Kit

Summary

Gene Symbol: Kit
Description: KIT proto-oncogene receptor tyrosine kinase
Alias: CD117, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, SCO1, SCO5, SOW3, Ssm, Tr-kit, c-KIT, mast/stem cell growth factor receptor Kit, Dominant white spotting, SCFR, Steel Factor Receptor, belly-spot, c-kit proto-oncogene protein, dominant spotting, kit oncogene, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, spotted sterile male, tyrosine-protein kinase Kit
Species: mouse
Products:     Kit

Top Publications

  1. Cosgun K, Rahmig S, Mende N, Reinke S, Hauber I, Schäfer C, et al. Kit regulates HSC engraftment across the human-mouse species barrier. Cell Stem Cell. 2014;15:227-38 pubmed publisher
    ..Previously we showed that mutations in the Kit receptor enhance engraftment of transplanted HSCs in the mouse...
  2. Gerbaulet A, Wickenhauser C, Scholten J, Peschke K, Drube S, Horny H, et al. Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit. Blood. 2011;117:2012-21 pubmed publisher
    Signaling through the receptor tyrosine kinase kit controls proliferation and differentiation of hematopoietic precursor cells and mast cells...
  3. Jin C, Shelburne C, Li G, Potts E, Riebe K, Sempowski G, et al. Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation. J Clin Invest. 2011;121:941-55 pubmed publisher
    ..These results reveal how the physical attributes of allergens can co-opt MC endocytic circuitry and signaling responses to aggravate pathological responses of allergic asthma in mice. ..
  4. Feyerabend T, Weiser A, Tietz A, Stassen M, Harris N, Kopf M, et al. Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity. Immunity. 2011;35:832-44 pubmed publisher
    Immunological functions of mast cells remain poorly understood. Studies in Kit mutant mice suggest key roles for mast cells in certain antibody- and T cell-mediated autoimmune diseases...
  5. Ye L, Zhang E, Xiong Q, Astle C, Zhang P, Li Q, et al. Aging Kit mutant mice develop cardiomyopathy. PLoS ONE. 2012;7:e33407 pubmed publisher
    Both bone marrow (BM) and myocardium contain progenitor cells expressing the c-Kit tyrosine kinase. The aims of this study were to determine the effects of c-Kit mutations on: i. myocardial c-Kit(+) cells counts and ii...
  6. Jesty S, Steffey M, Lee F, Breitbach M, Hesse M, Reining S, et al. c-kit+ precursors support postinfarction myogenesis in the neonatal, but not adult, heart. Proc Natl Acad Sci U S A. 2012;109:13380-5 pubmed publisher
    We examined the myogenic response to infarction in neonatal and adult mice to determine the role of c-kit(+) cardiovascular precursor cells (CPC) that are known to be present in early heart development...
  7. Bosbach B, Deshpande S, Rossi F, Shieh J, Sommer G, de Stanchina E, et al. Imatinib resistance and microcytic erythrocytosis in a KitV558?;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor. Proc Natl Acad Sci U S A. 2012;109:E2276-83 pubmed publisher
    Most gastrointestinal stromal tumors (GISTs) harbor a gain-of-function mutation in the Kit receptor...
  8. Dudeck A, Dudeck J, Scholten J, Petzold A, Surianarayanan S, Köhler A, et al. Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens. Immunity. 2011;34:973-84 pubmed publisher
    ..Collectively, we demonstrate that mast cells are essential promoters of contact hypersensitivity, thereby highlighting their potential to promote immune responses to antigens entering via the skin. ..
  9. Regan J, Kendrick H, Magnay F, Vafaizadeh V, Groner B, Smalley M. c-Kit is required for growth and survival of the cells of origin of Brca1-mutation-associated breast cancer. Oncogene. 2012;31:869-83 pubmed publisher
    ..These cells also express high levels of the Kit gene and a recent study demonstrated a correlation between Brca1 loss and Kit over-expression in the mammary ..

More Information

Publications90

  1. Pittoni P, Tripodo C, Piconese S, Mauri G, Parenza M, Rigoni A, et al. Mast cell targeting hampers prostate adenocarcinoma development but promotes the occurrence of highly malignant neuroendocrine cancers. Cancer Res. 2011;71:5987-97 pubmed publisher
    Mast cells (MC) are c-Kit-expressing cells, best known for their primary involvement in allergic reactions, but recently reappraised as important players in either cancer promotion or inhibition...
  2. de Vries V, Pino Lagos K, Nowak E, Bennett K, Oliva C, Noelle R. Mast cells condition dendritic cells to mediate allograft tolerance. Immunity. 2011;35:550-61 pubmed publisher
    ..This study underscores the importance of MCs in conditioning DCs to mediate peripheral tolerance and shows a functional impact of peripherally produced TNF? and GM-CSF on the migration and function of tolerogenic DCs. ..
  3. Barrios F, Filipponi D, Campolo F, Gori M, Bramucci F, Pellegrini M, et al. SOHLH1 and SOHLH2 control Kit expression during postnatal male germ cell development. J Cell Sci. 2012;125:1455-64 pubmed publisher
    How Kit expression is regulated in the germline remains unknown. SOHLH1 and SOHLH2, two bHLH transcription factors specifically expressed in germ cells, are involved in spermatogonia and oocyte differentiation...
  4. Yokomizo T, Dzierzak E. Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos. Development. 2010;137:3651-61 pubmed publisher
    ..Clusters enriched with the c-Kit(+)CD31(+)SSEA1(-) cell population contain functional hematopoietic progenitors and stem cells...
  5. Cheng M, Zhou J, Wu M, Boriboun C, Thorne T, Liu T, et al. CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity. Circ Res. 2010;107:1083-93 pubmed publisher
    ..c-kit, a membrane-bound tyrosine kinase and the receptor for stem cell factor, has also been shown to play a critical ..
  6. Soucie E, Hanssens K, Mercher T, Georgin Lavialle S, Damaj G, Livideanu C, et al. In aggressive forms of mastocytosis, TET2 loss cooperates with c-KITD816V to transform mast cells. Blood. 2012;120:4846-9 pubmed publisher
    Although a role for oncogenic KIT in driving mast cell disease is clear, the mechanisms driving the multiple phenotypic and clinical manifestations of this disorder are not well elucidated...
  7. Cheng L, Hartmann K, Roers A, Krummel M, Locksley R. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity. 2013;38:166-75 pubmed publisher
    ..These data demonstrate how tissue mast cells acquire IgE and reveal a strategy by which extravascular cells monitor blood contents to capture molecules central to cellular function...
  8. Michel A, Schuler A, Friedrich P, Döner F, Bopp T, Radsak M, et al. Mast cell-deficient Kit(W-sh) "Sash" mutant mice display aberrant myelopoiesis leading to the accumulation of splenocytes that act as myeloid-derived suppressor cells. J Immunol. 2013;190:5534-44 pubmed publisher
    Mast cell-deficient Kit(W-sh) "sash" mice are widely used to investigate mast cell functions. However, mutations of c-Kit also affect additional cells of hematopoietic and nonimmune origin...
  9. Rabenhorst A, Schlaak M, Heukamp L, Förster A, Theurich S, von Bergwelt Baildon M, et al. Mast cells play a protumorigenic role in primary cutaneous lymphoma. Blood. 2012;120:2042-54 pubmed publisher
    ..Taken together, these experiments show that mast cells play a protumorigenic role in CTCL and CBCL. Our data provide a rationale for exploiting tumor-associated mast cells as a prognostic marker and therapeutic target in PCL. ..
  10. Sasaki T, Mizuochi C, Horio Y, Nakao K, Akashi K, Sugiyama D. Regulation of hematopoietic cell clusters in the placental niche through SCF/Kit signaling in embryonic mouse. Development. 2010;137:3941-52 pubmed publisher
    ..cell (HC) clusters in mouse placenta, defined as cells expressing the embryonic HSC markers CD31, CD34 and Kit, by immunohistochemistry. HC clusters were first observed in the placenta at 9.5 days post coitum (dpc)...
  11. Ramos L, Peña G, Cai B, Deitch E, Ulloa L. Mast cell stabilization improves survival by preventing apoptosis in sepsis. J Immunol. 2010;185:709-16 pubmed publisher
    ..Our study provides the first evidence that MCs have major immunological implications regulating cell death in sepsis and represent a pharmacological target for infectious disorders in a clinically realistic time frame. ..
  12. Wulff B, Parent A, Meleski M, DiPietro L, Schrementi M, Wilgus T. Mast cells contribute to scar formation during fetal wound healing. J Invest Dermatol. 2012;132:458-65 pubmed publisher
    ..produced at E18, which normally heal with a scar, healed with significantly smaller scars in mast cell-deficient Kit(W/W-v) mice compared with Kit(+/+) littermates...
  13. Ando T, Matsumoto K, Namiranian S, Yamashita H, Glatthorn H, Kimura M, et al. Mast cells are required for full expression of allergen/SEB-induced skin inflammation. J Invest Dermatol. 2013;133:2695-2705 pubmed publisher
    ..Therefore, this clinically relevant model provides mechanistic insights into the pathogenic mechanism of human AD. ..
  14. van Berlo J, Kanisicak O, Maillet M, Vagnozzi R, Karch J, Lin S, et al. c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature. 2014;509:337-41 pubmed publisher
    If and how the heart regenerates after an injury event is highly debated. c-kit-expressing cardiac progenitor cells have been reported as the primary source for generation of new myocardium after injury...
  15. Zaruba M, Soonpaa M, Reuter S, Field L. Cardiomyogenic potential of C-kit(+)-expressing cells derived from neonatal and adult mouse hearts. Circulation. 2010;121:1992-2000 pubmed publisher
    C-kit is a receptor tyrosine kinase family member expressed in hematopoietic stem cells. C-kit is also transiently expressed in cardiomyocyte precursors during development and in a rare cell population in the normal adult heart...
  16. Andreu P, Johansson M, Affara N, Pucci F, Tan T, Junankar S, et al. FcRgamma activation regulates inflammation-associated squamous carcinogenesis. Cancer Cell. 2010;17:121-34 pubmed publisher
    ..These findings support a model in which B cells, humoral immunity, and activating FcgammaRs are required for establishing chronic inflammatory programs that promote de novo carcinogenesis. ..
  17. Leveson Gower D, Sega E, Kalesnikoff J, Florek M, Pan Y, Pierini A, et al. Mast cells suppress murine GVHD in a mechanism independent of CD4+CD25+ regulatory T cells. Blood. 2013;122:3659-65 pubmed publisher
    ..role of mast cells in hematopoietic cell transplantation, we assessed graft-versus-host disease (GVHD) in C57BL/6-Kit(W-sh/W-sh) recipients, which virtually lack mast cells, compared with C57BL/6 WT recipients...
  18. Klein S, Seidler B, Kettenberger A, Sibaev A, Rohn M, Feil R, et al. Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity. Nat Commun. 2013;4:1630 pubmed publisher
    ..Here we generate a c-Kit(CreERT2) knock-in allele to target a distinct population of pacemaker cells called interstitial cells of Cajal...
  19. Boisset J, Clapes T, van der Linden R, Dzierzak E, Robin C. Integrin ?IIb (CD41) plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta. Biol Open. 2013;2:525-32 pubmed publisher
    ..By using ?IIb deficient embryos, we show that ?IIb is not only a reliable HSC marker but it also plays an important and specific function in maintaining the HSC activity in the mouse embryonic aorta. ..
  20. Tono T, Tsujimura T, Koshimizu U, Kasugai T, Adachi S, Isozaki K, et al. c-kit Gene was not transcribed in cultured mast cells of mast cell-deficient Wsh/Wsh mice that have a normal number of erythrocytes and a normal c-kit coding region. Blood. 1992;80:1448-53 pubmed
    The Wsh is a mutant allele at the W (c-kit) locus of mice. Mice of Wsh/Wsh genotype have white hairs and black eyes. Although adult C57BL/6-Wsh/Wsh mice were not anemic, they showed a remarkable depletion of mast cells...
  21. Huang E, Nocka K, Beier D, Chu T, Buck J, Lahm H, et al. The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell. 1990;63:225-33 pubmed
    ..mouse affect the same cellular targets as mutations at the white spotting locus (W), which is allelic with the c-kit proto-oncogene...
  22. Xu X, Zhang D, Zhang H, Wolters P, Killeen N, Sullivan B, et al. Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med. 2006;203:2907-17 pubmed
    ..These findings suggest that neutrophils, provoked by mycoplasma, greatly expand their capacity to synthesize histamine, thereby contributing to lung and airway inflammation...
  23. Wehrle Haller B, Morrison Graham K, Weston J. Ectopic c-kit expression affects the fate of melanocyte precursors in Patch mutant embryos. Dev Biol. 1996;177:463-74 pubmed
    ..In vivo, homozygous Ph embryos contain a subpopulation of crest-derived cells that express c-kit and tyrosinase-related protein-2 characteristic of MPs...
  24. Botchkareva N, Khlgatian M, Longley B, Botchkarev V, Gilchrest B. SCF/c-kit signaling is required for cyclic regeneration of the hair pigmentation unit. FASEB J. 2001;15:645-58 pubmed
    ..Stem cell factor (SCF) and its receptor c-kit are important for melanocyte survival during development, and mutations in these genes result in unpigmented hairs...
  25. Chabot B, Stephenson D, Chapman V, Besmer P, Bernstein A. The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature. 1988;335:88-9 pubmed
    ..Here we show that the mouse mutant W has a deletion of the c-kit proto-oncogene...
  26. Gromova P, Ralea S, Lefort A, Libert F, Rubin B, Erneux C, et al. Kit K641E oncogene up-regulates Sprouty homolog 4 and trophoblast glycoprotein in interstitial cells of Cajal in a murine model of gastrointestinal stromal tumours. J Cell Mol Med. 2009;13:1536-48 pubmed publisher
    ..Oncogenic mutations of the receptor tyrosine kinase KIT are present in most GIST...
  27. Wolters P, Mallen St Clair J, Lewis C, Villalta S, Baluk P, Erle D, et al. Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient Kit(W-sh)/Kit(W-sh) sash mice. Clin Exp Allergy. 2005;35:82-8 pubmed
    Mast cell-deficient Kit(W)/Kit(W-v) mice are an important resource for studying mast cell functions in vivo...
  28. Lu L, Lind E, Gondek D, Bennett K, Gleeson M, Pino Lagos K, et al. Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature. 2006;442:997-1002 pubmed
    ..Finally, immunohistochemical analysis clearly demonstrates the existence of this novel T(Reg)-IL-9-mast cell relationship within tolerant allografts. ..
  29. Allen J, Jaffer Z, Park S, Burgin S, Hofmann C, Sells M, et al. p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics. Blood. 2009;113:2695-705 pubmed publisher
    ..These data implicate Pak1 as an essential molecular target for modulating acute mast cell responses that contribute to allergic diseases. ..
  30. Sun J, Sukhova G, Yang M, Wolters P, MacFarlane L, Libby P, et al. Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice. J Clin Invest. 2007;117:3359-68 pubmed
  31. Galli S, Tsai M, Gordon J, Geissler E, Wershil B. Analyzing mast cell development and function using mice carrying mutations at W/c-kit or Sl/MGF (SCF) loci. Ann N Y Acad Sci. 1992;664:69-88 pubmed
    ..W/Wv mice have mutations affecting the c-kit tyrosine kinase receptor which is encoded at the W locus and which is necessary for normal mast cell development...
  32. Cable J, Barkway C, Steel K. Characteristics of stria vascularis melanocytes of viable dominant spotting (Wv/Wv) mouse mutants. Hear Res. 1992;64:6-20 pubmed
    ..Viable Dominant Spotting (Wv/Wv) mouse mutants have a white coat due to the absence of melanocytes...
  33. Supajatura V, Ushio H, Nakao A, Akira S, Okumura K, Ra C, et al. Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity. J Clin Invest. 2002;109:1351-9 pubmed
    ..Taken together, these results suggest that direct activation of mast cells via TLR2 or TLR4 by respective microligands contributes to innate and allergic immune responses. ..
  34. Mintz B, Russell E. Gene-induced embryological modifications of primordial germ cells in the mouse. J Exp Zool. 1957;134:207-37 pubmed
  35. Mackarehtschian K, Hardin J, Moore K, Boast S, Goff S, Lemischka I. Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity. 1995;3:147-61 pubmed
    ..Mice deficient for both c-kit and flk2 exhibited a more severe phenotype characterized by large overall decreases in hematopoietic cell numbers, ..
  36. Kitamura Y, Go S. Decreased production of mast cells in S1/S1d anemic mice. Blood. 1979;53:492-7 pubmed
  37. Weller K, Foitzik K, Paus R, Syska W, Maurer M. Mast cells are required for normal healing of skin wounds in mice. FASEB J. 2006;20:2366-8 pubmed
    ..explore whether MCs also contribute to wound repair, we studied experimentally induced skin wounds in MC-deficient Kit(W)/Kit(W-v) mice, normal Kit+/+ mice, and MC-reconstituted Kit(W)/Kit(W-v) mice...
  38. Yoshida H, Takakura N, Kataoka H, Kunisada T, Okamura H, Nishikawa S. Stepwise requirement of c-kit tyrosine kinase in mouse ovarian follicle development. Dev Biol. 1997;184:122-37 pubmed
    ..Receptor tyrosine kinase c-kit and its ligand SLF (Steel factor) are expressed on the surface of specific populations of follicle-forming cells in ..
  39. Sun J, Sukhova G, Wolters P, Yang M, Kitamoto S, Libby P, et al. Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat Med. 2007;13:719-24 pubmed
    ..Atheromata from compound mutant Ldlr(-/-) Kit(W-sh)(/W-sh) mice showed decreased lesion size, lipid deposition, T-cell and macrophage numbers, cell proliferation ..
  40. Berrozpe G, Timokhina I, Yukl S, Tajima Y, Ono M, Zelenetz A, et al. The W(sh), W(57), and Ph Kit expression mutations define tissue-specific control elements located between -23 and -154 kb upstream of Kit. Blood. 1999;94:2658-66 pubmed
    The Kit and PDGFRa receptor tyrosine kinases are encoded in close proximity at the murine white spotting (W) and patch (Ph) loci...
  41. Besmer P, Manova K, Duttlinger R, Huang E, Packer A, Gyssler C, et al. The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis. Dev Suppl. 1993;:125-37 pubmed
    The c-kit receptor tyrosine kinase belongs to the PDGF/CSF-1/c-kit receptor subfamily...
  42. Yoder M, Hiatt K, Dutt P, Mukherjee P, Bodine D, Orlic D. Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac. Immunity. 1997;7:335-44 pubmed
    ..Furthermore, 100 CD34+c-Kit+ day 9 yolk sac or para-aortic splanchnopleura (P-Sp) cells, known to give rise to embryonic HSC, similarly ..
  43. Maurer M, Wedemeyer J, Metz M, Piliponsky A, Weller K, Chatterjea D, et al. Mast cells promote homeostasis by limiting endothelin-1-induced toxicity. Nature. 2004;432:512-6 pubmed
    ..These findings identify a new biological function for mast cells: promotion of homeostasis by limiting the toxicity associated with an endogenous mediator. ..
  44. Biedermann T, Kneilling M, Mailhammer R, Maier K, Sander C, Kollias G, et al. Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2. J Exp Med. 2000;192:1441-52 pubmed
    ..abundant during DTHRs in and around mast cells of wild-type (WT) mice but absent in mast cell-deficient WBB6F(1)-Kit(W)/Kit(W-)(v) (Kit(W)/Kit(W)(-v)) mice...
  45. Huang E, Nocka K, Buck J, Besmer P. Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2. Mol Biol Cell. 1992;3:349-62 pubmed
    The c-kit ligand, KL, and its receptor, the proto-oncogene c-kit are encoded, respectively, at the steel (Sl) and white spotting (W) loci of the mouse...
  46. Broudy V. Stem cell factor and hematopoiesis. Blood. 1997;90:1345-64 pubmed
  47. Ottolenghi C, Pelosi E, Tran J, Colombino M, Douglass E, Nedorezov T, et al. Loss of Wnt4 and Foxl2 leads to female-to-male sex reversal extending to germ cells. Hum Mol Genet. 2007;16:2795-804 pubmed
    ..testis tubule differentiation in XY transgenic mice, and germ cell-depleted XX mice lacking Foxl2 and harboring a Kit mutation undergo partial female-to-male sex reversal...
  48. Thoren L, Liuba K, Bryder D, Nygren J, Jensen C, Qian H, et al. Kit regulates maintenance of quiescent hematopoietic stem cells. J Immunol. 2008;180:2045-53 pubmed
    ..Extensive studies have supported a role of the cytokine tyrosine kinase receptor Kit in sustaining cycling HSCs when competing with wild-type HSCs posttransplantation, but not in maintenance of ..
  49. Bernex F, De Sepulveda P, Kress C, Elbaz C, Delouis C, Panthier J. Spatial and temporal patterns of c-kit-expressing cells in WlacZ/+ and WlacZ/WlacZ mouse embryos. Development. 1996;122:3023-33 pubmed
    In the mouse, the Kit receptor and its ligand, the stem cell factor (SCF), are encoded at the W/Kit and Steel loci, respectively...
  50. Waskow C, Bartels S, Schlenner S, Costa C, Rodewald H. Kit is essential for PMA-inflammation-induced mast-cell accumulation in the skin. Blood. 2007;109:5363-70 pubmed
    ..Mast-cell development depends on the receptor tyrosine kinase Kit as shown by a greater than 95% reduction of mast-cell numbers in hypomorphic (Kit(W/Wv)) mutant mice that are ..
  51. Wilson Y, Richards K, Ford Perriss M, Panthier J, Murphy M. Neural crest cell lineage segregation in the mouse neural tube. Development. 2004;131:6153-62 pubmed
    ..We find that a subpopulation of cells on the most dorsomedial aspect of the NT express the receptor tyrosine kinase Kit (previously known as c-kit), emigrate exclusively into the developing dermis, and then express definitive markers ..
  52. Orr Urtreger A, Avivi A, Zimmer Y, Givol D, Yarden Y, Lonai P. Developmental expression of c-kit, a proto-oncogene encoded by the W locus. Development. 1990;109:911-23 pubmed
    Developmental expression of the c-kit proto-oncogene, a receptor tyrosine kinase encoded by the W locus, was investigated by in situ hybridization in normal mouse embryos...
  53. Besmer P, Murphy J, George P, Qiu F, Bergold P, Lederman L, et al. A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family. Nature. 1986;320:415-21 pubmed
    ..The viral genome of HZ4-FeSV contains a new oncogene designated v-kit, has the structure 5' delta gag-kit-delta pol-delta env 3' and specifies a gag-kit polyprotein of relative ..
  54. Koubova J, Menke D, Zhou Q, Capel B, Griswold M, Page D. Retinoic acid regulates sex-specific timing of meiotic initiation in mice. Proc Natl Acad Sci U S A. 2006;103:2474-9 pubmed
    ..Because RA signaling regulates Stra8 expression in both embryonic ovaries and adult testes, this portion of the meiotic initiation pathway may be identical in both sexes. ..
  55. Krishnamurthy M, Ayazi F, Li J, Lyttle A, Woods M, Wu Y, et al. c-Kit in early onset of diabetes: a morphological and functional analysis of pancreatic beta-cells in c-KitW-v mutant mice. Endocrinology. 2007;148:5520-30 pubmed
    c-Kit tyrosine receptor kinase, a well-established stem cell marker, is expressed in a variety of tissues including the pancreas...
  56. Rodewald H, Haller C. Antigen-receptor junctional diversity in growth-factor-receptor mutant mice. Dev Comp Immunol. 1998;22:351-65 pubmed
    ..Development of thymocytes, but not B cells, is entirely blocked in mice lacking both the receptor-tyrosine-kinase c-kit and the common cytokine receptor gamma chain (gamma c)...
  57. Dastych J, Taub D, Hardison M, Metcalfe D. Tyrosine kinase-deficient Wv c-kit induces mast cell adhesion and chemotaxis. Am J Physiol. 1998;275:C1291-9 pubmed
    ..are deficient in tissue mast cells, and mast cells cultured from these mice do not proliferate in response to the c-kit ligand, stem cell factor (SCF)...
  58. Kissel H, Timokhina I, Hardy M, Rothschild G, Tajima Y, Soares V, et al. Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses. EMBO J. 2000;19:1312-26 pubmed
    The Kit receptor tyrosine kinase functions in hemato- poiesis, melanogenesis and gametogenesis. Kit receptor-mediated cellular responses include proliferation, survival, adhesion, secretion and differentiation...
  59. Takakura N, Watanabe T, Suenobu S, Yamada Y, Noda T, Ito Y, et al. A role for hematopoietic stem cells in promoting angiogenesis. Cell. 2000;102:199-209 pubmed
    ..HSCs, which express Ang1, directly promoted migration of ECs in vivo and in vitro. These results indicate that HSCs are critical for angiogenesis. ..
  60. Mallen St Clair J, Pham C, Villalta S, Caughey G, Wolters P. Mast cell dipeptidyl peptidase I mediates survival from sepsis. J Clin Invest. 2004;113:628-34 pubmed
    ..These results indicate that mast cell DPPI harms the septic host and that DPPI is a novel potential therapeutic target for treatment of sepsis. ..
  61. Ohta H, Yomogida K, Dohmae K, Nishimune Y. Regulation of proliferation and differentiation in spermatogonial stem cells: the role of c-kit and its ligand SCF. Development. 2000;127:2125-31 pubmed
    ..mice with male sterility, such as those dysfunctioned at Steel (Sl) locus encoding the c-kit ligand or Dominant white spotting (W) locus encoding the receptor c-kit...
  62. Suzuki H, Sada A, Yoshida S, Saga Y. The heterogeneity of spermatogonia is revealed by their topology and expression of marker proteins including the germ cell-specific proteins Nanos2 and Nanos3. Dev Biol. 2009;336:222-31 pubmed publisher
    ..We propose that the first of these groups is most likely to include the stem cell population and that Nanos3 may function in transit amplifying cells. ..
  63. Motro B, Bernstein A. Dynamic changes in ovarian c-kit and Steel expression during the estrous reproductive cycle. Dev Dyn. 1993;197:69-79 pubmed
    ..with the cell autonomous and microenvironmental nature of W and Sl mutations, respectively, W encodes the c-kit receptor tyrosine kinase while Steel encodes the Kit ligand...
  64. Nigrovic P, Gray D, Jones T, Hallgren J, Kuo F, Chaletzky B, et al. Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy. Am J Pathol. 2008;173:1693-701 pubmed publisher
    ..cells was established in mice that lacked mast cells through defects in either stem cell factor or its receptor, Kit. Among available strains, C57BL/6-Kit(W-sh) (W(sh)) mice are experimentally advantageous because of their ..
  65. Hayashi S, Kunisada T, Ogawa M, Yamaguchi K, Nishikawa S. Exon skipping by mutation of an authentic splice site of c-kit gene in W/W mouse. Nucleic Acids Res. 1991;19:1267-71 pubmed
    The murine mutation dominant white spotting (W) is in the proto-oncogene, c-kit. The receptor tyrosine kinase encoded by this gene has pleiotropic effects on murine development including hemopoietic cells, pigment cells, and germ cells...
  66. Lyon M, Glenister P. A new allele sash (Wsh) at the W-locus and a spontaneous recessive lethal in mice. Genet Res. 1982;39:315-22 pubmed
  67. Paulson R, Vesely S, Siminovitch K, Bernstein A. Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1. Nat Genet. 1996;13:309-15 pubmed
    ..have used this approach in mammals to analyse the interactions between the Kit RTK encoded by the murine Dominant white spotting (W) locus and the Shp1 protein tyrosine phosphatase, the product of the murine motheaten (me) gene...
  68. Kluppel M, Nagle D, Bucan M, Bernstein A. Long-range genomic rearrangements upstream of Kit dysregulate the developmental pattern of Kit expression in W57 and Wbanded mice and interfere with distinct steps in melanocyte development. Development. 1997;124:65-77 pubmed
    Mutations in the murine dominant white spotting (W) locus cause pleiotropic developmental defects that affect hematopoietic cells, melanocytes, germ cells and the interstitial cells of Cajal in the gut...
  69. Makabe Kobayashi Y, Hori Y, Adachi T, Ishigaki Suzuki S, Kikuchi Y, Kagaya Y, et al. The control effect of histamine on body temperature and respiratory function in IgE-dependent systemic anaphylaxis. J Allergy Clin Immunol. 2002;110:298-303 pubmed
  70. Zhou J, Xing W, Friend D, Austen K, Katz H. Mast cell deficiency in Kit(W-sh) mice does not impair antibody-mediated arthritis. J Exp Med. 2007;204:2797-802 pubmed
    ..sought a mast cell requirement with mast cell-deficient mouse strains, but unexpectedly obtained full arthritis in Kit(W-sh) mice and full resistance in Kit(W/KitW-v) mice...
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