Gene Symbol: Klf11
Description: Kruppel-like factor 11
Alias: 9830142A17, D12Ertd427e, Tieg2, Tieg2b, Tieg3, Krueppel-like factor 11, TGFB inducible early growth response 2, TGFB inducible early growth response 3, TGFB-inducible early growth response protein 2b, TGFB-inducible early growth response protein 3, TIEG-3, klf11, transforming growth factor-beta-inducible early growth response protein 3
Species: mouse
Products:     Klf11

Top Publications

  1. Ellenrieder V, Buck A, Harth A, Jungert K, Buchholz M, Adler G, et al. KLF11 mediates a critical mechanism in TGF-beta signaling that is inactivated by Erk-MAPK in pancreatic cancer cells. Gastroenterology. 2004;127:607-20 pubmed
    ..Like the Smads, KLF11 is an early response transcription factor that mediates TGF-beta-induced growth inhibition in untransformed ..
  2. Bonnefond A, Lomberk G, Buttar N, Busiah K, Vaillant E, Lobbens S, et al. Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus. J Biol Chem. 2011;286:28414-24 pubmed publisher
    ..reporter experiments, and chromatin immunoprecipitation demonstrates that, among 16 different KLF proteins tested, KLF11 is the most reliable activator of this site. Congruently, the c...
  3. Fernandez Zapico M, Mladek A, Ellenrieder V, Folch Puy E, Miller L, Urrutia R. An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation. EMBO J. 2003;22:4748-58 pubmed
    b>KLF11 is a biochemical paradigm for a subset of proteins that repress transcription via a Mad1-like mSin3A interacting domain (SID)...
  4. Song C, Gavriilidis G, Asano H, Stamatoyannopoulos G. Functional study of transcription factor KLF11 by targeted gene inactivation. Blood Cells Mol Dis. 2005;34:53-9 pubmed
    ..b>KLF11 has been implicated in the regulation of cell growth and gene expression...
  5. Grunewald M, Johnson S, Lu D, Wang Z, Lomberk G, Albert P, et al. Mechanistic role for a novel glucocorticoid-KLF11 (TIEG2) protein pathway in stress-induced monoamine oxidase A expression. J Biol Chem. 2012;287:24195-206 pubmed publisher
    ..relationship between stress-induced MAO A and the transcription factor Kruppel-like factor 11 (KLF11, also called TIEG2, a member of the Sp/KLF- family), which inhibits cell growth...
  6. Zhang H, Chen Q, Yang M, Zhu B, Cui Y, Xue Y, et al. Mouse KLF11 regulates hepatic lipid metabolism. J Hepatol. 2013;58:763-70 pubmed publisher
    Missense mutations in human Krüppel-like factor 11 (KLF11) lead to the development of diabetes, as a result of impaired insulin synthesis in the pancreas. However, the role of KLF11 in peripheral tissues is largely unknown...
  7. Correa L, Zheng Y, Delaney A, Khan Z, Shenoy C, Daftary G. TGF-? Induces Endometriotic Progression via a Noncanonical, KLF11-Mediated Mechanism. Endocrinology. 2016;157:3332-43 pubmed publisher
    ..We propose a role for TGF? and its target transcription factor Krüppel-like factor 11 (KLF11) in mediating such mechanisms...
  8. Mathison A, Escande C, Calvo E, Seo S, White T, Salmonson A, et al. Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes. Endocrinology. 2015;156:3581-95 pubmed publisher
    ..Here, we report that Klf11-/- mice have decreased circulating insulin levels, alterations in the control of blood glucose and body weight, as ..
  9. Zhang H, Chen Q, Jiao T, Cui A, Sun X, Fang W, et al. Involvement of KLF11 in hepatic glucose metabolism in mice via suppressing of PEPCK-C expression. PLoS ONE. 2014;9:e89552 pubmed publisher
    ..Despite the strong evidences linking Krüppel-like factor 11 (KLF11) gene mutations to development of Type 2 diabetes, the precise physiological functions of KLF11 in vivo remain ..

More Information


  1. Ou X, Udemgba C, Wang N, Dai X, Lomberk G, Seo S, et al. Diabetes-causing gene, kruppel-like factor 11, modulates the antinociceptive response of chronic ethanol intake. Alcohol Clin Exp Res. 2014;38:401-8 pubmed publisher
    ..The transcription factor Kruppel-like factor 11 (KLF11), a human diabetes-causing gene that also regulates the neurotransmitter metabolic enzymes monoamine oxidase (MAO),..
  2. Zheng Y, Kong Y, Li F. Krüppel-like transcription factor 11 (KLF11) overexpression inhibits cardiac hypertrophy and fibrosis in mice. Biochem Biophys Res Commun. 2014;443:683-8 pubmed publisher
    ..The KLF family member KLF11 is originally identified as a transforming growth factor ? (TGF-?)-inducible gene and is one of the most studied ..
  3. Mathison A, Grzenda A, Lomberk G, Velez G, Buttar N, Tietz P, et al. Role for Krüppel-like transcription factor 11 in mesenchymal cell function and fibrosis. PLoS ONE. 2013;8:e75311 pubmed publisher
    Krüppel-like factor 11 (KLF11) and the highly homologous KLF10 proteins are transcription factors originating from duplication of the Drosophila melanogaster ancestor cabut...
  4. Fan Y, Guo Y, Zhang J, Subramaniam M, Song C, Urrutia R, et al. Krüppel-like factor-11, a transcription factor involved in diabetes mellitus, suppresses endothelial cell activation via the nuclear factor-?B signaling pathway. Arterioscler Thromb Vasc Biol. 2012;32:2981-8 pubmed publisher
    ..Emerging data demonstrate that mutations of Krüppel-like factor-11 (KLF11), a gene coding maturity-onset diabetes mellitus of the young type 7 (MODY7), contribute to the development of ..
  5. Wang Z, Peters B, Klussmann S, Bender H, Herb A, Krieglstein K. Gene structure and evolution of Tieg3, a new member of the Tieg family of proteins. Gene. 2004;325:25-34 pubmed
    ..So far, Tieg1 and Tieg2 have been identified in human and mouse...
  6. Jiang L, Chen Y, Chan C, Lu G, Wang H, Li J, et al. Dynamic transcriptional changes of TIEG1 and TIEG2 during mouse tissue development. Anat Rec (Hoboken). 2010;293:858-64 pubmed publisher
    ..In this study, we aimed to investigate the transcriptional level of both TIEG1 and TIEG2 during development in various mice organs, including the brain cortex, cerebellum and stem, brain striatum, muscle,..
  7. Daftary G, Zheng Y, Tabbaa Z, Schoolmeester J, Gada R, Grzenda A, et al. A novel role of the Sp/KLF transcription factor KLF11 in arresting progression of endometriosis. PLoS ONE. 2013;8:e60165 pubmed publisher
    ..In this study, we evaluated the role of the Sp/KLF transcription factor KLF11/Klf11 in the pathogenesis of endometriosis...
  8. Hsieh C, Fukumoto S, Layne M, Maemura K, Charles H, Patel A, et al. Striated muscle preferentially expressed genes alpha and beta are two serine/threonine protein kinases derived from the same gene as the aortic preferentially expressed gene-1. J Biol Chem. 2000;275:36966-73 pubmed
    ..This developmental regulation suggests that both SPEGalpha and SPEGbeta can serve as sensitive markers for striated muscle differentiation and that they may be important for adult striated muscle function. ..
  9. Richards E, Zheng Y, Shenoy C, Ainsworth A, Delaney A, Jones T, et al. KLF11 is an Epigenetic Mediator of DRD2/Dopaminergic Signaling in Endometriosis. Reprod Sci. 2017;24:1129-1138 pubmed publisher
    ..Transcription factor KLF11 has been implicated in the pathogenesis of several human endocrine and reproductive tract diseases including ..
  10. Zheng Y, Khan Z, Zanfagnin V, Correa L, Delaney A, Daftary G. Epigenetic Modulation of Collagen 1A1: Therapeutic Implications in Fibrosis and Endometriosis. Biol Reprod. 2016;94:87 pubmed publisher
    ..Transcription factor KLF11 is specifically diminished in endometriosis lesions...
  11. Hayashi S, Manabe I, Suzuki Y, Relaix F, Oishi Y. Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice. elife. 2016;5: pubmed publisher
    ..These results indicate that Klf5 is an essential regulator of skeletal muscle differentiation, acting in concert with myogenic transcription factors such as MyoD and Mef2. ..
  12. Scohy S, Gabant P, Van Reeth T, Hertveldt V, Dreze P, Van Vooren P, et al. Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family. Genomics. 2000;70:93-101 pubmed
    ..of this family was also identified in a human EST database; this sequence was found to be identical to KLF11 (TIEG2), recently identified by Cook et al. (1998, J. Biol. Chem. 273: 25929-25936)...
  13. Shenoy C, Khan Z, Zheng Y, Jones T, Khazaie K, Daftary G. Progressive Fibrosis: A Progesterone- and KLF11-Mediated Sexually Dimorphic Female Response. Endocrinology. 2017;158:3605-3619 pubmed publisher
    ..Endometriosis-related fibrosis is regulated epigenetically through transcription factor Krüppel-like factor 11 (KLF11)...
  14. Delaney A, Khan Z, Zheng Y, Correa L, Zanfagnin V, Shenoy C, et al. KLF10 Mediated Epigenetic Dysregulation of Epithelial CD40/CD154 Promotes Endometriosis. Biol Reprod. 2016;95:62 pubmed publisher
    ..We previously showed that loss of KLF11, a transcription factor implicated in uterine disease, results in progression of endometriosis...
  15. Harris S, Johnson S, Duncan J, Udemgba C, Meyer J, Albert P, et al. Evidence revealing deregulation of the KLF11-MAO A pathway in association with chronic stress and depressive disorders. Neuropsychopharmacology. 2015;40:1373-82 pubmed publisher
    ..In the current study, we compared the protein levels of a MAO A-transcriptional activator, Kruppel-like factor 11 (KLF11 , also recognized as transforming growth factor-beta-inducible early gene 2) between the brains of 18 human ..
  16. Renga B, Mencarelli A, Vavassori P, Brancaleone V, Fiorucci S. The bile acid sensor FXR regulates insulin transcription and secretion. Biochim Biophys Acta. 2010;1802:363-72 pubmed publisher
    ..Genomic effects of FXR activation relay on the induction of the glucose regulated transcription factor KLF11. Indeed, results from silencing experiments of KLF11 demonstrate that this transcription factor is essential for ..
  17. Yin K, Fan Y, Hamblin M, Zhang J, Zhu T, Li S, et al. KLF11 mediates PPAR? cerebrovascular protection in ischaemic stroke. Brain. 2013;136:1274-87 pubmed publisher
    ..we screened for (PPAR?) co-regulators using a genome-wide and high-throughput co-activation system and revealed KLF11 as a novel (PPAR?) co-regulator, which interacted with (PPAR?) and regulated its function in mouse cerebral ..
  18. Gohla G, Krieglstein K, Spittau B. Tieg3/Klf11 induces apoptosis in OLI-neu cells and enhances the TGF-beta signaling pathway by transcriptional repression of Smad7. J Cell Biochem. 2008;104:850-61 pubmed publisher
    ..The recently identified TGF-beta-inducible zinc finger protein Tieg3/Klf11 belongs to the family of Sp1/Klf-like transcription factors and shares all structural and functional features with ..