Gene Symbol: Kifc1
Description: kinesin family member C1
Alias: 100042970, Gm4137, HSET, KNSL2, Kifc5a, Knsl2a, Tctex-7, Tctex-7A, Tctex7, Tctex7a, kinesin-like protein KIFC1, kifc1, kinesin family c-terminal 5A, kinesin motor protein KIFC4, kinesin-like 2a, kinesin-related protein KIFC5A
Species: mouse
Products:     Kifc1

Top Publications

  1. Navolanic P, Sperry A. Identification of isoforms of a mitotic motor in mammalian spermatogenesis. Biol Reprod. 2000;62:1360-9 pubmed
    We have isolated the full-length coding sequence for mouse KIFC5A (kinesin family c-terminal 5A) cDNA, encoding a motor protein found in the testes...
  2. Ha H, Howard C, Yeom Y, Abe K, Uehara H, Artzt K, et al. Several testis-expressed genes in the mouse t-complex have expression differences between wild-type and t-mutant mice. Dev Genet. 1991;12:318-32 pubmed
    ..Interestingly, four Tctex genes show differences in the amount of transcript between wild-type and t-mutant testes. The chromosomal location and expression pattern imply that Tctex genes might be candidate genes for sterility or TRD. ..
  3. Yeom Y, Abe K, Bennett D, Artzt K. Testis-/embryo-expressed genes are clustered in the mouse H-2K region. Proc Natl Acad Sci U S A. 1992;89:773-7 pubmed
    ..Surprisingly, virtually all of these genes are expressed in testis and/or embryos. The genomic organization of this region is contrasted with the 150 kb of the homologous area where only three genes and an endogenous retrovirus reside. ..
  4. Saito N, Okada Y, Noda Y, Kinoshita Y, Kondo S, Hirokawa N. KIFC2 is a novel neuron-specific C-terminal type kinesin superfamily motor for dendritic transport of multivesicular body-like organelles. Neuron. 1997;18:425-38 pubmed
    ..homologue of CHO2 antigen, a member of the kar3-type mitotic motor subfamily, and we designated this protein KIFC1. The other protein, KIFC2 (792 amino acids), is novel, with no significant similarity to known kinesin superfamily ..
  5. Nath S, Bananis E, Sarkar S, Stockert R, Sperry A, Murray J, et al. Kif5B and Kifc1 interact and are required for motility and fission of early endocytic vesicles in mouse liver. Mol Biol Cell. 2007;18:1839-49 pubmed
    ..antibodies confirmed that dynein was not associated with these vesicles and that Kif5B and the minus-end kinesin Kifc1 mediated their plus- and minus-end motility, respectively...
  6. Kypri E, Christodoulou A, Maimaris G, Lethan M, Markaki M, Lysandrou C, et al. The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis. Cell Mol Life Sci. 2014;71:517-38 pubmed publisher
    ..They have been implicated, together with their interacting minus-end directed motor protein KIFC5A, in the regulation of centriole duplication in mammalian cells...
  7. Himmelbauer H, Artzt K, Barlow D, Fischer Lindahl K, Lyon M, Klein J, et al. Encyclopedia of the mouse genome III. October 1993. Mouse chromosome 17. Mamm Genome. 1993;4 Spec No:S230-52 pubmed
  8. Christodoulou A, Lederer C, Surrey T, Vernos I, Santama N. Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is implicated in the regulation of centrosome duplication. J Cell Sci. 2006;119:2035-47 pubmed
    ..Here, we characterise KIFC5A, a mouse kinesin-like protein that is highly expressed in dividing cells and tissues, and is subject to ..
  9. Wang R, Sperry A. Identification of a novel Leucine-rich repeat protein and candidate PP1 regulatory subunit expressed in developing spermatids. BMC Cell Biol. 2008;9:9 pubmed publisher
    ..Although the molecular motor KIFC1 has been shown to associate with the manchette, its precise role in function of the manchette and the identity of ..

More Information


  1. Zanivan S, Gnad F, Wickström S, Geiger T, Macek B, Cox J, et al. Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res. 2008;7:5314-26 pubmed
    ..Thus, solid tumor can be analyzed by MS-based proteomics with similar efficiency as cell culture models and in amounts compatible with biopsies. ..