Kif3a

Summary

Gene Symbol: Kif3a
Description: kinesin family member 3A
Alias: Kif3, Kifl, Kns3, kinesin-like protein KIF3A, N-4 kinesin, kinesin-II subunit, microtubule plus end-directed kinesin motor 3A
Species: mouse
Products:     Kif3a

Top Publications

  1. Kovacs J, Whalen E, Liu R, Xiao K, Kim J, Chen M, et al. Beta-arrestin-mediated localization of smoothened to the primary cilium. Science. 2008;320:1777-81 pubmed publisher
    ..demonstrated that beta-arrestins mediate the activity-dependent interaction of Smo and the kinesin motor protein Kif3A. This multimeric complex localized to primary cilia and was disrupted in cells transfected with beta-arrestin ..
  2. Song B, Haycraft C, Seo H, Yoder B, Serra R. Development of the post-natal growth plate requires intraflagellar transport proteins. Dev Biol. 2007;305:202-16 pubmed
    ..This study tested the hypothesis that IFT plays an important role in post-natal skeletal development. Kif3a, a subunit of the Kinesin II motor complex, that is required for intraflagellar transport and the formation of ..
  3. Lolkema M, Mans D, Snijckers C, van Noort M, van Beest M, Voest E, et al. The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2. FEBS Lett. 2007;581:4571-6 pubmed
    ..The interaction with kinesin-2 facilitates pVHL binding to microtubules. These data suggest that microtubule-dependent functions of pVHL are influenced by kinesin-2. ..
  4. Huangfu D, Liu A, Rakeman A, Murcia N, Niswander L, Anderson K. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature. 2003;426:83-7 pubmed
    ..Genetic analysis shows that Wim, Polaris and the IFT motor protein Kif3a are required for Hedgehog signalling at a step downstream of Patched1 (the Hedgehog receptor) and upstream of ..
  5. Patel V, Li L, Cobo Stark P, Shao X, Somlo S, Lin F, et al. Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia. Hum Mol Genet. 2008;17:1578-90 pubmed publisher
    ..We have previously shown that kidney-specific inactivation of the ciliogenic gene Kif3a during embryonic development produces kidney cysts and renal failure...
  6. Lin F, Hiesberger T, Cordes K, Sinclair A, Goldstein L, Somlo S, et al. Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Proc Natl Acad Sci U S A. 2003;100:5286-91 pubmed
    ..To directly determine whether cilia are essential to maintain tubular integrity, we conditionally inactivated KIF3A, a subunit of kinesin-II that is essential for cilia formation, in renal epithelia...
  7. Insinna C, Humby M, Sedmak T, Wolfrum U, Besharse J. Different roles for KIF17 and kinesin II in photoreceptor development and maintenance. Dev Dyn. 2009;238:2211-22 pubmed publisher
    ..In contrast, dominant-negative KIF17 has no obvious effect on inner segment or synaptic organization but has an immediate impact on outer segment assembly. ..
  8. Zhu D, Shi S, Wang H, Liao K. Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3T3-L1 preadipocytes. J Cell Sci. 2009;122:2760-8 pubmed publisher
    ..The blockade of primary-cilium formation by suppressing IFT88 or Kif3a inhibited 3T3-L1 adipocyte differentiation...
  9. Avasthi P, Watt C, Williams D, Le Y, Li S, Chen C, et al. Trafficking of membrane proteins to cone but not rod outer segments is dependent on heterotrimeric kinesin-II. J Neurosci. 2009;29:14287-98 pubmed publisher
    ..in anterograde intraflagellar transport by photoreceptor-specific deletions of kinesin family member 3A (KIF3A), its obligatory motor subunit...

More Information

Publications80

  1. Marszalek J, Ruiz Lozano P, Roberts E, Chien K, Goldstein L. Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II. Proc Natl Acad Sci U S A. 1999;96:5043-8 pubmed
    ..New insight into this problem was obtained by analyzing mouse mutants lacking the KIF3A motor subunit of the kinesin-II motor complex...
  2. Lancaster M, Schroth J, Gleeson J. Subcellular spatial regulation of canonical Wnt signalling at the primary cilium. Nat Cell Biol. 2011;13:700-7 pubmed publisher
    ..Together these data explain a spatial mechanism of Wnt signalling regulation that may provide insight into ciliary regulation of other signalling pathways. ..
  3. Wong S, Seol A, So P, Ermilov A, Bichakjian C, Epstein E, et al. Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis. Nat Med. 2009;15:1055-61 pubmed publisher
    ..cell carcinomas (BCCs) are frequently ciliated, and we test the role of cilia in BCC by conditionally deleting Kif3a (encoding kinesin family member 3A) or Ift88 (encoding intraflagellar transport protein 88), genes required for ..
  4. Kondo S, Sato Yoshitake R, Noda Y, Aizawa H, Nakata T, Matsuura Y, et al. KIF3A is a new microtubule-based anterograde motor in the nerve axon. J Cell Biol. 1994;125:1095-107 pubmed
    ..Here we characterized a new member of the kinesin super-family, KIF3A (50-nm rod with globular head and tail), and found that it is localized in neurons, associated with membrane ..
  5. Han Y, Spassky N, Romaguera Ros M, Garcia Verdugo J, Aguilar A, Schneider Maunoury S, et al. Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells. Nat Neurosci. 2008;11:277-84 pubmed publisher
    ..We conclude that Shh signaling, acting through the primary cilia, has a critical role in the expansion and establishment of postnatal hippocampal progenitors. ..
  6. Brugmann S, Allen N, James A, Mekonnen Z, Madan E, Helms J. A primary cilia-dependent etiology for midline facial disorders. Hum Mol Genet. 2010;19:1577-92 pubmed publisher
    ..Elimination of the intraflagellar transport protein Kif3a leads to excessive Hedgehog responsiveness in facial mesenchyme, which is accompanied by broader expression ..
  7. Chizhikov V, Davenport J, Zhang Q, Shih E, Cabello O, Fuchs J, et al. Cilia proteins control cerebellar morphogenesis by promoting expansion of the granule progenitor pool. J Neurosci. 2007;27:9780-9 pubmed
    ..and maintenance, IFT88, (also known as polaris or Tg737), which encodes intraflagellar transport 88 homolog, and Kif3a, which encodes kinesin family member 3a...
  8. Kolpakova Hart E, Jinnin M, Hou B, Fukai N, Olsen B. Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms. Dev Biol. 2007;309:273-84 pubmed
    ..Here we demonstrate that conditional inactivation of the Kif3a subunit of the kinesin-2 intraflagellar transport motor in mesenchymal skeletal progenitor cells results in severe ..
  9. Huang C, Huang C, Chang C. Association of the testis-specific TRIM/RBCC protein RNF33/TRIM60 with the cytoplasmic motor proteins KIF3A and KIF3B. Mol Cell Biochem. 2012;360:121-31 pubmed publisher
    ..RNF33 was shown to interact with the kinesin-2 family members 3A (KIF3A) and 3B (KIF3B) motor proteins in the heterodimeric form known to transport cargos along the microtubule...
  10. Chang B, Khanna H, Hawes N, Jimeno D, He S, Lillo C, et al. In-frame deletion in a novel centrosomal/ciliary protein CEP290/NPHP6 perturbs its interaction with RPGR and results in early-onset retinal degeneration in the rd16 mouse. Hum Mol Genet. 2006;15:1847-57 pubmed
    ..Our findings suggest a critical function for CEP290 in ciliary transport and provide insights into the mechanism of early-onset photoreceptor degeneration. ..
  11. Takeda S, Yonekawa Y, Tanaka Y, Okada Y, Nonaka S, Hirokawa N. Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis. J Cell Biol. 1999;145:825-36 pubmed
    b>KIF3A is a classical member of the kinesin superfamily proteins (KIFs), ubiquitously expressed although predominantly in neural tissues, and which forms a heterotrimeric KIF3 complex with KIF3B or KIF3C and an associated protein, KAP3...
  12. Corbit K, Shyer A, Dowdle W, Gaulden J, Singla V, Chen M, et al. Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms. Nat Cell Biol. 2008;10:70-6 pubmed
    ..Using three separate mutations that disrupt ciliogenesis (affecting Kif3a, Ift88 and Ofd1), we show in this study that the primary cilium restricts the activity of the canonical Wnt ..
  13. Han Y, Kim H, Dlugosz A, Ellison D, Gilbertson R, Alvarez Buylla A. Dual and opposing roles of primary cilia in medulloblastoma development. Nat Med. 2009;15:1062-5 pubmed publisher
    ..Primary cilia could serve as a diagnostic tool and provide new insights into the mechanism of tumorigenesis. ..
  14. Marszalek J, Liu X, Roberts E, Chui D, Marth J, Williams D, et al. Genetic evidence for selective transport of opsin and arrestin by kinesin-II in mammalian photoreceptors. Cell. 2000;102:175-87 pubmed
    ..cilium, and to identify its potential cargoes, we used Cre-loxP mutagenesis to remove the kinesin-II subunit, KIF3A, specifically from photoreceptors...
  15. Kodani A, Salomé Sirerol Piquer M, Seol A, Garcia Verdugo J, Reiter J. Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. EMBO J. 2013;32:597-607 pubmed publisher
    Formation of cilia, microtubule-based structures that function in propulsion and sensation, requires Kif3a, a subunit of Kinesin II essential for intraflagellar transport (IFT)...
  16. Spassky N, Han Y, Aguilar A, Strehl L, Besse L, Laclef C, et al. Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool. Dev Biol. 2008;317:246-59 pubmed publisher
    ..J Comp Neurol 144, 131-64.]. Here, we show that 1) this cilium can be conditionally ablated by crossing Kif3a(fl/-) mice with hGFAP-Cre mice, 2) removal of Kif3a from GCPs disrupts cerebellar development, and 3) these ..
  17. Yamazaki H, Nakata T, Okada Y, Hirokawa N. KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport. J Cell Biol. 1995;130:1387-99 pubmed
    ..brain kinesin superfamily, KIF3B, and found that its amino acid sequence is highly homologous but not identical to KIF3A, which we previously cloned and named KIF3 (47% identical)...
  18. Imamura T, Huang J, Usui I, Satoh H, Bever J, Olefsky J. Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin. Mol Cell Biol. 2003;23:4892-900 pubmed
    ..In this study, we investigated the role of Rab4, a small GTPase-binding protein, and the motor protein KIF3 (kinesin II in mice) in insulin-induced GLUT4 exocytosis in 3T3-L1 adipocytes...
  19. Tanaka Y, Okada Y, Hirokawa N. FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination. Nature. 2005;435:172-7 pubmed
    ..Thus, we propose that NVP flow is a new mode of extracellular transport that forms a left-right gradient of morphogens. ..
  20. Haraguchi K, Hayashi T, Jimbo T, Yamamoto T, Akiyama T. Role of the kinesin-2 family protein, KIF3, during mitosis. J Biol Chem. 2006;281:4094-9 pubmed
    ..Kinesin-2 is composed of two microtubule-based motor subunits, KIF3A/3B, and a kinesin-associated protein known as KAP3, which links KIF3A/3B to cargo that is carried to cellular ..
  21. Haycraft C, Zhang Q, Song B, Jackson W, Detloff P, Serra R, et al. Intraflagellar transport is essential for endochondral bone formation. Development. 2007;134:307-16 pubmed
    ..Overall these data provide evidence that IFT is essential for normal formation of the appendicular skeleton through disruption of multiple signaling pathways. ..
  22. Cano D, Sekine S, Hebrok M. Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis. Gastroenterology. 2006;131:1856-69 pubmed
    ..Here, we investigate the role of cilia in pancreas formation and function by analyzing mice that lack cilia in pancreatic cells...
  23. Aizawa H, Sekine Y, Takemura R, Zhang Z, Nangaku M, Hirokawa N. Kinesin family in murine central nervous system. J Cell Biol. 1992;119:1287-96 pubmed
    ..indicated that KIF1 and KIF5 are murine counterparts of unc104 and kinesin heavy chain, respectively, while KIF2, KIF3, and KIF4 are as yet unidentified new species...
  24. Huangfu D, Anderson K. Cilia and Hedgehog responsiveness in the mouse. Proc Natl Acad Sci U S A. 2005;102:11325-30 pubmed
    ..Dnchc2 and Kif3a, essential subunits of the retrograde and anterograde IFT motors, are also required for both formation of Gli ..
  25. Kolpakova Hart E, Nicolae C, Zhou J, Olsen B. Col2-Cre recombinase is co-expressed with endogenous type II collagen in embryonic renal epithelium and drives development of polycystic kidney disease following inactivation of ciliary genes. Matrix Biol. 2008;27:505-12 pubmed publisher
    ..We demonstrate that conditional ablation of the Kif3a or Pkd1 genes encoding primary cilium/intraflagellar transport-associated proteins using type II collagen-specific ..
  26. Koyama E, Young B, Nagayama M, Shibukawa Y, Enomoto Iwamoto M, Iwamoto M, et al. Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis. Development. 2007;134:2159-69 pubmed
    The motor protein Kif3a and primary cilia regulate important developmental processes, but their roles in skeletogenesis remain ill-defined...
  27. Chen M, Wilson C, Li Y, Law K, Lu C, Gacayan R, et al. Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 2009;23:1910-28 pubmed publisher
    ..Taken together, these studies delineate important aspects of cilium-dependent and cilium-independent Hh signal transduction and provide significant mechanistic insight into Hh signaling in diverse species. ..
  28. Ichinose S, Ogawa T, Hirokawa N. Mechanism of Activity-Dependent Cargo Loading via the Phosphorylation of KIF3A by PKA and CaMKIIa. Neuron. 2015;87:1022-35 pubmed publisher
    ..To elucidate this mechanism, we investigated the activity-dependent transport of N-cadherin via its transporter, KIF3A. First, by comparing KIF3A-bound cargo vesicles with unbound KIF3A, we identified critical KIF3A phosphorylation ..
  29. Qiu N, Xiao Z, Cao L, Buechel M, David V, Roan E, et al. Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia. J Cell Sci. 2012;125:1945-57 pubmed publisher
    We investigated whether Kif3a in osteoblasts has a direct role in regulating postnatal bone formation. We conditionally deleted Kif3a in osteoblasts by crossing osteocalcin (Oc; also known as Bglap)-Cre with Kif3a(flox/null) mice...
  30. Paez Gonzalez P, Abdi K, Luciano D, Liu Y, Soriano Navarro M, Rawlins E, et al. Ank3-dependent SVZ niche assembly is required for the continued production of new neurons. Neuron. 2011;71:61-75 pubmed publisher
  31. Zhu Y, Jong M, Frazer K, Gong E, Krauss R, Cheng J, et al. Genomic interval engineering of mice identifies a novel modulator of triglyceride production. Proc Natl Acad Sci U S A. 2000;97:1137-42 pubmed
  32. Raya A, Kawakami Y, Rodriguez Esteban C, Buscher D, Koth C, Itoh T, et al. Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. Genes Dev. 2003;17:1213-8 pubmed
    ..Our findings provide evidence for a mechanism involving Notch activity that translates an initial symmetry-breaking event into asymmetric gene expression. ..
  33. Jiang L, Wei Y, Ronquillo C, Marc R, Yoder B, Frederick J, et al. Heterotrimeric kinesin-2 (KIF3) mediates transition zone and axoneme formation of mouse photoreceptors. J Biol Chem. 2015;290:12765-78 pubmed publisher
    ..We generated embryonic retina-specific (prefix "emb") and adult tamoxifen-induced (prefix "tam") deletions of KIF3a and IFT88 in adult mice to study photoreceptor ciliogenesis and protein trafficking...
  34. Jiang S, Chiou Y, Wang E, Chien Y, Ho H, Tsai F, et al. Essential role of nephrocystin in photoreceptor intraflagellar transport in mouse. Hum Mol Genet. 2009;18:1566-77 pubmed publisher
    ..Our novel findings provide a clue to unraveling the regulatory mechanism of nephrocystin in IFT machinery. ..
  35. Goggolidou P, Stevens J, Agueci F, Keynton J, Wheway G, Grimes D, et al. ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis. Development. 2014;141:3966-77 pubmed publisher
    ..This identifies potential novel components of cytoplasmic dynein 2 and furthermore provides fresh insights into the molecular pathogenesis of human skeletal ciliopathies. ..
  36. van Asselt S, de Vries E, van Dullemen H, Brouwers A, Walenkamp A, Giles R, et al. Pancreatic cyst development: insights from von Hippel-Lindau disease. Cilia. 2013;2:3 pubmed publisher
    ..Based on preclinical studies, cilia loss in ductal cells is probably an important early event in pancreatic cyst development. ..
  37. Lakhia R, Hajarnis S, Williams D, Aboudehen K, Yheskel M, Xing C, et al. MicroRNA-21 Aggravates Cyst Growth in a Model of Polycystic Kidney Disease. J Am Soc Nephrol. 2016;27:2319-30 pubmed publisher
    ..Our results suggest that inhibiting miR-21 is a potential new therapeutic approach to slow cyst growth in PKD. ..
  38. Grimes D, Keynton J, Buenavista M, Jin X, Patel S, Kyosuke S, et al. Genetic Analysis Reveals a Hierarchy of Interactions between Polycystin-Encoding Genes and Genes Controlling Cilia Function during Left-Right Determination. PLoS Genet. 2016;12:e1006070 pubmed publisher
    ..Our demonstration that PKD1L1 protein can mediate a response to flow coheres with a mechanosensation model of flow sensation in which the force of fluid flow drives asymmetric gene expression in the embryo. ..
  39. Feistel K, Blum M. Three types of cilia including a novel 9+4 axoneme on the notochordal plate of the rabbit embryo. Dev Dyn. 2006;235:3348-58 pubmed
    ..Transcription of ciliary marker genes Foxj1, Rfx3, lrd, polaris, and Kif3a initiated in Hensen's node and persisted in the nascent notochord...
  40. Sipe C, Lu X. Kif3a regulates planar polarization of auditory hair cells through both ciliary and non-ciliary mechanisms. Development. 2011;138:3441-9 pubmed publisher
    ..Here, we show that the microtubule motor subunit Kif3a regulates hair cell polarization through both ciliary and non-ciliary mechanisms...
  41. Wang L, Hou S, Han Y. Hedgehog signaling promotes basal progenitor expansion and the growth and folding of the neocortex. Nat Neurosci. 2016;19:888-96 pubmed publisher
    ..Thus, robust SHH signaling in the human fetal neocortex may contribute to bRG and IPC expansion and neocortical growth and folding. ..
  42. Jimeno D, Lillo C, Roberts E, Goldstein L, Williams D. Kinesin-2 and photoreceptor cell death: requirement of motor subunits. Exp Eye Res. 2006;82:351-3 pubmed
    ..The removal of one of the kinesin-2 motor proteins, KIF3A, by photoreceptor-specific conditional mutagenesis, has been shown to cause rapid photoreceptor cell degeneration...
  43. Jones C, Roper V, Foucher I, Qian D, Banizs B, Petit C, et al. Ciliary proteins link basal body polarization to planar cell polarity regulation. Nat Genet. 2008;40:69-77 pubmed
    ..Thus, our data uncover a distinct requirement for ciliary genes in basal body positioning and morphological polarization during PCP regulation. ..
  44. Yoshiba S, Shiratori H, Kuo I, Kawasumi A, Shinohara K, Nonaka S, et al. Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2. Science. 2012;338:226-31 pubmed publisher
    ..Whereas Kif3a mutant embryos, which lack all cilia, failed to respond to an artificial flow, restoration of primary cilia in ..
  45. Reed A, Loh N, Terryn S, Lippiat J, Partridge C, Galvanovskis J, et al. CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease. Am J Physiol Renal Physiol. 2010;298:F365-80 pubmed publisher
    ..Thus, the CLC-5 and KIF3B interaction is important for CLC-5 plasma membrane expression and for facilitating endocytosis and microtubular transport in the kidney. ..
  46. Lu D, Rauhauser A, Li B, Ren C, McEnery K, Zhu J, et al. Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease. Kidney Int. 2016;89:1307-23 pubmed publisher
    ..The Kif3a knockout mouse is an established non-orthologous mouse model of cystic kidney disease...
  47. Guinot A, Lehmann H, Wild P, Frew I. Combined deletion of Vhl, Trp53 and Kif3a causes cystic and neoplastic renal lesions. J Pathol. 2016;239:365-73 pubmed publisher
    ..Supporting this idea, genetic ablation of the primary cilium by deletion of the kinesin family member 3A (Kif3a) gene cooperates with loss of Vhl to accelerate cyst formation in mouse kidneys...
  48. Lehmann H, Vicari D, Wild P, Frew I. Combined Deletion of Vhl and Kif3a Accelerates Renal Cyst Formation. J Am Soc Nephrol. 2015;26:2778-88 pubmed publisher
    ..deletion of Vhl together with ablation of the primary cilium via deletion of the kinesin family member 3A (Kif3a) gene...
  49. Schock E, Struve J, Chang C, Williams T, Snedeker J, Attia A, et al. A tissue-specific role for intraflagellar transport genes during craniofacial development. PLoS ONE. 2017;12:e0174206 pubmed publisher
    ..cilia during craniofacial development we conditionally deleted three separate intraflagellar transport genes, Kif3a, Ift88 and Ttc21b with three distinct drivers, Wnt1-Cre, Crect and AP2-Cre which drive recombination in neural ..
  50. Dinsmore C, Reiter J. Endothelial primary cilia inhibit atherosclerosis. EMBO Rep. 2016;17:156-66 pubmed publisher
    ..Removing endothelial cilia increased inflammatory gene expression and decreased eNOS activity, indicating that endothelial cilia inhibit pro-atherosclerotic signaling in the aorta. ..
  51. Chen J, Hoey D, Chua M, Bellon R, Jacobs C. Mechanical signals promote osteogenic fate through a primary cilia-mediated mechanism. FASEB J. 2016;30:1504-11 pubmed publisher
    ..cellsin vivo Furthermore, we used an inducible Cre/Lox recombination system to delete kinesin family member 3A (Kif3a), a gene that is essential for primary cilia formation, at will in transplanted cells and their progeny, ..
  52. Supp D, Potter S, Brueckner M. Molecular motors: the driving force behind mammalian left-right development. Trends Cell Biol. 2000;10:41-5 pubmed
    ..Recently, it has been shown that, in addition, they have a unique role during embryonic patterning: they are required to orient and establish the left-right axis in early vertebrate development. ..
  53. Albracht C, Rank K, Obrzut S, Rayment I, Gilbert S. Kinesin-2 KIF3AB exhibits novel ATPase characteristics. J Biol Chem. 2014;289:27836-48 pubmed publisher
    ..To define the ATPase mechanism and coordination of KIF3A and KIF3B stepping, a presteady-state kinetic analysis was pursued...
  54. Cheng L, Desai J, Miranda C, Duncan J, Qiu W, Nugent A, et al. Human CFEOM1 mutations attenuate KIF21A autoinhibition and cause oculomotor axon stalling. Neuron. 2014;82:334-49 pubmed publisher
    ..The interaction between Kif21a and Map1b is likely to play a critical role in the pathogenesis of CFEOM1 and highlights a selective vulnerability of the developing oculomotor nerve to perturbations of the axon cytoskeleton. ..
  55. Lehti M, Kotaja N, Sironen A. KIF3A is essential for sperm tail formation and manchette function. Mol Cell Endocrinol. 2013;377:44-55 pubmed publisher
    b>KIF3A motor protein is responsible for intraflagellar transport, which is required for protein delivery during axoneme formation in ciliated cells. The function of KIF3A during spermatogenesis is not known...
  56. Guo H, Zhang C, Liu Q, Li Q, Lian G, Wu D, et al. The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation. Cell Res. 2012;22:1246-57 pubmed publisher
    ..Here, we demonstrate that Axin interacts with the ADP-ribosylase tankyrase 2 (TNKS2) and the kinesin motor protein KIF3A, forming a ternary complex crucial for GLUT4 translocation in response to insulin...
  57. Trivedi D, Colin E, Louie C, Williams D. Live-cell imaging evidence for the ciliary transport of rod photoreceptor opsin by heterotrimeric kinesin-2. J Neurosci. 2012;32:10587-93 pubmed publisher
    ..of opsin in these cilia, as well as in cilia of mouse rod photoreceptor cells, was reduced significantly when KIF3A, the obligate motor subunit of heterotrimeric kinesin-2, was deficient...
  58. Tong C, Han Y, Shah J, Obernier K, Guinto C, Alvarez Buylla A. Primary cilia are required in a unique subpopulation of neural progenitors. Proc Natl Acad Sci U S A. 2014;111:12438-43 pubmed publisher
    ..cilia using conditional alleles for genes essential for intraflagellar transport [kinesin family member 3A (Kif3a) and intraflagellar transport 88 (Ift88)] and Cre drivers that are activated at early [Nestin; embryonic day 10...
  59. Guadiana S, Semple Rowland S, Daroszewski D, Madorsky I, Breunig J, Mykytyn K, et al. Arborization of dendrites by developing neocortical neurons is dependent on primary cilia and type 3 adenylyl cyclase. J Neurosci. 2013;33:2626-38 pubmed publisher
    ..transport proteins and accelerated ciliogenesis in neonatal neocortex, the induction of which required Kif3a, an anterograde motor critical for cilia protein trafficking and growth...
  60. Croyle M, Lehman J, O Connor A, Wong S, Malarkey E, Iribarne D, et al. Role of epidermal primary cilia in the homeostasis of skin and hair follicles. Development. 2011;138:1675-85 pubmed publisher
    ..Here, epidermal cilia function was analyzed using conditional alleles of the ciliogenic genes Ift88 and Kif3a. At birth, epidermal cilia mutants appeared normal, but developed basaloid hyperplasia and ingrowths into the ..
  61. Snedeker J, Schock E, Struve J, Chang C, Cionni M, Tran P, et al. Unique spatiotemporal requirements for intraflagellar transport genes during forebrain development. PLoS ONE. 2017;12:e0173258 pubmed publisher
    ..We have genetically ablated Kif3a, Ift88, and Ttc21b in a series of specific spatiotemporal domains...
  62. Foerster P, Daclin M, Asm S, Faucourt M, Boletta A, Genovesio A, et al. mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis. Development. 2017;144:201-210 pubmed publisher
    ..These results suggest that primary cilia regulate ventricle morphogenesis by acting as a brake on the mTORC1 pathway. This opens new avenues for the diagnosis and treatment of hydrocephalus. ..
  63. Lee H, Ko H. Ciliary smoothened-mediated noncanonical hedgehog signaling promotes tubulin acetylation. Biochem Biophys Res Commun. 2016;480:574-579 pubmed publisher
    ..In Kif3a-/- MEFs, which cannot form primary cilia, we observed that primary cilia were required for transducing ..
  64. Saito N, Okada Y, Noda Y, Kinoshita Y, Kondo S, Hirokawa N. KIFC2 is a novel neuron-specific C-terminal type kinesin superfamily motor for dendritic transport of multivesicular body-like organelles. Neuron. 1997;18:425-38 pubmed
  65. Pennesi M, Cho J, Yang Z, Wu S, Zhang J, Wu S, et al. BETA2/NeuroD1 null mice: a new model for transcription factor-dependent photoreceptor degeneration. J Neurosci. 2003;23:453-61 pubmed
    ..Loss of BETA2/NeuroD1 results in an age-related degeneration of both rods and cones. ..
  66. Papal S, Cortese M, Legendre K, Sorusch N, Dragavon J, Sahly I, et al. The giant spectrin ?V couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route. Hum Mol Genet. 2013;22:3773-88 pubmed publisher
  67. Cambray S, Pedraza N, Rafel M, Garí E, Aldea M, Gallego C. Protein kinase KIS localizes to RNA granules and enhances local translation. Mol Cell Biol. 2009;29:726-35 pubmed publisher
    ..related to microtubule dynamics and axon development, interacts with three proteins found in RNA granules: KIF3A, NonO, and eEF1A...
  68. Lehti M, Kotaja N, Sironen A. KIF1-binding protein interacts with KIF3A in haploid male germ cells. Reproduction. 2015;150:209-16 pubmed publisher
    ..Previously, we have demonstrated that a microtubule-based anterograde transport motor protein KIF3A is required for the sperm tail formation and nuclear shaping during spermatogenesis...
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    ..Loss of primary cilia caused by deletion of Kif3a results in activation of AC5 and increased cAMP levels...
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    ..We generated mice in which the intraflagellar transport protein Kif3a was deleted in cranial neural crest cells...
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    ..Thus, the observation of a disassembly phenotype in vivo provides an entry point to understand and categorize ciliary disease. AUTHOR AUDIO: ..