Kif1b

Summary

Gene Symbol: Kif1b
Description: kinesin family member 1B
Alias: A530096N05Rik, AI448212, AI506502, D4Mil1e, KIF1Bp130, KIF1Bp204, kinesin-like protein KIF1B, N-3 kinesin, kinesin heavy chain member 1B
Species: mouse
Products:     Kif1b

Top Publications

  1. Nangaku M, Sato Yoshitake R, Okada Y, Noda Y, Takemura R, Yamazaki H, et al. KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria. Cell. 1994;79:1209-20 pubmed
    ..further elucidate the mechanism of organelle transport, we cloned a novel member of the mouse kinesin superfamily, KIF1B. This N-terminal-type motor protein is expressed ubiquitously in various kinds of tissues...
  2. Zhao C, Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, et al. Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta. Cell. 2001;105:587-97 pubmed
    The kinesin superfamily motor protein KIF1B has been shown to transport mitochondria. Here, we describe an isoform of KIF1B, KIF1Bbeta, that is distinct from KIF1B in its cargo binding domain...
  3. Tan Z, Sun X, Hou F, Oh H, Hilgenberg L, Hol E, et al. Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration. Cell Death Differ. 2007;14:1721-32 pubmed
  4. Vidal R, Ramírez O, Sandoval L, Koenig Robert R, Hartel S, Couve A. Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport. Mol Cell Neurosci. 2007;35:501-12 pubmed
    ..Finally, we report that a kinesin-I mutant severely impairs receptor transport. We conclude that Marlin-1 and kinesin-1 link GABA(B)Rs to the tubulin cytoskeleton in neurons. ..
  5. Xie Q, Yang Y, Huang J, Ninkovic J, Walcher T, Wolf L, et al. Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain. PLoS ONE. 2013;8:e54507 pubmed publisher
    ..lenses combined with in vivo Pax6-binding data yielded 76 putative Pax6-direct targets, including the Gaa, Isl1, Kif1b, Mtmr2, Pcsk1n, and Snca genes. RNA and ChIP data were validated for all these genes...
  6. Blehm B, Schroer T, Trybus K, Chemla Y, Selvin P. In vivo optical trapping indicates kinesin's stall force is reduced by dynein during intracellular transport. Proc Natl Acad Sci U S A. 2013;110:3381-6 pubmed publisher
    ..Finally, inward (?minus-end) stalls in vivo were 2-3 pN, which is higher than the 1.1-pN stall force of a single dynein, implying multiple active dynein. ..
  7. Dillman A, Hauser D, Gibbs J, Nalls M, McCoy M, Rudenko I, et al. mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex. Nat Neurosci. 2013;16:499-506 pubmed publisher
    ..We provide this data set and analysis as a resource for understanding gene expression in the embryonic and adult cerebral cortex. ..
  8. Yang H, Chen Y, Takita J, Soeda E, Piao H, Hayashi Y. Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2. Oncogene. 2001;20:5075-83 pubmed
    ..2 in one of the 24 NB cell lines, NB-1, and cloned the human homologue (KIF1B-beta) of the mouseKif1B-beta gene in this region...
  9. Mok H, Shin H, Kim S, Lee J, Yoon J, Kim E. Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins. J Neurosci. 2002;22:5253-8 pubmed
    Mutation in KIF1B, a kinesin superfamily motor protein, causes a peripheral neuropathy known as Charcot-Marie-Tooth disease type 2A (CMT2A). Little is known, however, about how a defective KIF1B gene leads to CMT2A...

More Information

Publications25

  1. Conforti L, Dell Agnello C, Calvaresi N, Tortarolo M, Giorgini A, Coleman M, et al. Kif1Bbeta isoform is enriched in motor neurons but does not change in a mouse model of amyotrophic lateral sclerosis. J Neurosci Res. 2003;71:732-9 pubmed
    The kinesin superfamily motor protein Kif1B is expressed in two isoforms, Kif1Balpha and Kif1Bbeta, with distinct cargo-binding domains...
  2. Fell S, Li S, Wallis K, Kock A, Surova O, Rraklli V, et al. Neuroblast differentiation during development and in neuroblastoma requires KIF1B?-mediated transport of TRKA. Genes Dev. 2017;31:1036-1053 pubmed publisher
    We recently identified pathogenic KIF1B? mutations in sympathetic nervous system malignancies that are defective in developmental apoptosis...
  3. Beaven D. Morals and ethics in medical research. N Z Med J. 1975;81:519-24 pubmed
  4. Gong T, Winnicki R, Kohrman D, Lomax M. A novel mouse kinesin of the UNC-104/KIF1 subfamily encoded by the Kif1b gene. Gene. 1999;239:117-27 pubmed
    ..The shorter 7.8 kb mRNA encodes a 130 kDa kinesin, KIF1Bp130, whereas the 10 kb mRNA encodes a 204 kDa kinesin, KIF1Bp204...
  5. Gong T, Burmeister M, Lomax M. The novel gene D4Mil1e maps to mouse chromosome 4 and human chromosome 1p36. Mamm Genome. 1996;7:790-1 pubmed
  6. Tanaka Y, Niwa S, Dong M, Farkhondeh A, Wang L, Zhou R, et al. The Molecular Motor KIF1A Transports the TrkA Neurotrophin Receptor and Is Essential for Sensory Neuron Survival and Function. Neuron. 2016;90:1215-1229 pubmed publisher
  7. Kong X, Wang D, Zhou C, Zhou H, Liang C. Loss of function of KIF1B impairs oocyte meiotic maturation and early embryonic development in mice. Mol Reprod Dev. 2016;83:1027-1040 pubmed publisher
    Kinesin family member 1B (KIF1B) is an important microtubule-dependent monomeric motor in mammals, although little is known about its role in meiosis...
  8. Hirokawa N, Takemura R. Biochemical and molecular characterization of diseases linked to motor proteins. Trends Biochem Sci. 2003;28:558-65 pubmed
    ..Studies using knockout mice for kinesin KIF1B have led to the identification of the cause of a human hereditary neuropathy, Charcot-Marie-Tooth disease type 2A...
  9. Charalambous D, Pasciuto E, Mercaldo V, Pilo Boyl P, Munck S, Bagni C, et al. KIF1B? transports dendritically localized mRNPs in neurons and is recruited to synapses in an activity-dependent manner. Cell Mol Life Sci. 2013;70:335-56 pubmed publisher
    b>KIF1B? is a kinesin-like, microtubule-based molecular motor protein involved in anterograde axonal vesicular transport in vertebrate and invertebrate neurons...
  10. Reed B, Cefalu C, Bellaire B, Cardelli J, Louis T, Salamon J, et al. GLUT1CBP(TIP2/GIPC1) interactions with GLUT1 and myosin VI: evidence supporting an adapter function for GLUT1CBP. Mol Biol Cell. 2005;16:4183-201 pubmed
  11. Teng J, Rai T, Tanaka Y, Takei Y, Nakata T, Hirasawa M, et al. The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium. Nat Cell Biol. 2005;7:474-82 pubmed
    ..Furthermore, in KAP3-deficient cells, the subcellular localization of N-cadherin was disrupted. Taken together, these results suggest a potential tumour-suppressing activity for this molecular motor. ..
  12. Kneussel M, Brandstätter J, Laube B, Stahl S, Muller U, Betz H. Loss of postsynaptic GABA(A) receptor clustering in gephyrin-deficient mice. J Neurosci. 1999;19:9289-97 pubmed
    ..In addition, gephyrin may be important for efficient membrane insertion and/or metabolic stabilization of inhibitory receptors at developing postsynaptic sites. ..
  13. Okada Y, Yamazaki H, Sekine Aizawa Y, Hirokawa N. The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors. Cell. 1995;81:769-80 pubmed
    ..Thus, we suggest that the membrane proteins are sorted into different classes of transport organelles in the cell body and are transported by their specific motor proteins through the axon. ..
  14. Matthews R, Sardovia M, Lewis N, Zand R. Biphasic kinetic plots and specific analogs distinguishing and describing amino acid transport sites in S37 ascites tumor cells. Biochim Biophys Acta. 1975;394:182-92 pubmed
    ..We demonstrate that the carboxyl group is not a prerequisite molecular feature for inhibitory interaction with the A or L system. ..
  15. Schlisio S, Kenchappa R, Vredeveld L, George R, Stewart R, Greulich H, et al. The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor. Genes Dev. 2008;22:884-93 pubmed publisher
  16. Conforti L, Buckmaster E, Tarlton A, Brown M, Lyon M, Perry V, et al. The major brain isoform of kif1b lacks the putative mitochondria-binding domain. Mamm Genome. 1999;10:617-22 pubmed
    ..identified a member of the kinesin superfamily whose predicted gene product has the N-terminal motor domain of Kif1b and a novel C-terminal cargo-binding domain homologous to Kif1a...