Kiss1

Summary

Gene Symbol: Kiss1
Description: KiSS-1 metastasis-suppressor
Alias: kisspeptin, metastatin, metastasis-suppressor KiSS-1, 0610012C01Rik, Kiss1 metastasis-suppressor, kisspeptin-1, metastin
Species: mouse
Products:     Kiss1

Top Publications

  1. Luque R, Kineman R, Tena Sempere M. Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line. Endocrinology. 2007;148:4601-11 pubmed
    ..In sum, our present data further characterize the functional relevance and putative key mediators (such as leptin and NPY) of the metabolic regulation of the hypothalamic KiSS-1 system in the mouse. ..
  2. Yeo S, Herbison A. Projections of arcuate nucleus and rostral periventricular kisspeptin neurons in the adult female mouse brain. Endocrinology. 2011;152:2387-99 pubmed publisher
    The important role of kisspeptin neurons in the regulation of GnRH neuron activity is now well accepted...
  3. Navarro V, Fernandez Fernandez R, Castellano J, Roa J, Mayen A, Barreiro M, et al. Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54. J Physiol. 2004;561:379-86 pubmed
    ..loss-of-function mutations of the gene encoding GPR54, the putative receptor for the KiSS-1-derived peptide metastin, have been linked to hypogonadotrophic hypogonadism, both in rodents and humans...
  4. Navarro V, Gottsch M, Chavkin C, Okamura H, Clifton D, Steiner R. Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. J Neurosci. 2009;29:11859-66 pubmed publisher
    b>Kisspeptin is encoded by the Kiss1 gene, and kisspeptin signaling plays a critical role in reproduction...
  5. Clarkson J, d Anglemont de Tassigny X, Moreno A, Colledge W, Herbison A. Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge. J Neurosci. 2008;28:8691-7 pubmed publisher
    b>Kisspeptin and its receptor GPR54 have recently been identified as key signaling partners in the neural control of fertility in animal models and humans...
  6. Terao Y, Kumano S, Takatsu Y, Hattori M, Nishimura A, Ohtaki T, et al. Expression of KiSS-1, a metastasis suppressor gene, in trophoblast giant cells of the rat placenta. Biochim Biophys Acta. 2004;1678:102-10 pubmed
    b>Metastin is encoded by a putative human metastasis suppressor gene KiSS-1, and is the cognate ligand of a G-protein-coupled receptor designated OT7T175...
  7. Messager S, Chatzidaki E, Ma D, Hendrick A, Zahn D, Dixon J, et al. Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proc Natl Acad Sci U S A. 2005;102:1761-6 pubmed
    ..In the present study, we investigate the possible central mode of action of GPR54 and kisspeptin ligand...
  8. Gottsch M, Cunningham M, Smith J, Popa S, Acohido B, Crowley W, et al. A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology. 2004;145:4073-7 pubmed
    ..targeted disruptions in the GPR54 gene cause hypogonadotropic hypogonadism in humans and mice, suggesting that kisspeptin signaling may be important for the regulation of gonadotropin secretion...
  9. Navarro V, Castellano J, Fernandez Fernandez R, Tovar S, Roa J, Mayen A, et al. Effects of KiSS-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat. Endocrinology. 2005;146:1689-97 pubmed
    ..Overall, it is proposed that the KiSS-1/GPR54 system is a novel, pivotal downstream element in the neuroendocrine network governing gonadotropin secretion. ..

More Information

Publications82

  1. Han S, Gottsch M, Lee K, Popa S, Smith J, Jakawich S, et al. Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty. J Neurosci. 2005;25:11349-56 pubmed
    We examined the role of kisspeptin and its receptor, the G-protein-coupled receptor GPR54, in governing the onset of puberty in the mouse...
  2. Donato J, Cravo R, Frazao R, Gautron L, Scott M, Lachey J, et al. Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. J Clin Invest. 2011;121:355-68 pubmed publisher
    ..Here, we found that genetic deletion of LepR selectively from hypothalamic Kiss1 neurons in mice had no effect on puberty or fertility, indicating that direct leptin signaling in Kiss1 neurons is ..
  3. Mayer C, Acosta Martinez M, Dubois S, Wolfe A, Radovick S, Boehm U, et al. Timing and completion of puberty in female mice depend on estrogen receptor alpha-signaling in kisspeptin neurons. Proc Natl Acad Sci U S A. 2010;107:22693-8 pubmed publisher
    ..Here we test whether these mechanisms are mediated by neurons that express kisspeptin, a neuropeptide that modulates GnRH neurosecretion...
  4. Calder M, Chan Y, Raj R, Pampillo M, Elbert A, Noonan M, et al. Implantation failure in female Kiss1-/- mice is independent of their hypogonadic state and can be partially rescued by leukemia inhibitory factor. Endocrinology. 2014;155:3065-78 pubmed publisher
    The hypothalamic kisspeptin signaling system is a major positive regulator of the reproductive neuroendocrine axis, and loss of Kiss1 in the mouse results in infertility, a condition generally attributed to its hypogonadotropic ..
  5. Smith J, Dungan H, Stoll E, Gottsch M, Braun R, Eacker S, et al. Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse. Endocrinology. 2005;146:2976-84 pubmed
    Kisspeptins are products of the Kiss1 gene, which bind to GPR54, a G protein-coupled receptor. Kisspeptins and GPR54 have been implicated in the neuroendocrine regulation of GnRH secretion...
  6. Quennell J, Howell C, Roa J, Augustine R, Grattan D, Anderson G. Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice. Endocrinology. 2011;152:1541-50 pubmed publisher
    ..deficiency or leptin resistance due to a high-fat diet (HFD) can regulate the potent reproductive neuropeptide kisspeptin. In mice with normalized levels of estradiol, leptin deficiency markedly reduced kisspeptin gene expression, ..
  7. Navarro V, Castellano J, Fernandez Fernandez R, Tovar S, Roa J, Mayen A, et al. Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54. Endocrinology. 2005;146:156-63 pubmed
    Loss-of-function mutations of the gene encoding GPR54, the putative receptor for the KiSS-1-derived peptide metastin, have been recently associated with hypogonadotropic hypogonadism, in both rodents and humans...
  8. d Anglemont de Tassigny X, Fagg L, Dixon J, Day K, Leitch H, Hendrick A, et al. Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. Proc Natl Acad Sci U S A. 2007;104:10714-9 pubmed
    ..is functional in these mice as shown by robust luteinizing hormone secretion after peripheral administration of kisspeptin. The virtually identical phenotype of Gpr54- and Kiss1-null mice provides direct proof that kisspeptins are the ..
  9. Liu X, Lee K, Herbison A. Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels. Endocrinology. 2008;149:4605-14 pubmed publisher
    ..imaging in GnRH transgenic mouse lines to determine the mechanisms underlying the potent excitatory effects of kisspeptin upon GnRH neurons in the acute brain slice preparation...
  10. Clarkson J, d Anglemont de Tassigny X, Colledge W, Caraty A, Herbison A. Distribution of kisspeptin neurones in the adult female mouse brain. J Neuroendocrinol. 2009;21:673-82 pubmed publisher
    b>Kisspeptin-GPR54 signalling is essential for normal reproductive functioning. However, the distribution of kisspeptin neuronal cell bodies and their projections is not well established...
  11. Kauffman A. Coming of age in the kisspeptin era: sex differences, development, and puberty. Mol Cell Endocrinol. 2010;324:51-63 pubmed publisher
    ..Recently, the neural kisspeptin system has been implicated as an important regulator of GnRH neurons...
  12. Irwig M, Fraley G, Smith J, Acohido B, Popa S, Cunningham M, et al. Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat. Neuroendocrinology. 2004;80:264-72 pubmed
    ..To assess the possible effects of kisspeptins on gonadotropin secretion, we injected kisspeptin-52 into the lateral cerebral ventricles of adult male rats and found that kisspeptin-52 increased the serum ..
  13. Bakker J, Pierman S, González Martínez D. Effects of aromatase mutation (ArKO) on the sexual differentiation of kisspeptin neuronal numbers and their activation by same versus opposite sex urinary pheromones. Horm Behav. 2010;57:390-5 pubmed publisher
    ..Here we asked whether the sexually dimorphic population of kisspeptin neurons in the rostral periventricular area of the third ventricle (RP3V) could relay sexually dimorphic ..
  14. Lapatto R, Pallais J, Zhang D, Chan Y, Mahan A, Cerrato F, et al. Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- mice. Endocrinology. 2007;148:4927-36 pubmed
    The G protein-coupled receptor Gpr54 and its ligand metastin (derived from the Kiss1 gene product kisspeptin) are key gatekeepers of sexual maturation...
  15. Smith J, Cunningham M, Rissman E, Clifton D, Steiner R. Regulation of Kiss1 gene expression in the brain of the female mouse. Endocrinology. 2005;146:3686-92 pubmed
    The Kiss1 gene encodes a family of neuropeptides called kisspeptins, which activate the receptor G protein-coupled receptor-54 and play a role in the neuroendocrine regulation of GnRH secretion...
  16. Cravo R, Margatho L, Osborne Lawrence S, Donato J, Atkin S, Bookout A, et al. Characterization of Kiss1 neurons using transgenic mouse models. Neuroscience. 2011;173:37-56 pubmed publisher
    Humans and mice with loss-of-function mutations of the genes encoding kisspeptins (Kiss1) or kisspeptin receptor (Kiss1r) are infertile due to hypogonadotropic hypogonadism...
  17. Fiorini Z, Jasoni C. A novel developmental role for kisspeptin in the growth of gonadotrophin-releasing hormone neurites to the median eminence in the mouse. J Neuroendocrinol. 2010;22:1113-25 pubmed publisher
    The puberty- and fertility-regulating neuropeptide kisspeptin (KISS1) exerts dramatic effects on the physiology of adult gonadotrophin-releasing hormone (GnRH) neurones as a master regulator of mammalian reproduction...
  18. Gaskins G, Glanowska K, Moenter S. Activation of neurokinin 3 receptors stimulates GnRH release in a location-dependent but kisspeptin-independent manner in adult mice. Endocrinology. 2013;154:3984-9 pubmed publisher
    ..Senktide also induced GnRH secretion in the ME of kisspeptin-knockout (Kiss1 knockout) mice. Interestingly, release amplitude was lower compared with wild-type mice...
  19. Padilla S, Qiu J, Nestor C, Zhang C, Smith A, Whiddon B, et al. AgRP to Kiss1 neuron signaling links nutritional state and fertility. Proc Natl Acad Sci U S A. 2017;114:2413-2418 pubmed publisher
    ..The reproductive neuroendocrine circuit is well established, composed of two populations of kisspeptin-expressing neurons (located in the anteroventral periventricular hypothalamus, Kiss1AVPV, and arcuate ..
  20. Colledge W, Doran J, Mei H. Model systems for studying kisspeptin signalling: mice and cells. Adv Exp Med Biol. 2013;784:481-503 pubmed publisher
    ..the regulatory mechanisms that control Kiss1 neuronal activity and to examine the molecular consequences of kisspeptin signalling...
  21. Frazao R, Cravo R, Donato J, Ratra D, Clegg D, Elmquist J, et al. Shift in Kiss1 cell activity requires estrogen receptor ?. J Neurosci. 2013;33:2807-20 pubmed publisher
    ..b>Kiss1 neurons are fundamental players in this network, but it is currently unclear whether different conditions of ..
  22. Treen A, Luo V, Chalmers J, Dalvi P, Tran D, Ye W, et al. Divergent Regulation of ER and Kiss Genes by 17β-Estradiol in Hypothalamic ARC Versus AVPV Models. Mol Endocrinol. 2016;30:217-33 pubmed publisher
    b>Kisspeptin (Kiss) and G-protein-coupled receptor (Gpr)54 have emerged as key regulators of reproduction...
  23. Jacobs D, Veitch R, Chappell P. Evaluation of Immortalized AVPV- and Arcuate-Specific Neuronal Kisspeptin Cell Lines to Elucidate Potential Mechanisms of Estrogen Responsiveness and Temporal Gene Expression in Females. Endocrinology. 2016;157:3410-9 pubmed publisher
    In females, ovarian estradiol modulates kisspeptin (Kiss-1) synthesis to act as an obligatory regulator of downstream gonadotropin release in vivo, via stimulation of GnRH neurons...
  24. Beymer M, Negrón A, Yu G, Wu S, Mayer C, Lin R, et al. Kisspeptin cell-specific PI3K signaling regulates hypothalamic kisspeptin expression and participates in the regulation of female fertility. Am J Physiol Endocrinol Metab. 2014;307:E969-82 pubmed publisher
    Hypothalamic kisspeptin neurons integrate and translate cues from the internal and external environments that regulate gonadotropin-releasing hormone (GnRH) secretion and maintain fertility in mammals...
  25. Zhang C, Rønnekleiv O, Kelly M. Kisspeptin inhibits a slow afterhyperpolarization current via protein kinase C and reduces spike frequency adaptation in GnRH neurons. Am J Physiol Endocrinol Metab. 2013;304:E1237-44 pubmed publisher
    b>Kisspeptin signaling via its cognate receptor G protein-coupled receptor 54 (GPR54) in gonadotropin-releasing hormone (GnRH) neurons plays a critical role in regulating pituitary secretion of luteinizing hormone and thus reproductive ..
  26. Hellier V, Brock O, Candlish M, Desroziers E, Aoki M, Mayer C, et al. Female sexual behavior in mice is controlled by kisspeptin neurons. Nat Commun. 2018;9:400 pubmed publisher
    ..We show that male odors detected in the vomeronasal organ activate kisspeptin neurons in female mice...
  27. Navenot J, Evans B, Oishi S, Setsuda S, Fujii N, Peiper S. The metastasis suppressor KISS1 lacks antimetastatic activity in the C8161.9 xenograft model of melanoma. Melanoma Res. 2012;22:140-50 pubmed publisher
    ..9) to test a pharmacological approach to the effect of the metastasis suppressor KISS1. A KISS1 analog was used to inhibit the metastatic development of C8161.9 cells in nude mice...
  28. Qiu J, Nestor C, Zhang C, Padilla S, Palmiter R, Kelly M, et al. High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons. elife. 2016;5: pubmed publisher
    b>Kisspeptin (Kiss1) and neurokinin B (NKB) neurocircuits are essential for pubertal development and fertility...
  29. Clarkson J, Han S, Liu X, Lee K, Herbison A. Neurobiological mechanisms underlying kisspeptin activation of gonadotropin-releasing hormone (GnRH) neurons at puberty. Mol Cell Endocrinol. 2010;324:45-50 pubmed publisher
    Studies undertaken in many species indicate that kisspeptin-Gpr54 signaling is essential for the activation of gonadotropin-releasing hormone (GnRH) neurons to bring about puberty...
  30. Colledge W, d Anglemont de Tassigny X. The role of kisspeptin signalling in the regulation of the GnRH-gonadotrophin ovarian axis in mice. Ann Endocrinol (Paris). 2010;71:198-200 pubmed publisher
    ..Mutations that interfere with kisspeptin signalling prevent normal pubertal development in humans and mice...
  31. Kim J, Semaan S, Clifton D, Steiner R, Dhamija S, Kauffman A. Regulation of Kiss1 expression by sex steroids in the amygdala of the rat and mouse. Endocrinology. 2011;152:2020-30 pubmed publisher
    b>Kisspeptin (encoded by the Kiss1 gene) is an important regulator of reproduction...
  32. Popa S, Moriyama R, Caligioni C, Yang J, Cho C, Concepcion T, et al. Redundancy in Kiss1 expression safeguards reproduction in the mouse. Endocrinology. 2013;154:2784-94 pubmed publisher
    b>Kisspeptin (Kiss1) signaling to GnRH neurons is widely acknowledged to be a prerequisite for puberty and reproduction...
  33. Gill J, Wang O, Kakar S, Martinelli E, Carroll R, Kaiser U. Reproductive hormone-dependent and -independent contributions to developmental changes in kisspeptin in GnRH-deficient hypogonadal mice. PLoS ONE. 2010;5:e11911 pubmed publisher
    b>Kisspeptin is a potent activator of GnRH-induced gonadotropin secretion and is a proposed central regulator of pubertal onset...
  34. Spampinato S, Trabucco A, Biasiotta A, Biagioni F, Cruccu G, Copani A, et al. Hyperalgesic activity of kisspeptin in mice. Mol Pain. 2011;7:90 pubmed publisher
    b>Kisspeptin is a neuropeptide known for its role in the hypothalamic regulation of the reproductive axis...
  35. Maguire C, Song Y, Wu M, Leon S, Carroll R, Alreja M, et al. Tac1 Signaling Is Required for Sexual Maturation and Responsiveness of GnRH Neurons to Kisspeptin in the Male Mouse. Endocrinology. 2017;158:2319-2329 pubmed publisher
    The tachykinins substance P (SP) and neurokinin A (Tac1) have emerged as novel regulators of kisspeptin/GnRH release. Recently, we documented that SP modulates reproductive function in the female mouse...
  36. Piet R, Boehm U, Herbison A. Estrous cycle plasticity in the hyperpolarization-activated current ih is mediated by circulating 17?-estradiol in preoptic area kisspeptin neurons. J Neurosci. 2013;33:10828-39 pubmed publisher
    ..We examined here whether gonadal steroids modulated the excitability of kisspeptin neurons located in the rostral periventricular region of the third ventricle (RP3V) of female mice...
  37. Clarkson J, Busby E, Kirilov M, Schütz G, Sherwood N, Herbison A. Sexual differentiation of the brain requires perinatal kisspeptin-GnRH neuron signaling. J Neurosci. 2014;34:15297-305 pubmed publisher
    ..b>Kisspeptin neurons have recently been identified to be potent, direct activators of GnRH neurons...
  38. Krull A, Larsen S, Clifton D, Neal Perry G, Steiner R. A Comprehensive Method To Quantify Adaptations by Male and Female Mice With Hot Flashes Induced by the Neurokinin B Receptor Agonist Senktide. Endocrinology. 2017;158:3259-3268 pubmed publisher
    ..This dynamic model may be used to fully explore the cellular and molecular bases for VMS and to develop and test new therapeutic options. ..
  39. Yang J, Yasrebi A, Snyder M, Roepke T. The interaction of fasting, caloric restriction, and diet-induced obesity with 17?-estradiol on the expression of KNDy neuropeptides and their receptors in the female mouse. Mol Cell Endocrinol. 2016;437:35-50 pubmed publisher
    Arcuate neurons that coexpress kisspeptin (Kiss1), neurokinin B (Tac2), and dynorphin (Pdyn) mediate negative feedback of 17?-estradiol (E2) on the HPG axis...
  40. Salehi S, Adeshina I, Chen H, Zirkin B, Hussain M, Wondisford F, et al. Developmental and endocrine regulation of kisspeptin expression in mouse Leydig cells. Endocrinology. 2015;156:1514-22 pubmed publisher
    b>Kisspeptin, encoded by the Kiss1 gene, binds to a specific G protein-coupled receptor (kisspeptin1 receptor) to regulate the central reproductive axis...
  41. de Croft S, Piet R, Mayer C, Mai O, Boehm U, Herbison A. Spontaneous kisspeptin neuron firing in the adult mouse reveals marked sex and brain region differences but no support for a direct role in negative feedback. Endocrinology. 2012;153:5384-93 pubmed publisher
    b>Kisspeptin-Gpr54 signaling is critical for the GnRH neuronal network controlling fertility...
  42. Kumar D, Candlish M, Periasamy V, Avcu N, Mayer C, Boehm U. Specialized subpopulations of kisspeptin neurons communicate with GnRH neurons in female mice. Endocrinology. 2015;156:32-8 pubmed publisher
    The neuropeptide kisspeptin is a potent stimulator of GnRH neurons and has been implicated as a major regulator of the hypothalamus-pituitary-gonadal axis...
  43. Tolson K, Garcia C, Yen S, Simonds S, Stefanidis A, Lawrence A, et al. Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity. J Clin Invest. 2014;124:3075-9 pubmed publisher
    The neuropeptide kisspeptin regulates reproduction by stimulating gonadotropin-releasing hormone (GnRH) neurons via the kisspeptin receptor KISS1R...
  44. Mayer C, Boehm U. Female reproductive maturation in the absence of kisspeptin/GPR54 signaling. Nat Neurosci. 2011;14:704-10 pubmed publisher
    ..The identification of the neuropeptide kisspeptin as a potent activator of GnRH neuronal activity suggests that kisspeptin-releasing neurons might coordinate ..
  45. Qiu X, Dowling A, Marino J, Faulkner L, Bryant B, Bruning J, et al. Delayed puberty but normal fertility in mice with selective deletion of insulin receptors from Kiss1 cells. Endocrinology. 2013;154:1337-48 pubmed publisher
    Pubertal onset only occurs in a favorable, anabolic hormonal environment. The neuropeptide kisspeptin, encoded by the Kiss1 gene, modifies GnRH neuronal activity to initiate puberty and maintain fertility, but the factors that regulate ..
  46. Dubois S, Acosta Martínez M, DeJoseph M, Wolfe A, Radovick S, Boehm U, et al. Positive, but not negative feedback actions of estradiol in adult female mice require estrogen receptor α in kisspeptin neurons. Endocrinology. 2015;156:1111-20 pubmed publisher
    Hypothalamic kisspeptin (Kiss1) neurons express estrogen receptor α (ERα) and exert control over GnRH/LH secretion in female rodents...
  47. Nestor C, Qiu J, Padilla S, Zhang C, Bosch M, Fan W, et al. Optogenetic Stimulation of Arcuate Nucleus Kiss1 Neurons Reveals a Steroid-Dependent Glutamatergic Input to POMC and AgRP Neurons in Male Mice. Mol Endocrinol. 2016;30:630-44 pubmed publisher
    b>Kisspeptin (Kiss1) neurons are essential for reproduction, but their role in the control of energy balance and other homeostatic functions remains unclear...
  48. Sato K, Shirai R, Hontani M, Shinooka R, Hasegawa A, Kichise T, et al. Potent Vasoconstrictor Kisspeptin-10 Induces Atherosclerotic Plaque Progression and Instability: Reversal by its Receptor GPR54 Antagonist. J Am Heart Assoc. 2017;6: pubmed publisher
    b>Kisspeptin-10 (KP-10), a potent vasoconstrictor and inhibitor of angiogenesis, and its receptor, GPR54, have currently received much attention in relation to pre-eclampsia...
  49. Alreja M. Electrophysiology of kisspeptin neurons. Adv Exp Med Biol. 2013;784:349-62 pubmed publisher
    b>Kisspeptin is an important regulator of reproduction...
  50. Jiffar T, Yilmaz T, Lee J, Hanna E, el Naggar A, Yu D, et al. KiSS1 mediates platinum sensitivity and metastasis suppression in head and neck squamous cell carcinoma. Oncogene. 2011;30:3163-73 pubmed publisher
    ..biology-based approach utilizing high-throughput PCR arrays, and we identified a significant suppression of KiSS1 mRNA and protein expression in the CR cells, but no significant regions of genomic loss with array comparative ..
  51. de Croft S, Boehm U, Herbison A. Neurokinin B activates arcuate kisspeptin neurons through multiple tachykinin receptors in the male mouse. Endocrinology. 2013;154:2750-60 pubmed publisher
    b>Kisspeptin neurons located in the arcuate nucleus (ARN) coexpress dynorphin and neurokinin B (NKB) and may interact to influence gonadotropin secretion...
  52. Liu X, Herbison A. Kisspeptin regulation of arcuate neuron excitability in kisspeptin receptor knockout mice. Endocrinology. 2015;156:1815-27 pubmed publisher
    The G protein-coupled receptor 54 (GPR54) is critical for kisspeptin to activate GnRH neurons to modulate fertility...
  53. Stafford L, Xia C, Ma W, Cai Y, Liu M. Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor. Cancer Res. 2002;62:5399-404 pubmed
    ..b>KiSS1 is a metastasis suppressor gene that has been shown to inhibit metastasis of human melanomas and breast carcinomas...
  54. Naulé L, Robert V, Parmentier C, Martini M, Keller M, Cohen Solal M, et al. Delayed pubertal onset and prepubertal Kiss1 expression in female mice lacking central oestrogen receptor beta. Hum Mol Genet. 2015;24:7326-38 pubmed publisher
    ..In agreement with these data, the number of kisspeptin-immunoreactive neurons was decreased by 57-72% in the three subdivisions of the rostral periventricular area of ..
  55. Clarkson J, Herbison A. Dual phenotype kisspeptin-dopamine neurones of the rostral periventricular area of the third ventricle project to gonadotrophin-releasing hormone neurones. J Neuroendocrinol. 2011;23:293-301 pubmed publisher
    The neuropeptide kisspeptin and its G-protein-coupled receptor, Gpr54, are critical regulators of fertility...
  56. Gottsch M, Navarro V, Zhao Z, Glidewell Kenney C, Weiss J, Jameson J, et al. Regulation of Kiss1 and dynorphin gene expression in the murine brain by classical and nonclassical estrogen receptor pathways. J Neurosci. 2009;29:9390-5 pubmed publisher
    b>Kisspeptin is a product of the Kiss1 gene and is expressed in the forebrain. Neurons that express Kiss1 play a crucial role in the regulation of pituitary luteinizing hormone secretion and reproduction...
  57. Yip S, Boehm U, Herbison A, Campbell R. Conditional Viral Tract Tracing Delineates the Projections of the Distinct Kisspeptin Neuron Populations to Gonadotropin-Releasing Hormone (GnRH) Neurons in the Mouse. Endocrinology. 2015;156:2582-94 pubmed publisher
    b>Kisspeptin neurons play an essential role in the regulation of fertility through direct regulation of the GnRH neurons...
  58. Greenwald Yarnell M, Marsh C, Allison M, Patterson C, Kasper C, Mackenzie A, et al. ERα in Tac2 Neurons Regulates Puberty Onset in Female Mice. Endocrinology. 2016;157:1555-65 pubmed publisher
    A variety of data suggest that estrogen action on kisspeptin (Kiss1)-containing arcuate nucleus neurons (which coexpress Kiss1, neurokinin B (the product of Tac2) and dynorphin (KNDy) neurons restrains reproductive onset and function, but ..
  59. Stephens S, Chahal N, Munaganuru N, Parra R, Kauffman A. Estrogen Stimulation of Kiss1 Expression in the Medial Amygdala Involves Estrogen Receptor-? But Not Estrogen Receptor-?. Endocrinology. 2016;157:4021-4031 pubmed
    The neuropeptide kisspeptin, encoded by Kiss1, regulates reproduction by stimulating GnRH secretion...
  60. Hanchate N, Parkash J, Bellefontaine N, Mazur D, Colledge W, d Anglemont de Tassigny X, et al. Kisspeptin-GPR54 signaling in mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation. J Neurosci. 2012;32:932-45 pubmed publisher
    ..Here we show that kisspeptin, a potent activator of GnRH neuronal activity, directly communicates with neurons that synthesize the gaseous ..
  61. Kumar D, Periasamy V, Freese M, Voigt A, Boehm U. In Utero Development of Kisspeptin/GnRH Neural Circuitry in Male Mice. Endocrinology. 2015;156:3084-90 pubmed publisher
    The neuropeptide kisspeptin is a major regulator of the hypothalamus-pituitary-gonadal axis...
  62. Liu X, Brown R, Herbison A, Grattan D. Lactational anovulation in mice results from a selective loss of kisspeptin input to GnRH neurons. Endocrinology. 2014;155:193-203 pubmed publisher
    ..Because kisspeptin neurons are critical for fertility, the aim of this study was to test the hypothesis that reduced kisspeptin ..
  63. Zhang C, Bosch M, Qiu J, Rønnekleiv O, Kelly M. 17β-Estradiol increases persistent Na(+) current and excitability of AVPV/PeN Kiss1 neurons in female mice. Mol Endocrinol. 2015;29:518-27 pubmed publisher
    ..between anteroventral periventricular/periventricular preoptic nucleus (AVPV/PeN) and arcuate nucleus (ARC) kisspeptin (Kiss1) neurons in females...
  64. Brown R, Herbison A, Grattan D. Prolactin regulation of kisspeptin neurones in the mouse brain and its role in the lactation-induced suppression of kisspeptin expression. J Neuroendocrinol. 2014;26:898-908 pubmed publisher
    ..The aim of the present study was to test the hypothesis that elevated prolactin causes suppression of kisspeptin expression in the hypothalamus, resulting in reduced release of gonadotrophin-releasing hormone (GnRH) and ..
  65. Brock O, Bakker J. The two kisspeptin neuronal populations are differentially organized and activated by estradiol in mice. Endocrinology. 2013;154:2739-49 pubmed publisher
    In rodents, kisspeptin-expressing neurons are localized in 2 hypothalamic brain nuclei (anteroventral periventricular nucleus/periventricular nucleus continuum [AVPv/PeN] and arcuate nucleus [ARC]) and modulated by sex steroids...
  66. Mei H, Walters C, Carter R, Colledge W. Gpr54-/- mice show more pronounced defects in spermatogenesis than Kiss1-/- mice and improved spermatogenesis with age when exposed to dietary phytoestrogens. Reproduction. 2011;141:357-66 pubmed publisher
    Mice with mutations in the kisspeptin signaling pathway (Kiss1(-/-) or Gpr54(-/-)) have low gonadotrophic hormone levels, small testes, and impaired spermatogenesis...
  67. Yap C, Wharfe M, Mark P, Waddell B, Smith J. Diurnal regulation of hypothalamic kisspeptin is disrupted during mouse pregnancy. J Endocrinol. 2016;229:307-18 pubmed publisher
    b>Kisspeptin, the neuropeptide product of the Kiss1 gene, is critical in driving the hypothalamic-pituitary-gonadal (HPG) axis...
  68. Navarro V, Bosch M, León S, Simavli S, True C, Pinilla L, et al. The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Endocrinology. 2015;156:627-37 pubmed publisher
    ..NKB has emerged as regulator of kisspeptin release in the arcuate nucleus (ARC), whereas the roles of SP and NKA in reproduction remain unknown...
  69. Smith J, Spencer S. Preweaning over- and underfeeding alters onset of puberty in the rat without affecting kisspeptin. Biol Reprod. 2012;86:145, 1-8 pubmed publisher
    ..would alter puberty onset and influence concentrations of a neuropeptide crucial for successful puberty, kisspeptin. We manipulated Wistar rat litter sizes to derive small (SL), control (CL), and large (LL) litters containing 4, ..
  70. Poling M, Kauffman A. Sexually dimorphic testosterone secretion in prenatal and neonatal mice is independent of kisspeptin-Kiss1r and GnRH signaling. Endocrinology. 2012;153:782-93 pubmed publisher
    b>Kisspeptin, encoded by the Kiss1 gene, stimulates GnRH secretion and is therefore critical for sex steroid secretion at puberty and in adulthood...
  71. Dubois S, Wolfe A, Radovick S, Boehm U, Levine J. Estradiol Restrains Prepubertal Gonadotropin Secretion in Female Mice via Activation of ERα in Kisspeptin Neurons. Endocrinology. 2016;157:1546-54 pubmed publisher
    Elimination of estrogen receptorα (ERα) from kisspeptin (Kiss1) neurons results in premature LH release and pubertal onset, implicating these receptors in 17β-estradiol (E2)-mediated negative feedback regulation of GnRH release ..
  72. Torsoni M, Borges B, Cote J, Allen S, Mahany E, García Galiano D, et al. AMPK?2 in Kiss1 Neurons Is Required for Reproductive Adaptations to Acute Metabolic Challenges in Adult Female Mice. Endocrinology. 2016;157:4803-4816 pubmed
    ..Subsets of kisspeptin neurons in the anteroventral periventricular nucleus (20% in females) and arcuate nucleus (45% in males and 65% ..
  73. Martin C, Navarro V, Simavli S, Vong L, Carroll R, Lowell B, et al. Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone. J Neurosci. 2014;34:6047-56 pubmed publisher
    ..Intracerebroventricular administration of kisspeptin-10 to Vgat-Cre;Lepr(lox/lox) female mice elicited robust gonadotropin responses, suggesting normal gonadotropin-..