Kitl

Summary

Gene Symbol: Kitl
Description: kit ligand
Alias: Clo, Con, Kitlg, Mgf, SCF, SLF, blz, contrasted, kit ligand, C-kit ligand, Steel factor, cloud gray, grizzle-belly, hematopoietic growth factor KL, mast cell growth factor, stem cell factor
Species: mouse
Products:     Kitl

Top Publications

  1. Wehrle Haller B, Weston J. Altered cell-surface targeting of stem cell factor causes loss of melanocyte precursors in Steel17H mutant mice. Dev Biol. 1999;210:71-86 pubmed
    ..The Sl locus encodes stem cell factor (SCF), which is the ligand of c-kit, a receptor tyrosine kinase encoded by the W locus...
  2. Manova K, Huang E, Angeles M, De Leon V, Sanchez S, Pronovost S, et al. The expression pattern of the c-kit ligand in gonads of mice supports a role for the c-kit receptor in oocyte growth and in proliferation of spermatogonia. Dev Biol. 1993;157:85-99 pubmed
    ..These data are consistent with a role for KL in oocyte growth and in facilitating proliferation and/or differentiation of type A spermatogonia. ..
  3. Kinashi T, Springer T. Steel factor and c-kit regulate cell-matrix adhesion. Blood. 1994;83:1033-8 pubmed
    Steel (SI) and white spotting (W) loci encode steel factor (c-kit ligand) and the c-kit tyrosine kinase receptor, respectively...
  4. Packer A, Hsu Y, Besmer P, Bachvarova R. The ligand of the c-kit receptor promotes oocyte growth. Dev Biol. 1994;161:194-205 pubmed
    ..These studies demonstrate that c-kit and KL are required for maintenance of oocyte growth in vitro. ..
  5. Ikuta K, Weissman I. Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Proc Natl Acad Sci U S A. 1992;89:1502-6 pubmed
    The interaction of the mouse c-kit receptor, designated Kit receptor, and steel factor promotes the proliferation and differentiation of hematopoietic progenitor cells...
  6. Chou S, Lodish H. Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells. Proc Natl Acad Sci U S A. 2010;107:7799-804 pubmed publisher
    ..and are not T cells; rather, we purified these HSC-supportive stromal cells based on the surface phenotype of SCF(+)DLK(+)...
  7. Keshet E, Lyman S, Williams D, Anderson D, Jenkins N, Copeland N, et al. Embryonic RNA expression patterns of the c-kit receptor and its cognate ligand suggest multiple functional roles in mouse development. EMBO J. 1991;10:2425-35 pubmed
    ..More recently, the Sl locus has been shown to encode a ligand for c-kit, which is variously known as mast cell growth factor (MGF), stem cell growth factor and c-kit ligand...
  8. Ueda S, Mizuki M, Ikeda H, Tsujimura T, Matsumura I, Nakano K, et al. Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis: contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration. Blood. 2002;99:3342-9 pubmed
    b>Stem cell factor (SCF) has crucial roles in proliferation, survival, and differentiation of hematopoietic stem cells and mast cells through binding to c-Kit receptor (KIT). Chemotaxis is another unique function of SCF...
  9. Huang E, Nocka K, Beier D, Chu T, Buck J, Lahm H, et al. The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell. 1990;63:225-33 pubmed
    ..Linkage analysis maps the KL gene to the Sl locus on mouse chromosome 10, and KL sequences are deleted in the genome of the Sl mouse. These results indicate that the Sl locus encodes the ligand of the c-kit receptor, KL. ..

More Information

Publications62

  1. McCoshen J, McCallion D. A study of the primordial germ cells during their migratory phase in Steel mutant mice. Experientia. 1975;31:589-90 pubmed
  2. Mahakali Zama A, Hudson F, Bedell M. Analysis of hypomorphic KitlSl mutants suggests different requirements for KITL in proliferation and migration of mouse primordial germ cells. Biol Reprod. 2005;73:639-47 pubmed
    ..It is well established that Kit ligand (KITL, also known as stem cell factor and mast cell growth factor) is required for the survival and proliferation of PGCs...
  3. Christensen J, Wright D, Wagers A, Weissman I. Circulation and chemotaxis of fetal hematopoietic stem cells. PLoS Biol. 2004;2:E75 pubmed
    ..marrow HSCs, the migratory response of fetal liver HSCs to SDF-1alpha is greatly increased in the presence of Steel factor (SLF), suggesting an important role for SLF in HSC homing to and seeding of the fetal hematopoietic tissues...
  4. Wehrle Haller B, Meller M, Weston J. Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survival. Dev Biol. 2001;232:471-83 pubmed
    ..In mouse embryos, MPs express the receptor tyrosine kinase, KIT, and require its cognate ligand, Mast cell growth factor (MGF), for survival and differentiation...
  5. Botchkareva N, Khlgatian M, Longley B, Botchkarev V, Gilchrest B. SCF/c-kit signaling is required for cyclic regeneration of the hair pigmentation unit. FASEB J. 2001;15:645-58 pubmed
    ..b>Stem cell factor (SCF) and its receptor c-kit are important for melanocyte survival during development, and mutations in these ..
  6. Thomas F, Ismail R, Jiang J, Vanderhyden B. Kit ligand 2 promotes murine oocyte growth in vitro. Biol Reprod. 2008;78:167-75 pubmed
    Oocyte-granulosa cell communication, mediated by paracrine factors, is essential for oocyte development. Kit ligand (KITL) is expressed in granulosa cells as soluble (KITL1) or membrane-associated (KITL2) proteins...
  7. Thomas F, Vanderhyden B. Oocyte-granulosa cell interactions during mouse follicular development: regulation of kit ligand expression and its role in oocyte growth. Reprod Biol Endocrinol. 2006;4:19 pubmed
    ..Particular emphasis is given to granulosa cell-derived Kit Ligand (KitL), whose functional importance for oocyte growth has been demonstrated by a wide range of in vivo and in ..
  8. Takano N, Kawakami T, Kawa Y, Asano M, Watabe H, Ito M, et al. Fibronectin combined with stem cell factor plays an important role in melanocyte proliferation, differentiation and migration in cultured mouse neural crest cells. Pigment Cell Res. 2002;15:192-200 pubmed
    b>Stem cell factor (SCF) is essential to the migration and differentiation of melanocytes during embryogenesis because mutations in either the SCF gene, or its ligand, KIT, result in defects in coat pigmentation in mice...
  9. Erlandsson A, Larsson J, Forsberg Nilsson K. Stem cell factor is a chemoattractant and a survival factor for CNS stem cells. Exp Cell Res. 2004;301:201-10 pubmed
    ..Several extrinsic factors are known to be involved in the regulation of neural migration. We asked if stem cell factor (SCF), well known as a chemoattractant and survival factor in the hematopoietic lineage, could elicit similar ..
  10. Runyan C, Schaible K, Molyneaux K, Wang Z, Levin L, Wylie C. Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration. Development. 2006;133:4861-9 pubmed
    ..We then show that germ cell apoptosis in the midline is activated by down-regulation of Steel factor (kit ligand) expression in the midline between E9.5 and E10.5...
  11. Broudy V. Stem cell factor and hematopoiesis. Blood. 1997;90:1345-64 pubmed
  12. Tajima Y, Moore M, Soares V, Ono M, Kissel H, Besmer P. Consequences of exclusive expression in vivo of Kit-ligand lacking the major proteolytic cleavage site. Proc Natl Acad Sci U S A. 1998;95:11903-8 pubmed
  13. Blume Jensen P, Jiang G, Hyman R, Lee K, O GORMAN S, Hunter T. Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility. Nat Genet. 2000;24:157-62 pubmed
    The c-kit-encoded transmembrane tyrosine kinase receptor for stem cell factor (Kit/SCF-R) is required for normal haematopoiesis, melanogenesis and gametogenesis...
  14. Schmidt Ott K, Chen X, Paragas N, Levinson R, Mendelsohn C, Barasch J. c-kit delineates a distinct domain of progenitors in the developing kidney. Dev Biol. 2006;299:238-49 pubmed
    ..In this study, through analysis of the stem cell factor (SCF)/c-kit ligand receptor pair, we describe an additional distinct cell population in the early developing ..
  15. Kitamura Y, Go S. Decreased production of mast cells in S1/S1d anemic mice. Blood. 1979;53:492-7 pubmed
  16. Galli S, Tsai M, Gordon J, Geissler E, Wershil B. Analyzing mast cell development and function using mice carrying mutations at W/c-kit or Sl/MGF (SCF) loci. Ann N Y Acad Sci. 1992;664:69-88 pubmed
    ..factor expressed in the microenvironments where mast cells ordinarily develop: the c-kit receptor ligand, SCF. As a result, W/Wv mice virtually lack tissue mast cells...
  17. Ren X, Hu B, Colletti L. Stem cell factor and its receptor, c-kit, are important for hepatocyte proliferation in wild-type and tumor necrosis factor receptor-1 knockout mice after 70% hepatectomy. Surgery. 2008;143:790-802 pubmed publisher
    b>Stem cell factor (SCF) has well-known proliferative effects on hematopoietic cells. SCF also has effects on differentiation and proliferation in other cell types...
  18. Brannan C, Lyman S, Williams D, Eisenman J, Anderson D, Cosman D, et al. Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains. Proc Natl Acad Sci U S A. 1991;88:4671-4 pubmed
    ..0-kilobase intragenic deletion in mast cell growth factor (MGF) genomic sequences, providing conclusive evidence that Sl encodes MGF...
  19. Duttlinger R, Manova K, Chu T, Gyssler C, Zelenetz A, Bachvarova R, et al. W-sash affects positive and negative elements controlling c-kit expression: ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis. Development. 1993;118:705-17 pubmed
    ..the mesenchyme around the otic vesicle and the floorplate of the neural tube, structures known to express the c-kit ligand in wild-type embryos...
  20. Wehrle Haller B, Morrison Graham K, Weston J. Ectopic c-kit expression affects the fate of melanocyte precursors in Patch mutant embryos. Dev Biol. 1996;177:463-74 pubmed
    ..trunk neural crest cells from homozygous Ph embryos give rise to pigmented melanocytes in vitro in response to Steel factor (SlF)...
  21. Iemura A, Tsai M, Ando A, Wershil B, Galli S. The c-kit ligand, stem cell factor, promotes mast cell survival by suppressing apoptosis. Am J Pathol. 1994;144:321-8 pubmed
    b>Stem cell factor (SCF) and its receptor (SCFR), a member of the receptor tyrosine kinase III family that is encoded by the c-kit gene, critically regulate several complex biological programs including hematopoiesis, mast cell development, ..
  22. Ingram D, Yang F, Travers J, Wenning M, Hiatt K, New S, et al. Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo. J Exp Med. 2000;191:181-8 pubmed
    ..Haploinsufficiency at Nf1 also increased mast cell proliferation, survival, and colony formation in response to Steel factor, the ligand for c-kit...
  23. Bernstein A, Forrester L, Reith A, Dubreuil P, Rottapel R. The murine W/c-kit and Steel loci and the control of hematopoiesis. Semin Hematol. 1991;28:138-42 pubmed
    ..Further analysis of the W/Sl pathway should provide a more complete understanding of the early events in hematopoiesis, and may also lead to novel therapeutic applications involving the protein product of the Sl locus. ..
  24. Matsui Y, Zsebo K, Hogan B. Embryonic expression of a haematopoietic growth factor encoded by the Sl locus and the ligand for c-kit. Nature. 1990;347:667-9 pubmed
    ..The haematopoietic growth factor SCF (stem cell factor) has been identified as the product of the Sl locus and a ligand for c-kit...
  25. Perez Losada J, Sanchez Martin M, Rodríguez García A, Sanchez M, Orfao A, Flores T, et al. Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway. Blood. 2002;100:1274-86 pubmed
    The stem cell factor c-kit signaling pathway (SCF/c-kit) has been previously implicated in normal hematopoiesis, melanogenesis, and gametogenesis through the formation and migration of c-kit(+) cells...
  26. Anderson D, Lyman S, Baird A, Wignall J, Eisenman J, Rauch C, et al. Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms. Cell. 1990;63:235-43 pubmed
    We have previously reported the identification of a novel mast cell growth factor (MGF) that was shown to be a ligand for c-kit and is encoded by a gene that maps near the steel locus on mouse chromosome 10...
  27. Copeland N, Gilbert D, Cho B, Donovan P, Jenkins N, Cosman D, et al. Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles. Cell. 1990;63:175-83 pubmed
    ..In the accompanying article we report the identification and purification of mast cell growth factor (MGF), a c-kit ligand. Here we describe the cloning of sequences encoding MGF...
  28. Barker J. Early transplantation to a normal microenvironment prevents the development of Steel hematopoietic stem cell defects. Exp Hematol. 1997;25:542-7 pubmed
    ..either inherently defective or lose competitive ability by residence in an environment lacking membrane-bound Steel factor. In the present report, any long-term effects of the Steel microenvironment were eradicated by transferring ..
  29. Izbeki F, Asuzu D, Lorincz A, Bardsley M, Popko L, Choi K, et al. Loss of Kitlow progenitors, reduced stem cell factor and high oxidative stress underlie gastric dysfunction in progeric mice. J Physiol. 2010;588:3101-17 pubmed publisher
    ..Klotho-deficient mice were marantic and had low insulin, insulin-like growth factor-I and membrane-bound stem cell factor. Klotho deficiency accentuated oxidative stress and ICC loss...
  30. Gu Y, Runyan C, Shoemaker A, Surani A, Wylie C. Steel factor controls primordial germ cell survival and motility from the time of their specification in the allantois, and provides a continuous niche throughout their migration. Development. 2009;136:1295-303 pubmed publisher
    b>Steel factor is an essential survival and proliferation factor for primordial germ cells (PGCs) during their migration in the early mouse embryo...
  31. Hultman K, Bahary N, Zon L, Johnson S. Gene Duplication of the zebrafish kit ligand and partitioning of melanocyte development functions to kit ligand a. PLoS Genet. 2007;3:e17 pubmed
    ..We examine the partitioning of expression patterns and functions of two zebrafish kit ligands, kit ligand a (kitla) and kit ligand b (kitlb), and discuss their possible coevolution with the duplicated zebrafish kit ..
  32. Ding L, Saunders T, Enikolopov G, Morrison S. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature. 2012;481:457-62 pubmed publisher
    ..Thus, the cellular sources of these factors are undetermined. Stem cell factor (SCF; also known as KITL) is a key niche component that maintains HSCs...
  33. Huang E, Nocka K, Buck J, Besmer P. Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2. Mol Biol Cell. 1992;3:349-62 pubmed
    The c-kit ligand, KL, and its receptor, the proto-oncogene c-kit are encoded, respectively, at the steel (Sl) and white spotting (W) loci of the mouse...
  34. Eklund K, Ghildyal N, Austen K, Friend D, Schiller V, Stevens R. Mouse bone marrow-derived mast cells (mBMMC) obtained in vitro from mice that are mast cell-deficient in vivo express the same panel of granule proteases as mBMMC and serosal mast cells from their normal littermates. J Exp Med. 1994;180:67-73 pubmed
    ..and WCB6F1/J-Sl/Sld (Sl/Sld) mice which are mast cell-deficient in vivo due to defects in their c-kit and c-kit ligand genes, respectively...
  35. Motro B, van der Kooy D, Rossant J, Reith A, Bernstein A. Contiguous patterns of c-kit and steel expression: analysis of mutations at the W and Sl loci. Development. 1991;113:1207-21 pubmed
  36. Sugiyama D, Kulkeaw K, Mizuochi C, Horio Y, Okayama S. Hepatoblasts comprise a niche for fetal liver erythropoiesis through cytokine production. Biochem Biophys Res Commun. 2011;410:301-6 pubmed publisher
    ..mRNA analysis suggested that Dlk-1-expressing hepatoblasts primarily expressed EPO and SCF, genes encoding erythropoietic cytokines...
  37. Motro B, Bernstein A. Dynamic changes in ovarian c-kit and Steel expression during the estrous reproductive cycle. Dev Dyn. 1993;197:69-79 pubmed
    ..nature of W and Sl mutations, respectively, W encodes the c-kit receptor tyrosine kinase while Steel encodes the Kit ligand. Both c-kit and Steel are expressed in various cells in which no corresponding mutant phenotype has yet been ..
  38. Wehrle Haller B, Weston J. Soluble and cell-bound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathway. Development. 1995;121:731-42 pubmed
    ..Melanocyte precursors transiently require the c-kit ligand, Steel factor for survival...
  39. Arguello F, Furlanetto R, Baggs R, Graves B, Harwell S, Cohen H, et al. Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv). Cancer Res. 1992;52:2304-9 pubmed
    ..The Sl locus encodes for a multipotent growth factor known as stem cell factor. The W locus encodes the c-kit protein tyrosine kinase receptor whose ligand is the stem cell factor...
  40. Zsebo K, Williams D, Geissler E, Broudy V, Martin F, Atkins H, et al. Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell. 1990;63:213-24 pubmed
    We have cloned a partial cDNA encoding murine stem cell factor (SCF) and show that the gene is syntenic with the Sl locus on mouse chromosome 10...
  41. Flanagan J, Chan D, Leder P. Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant. Cell. 1991;64:1025-35 pubmed
    ..These results provide evidence that cell surface KL has a critical role in the intact organism. ..
  42. Majumdar M, Feng L, Medlock E, Toksoz D, Williams D. Identification and mutation of primary and secondary proteolytic cleavage sites in murine stem cell factor cDNA yields biologically active, cell-associated protein. J Biol Chem. 1994;269:1237-42 pubmed
    ..of melanocytes, germ cells, and hematopoietic cells of Steel mice demonstrate the critical role of stem cell factor (SCF) in development...
  43. Liu L, Rajareddy S, Reddy P, Jagarlamudi K, Du C, Shen Y, et al. Phosphorylation and inactivation of glycogen synthase kinase-3 by soluble kit ligand in mouse oocytes during early follicular development. J Mol Endocrinol. 2007;38:137-46 pubmed
    ..between mammalian oocytes and their surrounding granulosa cells through the Kit-Kit ligand (KL, or stem cell factor, SCF) system has been shown to be crucial for follicular development. Our previous studies (Reddy et al...
  44. Yoshida H, Hayashi S, Shultz L, Yamamura K, Nishikawa S, Kunisada T. Neural and skin cell-specific expression pattern conferred by steel factor regulatory sequence in transgenic mice. Dev Dyn. 1996;207:222-32 pubmed
    We have produced transgenic mice expressing a lacZ reporter gene under the control of a fragment of a Steel factor (SLF)...
  45. Williams D, Eisenman J, Baird A, Rauch C, Van Ness K, March C, et al. Identification of a ligand for the c-kit proto-oncogene. Cell. 1990;63:167-74 pubmed
    We report the purification and N-terminal amino acid sequence of a novel mast cell growth factor, termed MGF, from the supernatants of a murine stromal cell line...
  46. Kawaguchi N, Horiuchi K, Becherer J, Toyama Y, Besmer P, Blobel C. Different ADAMs have distinct influences on Kit ligand processing: phorbol-ester-stimulated ectodomain shedding of Kitl1 by ADAM17 is reduced by ADAM19. J Cell Sci. 2007;120:943-52 pubmed
    b>Kit ligand (Kitl), the ligand for the Kit receptor tyrosine kinase, plays important roles in hematopoiesis, gametogenesis and melanogenesis...
  47. Yee N, Paek I, Besmer P. Role of kit-ligand in proliferation and suppression of apoptosis in mast cells: basis for radiosensitivity of white spotting and steel mutant mice. J Exp Med. 1994;179:1777-87 pubmed
    The receptor tyrosine kinase Kit and its cognate ligand KL/steel factor are encoded at the white spotting (W) and Steel (Sl) loci of the mouse, respectively...
  48. Miyazawa K, Williams D, Gotoh A, Nishimaki J, Broxmeyer H, Toyama K. Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form. Blood. 1995;85:641-9 pubmed
    Alternative splicing of exon 6 results in the production of two isoforms of Steel factor (SLF): the membrane-bound and soluble forms...
  49. Motro B, Wojtowicz J, Bernstein A, van der Kooy D. Steel mutant mice are deficient in hippocampal learning but not long-term potentiation. Proc Natl Acad Sci U S A. 1996;93:1808-13 pubmed
    ..W encodes the Kit receptor tyrosine kinase, while Sl encodes the Kit ligand, Steel factor, and the receptor-ligand pair are contiguously expressed at anatomical sites expected from the phenotypes of W ..
  50. Kluppel M, Nagle D, Bucan M, Bernstein A. Long-range genomic rearrangements upstream of Kit dysregulate the developmental pattern of Kit expression in W57 and Wbanded mice and interfere with distinct steps in melanocyte development. Development. 1997;124:65-77 pubmed
  51. Barker J. Sl/Sld hematopoietic progenitors are deficient in situ. Exp Hematol. 1994;22:174-7 pubmed
    ..Results suggest that the absence of membrane-bound Steel factor in the mutant donor has a direct effect on Steel hematopoietic progenitors, which is not alleviated during ..
  52. Besmer P, Manova K, Duttlinger R, Huang E, Packer A, Gyssler C, et al. The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis. Dev Suppl. 1993;:125-37 pubmed
    ..The kit-ligand, KL, also called steel factor, is synthesized from two alternatively spliced mRNAs as transmembrane proteins that can either be ..
  53. Steel K, Davidson D, Jackson I. TRP-2/DT, a new early melanoblast marker, shows that steel growth factor (c-kit ligand) is a survival factor. Development. 1992;115:1111-9 pubmed