Kitl

Summary

Gene Symbol: Kitl
Description: kit ligand
Alias: Clo, Con, Kitlg, Mgf, SCF, SLF, blz, contrasted, C-kit ligand, Steel factor, cloud gray, grizzle-belly, hematopoietic growth factor KL, mast cell growth factor, stem cell factor
Species: mouse

Top Publications

  1. ncbi Stem cell factor and hematopoiesis
    V C Broudy
    Department of Medicine, University of Washington, Seattle 98195 7710, USA
    Blood 90:1345-64. 1997
  2. ncbi Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor
    K M Zsebo
    Amgen Inc, Amgen Center, Thousand Oaks, California 91320
    Cell 63:213-24. 1990
  3. doi Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
    Kazuyo Moro
    Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Nature 463:540-4. 2010
  4. ncbi Embryonic expression of a haematopoietic growth factor encoded by the Sl locus and the ligand for c-kit
    Y Matsui
    Department of Cell Biology, Vanderbilt University Medical School, Nashville, Tennessee 37232 2172
    Nature 347:667-9. 1990
  5. ncbi The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus
    E Huang
    Molecular Biology Program, Sloan Kettering Institute, New York, New York
    Cell 63:225-33. 1990
  6. ncbi Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms
    D M Anderson
    Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101
    Cell 63:235-43. 1990
  7. pmc Stem cell factor and its receptor, c-kit, are important for hepatocyte proliferation in wild-type and tumor necrosis factor receptor-1 knockout mice after 70% hepatectomy
    Xiaodan Ren
    Department of Surgery, University of Michigan Medical School, Ann Arbor, Mich
    Surgery 143:790-802. 2008
  8. ncbi Contiguous patterns of c-kit and steel expression: analysis of mutations at the W and Sl loci
    B Motro
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Development 113:1207-21. 1991
  9. ncbi Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles
    N G Copeland
    Mammalian Genetics Laboratory, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702
    Cell 63:175-83. 1990
  10. ncbi Sl/Sld hematopoietic progenitors are deficient in situ
    J E Barker
    Jackson Laboratory, Bar Harbor, ME 04609
    Exp Hematol 22:174-7. 1994

Research Grants

  1. Novel Mechanisms of C-Kit Regulation in Mast Cells
    Reuben Kapur; Fiscal Year: 2007
  2. REGULATION OF ENERGY BALANCE BY MELANOCORTIN ANTAGONISTS
    Gregory Barsh; Fiscal Year: 2003
  3. Testicular tumor susceptibility at the agouti locus
    JASON HEANEY; Fiscal Year: 2007
  4. CONTROL OF COLONIC MOTILITY IN HEALTH AND DISEASE
    SUSHIL SARNA; Fiscal Year: 2002
  5. SENESCENE AND PREB CELL DEVELOPMENT
    Richard Riley; Fiscal Year: 2003
  6. Mechanisms of adhesion and growth control in stem cells
    Reuben Kapur; Fiscal Year: 2007
  7. Genetics of Dark Skin in Mice
    Gregory Barsh; Fiscal Year: 2006
  8. Immunobiological Role of Fertilization Antigen(FA-1)
    RAJESH NAZ; Fiscal Year: 2007
  9. SCF in liver repair after hepatectomy or toxic injury
    Lisa Colletti; Fiscal Year: 2006
  10. MEDICAL SCIENTIST TRAINING PROGRAM
    Gregory Barsh; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications124 found, 100 shown here

  1. ncbi Stem cell factor and hematopoiesis
    V C Broudy
    Department of Medicine, University of Washington, Seattle 98195 7710, USA
    Blood 90:1345-64. 1997
  2. ncbi Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor
    K M Zsebo
    Amgen Inc, Amgen Center, Thousand Oaks, California 91320
    Cell 63:213-24. 1990
    We have cloned a partial cDNA encoding murine stem cell factor (SCF) and show that the gene is syntenic with the Sl locus on mouse chromosome 10...
  3. doi Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
    Kazuyo Moro
    Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Nature 463:540-4. 2010
    ..Thus, FALC Lin(-)c-Kit(+)Sca-1(+) cells are T(H)2-type innate lymphocytes, and we propose that these cells be called 'natural helper cells'...
  4. ncbi Embryonic expression of a haematopoietic growth factor encoded by the Sl locus and the ligand for c-kit
    Y Matsui
    Department of Cell Biology, Vanderbilt University Medical School, Nashville, Tennessee 37232 2172
    Nature 347:667-9. 1990
    ..The haematopoietic growth factor SCF (stem cell factor) has been identified as the product of the Sl locus and a ligand for c-kit...
  5. ncbi The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus
    E Huang
    Molecular Biology Program, Sloan Kettering Institute, New York, New York
    Cell 63:225-33. 1990
    ..Linkage analysis maps the KL gene to the Sl locus on mouse chromosome 10, and KL sequences are deleted in the genome of the Sl mouse. These results indicate that the Sl locus encodes the ligand of the c-kit receptor, KL...
  6. ncbi Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms
    D M Anderson
    Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101
    Cell 63:235-43. 1990
    We have previously reported the identification of a novel mast cell growth factor (MGF) that was shown to be a ligand for c-kit and is encoded by a gene that maps near the steel locus on mouse chromosome 10...
  7. pmc Stem cell factor and its receptor, c-kit, are important for hepatocyte proliferation in wild-type and tumor necrosis factor receptor-1 knockout mice after 70% hepatectomy
    Xiaodan Ren
    Department of Surgery, University of Michigan Medical School, Ann Arbor, Mich
    Surgery 143:790-802. 2008
    b>Stem cell factor (SCF) has well-known proliferative effects on hematopoietic cells. SCF also has effects on differentiation and proliferation in other cell types...
  8. ncbi Contiguous patterns of c-kit and steel expression: analysis of mutations at the W and Sl loci
    B Motro
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Development 113:1207-21. 1991
    ....
  9. ncbi Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles
    N G Copeland
    Mammalian Genetics Laboratory, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702
    Cell 63:175-83. 1990
    ..In the accompanying article we report the identification and purification of mast cell growth factor (MGF), a c-kit ligand. Here we describe the cloning of sequences encoding MGF...
  10. ncbi Sl/Sld hematopoietic progenitors are deficient in situ
    J E Barker
    Jackson Laboratory, Bar Harbor, ME 04609
    Exp Hematol 22:174-7. 1994
    ..Results suggest that the absence of membrane-bound Steel factor in the mutant donor has a direct effect on Steel hematopoietic progenitors, which is not alleviated during ..
  11. ncbi Early transplantation to a normal microenvironment prevents the development of Steel hematopoietic stem cell defects
    J E Barker
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Exp Hematol 25:542-7. 1997
    ..either inherently defective or lose competitive ability by residence in an environment lacking membrane-bound Steel factor. In the present report, any long-term effects of the Steel microenvironment were eradicated by transferring ..
  12. ncbi Dynamic changes in ovarian c-kit and Steel expression during the estrous reproductive cycle
    B Motro
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Dev Dyn 197:69-79. 1993
    ....
  13. ncbi Post-transcriptional stabilization by interleukin-1beta of interleukin-6 mRNA induced by c-kit ligand and interleukin-10 in mouse bone marrow-derived mast cells
    J M Lu-Kuo
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 271:22169-74. 1996
    ....
  14. ncbi Stem cell factor is a chemoattractant and a survival factor for CNS stem cells
    Anna Erlandsson
    Department of Medical Biochemistry and Microbiology, Uppsala University, Biomedical Center, 751 23 Uppsala, Sweden
    Exp Cell Res 301:201-10. 2004
    ..Several extrinsic factors are known to be involved in the regulation of neural migration. We asked if stem cell factor (SCF), well known as a chemoattractant and survival factor in the hematopoietic lineage, could elicit similar ..
  15. ncbi Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis: contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration
    Shuji Ueda
    Department of Hematology and Oncology, and the Department of Microbiology, Osaka University Graduate School of Medicine, Osaka, Japan
    Blood 99:3342-9. 2002
    b>Stem cell factor (SCF) has crucial roles in proliferation, survival, and differentiation of hematopoietic stem cells and mast cells through binding to c-Kit receptor (KIT). Chemotaxis is another unique function of SCF...
  16. doi Steel factor controls primordial germ cell survival and motility from the time of their specification in the allantois, and provides a continuous niche throughout their migration
    Ying Gu
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Development 136:1295-303. 2009
    b>Steel factor is an essential survival and proliferation factor for primordial germ cells (PGCs) during their migration in the early mouse embryo...
  17. ncbi Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration
    Christopher Runyan
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Development 133:4861-9. 2006
    ..We then show that germ cell apoptosis in the midline is activated by down-regulation of Steel factor (kit ligand) expression in the midline between E9.5 and E10.5...
  18. pmc Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation
    K Ikuta
    Howard Hughes Medical Institute, Stanford University School of Medicine, CA 94305
    Proc Natl Acad Sci U S A 89:1502-6. 1992
    The interaction of the mouse c-kit receptor, designated Kit receptor, and steel factor promotes the proliferation and differentiation of hematopoietic progenitor cells...
  19. ncbi Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility
    P Blume-Jensen
    Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, California, USA
    Nat Genet 24:157-62. 2000
    The c-kit-encoded transmembrane tyrosine kinase receptor for stem cell factor (Kit/SCF-R) is required for normal haematopoiesis, melanogenesis and gametogenesis...
  20. pmc Role of kit-ligand in proliferation and suppression of apoptosis in mast cells: basis for radiosensitivity of white spotting and steel mutant mice
    N S Yee
    Molecular Biology Program, Sloan Kettering Institute, New York
    J Exp Med 179:1777-87. 1994
    The receptor tyrosine kinase Kit and its cognate ligand KL/steel factor are encoded at the white spotting (W) and Steel (Sl) loci of the mouse, respectively...
  21. pmc Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo
    D A Ingram
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Exp Med 191:181-8. 2000
    ..Haploinsufficiency at Nf1 also increased mast cell proliferation, survival, and colony formation in response to Steel factor, the ligand for c-kit...
  22. pmc Stem cell factor restores hepatocyte proliferation in IL-6 knockout mice following 70% hepatectomy
    Xiaodan Ren
    Department of Surgery, University of Michigan, Medical School, Ann Arbor, Michigan 48109 0331, USA
    J Clin Invest 112:1407-18. 2003
    b>Stem cell factor (SCF) is a molecule with known proliferative effects on hematopoietic cells. More recent studies suggest that this molecule may also have effects on cellular differentiation and proliferation in other types of cells...
  23. pmc Circulation and chemotaxis of fetal hematopoietic stem cells
    Julie L Christensen
    Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    PLoS Biol 2:E75. 2004
    ..marrow HSCs, the migratory response of fetal liver HSCs to SDF-1alpha is greatly increased in the presence of Steel factor (SLF), suggesting an important role for SLF in HSC homing to and seeding of the fetal hematopoietic tissues...
  24. ncbi Stem cell factor increases colony-forming unit-spleen number in vitro in synergy with interleukin-6, and in vivo in Sl/Sld mice as a single factor
    D M Bodine
    Clinical Hematology Branch NHLBI, Bethesda, MD 20892
    Blood 79:913-9. 1992
    ..In this report, we describe the effects of stem cell factor (SCF) on CFU-S and repopulating stem cells...
  25. ncbi Analyzing mast cell development and function using mice carrying mutations at W/c-kit or Sl/MGF (SCF) loci
    S J Galli
    Department of Pathology, Beth Israel Hospital, Boston, Massachusetts
    Ann N Y Acad Sci 664:69-88. 1992
    ..factor expressed in the microenvironments where mast cells ordinarily develop: the c-kit receptor ligand, SCF. As a result, W/Wv mice virtually lack tissue mast cells...
  26. ncbi Analysis of hypomorphic KitlSl mutants suggests different requirements for KITL in proliferation and migration of mouse primordial germ cells
    Aparna Mahakali Zama
    Department of Genetics, University of Georgia, Athens, Georgia 30602 7223, USA
    Biol Reprod 73:639-47. 2005
    ..It is well established that Kit ligand (KITL, also known as stem cell factor and mast cell growth factor) is required for the survival and proliferation of PGCs...
  27. ncbi Identification of a ligand for the c-kit proto-oncogene
    D E Williams
    Department of Experimental Hematology, Immunex Corporation, Seattle, Washington 98101
    Cell 63:167-74. 1990
    We report the purification and N-terminal amino acid sequence of a novel mast cell growth factor, termed MGF, from the supernatants of a murine stromal cell line...
  28. ncbi A study of the primordial germ cells during their migratory phase in Steel mutant mice
    J A McCoshen
    Experientia 31:589-90. 1975
  29. pmc The c-kit ligand, stem cell factor, promotes mast cell survival by suppressing apoptosis
    A Iemura
    Department of Pathology, Beth Israel Hospital, Boston, MA 02215
    Am J Pathol 144:321-8. 1994
    b>Stem cell factor (SCF) and its receptor (SCFR), a member of the receptor tyrosine kinase III family that is encoded by the c-kit gene, critically regulate several complex biological programs including hematopoiesis, mast cell development, ..
  30. ncbi Soluble and cell-bound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathway
    B Wehrle-Haller
    Institute of Neuroscience, University of Oregon, Eugene 97403
    Development 121:731-42. 1995
    ..Melanocyte precursors transiently require the c-kit ligand, Steel factor for survival...
  31. ncbi The murine W/c-kit and Steel loci and the control of hematopoiesis
    A Bernstein
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canda
    Semin Hematol 28:138-42. 1991
    ..Further analysis of the W/Sl pathway should provide a more complete understanding of the early events in hematopoiesis, and may also lead to novel therapeutic applications involving the protein product of the Sl locus...
  32. ncbi TRP-2/DT, a new early melanoblast marker, shows that steel growth factor (c-kit ligand) is a survival factor
    K P Steel
    MRC Institute of Hearing Research, University Park, Nottingham, UK
    Development 115:1111-9. 1992
    ....
  33. pmc Consequences of exclusive expression in vivo of Kit-ligand lacking the major proteolytic cleavage site
    Y Tajima
    Molecular Biology, Cornell University, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 95:11903-8. 1998
    ....
  34. ncbi Altered cell-surface targeting of stem cell factor causes loss of melanocyte precursors in Steel17H mutant mice
    B Wehrle-Haller
    Department of Pathology, Centre Medical Universitaire, 1, rue Michel Servet, Geneva 4, 1211, Switzerland
    Dev Biol 210:71-86. 1999
    ..The Sl locus encodes stem cell factor (SCF), which is the ligand of c-kit, a receptor tyrosine kinase encoded by the W locus...
  35. ncbi Ectopic c-kit expression affects the fate of melanocyte precursors in Patch mutant embryos
    B Wehrle-Haller
    Institute of Neuroscience, University of Oregon, Eugene 97403 1254, USA
    Dev Biol 177:463-74. 1996
    ..trunk neural crest cells from homozygous Ph embryos give rise to pigmented melanocytes in vitro in response to Steel factor (SlF)...
  36. ncbi W-sash affects positive and negative elements controlling c-kit expression: ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis
    R Duttlinger
    Molecular Biology Program, Sloan Kettering Institute, New York, NY
    Development 118:705-17. 1993
    ..Molecular analysis of Wsh chromosomal DNA revealed a deletion or rearrangement in the vicinity of the c-kit gene. These results provide an explanation for the Wsh phenotype and have implications for the control of c-kit expression...
  37. ncbi Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway
    Jesus Perez-Losada
    Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer, Servicio de Citometría, Universidad de Salamanca, Spain
    Blood 100:1274-86. 2002
    The stem cell factor c-kit signaling pathway (SCF/c-kit) has been previously implicated in normal hematopoiesis, melanogenesis, and gametogenesis through the formation and migration of c-kit(+) cells...
  38. pmc Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2
    E J Huang
    Program in Molecular Biology, Sloan Kettering Institute, New York, New York 10021
    Mol Biol Cell 3:349-62. 1992
    ..These results indicate an important function for both the soluble and the cell associate form of KL. The respective roles of the soluble and cell associated forms of KL in the proliferative and migratory functions of c-kit are discussed...
  39. ncbi Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv)
    F Arguello
    Strong Children s Research Center, University of Rochester School of Medicine, New York 14642
    Cancer Res 52:2304-9. 1992
    ..The Sl locus encodes for a multipotent growth factor known as stem cell factor. The W locus encodes the c-kit protein tyrosine kinase receptor whose ligand is the stem cell factor...
  40. ncbi Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant
    J G Flanagan
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115
    Cell 64:1025-35. 1991
    ..These results provide evidence that cell surface KL has a critical role in the intact organism...
  41. ncbi Phosphorylation and inactivation of glycogen synthase kinase-3 by soluble kit ligand in mouse oocytes during early follicular development
    Lian Liu
    Department of Medical Biochemistry and Biophysics, Umea University, Umea, Sweden
    J Mol Endocrinol 38:137-46. 2007
    ..between mammalian oocytes and their surrounding granulosa cells through the Kit-Kit ligand (KL, or stem cell factor, SCF) system has been shown to be crucial for follicular development. Our previous studies (Reddy et al...
  42. ncbi The ligand of the c-kit receptor promotes oocyte growth
    A I Packer
    Department of Cell Biology and Anatomy, Cornell University Medical College, New York, New York 10021
    Dev Biol 161:194-205. 1994
    ..These studies demonstrate that c-kit and KL are required for maintenance of oocyte growth in vitro...
  43. ncbi c-kit delineates a distinct domain of progenitors in the developing kidney
    Kai M Schmidt-Ott
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Dev Biol 299:238-49. 2006
    ..In this study, through analysis of the stem cell factor (SCF)/c-kit ligand receptor pair, we describe an additional distinct cell population in the early developing ..
  44. ncbi Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons
    F Guillemot
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Cell 75:463-76. 1993
    ..These observations suggest that Mash-1, like its Drosophila homologs of the AS-C, controls a basic operation in development of neuronal progenitors in distinct neural lineages...
  45. ncbi Steel factor and c-kit regulate cell-matrix adhesion
    T Kinashi
    Center for Blood Research, Boston, MA 02115
    Blood 83:1033-8. 1994
    Steel (SI) and white spotting (W) loci encode steel factor (c-kit ligand) and the c-kit tyrosine kinase receptor, respectively...
  46. pmc SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia
    Jinke Cheng
    Department of Cardiology, The University of Texas MD Anderson Cancer Center, The University of Texas, Houston Health Science Center, Houston, TX 77030, USA
    Cell 131:584-95. 2007
    ..These results show that SENP1 plays a key role in the regulation of the hypoxic response through regulation of HIF1alpha stability and that SUMOylation can serve as a direct signal for ubiquitin-dependent degradation...
  47. ncbi Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survival
    B Wehrle-Haller
    Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403 1254, USA
    Dev Biol 232:471-83. 2001
    ..In mouse embryos, MPs express the receptor tyrosine kinase, KIT, and require its cognate ligand, Mast cell growth factor (MGF), for survival and differentiation...
  48. ncbi Neural and skin cell-specific expression pattern conferred by steel factor regulatory sequence in transgenic mice
    H Yoshida
    Department of Molecular Genetics, Faculty of Medicine, Kyoto University, Japan
    Dev Dyn 207:222-32. 1996
    We have produced transgenic mice expressing a lacZ reporter gene under the control of a fragment of a Steel factor (SLF)...
  49. ncbi Long-range genomic rearrangements upstream of Kit dysregulate the developmental pattern of Kit expression in W57 and Wbanded mice and interfere with distinct steps in melanocyte development
    M Kluppel
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Development 124:65-77. 1997
    ....
  50. pmc Oocyte-granulosa cell interactions during mouse follicular development: regulation of kit ligand expression and its role in oocyte growth
    Fiona H Thomas
    Department of Cellular and Molecular Medicine, University of Ottawa, and Centre for Cancer Therapeutics, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada
    Reprod Biol Endocrinol 4:19. 2006
    ..Particular emphasis is given to granulosa cell-derived Kit Ligand (KitL), whose functional importance for oocyte growth has been demonstrated by a wide range of in vivo and in vitro ..
  51. ncbi Kit ligand 2 promotes murine oocyte growth in vitro
    Fiona H Thomas
    Department of Cellular and Molecular Medicine, University of Ottawa and Centre for Cancer Therapeutics, Ottawa Health Research Institute, Ottawa, ON, Canada
    Biol Reprod 78:167-75. 2008
    Oocyte-granulosa cell communication, mediated by paracrine factors, is essential for oocyte development. Kit ligand (KITL) is expressed in granulosa cells as soluble (KITL1) or membrane-associated (KITL2) proteins...
  52. ncbi Fibronectin combined with stem cell factor plays an important role in melanocyte proliferation, differentiation and migration in cultured mouse neural crest cells
    Nagako Takano
    Department of Dermatology, St Marianna University School of Medicine, Kanagawa, Japan
    Pigment Cell Res 15:192-200. 2002
    b>Stem cell factor (SCF) is essential to the migration and differentiation of melanocytes during embryogenesis because mutations in either the SCF gene, or its ligand, KIT, result in defects in coat pigmentation in mice...
  53. pmc Gene Duplication of the zebrafish kit ligand and partitioning of melanocyte development functions to kit ligand a
    Keith A Hultman
    Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri, United States of America
    PLoS Genet 3:e17. 2007
    ....
  54. ncbi Decreased production of mast cells in S1/S1d anemic mice
    Y Kitamura
    Blood 53:492-7. 1979
  55. pmc Embryonic RNA expression patterns of the c-kit receptor and its cognate ligand suggest multiple functional roles in mouse development
    E Keshet
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI FCRDC, Frederick, MD 21702 1201
    EMBO J 10:2425-35. 1991
    ..More recently, the Sl locus has been shown to encode a ligand for c-kit, which is variously known as mast cell growth factor (MGF), stem cell growth factor and c-kit ligand...
  56. ncbi AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene
    H Okada
    Department of Cell Biology, Cancer Institute, Tokyo, Japan
    Oncogene 17:2287-93. 1998
    ..The results suggest that the expression of a particular set of hematopoiesis-related genes is closely correlated with the PEBP2/CBF function...
  57. ncbi The expression pattern of the c-kit ligand in gonads of mice supports a role for the c-kit receptor in oocyte growth and in proliferation of spermatogonia
    K Manova
    Department of Cell Biology and Anatomy, Cornell University Medical College, New York, New York 10021
    Dev Biol 157:85-99. 1993
    ..These data are consistent with a role for KL in oocyte growth and in facilitating proliferation and/or differentiation of type A spermatogonia...
  58. ncbi Expression of CSF-1/c-fms and SF/c-kit mRNA during preimplantation mouse development
    R J Arceci
    Pediatric Hematology Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115
    Dev Biol 151:1-8. 1992
    ..and c-kit are structurally related tyrosine kinase receptors for colony-stimulating factor-1 (CSF-1) and for steel factor (SF), respectively...
  59. pmc Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains
    C I Brannan
    Mammalian Genetics Laboratory, National Cancer Institute Frederick Cancer Research and Development Center, MD 21702 1201
    Proc Natl Acad Sci U S A 88:4671-4. 1991
    ..0-kilobase intragenic deletion in mast cell growth factor (MGF) genomic sequences, providing conclusive evidence that Sl encodes MGF...
  60. ncbi Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form
    K Miyazawa
    First Department of Internal Medicine Hematology and Oncology, Tokyo Medical College, Japan
    Blood 85:641-9. 1995
    Alternative splicing of exon 6 results in the production of two isoforms of Steel factor (SLF): the membrane-bound and soluble forms...
  61. ncbi c-kit ligand mediates increased expression of cytosolic phospholipase A2, prostaglandin endoperoxide synthase-1, and hematopoietic prostaglandin D2 synthase and increased IgE-dependent prostaglandin D2 generation in immature mouse mast cells
    M Murakami
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 270:3239-46. 1995
    ....
  62. ncbi Different ADAMs have distinct influences on Kit ligand processing: phorbol-ester-stimulated ectodomain shedding of Kitl1 by ADAM17 is reduced by ADAM19
    Nobuko Kawaguchi
    Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Cell Sci 120:943-52. 2007
    Kit ligand (Kitl), the ligand for the Kit receptor tyrosine kinase, plays important roles in hematopoiesis, gametogenesis and melanogenesis...
  63. ncbi Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system
    M E Dickinson
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110
    Development 120:1453-71. 1994
    ..Rather, our experiments indicate that Wnt-1 can act as a mitogen in the developing CNS...
  64. pmc Mouse bone marrow-derived mast cells (mBMMC) obtained in vitro from mice that are mast cell-deficient in vivo express the same panel of granule proteases as mBMMC and serosal mast cells from their normal littermates
    K K Eklund
    Department of Medicine, Harvard Medical School, Boston, Massachusetts
    J Exp Med 180:67-73. 1994
    ....
  65. pmc NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche
    Chiung Ying Chang
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
    Nature 495:98-102. 2013
    ..Our findings reveal how melanocyte and hair follicle stem cell behaviours maintain reliance upon cooperative factors within the niche, and how this can be uncoupled in injury, stress and disease states...
  66. ncbi Splenic primitive hematopoietic stem cell (PHSC) activity is enhanced by steel factor because of PHSC proliferation
    D E Harrison
    Jackson Laboratory, Bar Harbor, ME 04609 0800
    Blood 83:3146-51. 1994
    ..However, a dose of 5FU on day 4 of the SI factor treatments almost totally prevented the increase in splenic PHSC activity. Apparently this increased activity requires PHSC cycling throughout the period of SI factor treatment...
  67. pmc Regulation of p53-mediated apoptosis and cell cycle arrest by Steel factor
    J L Abrahamson
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Mol Cell Biol 15:6953-60. 1995
    ..We have investigated the consequences of activating the Kit signalling pathway by its ligand Steel factor on these opposing functions of the p53 protein in Friend erythroleukemia cells...
  68. ncbi Dissecting the hematopoietic microenvironment. II. The kinetics of the erythron of the S1/S1d mouse and the dual nature of its anemia
    N S Wolf
    Cell Tissue Kinet 11:325-34. 1978
    ..The cause of the moderately high level of erythropoiesis in the S1/S1d is a mean daily loss of 2.5--3.0% of its total blood volume via the intestinal tract...
  69. pmc Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma
    Nandini Krishnamoorthy
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, 3459 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    Nat Med 14:565-73. 2008
    ..mite (HDM) or the mucosal adjuvant cholera toxin promotes cell surface expression of c-Kit and its ligand, stem cell factor (SCF), on DCs...
  70. ncbi Linkage of Pep-2 and Apk on mouse chromosome 10
    J E Womack
    Biochem Genet 24:721-7. 1986
    ..8 +/- 3.9%-Pep-2-3.7 +/- 2.1%-Sl. Methods for rapid determination of Apk and Pep-2 alleles by cellulose acetate electrophoresis and a valuable linkage testing stock carrying the unique Apkm and Pep-2b alleles are described...
  71. ncbi The effect of hemopoietic microenvironment on splenic suppressor macrophages in congenitally anemic mice of genotype Sl/Sld
    Y Shibata
    J Immunol 135:3905-10. 1985
    ..Splenic suppressor M phi, defined by PGE-mediated inhibition of Con A-induced T lymphocyte proliferation are induced by the i.p. administration of Corynebacterium parvum (CP)...
  72. ncbi The cloning and sequencing of cDNAs encoding two isoforms of feline stem cell factor
    S P Dunham
    Department of Veterinary Pathology, University of Glasgow Veterinary School, U K
    DNA Seq 6:233-7. 1996
    cDNA clones encoding two isoforms of feline stem cell factor (fSCF) have been isolated using RT-PCR and their sequences determined...
  73. ncbi Paleocortex is specified in mice in which dorsal telencephalic patterning is severely disrupted
    Aditee Vyas
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
    J Comp Neurol 466:545-53. 2003
    ..Furthermore, our in vitro data reveal that, if mechanisms outside the lateral telencephalon are involved in the specification of the paleocortex, they must act extremely early, prior to E10.5...
  74. ncbi Mesenchymal cells are required for functional development of thymic epithelial cells
    Manami Itoi
    Department of Immunology and Microbiology, Meiji University of Oriental Medicine, Hiyoshi cho, Nantan, Kyoto 629 0392, Japan
    Int Immunol 19:953-64. 2007
    ..of the ph/ph thymus anlage show severely impaired proliferation and expression of functional molecules, such as SCF, Delta-like 4 and MHC class II, which have crucial roles in T cell development...
  75. ncbi Reduced blood and marrow neutrophils and granulocytic colony-forming cells in S1/S1d mice
    F W Ruscetti
    Proc Soc Exp Biol Med 152:398-402. 1976
  76. ncbi The kit ligand: a cell surface molecule altered in steel mutant fibroblasts
    J G Flanagan
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115
    Cell 63:185-94. 1990
    ....
  77. pmc Somatic excision demonstrates that c-Jun induces cellular migration and invasion through induction of stem cell factor
    Sanjay Katiyar
    Departments of Cancer Biology and Medical Oncology, The Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Mol Cell Biol 27:1356-69. 2007
    ..and growth factors, differentially expressed and showing loss of secretion upon c-jun deletion, identified stem cell factor (SCF) as a c-Jun target gene. Immunoneutralizing antibody to SCF reduced migration of wild-type cells...
  78. ncbi Gene knockouts that cause female infertility: search for novel contraceptive targets
    Rajesh K Naz
    Department of Obstetrics and Gynecology, The West Virginia University, School of Medicine, Health Science Center, Morgantown, WV 26506 9186, USA
    Front Biosci 10:2447-59. 2005
    ..These molecules will provide novel targets of contraception including contraceptive vaccine development...
  79. ncbi Congenic mice provide in vivo evidence for a genetic locus that modulates serum insulin-like growth factor-I and bone acquisition
    K M Delahunty
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Endocrinology 147:3915-23. 2006
    ..Congenic mice establish proof of concept of shared genetic determinants for both circulating IGF-I and bone acquisition...
  80. ncbi H beta 58, an insertional mutation affecting early postimplantation development of the mouse embryo
    G Radice
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Development 111:801-11. 1991
    ..7 kb mRNA encoded at the H beta 58 locus, thus identifying a gene whose disruption appears to be responsible for the mutant phenotype...
  81. pmc BMP4, SCF, and hypoxia cooperatively regulate the expansion of murine stress erythroid progenitors
    John M Perry
    Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Blood 109:4494-502. 2007
    ..of the Kit receptor results in a severe defect in the expansion of stress BFU-E, indicating a role for the Kit/SCF signaling pathway in stress erythropoiesis...
  82. ncbi Chemoattractant action and molecular signaling pathways of Kit ligand on mouse primordial germ cells
    Donatella Farini
    Department of Public Health and Cell Biology, Section of Histology and Embryology, University of Rome Tor Vergata, Via Montpellier 1, 00173 Rome, Italy
    Dev Biol 306:572-83. 2007
    ....
  83. ncbi Deletion of membrane-bound steel factor results in osteopenia in mice
    Sutada Lotinun
    Department of Orthopedics, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Bone Miner Res 20:644-52. 2005
    To examine the functional role of membrane-bound SLF, we evaluated the growing skeletons of WT and SLF mutant (Sl/Sl(d)) mice that do not produce this protein using DXA, bone histomorphometry, cell culture, and flow cytometry...
  84. doi Pulmonary IL-17E (IL-25) production and IL-17RB+ myeloid cell-derived Th2 cytokine production are dependent upon stem cell factor-induced responses during chronic allergic pulmonary disease
    Vladislav Dolgachev
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 183:5705-15. 2009
    In the present studies local neutralization of allergen-induced stem cell factor (SCF) leads to decreased production of Th2 cytokines, a reduction in inflammation, allergen-specific serum IgE/IgG1, and attenuation of severe asthma-like ..
  85. pmc Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells
    Tatiana G Jones
    Division of Rheumatology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:5251-60. 2009
    ..These findings implicate type 2 NKT cells and IL-9 as central regulators that function in the same pathway mediating the Ag-induced increase in numbers of pulmonary MCp...
  86. doi Stem cell factor rescues tyrosinase expression and pigmentation in discreet anatomic locations in albino mice
    Jillian C Vanover
    Department of Pediatrics, University of Kentucky College of Medicine, The Markey Cancer Center, The Graduate Center for Toxicology, Lexington, KY, USA
    Pigment Cell Melanoma Res 22:827-38. 2009
    The K14-SCF transgenic murine model of variant pigmentation is based on epidermal expression of stem cell factor (SCF) on the C57BL/6J background...
  87. pmc Kit ligand promotes first polar body extrusion of mouse preovulatory oocytes
    Yinghui Ye
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita, Japan
    Reprod Biol Endocrinol 7:26. 2009
    ..oocyte maturation, we performed DNA microarray analyses of ovarian transcripts in mice and identified Kit ligand (Kitl) as an ovarian factor stimulated by the LH/hCG surge...
  88. pmc Endochondral ossification is required for haematopoietic stem-cell niche formation
    Charles K F Chan
    Department of Pathology, Developmental Biology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, California, USA
    Nature 457:490-4. 2009
    ..Collectively, our data implicate endochondral ossification, bone formation that proceeds through a cartilage intermediate, as a requirement for adult HSC niche formation...
  89. doi Secretion of stem cell factor and granulocyte-macrophage colony-stimulating factor by mouse embryos in culture: influence of group culture
    A P Contramaestre
    Universidad Simon Bolivar, Departamento de Biologia de Organismos, Baruta, Venezuela
    Zygote 16:297-301. 2008
    ..to the blastocyst stage; (2) the release of granulocyte-macrophage colony-stimulating factor (GM-CSF) and stem cell factor (SCF) into the culture medium by the embryo; and (3) the levels of GM-CSF and SCF in the culture medium from ..
  90. ncbi Forestomach papillomas in flaky skin and steel-Dickie mutant mice
    J P Sundberg
    Jackson Laboratory, Bar Harbor, ME 04609
    J Vet Diagn Invest 4:312-7. 1992
    ..Phenotypic expression of the fsn and Sld mutant genes may play an essential role in the spontaneous development of forestomach papillomas in these mouse mutants...
  91. doi Oncostatin M-mediated regulation of KIT-ligand-induced extracellular signal-regulated kinase signaling maintains hematopoietic repopulating activity of Lin-CD34+CD133+ cord blood cells
    Robert A J Oostendorp
    Laboratory of Stem Cell Physiology, III Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Ismaningerstrasse 22, 81675 Munchen, Germany
    Stem Cells 26:2164-72. 2008
    ..Our results show that the loss of repopulating activity during KL stimulation is counteracted by OSM through the downregulation of ERK pathway signaling. Disclosure of potential conflicts of interest is found at the end of this article...
  92. ncbi Synergy between erythropoietin and stem cell factor during erythropoiesis can be quantitatively described without co-signaling effects
    Weijia Wang
    Institute of Biomaterials and Biomedical Engineering IBBME, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 164 College Street, Rm 407, Toronto, ON, Canada M5S 3G9
    Biotechnol Bioeng 99:1261-72. 2008
    ..we have investigated the synergistic generation of erythroid cells in response to erythropoietin (EPO) and stem cell factor (SCF)...
  93. pmc Pahhph-5: a mouse mutant deficient in phenylalanine hydroxylase
    J D McDonald
    McArdle Laboratory, University of Wisconsin, Madison 53706
    Proc Natl Acad Sci U S A 87:1965-7. 1990
    ..This mutant provides a useful genetic animal model affected in the same enzyme as in human phenylketonuria...
  94. ncbi Stem cell factor promotes mast cell survival via inactivation of FOXO3a-mediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim
    Christine Möller
    Department of Genetics and Pathology, The Rudbeck Laboratory, Uppsala University, Sweden
    Blood 106:1330-6. 2005
    ..Although it is well established that mast cell survival is dependent on stem cell factor (SCF), it has not been described how this process is regulated...
  95. ncbi Infertility due to growth arrest of ovarian follicles in Sl/Slt mice
    H Kuroda
    Department of Pathology, Osaka University Medical School, Japan
    Dev Biol 126:71-9. 1988
    ..This suggests that normal stromal cells are essential for the development of ovarian follicles...
  96. ncbi Changes in protooncogene expression correlated with general and sex-specific differentiation in murine primordial germ cells
    E C Coucouvanis
    Department of Biological Sciences, Stanford University, CA 94305
    Mech Dev 42:49-58. 1993
    ..Because c-kit and c-mos are expressed differentially in male and female day 13-15 germ cells, they may play roles in initiating or mediating progress along the sex-specific pathways of development that PGCs embark upon at this time...
  97. ncbi Steel factor stimulates the serine/threonine phosphorylation of the interleukin-3 receptor
    L Liu
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada
    J Biol Chem 269:16774-9. 1994
    ..numbers, was found to proliferate in a greater than additive fashion when grown in the presence of IL-3 and steel factor (SF)...
  98. ncbi Genetic analysis of hemopoietic cell cycling in mice suggests its involvement in organismal life span
    G de Haan
    Blood and Marrow Transplant Program, Division of Hematology Oncology, University of Kentucky Medical Center, Lexington, Kentucky 40536 0093, USA
    FASEB J 13:707-13. 1999
    ..These data indicate that steady-state cell turn-over, here measured in hemopoietic progenitor cells, may have a significant effect on the mean life span of mammals...
  99. ncbi Mouse primordial germ cells lacking beta1 integrins enter the germline but fail to migrate normally to the gonads
    R Anderson
    Department of Cell Biology and Neuroanatomy and Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    Development 126:1655-64. 1999
    ..These results demonstrate a role for beta1-containing integrins in the development of the germline, although an equivalent role for * integrin subunit(s) has yet to be established...
  100. ncbi HNF-3 beta as a regulator of floor plate development
    H Sasaki
    Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175
    Cell 76:103-15. 1994
    ..Earlier, several genes normally expressed in the floor plate (BMP-1, Steel factor, and HNF-3 alpha) are induced within the same ectopic dorsal domain as HNF-3 beta, and autoactivation of the ..

Research Grants95

  1. Novel Mechanisms of C-Kit Regulation in Mast Cells
    Reuben Kapur; Fiscal Year: 2007
    ..While several cytokines influence the growth, survival, and maturation of mast cells, stem cell factor (SCF) and its interaction via the tyrosine kinase receptor, c-Kit is essential for normal mast cell ..
  2. REGULATION OF ENERGY BALANCE BY MELANOCORTIN ANTAGONISTS
    Gregory Barsh; Fiscal Year: 2003
    ..abstract_text> ..
  3. Testicular tumor susceptibility at the agouti locus
    JASON HEANEY; Fiscal Year: 2007
    ..Chr19M, Ay/+ mice using BAG transgene complementation tests and conditional knockout mice, and 2) the TGCT frequency and expression levels of Raly and Eif2s2 in 129./W+ and 129.Chr19M, Avy/+ mice. ..
  4. CONTROL OF COLONIC MOTILITY IN HEALTH AND DISEASE
    SUSHIL SARNA; Fiscal Year: 2002
    ..In inflammatory bowel disease and other forms of gut inflammation it would be desirable to selectively stimulation phasic contractions and tone to minimize diarrhea, urgency of defecation and abdominal discomfort. ..
  5. SENESCENE AND PREB CELL DEVELOPMENT
    Richard Riley; Fiscal Year: 2003
    ..The experiments in this application will provide a cellular and molecular basis for understanding the temporal loss of B lymphopoiesis and altered generation of VH repertoire during senescence. ..
  6. Mechanisms of adhesion and growth control in stem cells
    Reuben Kapur; Fiscal Year: 2007
    ..Our proposed studies will provide unique insights into the physiologic significance of Lyn, Hck, and Fgr SFKs in the regulation of SC/P growth and actin-based functions. ..
  7. Genetics of Dark Skin in Mice
    Gregory Barsh; Fiscal Year: 2006
    ....
  8. Immunobiological Role of Fertilization Antigen(FA-1)
    RAJESH NAZ; Fiscal Year: 2007
    ....
  9. SCF in liver repair after hepatectomy or toxic injury
    Lisa Colletti; Fiscal Year: 2006
    ..This proposal examines a specific cytokine, stem cell factor (SCF), in hepatocyte protection and regeneration during acetaminophen-induced liver toxicity, as well as ..
  10. MEDICAL SCIENTIST TRAINING PROGRAM
    Gregory Barsh; Fiscal Year: 2007
    ..We propose to continue this trend of innovation and interdisciplinary training, in which training grant resources are leveraged, and 9 - 10 individuals are admitted per year for a program length of 7- 8 years. ..
  11. Attractin and Mahoganoid in Spongy Neurodegeneration
    Gregory Barsh; Fiscal Year: 2007
    ..Investigating the biochemical, cellular, and genetic relationships between Atrn, Mahoganoid, and PrP is likely to provide general insight into the pathogenesis of spongy degeneration. ..
  12. CONTROL OF COLONIC MOTILITY IN HEALTH AND DISEASE
    SUSHIL SARNA; Fiscal Year: 2007
    ..The inhibition of NF-kappaB activation is an emerging therapy in treating inflammatory disorders. ..
  13. Selection of the B cell repertoire in senescence
    Richard Riley; Fiscal Year: 2007
    ..These studies will advance understanding of the immune defects which accompany old age and their cellular and molecular mechanisms. ..
  14. Testicular tumor susceptibility at the agouti locus
    JASON HEANEY; Fiscal Year: 2007
    ..Chr19M, A(y)/+ mice using BAG transgene complementation tests and conditional knockout mice, and 2) the TGCT frequency and expression levels of Raly and Eif2s2 in 129.A(vy)/+ and 129.Chr19M, A(vy)/+ mice. ..
  15. CXC CHEMOKINES AND LIVER REGENERATION
    Lisa Colletti; Fiscal Year: 2002
    ..By providing insights into the hepatic regenerative process, these studies could potentially lead to novel treatments for the failing liver. ..
  16. CONTROL OF COLONIC MOTILITY IN HEALTH AND DISEASE
    SUSHIL SARNA; Fiscal Year: 1992
    ....
  17. Chronic stress-induced gene expression in colonic circular smooth muscle cells.
    Sushil K Sarna; Fiscal Year: 2010
    ..The findings of this proposal are expected to identify the potential molecular therapeutic approaches that may prevent or minimize the ill effects of chronic stress on colonic motility function. ..
  18. Role of Vav and Rac in KIT oncogenesis
    Reuben Kapur; Fiscal Year: 2010
    ..Our results are expected to provide new targets for molecular therapies for the treatment of diseases such as AML and SM. ..
  19. Role of Vav and Rac in KIT oncogenesis
    Reuben Kapur; Fiscal Year: 2011
    ..Our results are expected to provide new targets for molecular therapies for the treatment of diseases such as AML and SM. ..
  20. Selection of B cell repertoire in senescence
    Richard L Riley; Fiscal Year: 2010
    ..Insight into the defects in B cell production in old age may reveal their influence on developing and maintaining effective immune barriers to infectious disease. ..
  21. Mechanisms of Pulmonary Mast Cell Recruitment and Maturation
    Michael Gurish; Fiscal Year: 2009
    ....
  22. IMMUNOBIOLOGICAL ROLE OF FERTILIZATION ANTIGEN FA-1
    RAJESH NAZ; Fiscal Year: 2001
    ..Besides enabling the PI to study the structure-function relationship, these studies will help them investigate the potential utility of the human recombinant FA-1 antigen is immunocontraception and immunoinfertility in humans. ..
  23. Novel Mechanisms of C-Kit Regulation in Mast Cells
    Reuben Kapur; Fiscal Year: 2009
    ..While several cytokines influence the growth, survival, and maturation of mast cells, stem cell factor (SCF) and its interaction via the tyrosine kinase receptor, c-Kit is essential for normal mast cell ..
  24. Control of colonic motility in health and disease.
    SUSHIL SARNA; Fiscal Year: 2009
    ..Our findings are expected to suggest that alternate therapeutic approaches may be required to normalize motility dysfunction in different types of inflammation. ..
  25. VIP-induced gene expression in colonic smooth muscle cells
    Sushil K Sarna; Fiscal Year: 2010
    ..abstract_text> ..
  26. Control of colonic motility in health and disease.
    Sushil K Sarna; Fiscal Year: 2010
    ..Our findings are expected to suggest that alternate therapeutic approaches may be required to normalize motility dysfunction in different types of inflammation. ..
  27. Mechanisms of adhesion and growth control in stem cells
    Reuben Kapur; Fiscal Year: 2009
    ..Some of these pathways, such as those initiated by stem cell factor (SCF), the ligand for KIT, stromal cell derived factor-1 (SDF-1), and thrombopoietin (TPO), induce the ..
  28. VIP-induced gene expression in colonic smooth muscle cells
    SUSHIL SARNA; Fiscal Year: 2009
    ..abstract_text> ..
  29. Regulation of E2A in Normal and Aged B Lymphopoiesis
    Richard Riley; Fiscal Year: 2007
    ..More broadly, these studies will further our understanding of the immune defects which accompany old age and their cellular and molecular mechanisms. ..