Gene Symbol: KIS
Description: U2AF homology motif (UHM) kinase 1
Alias: 4732477C12Rik, 4930500M09Rik, AA673513, AI449218, AU021979, C820018A03Rik, KIS, Kist, P-CIP2, serine/threonine-protein kinase Kist, PAM COOH-terminal interactor protein 2, U2AF homology motif kinase 1, kinase interacting with leukemia-associated gene (stathmin), kinase interacting with stathmin
Species: mouse
Products:     KIS

Top Publications

  1. Maucuer A, Ozon S, Manceau V, Gavet O, Lawler S, Curmi P, et al. KIS is a protein kinase with an RNA recognition motif. J Biol Chem. 1997;272:23151-6 pubmed the first identification of a serine/threonine kinase that possesses an RNP-type RNA recognition motif: KIS. We originally isolated KIS in a two-hybrid screen through its interaction with stathmin, a small phosphoprotein ..
  2. Boehm M, Yoshimoto T, Crook M, Nallamshetty S, True A, Nabel G, et al. A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression. EMBO J. 2002;21:3390-401 pubmed
    ..Depletion of KIS using small interfering RNA (siRNA) inhibits S10 phosphorylation and enhances growth arrest...
  3. Manceau V, Kielkopf C, Sobel A, Maucuer A. Different requirements of the kinase and UHM domains of KIS for its nuclear localization and binding to splicing factors. J Mol Biol. 2008;381:748-62 pubmed publisher
    The protein kinase KIS is made by the juxtaposition of a unique kinase domain and a C-terminal domain with a U2AF homology motif (UHM), a sequence motif for protein interaction initially identified in the heterodimeric pre-mRNA splicing ..
  4. Cambray S, Pedraza N, Rafel M, Garí E, Aldea M, Gallego C. Protein kinase KIS localizes to RNA granules and enhances local translation. Mol Cell Biol. 2009;29:726-35 pubmed publisher
    ..We show that KIS, a serine/threonine kinase functionally related to microtubule dynamics and axon development, interacts with three ..
  5. Maucuer A, Camonis J, Sobel A. Stathmin interaction with a putative kinase and coiled-coil-forming protein domains. Proc Natl Acad Sci U S A. 1995;92:3100-4 pubmed
    ..Another is a previously unidentified, putative serine/threonine kinase, KIS, which might be regulated by stathmin or, more likely, be part of the kinases controlling its phosphorylation state...
  6. Bieche I, Manceau V, Curmi P, Laurendeau I, Lachkar S, Leroy K, et al. Quantitative RT-PCR reveals a ubiquitous but preferentially neural expression of the KIS gene in rat and human. Brain Res Mol Brain Res. 2003;114:55-64 pubmed
    b>KIS is the only known protein kinase that possesses an RNA recognition motif. This original structure indicates a role for KIS in the maturation of RNAs possibly by phosphorylating and regulating the activities of RNA associated factors...
  7. Langenickel T, Olive M, Boehm M, San H, Crook M, Nabel E. KIS protects against adverse vascular remodeling by opposing stathmin-mediated VSMC migration in mice. J Clin Invest. 2008;118:3848-59 pubmed publisher
    Vascular proliferative diseases are characterized by VSMC proliferation and migration. Kinase interacting with stathmin (KIS) targets 2 key regulators of cell proliferation and migration, the cyclin-dependent kinase inhibitor p27Kip1 and ..
  8. Francone V, Ifrim M, Rajagopal C, Leddy C, Wang Y, Carson J, et al. Signaling from the secretory granule to the nucleus: Uhmk1 and PAM. Mol Endocrinol. 2010;24:1543-58 pubmed publisher
    ..type 1 membrane enzyme essential for the production of amidated peptides, is basally phosphorylated by U2AF homology motif kinase 1 (Uhmk1) and other Ser/Thr kinases...
  9. Manceau V, Kremmer E, Nabel E, Maucuer A. The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice. PLoS ONE. 2012;7:e43946 pubmed publisher
    The brain-enriched protein kinase KIS (product of the gene UHMK1) has been shown to phosphorylate the human splicing factor SF1 in vitro...

More Information


  1. Pedraza N, Ortiz R, Cornadó A, Llobet A, Aldea M, Gallego C. KIS, a kinase associated with microtubule regulators, enhances translation of AMPA receptors and stimulates dendritic spine remodeling. J Neurosci. 2014;34:13988-97 pubmed publisher
    ..b>KIS is a protein kinase that associates with stathmin, a modulator of the tubulin cytoskeleton...