Kiss1r

Summary

Gene Symbol: Kiss1r
Description: KISS1 receptor
Alias: Gpr54, KiSS-1, kiSS-1R, kiSS-1 receptor, G-protein coupled receptor 54, G-protein coupled receptor OT7T175, kisspeptins receptor, metastin receptor, orphan G protein-coupled receptor 54
Species: mouse
Products:     Kiss1r

Top Publications

  1. Funes S, Hedrick J, Vassileva G, Markowitz L, Abbondanzo S, Golovko A, et al. The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system. Biochem Biophys Res Commun. 2003;312:1357-63 pubmed
    b>GPR54 is a G-protein-coupled receptor that displays a high percentage of identity in the transmembrane domains with the galanin receptors. The ligand for GPR54 has been identified as a peptide derived from the KiSS-1 gene...
  2. Kirilov M, Clarkson J, Liu X, Roa J, Campos P, Porteous R, et al. Dependence of fertility on kisspeptin-Gpr54 signaling at the GnRH neuron. Nat Commun. 2013;4:2492 pubmed publisher
    Signaling between kisspeptin and its receptor, G-protein-coupled receptor 54 (Gpr54), is now recognized as being essential for normal fertility. However, the key cellular location of kisspeptin-Gpr54 signaling is unknown...
  3. Seminara S, Messager S, Chatzidaki E, Thresher R, Acierno J, Shagoury J, et al. The GPR54 gene as a regulator of puberty. N Engl J Med. 2003;349:1614-27 pubmed
    ..pubertal development (idiopathic hypogonadotropic hypogonadism) was examined for mutations in a candidate gene, GPR54, which encodes a G protein-coupled receptor...
  4. Messager S, Chatzidaki E, Ma D, Hendrick A, Zahn D, Dixon J, et al. Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proc Natl Acad Sci U S A. 2005;102:1761-6 pubmed
    ..gatekeeper of the hypothalamic-pituitary-gonadal axis with the observation that G protein-coupled receptor 54 (GPR54) is required in mice and men for the pubertal onset of pulsatile luteinizing hormone (LH) and follicle-stimulating ..
  5. Calder M, Chan Y, Raj R, Pampillo M, Elbert A, Noonan M, et al. Implantation failure in female Kiss1-/- mice is independent of their hypogonadic state and can be partially rescued by leukemia inhibitory factor. Endocrinology. 2014;155:3065-78 pubmed publisher
    ..This study provides compelling reasons to explore this role in other species, particularly livestock and humans. ..
  6. Lapatto R, Pallais J, Zhang D, Chan Y, Mahan A, Cerrato F, et al. Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- mice. Endocrinology. 2007;148:4927-36 pubmed
    The G protein-coupled receptor Gpr54 and its ligand metastin (derived from the Kiss1 gene product kisspeptin) are key gatekeepers of sexual maturation...
  7. Gaytan F, García Galiano D, Dorfman M, Manfredi Lozano M, Castellano J, Dissen G, et al. Kisspeptin receptor haplo-insufficiency causes premature ovarian failure despite preserved gonadotropin secretion. Endocrinology. 2014;155:3088-97 pubmed publisher
    ..Whereas kisspeptins, the products of Kiss1 that act via Kiss1r (aka, Gpr54), are known to operate at the hypothalamus to control GnRH/gonadotropin secretion, additional actions ..
  8. Clarkson J, d Anglemont de Tassigny X, Moreno A, Colledge W, Herbison A. Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge. J Neurosci. 2008;28:8691-7 pubmed publisher
    Kisspeptin and its receptor GPR54 have recently been identified as key signaling partners in the neural control of fertility in animal models and humans...
  9. Clements M, McDonald T, Wang R, Xie G, O Dowd B, George S, et al. FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54. Biochem Biophys Res Commun. 2001;284:1189-93 pubmed
    ..and determined the coding sequences of human and mouse orthologs of the rat orphan G-protein-coupled receptor GPR54. Mouse and rat GPR54 are nearly 95% identical to each other, and both are approximately 85% identical to human ..

More Information

Publications70

  1. Herbison A, de Tassigny X, Doran J, Colledge W. Distribution and postnatal development of Gpr54 gene expression in mouse brain and gonadotropin-releasing hormone neurons. Endocrinology. 2010;151:312-21 pubmed publisher
    Kisspeptin and G protein-coupled receptor 54 (GPR54) are now acknowledged to play essential roles in the neural regulation of fertility...
  2. Liu X, Lee K, Herbison A. Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels. Endocrinology. 2008;149:4605-14 pubmed publisher
    ..These studies indicate that kisspeptin activates G protein-coupled receptor 54 (GPR54) to initiate a PLC-IP3R-calcium cascade that modulates both potassium and NSC channels to initiate depolarization ..
  3. Prentice L, d Anglemont de Tassigny X, McKinney S, Ruiz de Algara T, Yap D, Turashvili G, et al. The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent. BMC Genomics. 2011;12:209 pubmed publisher
    Humans and mice with loss of function mutations in GPR54 (KISS1R) or kisspeptin do not progress through puberty, caused by a failure to release GnRH...
  4. De Bond J, Tolson K, Nasamran C, Kauffman A, Smith J. Unaltered Hypothalamic Metabolic Gene Expression in Kiss1r Knockout Mice Despite Obesity and Reduced Energy Expenditure. J Neuroendocrinol. 2016;28: pubmed publisher
    Kisspeptin controls reproduction by stimulating gonadotrophin-releasing hormone neurones via its receptor Kiss1r. Kiss1r is also expressed other brain areas and in peripheral tissues, suggesting additional nonreproductive roles...
  5. Teplyuk N, Galindo M, Teplyuk V, Pratap J, Young D, Lapointe D, et al. Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors. J Biol Chem. 2008;283:27585-97 pubmed publisher
    ..g. Rgs2, Rgs4, Rgs5, Rgs16, Gpr23, Gpr30, Gpr54, Gpr64, and Gna13)...
  6. Dungan H, Gottsch M, Zeng H, Gragerov A, Bergmann J, Vassilatis D, et al. The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone. J Neurosci. 2007;27:12088-95 pubmed
    The Kiss1 gene codes for kisspeptin, which binds to GPR54, a G-protein-coupled receptor...
  7. Hatef A, Unniappan S. Gonadotropin-releasing hormone, kisspeptin, and gonadal steroids directly modulate nucleobindin-2/nesfatin-1 in murine hypothalamic gonadotropin-releasing hormone neurons and gonadotropes. Biol Reprod. 2017;96:635-651 pubmed publisher
    ..Synthetic nesfatin-1 increased Kiss1r and Gnrh expression in GT1-7 cells and Lh? in L?T2...
  8. Clarkson J, Shamas S, Mallinson S, Herbison A. Gonadal steroid induction of kisspeptin peptide expression in the rostral periventricular area of the third ventricle during postnatal development in the male mouse. J Neuroendocrinol. 2012;24:907-15 pubmed publisher
    Kisspeptin and its G-protein coupled receptor Gpr54 are essential for the pubertal activation of gonadotrophin-releasing hormone (GnRH) neurones, with Gpr54 mutation or deletion resulting in failed puberty and infertility in humans and ..
  9. Kauffman A. Coming of age in the kisspeptin era: sex differences, development, and puberty. Mol Cell Endocrinol. 2010;324:51-63 pubmed publisher
  10. Fayazi M, Calder M, Bhattacharya M, Vilos G, Power S, Babwah A. The pregnant mouse uterus exhibits a functional kisspeptin/KISS1R signaling system on the day of embryo implantation. Reprod Biol Endocrinol. 2015;13:105 pubmed publisher
    Expression of kisspeptin (protein) and Kiss1r (mRNA) was recently documented in the mouse uterus on D4 of pregnancy (the day of embryo implantation) suggesting that the uterine-based kisspeptin (KP)/kisspeptin receptor (KISS1R) signaling ..
  11. Koemeter Cox A, Sherwood T, Green J, Steiner R, Berbari N, Yoder B, et al. Primary cilia enhance kisspeptin receptor signaling on gonadotropin-releasing hormone neurons. Proc Natl Acad Sci U S A. 2014;111:10335-40 pubmed publisher
    ..Here, we show that the kisspeptin receptor (Kiss1r), a GPCR that is activated by kisspeptin to regulate the onset of puberty and adult reproductive function, is ..
  12. Novaira H, Sonko M, Hoffman G, Koo Y, Ko C, Wolfe A, et al. Disrupted kisspeptin signaling in GnRH neurons leads to hypogonadotrophic hypogonadism. Mol Endocrinol. 2014;28:225-38 pubmed publisher
    Landmark studies have shown that mutations in kisspeptin and the kisspeptin receptor (Kiss1r) result in reproductive dysfunction in humans and genetically altered mouse models...
  13. Liu X, Herbison A. Kisspeptin regulation of arcuate neuron excitability in kisspeptin receptor knockout mice. Endocrinology. 2015;156:1815-27 pubmed publisher
    The G protein-coupled receptor 54 (GPR54) is critical for kisspeptin to activate GnRH neurons to modulate fertility...
  14. Maguire J, Kirby H, Mead E, Kuc R, d Anglemont de Tassigny X, Colledge W, et al. Inotropic action of the puberty hormone kisspeptin in rat, mouse and human: cardiovascular distribution and characteristics of the kisspeptin receptor. PLoS ONE. 2011;6:e27601 pubmed publisher
    ..human, rat and mouse paced atria, with a role for the receptor confirmed using mice with targeted disruption of Kiss1r. The data demonstrated that kisspeptin receptor-like immunoreactivity localised to endothelial and smooth muscle ..
  15. García Galiano D, van Ingen Schenau D, Leon S, Krajnc Franken M, Manfredi Lozano M, Romero Ruiz A, et al. Kisspeptin signaling is indispensable for neurokinin B, but not glutamate, stimulation of gonadotropin secretion in mice. Endocrinology. 2012;153:316-28 pubmed publisher
    Kisspeptins (Kp), products of the Kiss1 gene that act via Gpr54 to potently stimulate GnRH secretion, operate as mediators of other regulatory signals of the gonadotropic axis...
  16. Dotterweich J, Tower R, Brandl A, Muller M, Hofbauer L, Beilhack A, et al. The KISS1 Receptor as an In Vivo Microenvironment Imaging Biomarker of Multiple Myeloma Bone Disease. PLoS ONE. 2016;11:e0155087 pubmed publisher
    ..From these studies, the KISS1 receptor (KISS1R), a G-protein-coupled receptor known to play a role in the regulation of endocrine functions, was identified as a ..
  17. Min L, Leon S, Li H, Pinilla L, Carroll R, Tena Sempere M, et al. RF9 Acts as a KISS1R Agonist In Vivo and In Vitro. Endocrinology. 2015;156:4639-48 pubmed publisher
    ..have suggested that the stimulatory effect of RF9 on gonadotropin secretion relies on intact kisspeptin receptor (KISS1R) signaling, but the underlying mechanisms remain to be elucidated...
  18. Chen J, Fu R, Cui Y, Pan J, Li Y, Zhang X, et al. LIM-homeodomain transcription factor Isl-1 mediates kisspeptin's effect on insulin secretion in mice. Mol Endocrinol. 2014;28:1276-90 pubmed publisher
    Kisspeptin and the G protein-coupled receptor 54 (GPR54) are highly abundant in the pancreas. In addition, circulating kisspeptin directly influences insulin secretion through GPR54...
  19. Tolson K, Garcia C, Delgado I, Marooki N, Kauffman A. Metabolism and Energy Expenditure, But Not Feeding or Glucose Tolerance, Are Impaired in Young Kiss1r KO Female Mice. Endocrinology. 2016;157:4192-4199 pubmed
    Kisspeptin regulates reproduction via signaling through the receptor, Kiss1r, in GnRH neurons...
  20. Poling M, Kauffman A. Sexually dimorphic testosterone secretion in prenatal and neonatal mice is independent of kisspeptin-Kiss1r and GnRH signaling. Endocrinology. 2012;153:782-93 pubmed publisher
    ..We determined whether kisspeptin-Kiss1r and GnRH signaling plays a role in sexually dimorphic perinatal T secretion in mice...
  21. Yeo S, Clarkson J, Herbison A. Kisspeptin-gpr54 signaling at the GnRH neuron is necessary for negative feedback regulation of luteinizing hormone secretion in female mice. Neuroendocrinology. 2014;100:191-7 pubmed publisher
    Kisspeptin-Gpr54 signaling is critical for regulating the activity of gonadotropin-releasing hormone (GnRH) neurons in mammals. Previous studies have shown that the negative feedback mechanism is disrupted in global Gpr54-null mutants...
  22. Ahow M, Min L, Pampillo M, Nash C, Wen J, Soltis K, et al. KISS1R signals independently of Gαq/11 and triggers LH secretion via the β-arrestin pathway in the male mouse. Endocrinology. 2014;155:4433-46 pubmed publisher
    ..Among these is kisspeptin (Kp), a potent trigger of GnRH secretion. Kp signals via the Kp receptor (KISS1R), a Gαq/11-coupled 7-transmembrane-spanning receptor...
  23. Han S, Gottsch M, Lee K, Popa S, Smith J, Jakawich S, et al. Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty. J Neurosci. 2005;25:11349-56 pubmed
    We examined the role of kisspeptin and its receptor, the G-protein-coupled receptor GPR54, in governing the onset of puberty in the mouse...
  24. d Anglemont de Tassigny X, Ackroyd K, Chatzidaki E, Colledge W. Kisspeptin signaling is required for peripheral but not central stimulation of gonadotropin-releasing hormone neurons by NMDA. J Neurosci. 2010;30:8581-90 pubmed publisher
    ..to stimulate GnRH/luteinizing hormone (LH) release after peripheral or central administration in Kiss1- or Gpr54 (Kiss1r)-null mutant mice...
  25. Jacobi J, Martin C, Nava G, Jeziorski M, Clapp C, Martinez de la Escalera G. 17-Beta-estradiol directly regulates the expression of adrenergic receptors and kisspeptin/GPR54 system in GT1-7 GnRH neurons. Neuroendocrinology. 2007;86:260-9 pubmed
    ..and showed for the first time that mRNAs for alpha(2)B-, beta(2)- and beta(3)-AR, for kisspeptin and its receptor GPR54 and for the novel estrogenic receptor GPR30 are expressed in GT1-7 cells...
  26. Kauffman A, Park J, McPhie Lalmansingh A, Gottsch M, Bodo C, Hohmann J, et al. The kisspeptin receptor GPR54 is required for sexual differentiation of the brain and behavior. J Neurosci. 2007;27:8826-35 pubmed
    b>GPR54 is a G-protein-coupled receptor, which binds kisspeptins and is widely expressed throughout the brain...
  27. Song W, Mondal P, Wolfe A, Alonso L, Stamateris R, Ong B, et al. Glucagon regulates hepatic kisspeptin to impair insulin secretion. Cell Metab. 2014;19:667-81 pubmed publisher
    ..These observations indicate a hormonal circuit between the liver and the endocrine pancreas in glycemia regulation and suggest in T2DM a sequential link between hyperglucagonemia via hepatic kisspeptin1 to impaired insulin secretion. ..
  28. Gaytan F, Sangiao Alvarellos S, Manfredi Lozano M, García Galiano D, Ruiz Pino F, Romero Ruiz A, et al. Distinct expression patterns predict differential roles of the miRNA-binding proteins, Lin28 and Lin28b, in the mouse testis: studies during postnatal development and in a model of hypogonadotropic hypogonadism. Endocrinology. 2013;154:1321-36 pubmed publisher
    ..and in a model of hypogonadotropic hypogonadism as a result of inactivation of the kisspeptin receptor, Gpr54. Lin28 and Lin28b mRNAs were expressed in mouse testis across postnatal maturation, but their levels disparately ..
  29. Dror T, Franks J, Kauffman A. Analysis of multiple positive feedback paradigms demonstrates a complete absence of LH surges and GnRH activation in mice lacking kisspeptin signaling. Biol Reprod. 2013;88:146 pubmed publisher
    Kisspeptin stimulates gonadotropin-releasing hormone (GnRH) neurons via the kisspeptin receptor, Kiss1r. In rodents, estrogen-responsive kisspeptin neurons in the rostral hypothalamus have been postulated to mediate estrogen-induced ..
  30. Quaynor S, Hu L, Leung P, Feng H, Mores N, Krsmanovic L, et al. Expression of a functional g protein-coupled receptor 54-kisspeptin autoregulatory system in hypothalamic gonadotropin-releasing hormone neurons. Mol Endocrinol. 2007;21:3062-70 pubmed
    The G protein-coupled receptor 54 (GPR54) and its endogenous ligand, kisspeptin, are essential for activation and regulation of the hypothalamic-pituitary-gonadal axis...
  31. Zhang P, Tang M, Zhong T, Lin Y, Zong T, Zhong C, et al. Expression and function of kisspeptin during mouse decidualization. PLoS ONE. 2014;9:e97647 pubmed publisher
    ..Quantitative PCR results demonstrated that Kiss1 and GPR54 mRNA levels showed dynamic increase in the mouse uterus during early pregnancy and artificially induced ..
  32. Dorfman M, Garcia Rudaz C, Alderman Z, Kerr B, Lomniczi A, Dissen G, et al. Loss of Ntrk2/Kiss1r signaling in oocytes causes premature ovarian failure. Endocrinology. 2014;155:3098-111 pubmed publisher
    ..A cell line expressing both NTRK2.T1 and the kisspeptin receptor (KISS1R) responds to BDNF stimulation with activation of Ntrk2 expression only if kisspeptin is present...
  33. Iremonger K, Porteous R, Herbison A. Spike and Neuropeptide-Dependent Mechanisms Control GnRH Neuron Nerve Terminal Ca2+ over Diverse Time Scales. J Neurosci. 2017;37:3342-3351 pubmed publisher
    ..These findings reveal new mechanisms by which neuroendocrine nerve terminal Ca2+ can be controlled in the brain. ..
  34. Zhao S, Kriegsfeld L. Daily changes in GT1-7 cell sensitivity to GnRH secretagogues that trigger ovulation. Neuroendocrinology. 2009;89:448-57 pubmed publisher
    ..These findings are consistent with the notion that GnRH cells are capable of intrinsic circadian cycles that may be fundamental for coordinating daily changes in sensitivity to signals impacting the reproductive axis. ..
  35. Clarkson J, Han S, Liu X, Lee K, Herbison A. Neurobiological mechanisms underlying kisspeptin activation of gonadotropin-releasing hormone (GnRH) neurons at puberty. Mol Cell Endocrinol. 2010;324:45-50 pubmed publisher
    Studies undertaken in many species indicate that kisspeptin-Gpr54 signaling is essential for the activation of gonadotropin-releasing hormone (GnRH) neurons to bring about puberty...
  36. DeFino M, Wacker J, Lyssand J, Wang E, Hague C. Differential regulation of GPR54 transcription by specificity protein-1 and partial estrogen response element in mouse pituitary cells. Biochem Biophys Res Commun. 2010;393:603-8 pubmed publisher
    Precise spatial and temporal expression of the recently identified G-protein coupled receptor GPR54 is critical for proper reproductive function and metastasis suppression...
  37. Herreboudt A, Kyle V, Lawrence J, Doran J, Colledge W. Kiss1 mutant placentas show normal structure and function in the mouse. Placenta. 2015;36:52-8 pubmed publisher
    ..In addition, kisspeptin signaling via the G-protein coupled receptor GPR54 (KISS1R) has been suggested to regulate human placental formation and correlations have been found between altered ..
  38. Witham E, Meadows J, Shojaei S, Kauffman A, Mellon P. Prenatal exposure to low levels of androgen accelerates female puberty onset and reproductive senescence in mice. Endocrinology. 2012;153:4522-32 pubmed publisher
    ..The absence of kisspeptin receptor in Kiss1r-null mice did not change the acceleration of puberty by the PNA and PPA paradigms, indicating that kisspeptin ..
  39. Merhi Z, Thornton K, Bonney E, Cipolla M, Charron M, Buyuk E. Ovarian kisspeptin expression is related to age and to monocyte chemoattractant protein-1. J Assist Reprod Genet. 2016;33:535-43 pubmed publisher
    The objective of this study was to test the hypothesis that ovarian kisspeptin (kiss1) and its receptor (kiss1r) expression are affected by age, obesity, and the age- and obesity-related chemokine monocyte chemoattractant protein-1 (MCP-1)..
  40. Tuomi J, Chidiac P, Jones D. Evidence for enhanced M3 muscarinic receptor function and sensitivity to atrial arrhythmia in the RGS2-deficient mouse. Am J Physiol Heart Circ Physiol. 2010;298:H554-61 pubmed publisher
    ..01). These results suggest that RGS2 is an important cholinergic regulator in the atrium and that RGS2(-/-) mice have enhanced susceptibility to AT/F via enhanced M3 muscarinic receptor activity. ..
  41. Liu X, Porteous R, d Anglemont de Tassigny X, Colledge W, Millar R, Petersen S, et al. Frequency-dependent recruitment of fast amino acid and slow neuropeptide neurotransmitter release controls gonadotropin-releasing hormone neuron excitability. J Neurosci. 2011;31:2421-30 pubmed publisher
    ..The latter response was essentially absent in Gpr54 knock-out mice and abolished by a Gpr54 antagonist...
  42. Navarro V, Bosch M, León S, Simavli S, True C, Pinilla L, et al. The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Endocrinology. 2015;156:627-37 pubmed publisher
    ..induced gonadotropin release in adult male and ovariectomized, estradiol-replaced female mice, which was absent in Kiss1r(-/-) mice, indicating a kisspeptin-dependent action...
  43. Tonsfeldt K, Goodall C, Latham K, Chappell P. Oestrogen induces rhythmic expression of the Kisspeptin-1 receptor GPR54 in hypothalamic gonadotrophin-releasing hormone-secreting GT1-7 cells. J Neuroendocrinol. 2011;23:823-30 pubmed publisher
    ..is through the up-regulation of receptors of known stimulators of GnRH, such as kisspeptin's cognate receptor, GPR54. Through analysis of mRNA and protein abundance patterns, we found that high levels of E(2) elicit circadian ..
  44. d Anglemont de Tassigny X, Fagg L, Carlton M, Colledge W. Kisspeptin can stimulate gonadotropin-releasing hormone (GnRH) release by a direct action at GnRH nerve terminals. Endocrinology. 2008;149:3926-32 pubmed publisher
    The G protein-coupled receptor GPR54, and its peptide ligand kisspeptin (Kp), are crucial for the induction and maintenance of mammalian reproductive function...
  45. Chan Y, Broder Fingert S, Wong K, Seminara S. Kisspeptin/Gpr54-independent gonadotrophin-releasing hormone activity in Kiss1 and Gpr54 mutant mice. J Neuroendocrinol. 2009;21:1015-23 pubmed publisher
    The kisspeptin/Gpr54 signalling pathway plays a critical role in reproduction by stimulating the secretion of gonadotrophin-releasing hormone (GnRH), yet mice carrying mutations in Kiss1 (which encodes kisspeptin) or Gpr54 exhibit ..
  46. Steyn F, Wan Y, Clarkson J, Veldhuis J, Herbison A, Chen C. Development of a methodology for and assessment of pulsatile luteinizing hormone secretion in juvenile and adult male mice. Endocrinology. 2013;154:4939-45 pubmed publisher
    ..Moreover, assessment of LH release in Gpr54 knockout mice demonstrates the lack of pulsatile LH release after the loss of kisspeptin-mediated pubertal ..
  47. Bellefontaine N, Chachlaki K, Parkash J, Vanacker C, Colledge W, d Anglemont de Tassigny X, et al. Leptin-dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction. J Clin Invest. 2014;124:2550-9 pubmed publisher
    ..Together, these data indicate that leptin plays a central role in regulating the hypothalamo-pituitary-gonadal axis in vivo through the activation of nNOS in neurons of the preoptic region. ..
  48. Liu X, Herbison A. RF9 excitation of GnRH neurons is dependent upon Kiss1r in the adult male and female mouse. Endocrinology. 2014;155:4915-24 pubmed publisher
    ..RF9 was found to have no effects at all on GnRH neurons in GnRH-GFP;Kiss1r-null mice, although these cells exhibited normal intrinsic electrical properties and remained responsive to GABA ..
  49. Mei H, Walters C, Carter R, Colledge W. Gpr54-/- mice show more pronounced defects in spermatogenesis than Kiss1-/- mice and improved spermatogenesis with age when exposed to dietary phytoestrogens. Reproduction. 2011;141:357-66 pubmed publisher
    Mice with mutations in the kisspeptin signaling pathway (Kiss1(-/-) or Gpr54(-/-)) have low gonadotrophic hormone levels, small testes, and impaired spermatogenesis...
  50. Kumar D, Freese M, Drexler D, Hermans Borgmeyer I, Marquardt A, Boehm U. Murine arcuate nucleus kisspeptin neurons communicate with GnRH neurons in utero. J Neurosci. 2014;34:3756-66 pubmed publisher
    ..Finally, we find that most GnRH neurons express the kisspeptin receptor GPR54 upon circuit formation, suggesting that the signaling system implicated in gatekeeping puberty becomes operative ..
  51. Yi T, Tan K, Cho S, Wang Y, Luo J, Zhang W, et al. Regulation of embryonic kidney branching morphogenesis and glomerular development by KISS1 receptor (Gpr54) through NFAT2- and Sp1-mediated Bmp7 expression. J Biol Chem. 2010;285:17811-20 pubmed publisher
    G-protein-coupled receptor 54 (Gpr54, KISS1 receptor) plays critical roles in puberty regulation, tumor metastasis suppression, and vasoconstriction. Bone morphogenetic protein-7 (Bmp7) is required for kidney organogenesis...
  52. Luque R, Kineman R, Tena Sempere M. Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line. Endocrinology. 2007;148:4601-11 pubmed
    ..Recently, the hypothalamic KiSS-1/GPR54 system has emerged as a fundamental regulator of the gonadotropic axis, which conveys the modulatory actions of ..
  53. Sato K, Shirai R, Hontani M, Shinooka R, Hasegawa A, Kichise T, et al. Potent Vasoconstrictor Kisspeptin-10 Induces Atherosclerotic Plaque Progression and Instability: Reversal by its Receptor GPR54 Antagonist. J Am Heart Assoc. 2017;6: pubmed publisher
    Kisspeptin-10 (KP-10), a potent vasoconstrictor and inhibitor of angiogenesis, and its receptor, GPR54, have currently received much attention in relation to pre-eclampsia...
  54. Stafford L, Xia C, Ma W, Cai Y, Liu M. Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor. Cancer Res. 2002;62:5399-404 pubmed
    ..Furthermore, activation of the KiSS1 receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. ..
  55. Tolson K, Garcia C, Yen S, Simonds S, Stefanidis A, Lawrence A, et al. Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity. J Clin Invest. 2014;124:3075-9 pubmed publisher
    ..regulates reproduction by stimulating gonadotropin-releasing hormone (GnRH) neurons via the kisspeptin receptor KISS1R. In addition to GnRH neurons, KISS1R is expressed in other brain areas and peripheral tissues, which suggests that ..
  56. Mayer C, Boehm U. Female reproductive maturation in the absence of kisspeptin/GPR54 signaling. Nat Neurosci. 2011;14:704-10 pubmed publisher
    ..Consistent with this, female mice lacking neurons that express the kisspeptin receptor GPR54 were also fertile...
  57. Szereszewski J, Pampillo M, Ahow M, Offermanns S, Bhattacharya M, Babwah A. GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a G?(q/11) and ?-arrestin-dependent manner. PLoS ONE. 2010;5:e12964 pubmed publisher
    G protein-coupled receptor 54 (GPR54) is a G(q/11)-coupled 7 transmembrane-spanning receptor (7TMR). Activation of GPR54 by kisspeptin (Kp) stimulates PIP(2) hydrolysis, Ca(2+) mobilization and ERK1/2 MAPK phosphorylation...
  58. Babwah A, Navarro V, Ahow M, Pampillo M, Nash C, Fayazi M, et al. GnRH Neuron-Specific Ablation of Gαq/11 Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Gαq/11-Independent GnRH Secretion. J Neurosci. 2015;35:12903-16 pubmed publisher
    ..KP signals via KISS1R, a Gαq/11-coupled receptor, and mice bearing a global deletion of Kiss1r (Kiss1r(-/-)) or a GnRH neuron-..
  59. Kumar D, Periasamy V, Freese M, Voigt A, Boehm U. In Utero Development of Kisspeptin/GnRH Neural Circuitry in Male Mice. Endocrinology. 2015;156:3084-90 pubmed publisher
    ..Although it has long been known that kisspeptin and its receptor G protein-coupled receptor 54 (GPR54) are expressed in the developing brain well before puberty onset, the potential role of kisspeptin/GPR54 signaling ..
  60. Hanchate N, Parkash J, Bellefontaine N, Mazur D, Colledge W, d Anglemont de Tassigny X, et al. Kisspeptin-GPR54 signaling in mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation. J Neurosci. 2012;32:932-45 pubmed publisher
    ..Using a transgenic Gpr54-null IRES-LacZ knock-in mouse model, we demonstrate that neurons containing neuronal NO synthase (nNOS), which are ..
  61. Cho S, Wang Y, Rodriguez M, Tan K, Zhang W, Luo J, et al. Haploinsufficiency in the prometastasis Kiss1 receptor Gpr54 delays breast tumor initiation, progression, and lung metastasis. Cancer Res. 2011;71:6535-46 pubmed publisher
    Activation of KISS1 receptor (KISS1R or GPR54) by its ligands (Kisspeptins) regulates a diverse function both in normal physiology and pathophysiology...