Gene Symbol: Klc3
Description: kinesin light chain 3
Alias: BC017147, Klct, kinesin light chain 3
Species: mouse
Products:     Klc3

Top Publications

  1. Bhullar B, Zhang Y, Junco A, Oko R, van der Hoorn F. Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion. J Biol Chem. 2003;278:16159-68 pubmed
    ..We recently isolated a novel KLC gene, klc3. klc3 is the only known KLC expressed in post-meiotic male germ cells...
  2. Rahman A, Friedman D, Goldstein L. Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins. J Biol Chem. 1998;273:15395-403 pubmed
    ..These results indicate that the mammalian nervous system contains multiple kinesin light chain gene products with potentially distinct functions. ..
  3. de Boer J, Donker I, de Wit J, Hoeijmakers J, Weeda G. Disruption of the mouse xeroderma pigmentosum group D DNA repair/basal transcription gene results in preimplantation lethality. Cancer Res. 1998;58:89-94 pubmed
  4. Yang J, Li T. The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin-1 vesicular cargos. Exp Cell Res. 2005;309:379-89 pubmed
    ..These findings indicate that ciliary rootlets may provide a scaffold for kinesin-1 vesicular cargos and, thus, play a role in the intracellular transport in ciliated cells. ..
  5. Lamerdin J, Stilwagen S, Ramirez M, Stubbs L, Carrano A. Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes. Genomics. 1996;34:399-409 pubmed
    ..The identification and description of two new genes provides potential candidate genes for disorders mapping to this region of 19q13.2. ..
  6. Muresan Z, Muresan V. Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1. J Cell Biol. 2005;171:615-25 pubmed
    ..These results indicate that the phosphorylation of APP regulates the formation of a pAPP-JIP-1 complex that accumulates in neurites independent of nonphosphorylated APP. ..
  7. Roux K, Crisp M, Liu Q, Kim D, Kozlov S, Stewart C, et al. Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization. Proc Natl Acad Sci U S A. 2009;106:2194-9 pubmed publisher
    ..These effects can be accounted for entirely by Nesp4's kinesin-binding function. The implication is that Nesp4 may contribute to microtubule-dependent nuclear positioning. ..
  8. Chung S, Marzban H, Aldinger K, Dixit R, Millen K, Schuurmans C, et al. Zac1 plays a key role in the development of specific neuronal subsets in the mouse cerebellum. Neural Dev. 2011;6:25 pubmed publisher
    ..We thus conclude that Zac1 is a critical regulator of normal cerebellar development, adding a new transcriptional regulator to the growing list of factors involved in generating neuronal diversity in the developing cerebellum. ..
  9. Zhang Y, Ou Y, Cheng M, Saadi H, Thundathil J, van der Hoorn F. KLC3 is involved in sperm tail midpiece formation and sperm function. Dev Biol. 2012;366:101-10 pubmed publisher
    b>Kinesin light chain 3 (KLC3) is the only known kinesin light chain expressed in post-meiotic male germ cells. We have reported that in rat spermatids KLC3 associates with outer dense fibers and mitochondrial sheath...

More Information


  1. Junco A, Bhullar B, Tarnasky H, van der Hoorn F. Kinesin light-chain KLC3 expression in testis is restricted to spermatids. Biol Reprod. 2001;64:1320-30 pubmed
    ..We report the cloning from a testicular cDNA expression library of a mammalian light chain, KLC3. The KLC3 gene is located in close proximity to the ERCC2 gene...
  2. Aoyama T, Hata S, Nakao T, Tanigawa Y, Oka C, Kawaichi M. Cayman ataxia protein caytaxin is transported by kinesin along neurites through binding to kinesin light chains. J Cell Sci. 2009;122:4177-85 pubmed publisher
    ..These data indicate that caytaxin binds to kinesin-1 and functions as an adaptor that mediates intracellular transport of specific cargos, one of which is the mitochondrion. ..