats, we found that glomerular Klf2 expression was reduced in comparison with nondiabetic rats...
  34. Weber J, Fuhrmann F, Feist R, Lahmann A, Al Baz M, Gentz L, et al. ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2. J Exp Med. 2015;212:217-33 pubmed publisher
    ..Bcl-6, ICOS co-stimulation was essential to maintain the phenotype by regulating the novel TFH transcription factor Klf2 via Foxo1...
  35. Kalinichenko V, Lim L, Stolz D, Shin B, Rausa F, Clark J, et al. Defects in pulmonary vasculature and perinatal lung hemorrhage in mice heterozygous null for the Forkhead Box f1 transcription factor. Dev Biol. 2001;235:489-506 pubmed
    ..Reduction in the level of Foxf1 caused neonatal pulmonary hemorrhage and abnormalities in alveologenesis, implicating this transcription factor in the regulation of mesenchyme-epithelial interaction critical for lung morphogenesis. ..
  36. Chakroborty D, Sarkar C, Yu H, Wang J, Liu Z, Dasgupta P, et al. Dopamine stabilizes tumor blood vessels by up-regulating angiopoietin 1 expression in pericytes and Kruppel-like factor-2 expression in tumor endothelial cells. Proc Natl Acad Sci U S A. 2011;108:20730-5 pubmed publisher
    ..1 (Ang1) in pericytes and the expression of the zinc finger transcriptional factor, Krüppel-like factor-2 (KLF2) in tumor endothelial cells...
  37. Doddaballapur A, Michalik K, Manavski Y, Lucas T, Houtkooper R, You X, et al. Laminar shear stress inhibits endothelial cell metabolism via KLF2-mediated repression of PFKFB3. Arterioscler Thromb Vasc Biol. 2015;35:137-45 pubmed publisher
    ..endothelial metabolism was reversed by silencing the flow-sensitive transcription factor Krüppel-like factor 2 (KLF2). Endothelial-specific deletion of KLF2 in mice induced glucose uptake in endothelial cells of perfused hearts...
  38. Chen J, Lu X, Zou K, Ye K. Krüppel-like factor 2 promotes liver steatosis through upregulation of CD36. J Lipid Res. 2014;55:32-40 pubmed publisher
    ..In the present study, we aim to investigate the roles of KLF2 in hepatic steatosis...
  39. Ahmad N, Lingrel J. Kruppel-like factor 2 transcriptional regulation involves heterogeneous nuclear ribonucleoproteins and acetyltransferases. Biochemistry. 2005;44:6276-85 pubmed
    Kruppel-like factor 2 (KLF2) is expressed in several cell types, and knockout animals have shown that KLF2 gene regulation is involved in multiple biological processes...
  40. Xu Z, Yoshida T, Wu L, Maiti D, Cebotaru L, Duh E. Transcription factor MEF2C suppresses endothelial cell inflammation via regulation of NF-κB and KLF2. J Cell Physiol. 2015;230:1310-20 pubmed publisher
    ..This inhibition of leukocyte adhesion by MEF2C was partially mediated by induction of KLF2. In mice, lipopolysaccharide (LPS)-induced leukocyte adhesion to the retinal vasculature was significantly ..
  41. Mahabeleshwar G, Qureshi M, Takami Y, Sharma N, Lingrel J, Jain M. A myeloid hypoxia-inducible factor 1?-Krüppel-like factor 2 pathway regulates gram-positive endotoxin-mediated sepsis. J Biol Chem. 2012;287:1448-57 pubmed publisher
    ..reduced expression of the myeloid anti-inflammatory transcription factor Krüppel-like transcription factor 2 (KLF2)...
  42. Redmond L, Dumur C, Archer K, Grayson D, Haar J, Lloyd J. Krüppel-like factor 2 regulated gene expression in mouse embryonic yolk sac erythroid cells. Blood Cells Mol Dis. 2011;47:1-11 pubmed publisher
    b>KLF2 is a Krüppel-like zinc-finger transcription factor required for blood vessel, lung, T-cell and erythroid development. KLF2-/- mice die by embryonic day 14.5 (E14.5), due to hemorrhaging and heart failure...
  43. Qiu D, Ye S, Ruiz B, Zhou X, Liu D, Zhang Q, et al. Klf2 and Tfcp2l1, Two Wnt/β-Catenin Targets, Act Synergistically to Induce and Maintain Naive Pluripotency. Stem Cell Reports. 2015;5:314-22 pubmed publisher
    ..self-renewal-promoting effect of Wnt/β-catenin signaling is mainly mediated by two of its downstream targets, Klf2 and Tfcp2l1...
  44. Bhattacharya R, SenBanerjee S, Lin Z, Mir S, Hamik A, Wang P, et al. Inhibition of vascular permeability factor/vascular endothelial growth factor-mediated angiogenesis by the Kruppel-like factor KLF2. J Biol Chem. 2005;280:28848-51 pubmed
    The Kruppel-like factor KLF2 was recently identified as a novel regulator of endothelial pro-inflammatory and pro-thrombotic function...
  45. Pang C, Lemsaddek W, Alhashem Y, Bondzi C, Redmond L, Ah Son N, et al. Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis. Mol Cell Biol. 2012;32:2628-44 pubmed publisher
    The Krüppel-like factor 1 (KLF1) and KLF2 positively regulate embryonic ?-globin expression and have additional overlapping roles in embryonic (primitive) erythropoiesis...
  46. He S, Yang L, Li D, Li M. Kruppel-Like Factor 2-Mediated Suppression of MicroRNA-155 Reduces the Proinflammatory Activation of Macrophages. PLoS ONE. 2015;10:e0139060 pubmed publisher
    Recent evidence indicates that significant interactions exist between Kruppel-like factor 2 (KLF2) and microRNAs (miRNAs) in endothelial cells...
  47. Yeo J, Jiang J, Tan Z, Yim G, Ng J, Goke J, et al. Klf2 is an essential factor that sustains ground state pluripotency. Cell Stem Cell. 2014;14:864-72 pubmed publisher
    ..In this study, we show that Krüppel-like factor 2 (Klf2) is phosphorylated by Erk2 and that phospho-Klf2 is proteosomally degraded...
  48. Choi D, Park E, Jung E, Seong Y, Hong M, Lee S, et al. ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4. Circ Res. 2017;120:1426-1439 pubmed publisher
    ..Consistently, freshly isolated LECs from Orai1 knockout embryos displayed reduced expression of KLF2, KLF4, VEGF-A, VEGF-C, and FGFR3 and elevated expression of p57...
  49. Banerjee S, Feinberg M, Watanabe M, Gray S, Haspel R, Denkinger D, et al. The Krüppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis. J Biol Chem. 2003;278:2581-4 pubmed
    ..In this study, we identify that a second family member, KLF2/Lung Krüppel-like factor (LKLF), as a negative regulator of adipocyte differentiation...
  50. Serr I, Fürst R, Ott V, Scherm M, Nikolaev A, Gökmen F, et al. miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity. Proc Natl Acad Sci U S A. 2016;113:E6659-E6668 pubmed
    ..Moreover, we identify Krueppel-like factor 2 (KLF2) as a target of miRNA92a in regulating human TFH precursor induction...
  51. Wu J, Srinivasan S, Neumann J, Lingrel J. The KLF2 transcription factor does not affect the formation of preadipocytes but inhibits their differentiation into adipocytes. Biochemistry. 2005;44:11098-105 pubmed
    Kruppel-like transcription factor 2 (KLF2), a critical gene for mouse embryogenesis, was recently identified as an inhibitor of adipogenesis...
  52. Dang X, Raffler N, Ley K. Transcriptional regulation of mouse L-selectin. Biochim Biophys Acta. 2009;1789:146-52 pubmed publisher
    ..Site-directed mutagenesis and chromatin immunoprecipitation showed that Mzf1, Klf2, Sp1, Ets1, and Irf1 bind to and activate the mouse sell promoter...
  53. Rabacal W, Pabbisetty S, Hoek K, Cendron D, Guo Y, Maseda D, et al. Transcription factor KLF2 regulates homeostatic NK cell proliferation and survival. Proc Natl Acad Sci U S A. 2016;113:5370-5 pubmed publisher
    ..In terms of NK cell expansion and survival, we now report that Kruppel-like factor 2 (KLF2) is a key transcription factor that underpins both of these events...
  54. Miyanari Y, Torres Padilla M. Control of ground-state pluripotency by allelic regulation of Nanog. Nature. 2012;483:470-3 pubmed publisher
    ..Our data highlight an unexpected role for allelic expression in controlling the dose of pluripotency factors in vivo, adding an extra level to the regulation of reprogramming. ..
  55. Nie X, Su L, Xu R, Guo Y, Zhou Y, Li J. Kruppel-like factor 2 might mediate the rapamycin-induced arterial thrombosis in vivo: implications for stent thrombosis in patients. Chin Med J (Engl). 2013;126:2636-40 pubmed
    ..This study was designed to examine the effects of rapamycin on the expression of the gene, Kruppel-like factor 2 (KLF2), and its transcriptional targets in mice...
  56. Ahmed M, Gaffen S. IL-17 inhibits adipogenesis in part via C/EBP?, PPAR? and Krüppel-like factors. Cytokine. 2013;61:898-905 pubmed publisher
    ..Specifically, IL-17 suppresses KLF15, a pro-adipogenic TF, and enhances expression of KLF2 and KLF3, which are anti-adipogenic...
  57. Tokudome T, Kishimoto I, Shindo T, Kawakami H, Koyama T, Otani K, et al. Importance of Endogenous Atrial and Brain Natriuretic Peptides in Murine Embryonic Vascular and Organ Development. Endocrinology. 2016;157:358-67 pubmed publisher
    ..These data demonstrate the importance of the endogenous ANP/BNP-GC-A system not only in the neovascularization of ischemic tissues but also in embryonic vascular development and organ morphogenesis. ..
  58. Pabbisetty S, Rabacal W, Volanakis E, Parekh V, Olivares Villagómez D, Cendron D, et al. Peripheral tolerance can be modified by altering KLF2-regulated Treg migration. Proc Natl Acad Sci U S A. 2016;113:E4662-70 pubmed publisher
    ..We now report that transcription factor Kruppel-like factor 2 (KLF2) controls naive Treg migration patterns via regulation of homeostatic and inflammatory homing receptors, and that ..
  59. Weinreich M, Odumade O, Jameson S, Hogquist K. T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells. Nat Immunol. 2010;11:709-16 pubmed publisher
    ..We demonstrate here that similar cells developed in mice deficient in the transcription factor KLF2. However, this was not due to intrinsic deficiency in KLF2 but instead was due to interleukin 4 (IL-4) produced by ..
  60. Zhang P, Ha T, Larouche M, Swanson D, Goldowitz D. Kruppel-Like Factor 4 Regulates Granule Cell Pax6 Expression and Cell Proliferation in Early Cerebellar Development. PLoS ONE. 2015;10:e0134390 pubmed publisher
    ..This paper is the first to describe a role for Klf4 in the cerebellum and provides insight into this gene's function in neuronal development. ..
  61. Matsuo H, Kondo Y, Kawasaki T, Imamura N. Cineromycin B isolated from Streptomyces cinerochromogenes inhibits adipocyte differentiation of 3T3-L1 cells via Krüppel-like factors 2 and 3. Life Sci. 2015;135:35-42 pubmed publisher
    ..indicated that cineromycin B is a unique adipocyte differentiation inhibitor, acting mainly via upregulation of KLF2 and KLF3, and these KLFs may play a role in the early stage of differentiation...
  62. Huang R, Wu D, Meliton A, Oh M, Krause M, Lloyd J, et al. Experimental Lung Injury Reduces Krüppel-like Factor 2 to Increase Endothelial Permeability via Regulation of RAPGEF3-Rac1 Signaling. Am J Respir Crit Care Med. 2017;195:639-651 pubmed publisher
    ..Although mechanosensitive transcription factor Krüppel-like factor 2 (KLF2) is a major regulator of endothelial function, its role in regulating pulmonary vascular integrity in lung injury ..
  63. Vinjamur D, Wade K, Mohamad S, Haar J, Sawyer S, Lloyd J. Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation. Haematologica. 2014;99:1565-73 pubmed publisher
    The Krüppel-like transcription factors KLF1 and KLF2 are essential for embryonic erythropoiesis...
  64. Kasper L, Fukuyama T, Brindle P. T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs. PLoS ONE. 2014;9:e102076 pubmed publisher
    ..MED23 null CD4 single-positive thymocytes also showed decreased expression of KLF2 (LKLF), a T-cell master regulatory transcription factor...
  65. Pabbisetty S, Rabacal W, Maseda D, Cendron D, Collins P, Hoek K, et al. KLF2 is a rate-limiting transcription factor that can be targeted to enhance regulatory T-cell production. Proc Natl Acad Sci U S A. 2014;111:9579-84 pubmed publisher
    ..We now report that transcription factor Krüppel-like factor 2 (KLF2) is necessary for the generation of iTregs but not tTregs...
  66. Winkelmann R, Sandrock L, Kirberg J, Jack H, Schuh W. KLF2--a negative regulator of pre-B cell clonal expansion and B cell activation. PLoS ONE. 2014;9:e97953 pubmed publisher
    ..We and others have previously shown that Krüppel-like factor 2 (KLF2), a regulator of T cell quiescence and migration, is upregulated in small resting precursor (pre)-B cells after ..
  67. Yang L, Zhou X, Guo R, Shi Y, Liang X, Heng X. Role of Krüppel-like factor 2 and protease-activated receptor-1 in vulnerable plaques of ApoE(-/-) mice and intervention with statin. Can J Cardiol. 2013;29:997-1005 pubmed publisher
    Krüppel-like factor 2 (KLF2) and protease-activated receptor-1 (PAR-1) are 2 novel factors that play important roles in inflammation and coagulation, yet their relationship with vulnerable plaques and statin remains uncertain...
  68. Roberts A, Lee B, Deguine J, John S, Shlomchik M, Barton G. Tissue-Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic Cells. Immunity. 2017;47:913-927.e6 pubmed publisher
    ..The transcription factors KLF2 and KLF4 control the expression of many genes within this AC clearance program...
  69. Soncin F, Fafeur V, Vandenbunder B. [Transcription factors and angiogenesis]. Pathol Biol (Paris). 1999;47:358-63 pubmed
    ..description of the phenotype of embryos obtained after gene inactivation by homologous recombination for ARNT or LKLF, and the study of transcriptional regulation in cultured endothelial cells for EGR1 or HOX-D3...
  70. Lin Y, Ryan J, Lewis J, Wani M, Lingrel J, Liu Z. TRAF2 exerts its antiapoptotic effect by regulating the expression of Krüppel-like factor LKLF. Mol Cell Biol. 2003;23:5849-56 pubmed
    ..one of the genes whose expression was dramatically decreased in TRAF2(-/-) cells was the lung Krüppel-like factor (LKLF). Our results indicate that the expression of LKLF requires TRAF2 but is independent of TNF signaling...
  71. Kwon I, Wang W, Xu S, Jin Z. Histone deacetylase 5 interacts with Krüppel-like factor 2 and inhibits its transcriptional activity in endothelium. Cardiovasc Res. 2014;104:127-37 pubmed publisher
    Vascular endothelial dysfunction and inflammation are hallmarks of atherosclerosis. Krüppel-like factor 2 (KLF2) is a key mediator of anti-inflammatory and anti-atherosclerotic properties of the endothelium...
  72. Nayak L, Goduni L, Takami Y, Sharma N, Kapil P, Jain M, et al. Kruppel-like factor 2 is a transcriptional regulator of chronic and acute inflammation. Am J Pathol. 2013;182:1696-704 pubmed publisher
    ..Kruppel-like factor 2 (KLF2) is a potent regulator of myeloid cell proinflammatory activation...