Kif17

Summary

Gene Symbol: Kif17
Description: kinesin family member 17
Alias: 5930435E01Rik, AW492270, Kif17b, mKIAA1405, kinesin-like protein KIF17, N-4 kinesin, kinesin 17
Species: mouse
Products:     Kif17

Top Publications

  1. Setou M, Nakagawa T, Seog D, Hirokawa N. Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science. 2000;288:1796-802 pubmed
    ..N-methyl-D-aspartate (NMDA) receptor 2B (NR2B subunit) show that they are transported along microtubules by KIF17, a neuron-specific molecular motor in neuronal dendrites...
  2. Chennathukuzhi V, Morales C, El Alfy M, Hecht N. The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells. Proc Natl Acad Sci U S A. 2003;100:15566-71 pubmed
    ..Targeted inactivation of TB-RBP leads to abnormalities in fertility and behavior. A testis-enriched kinesin KIF17b coimmunoprecipitates with TB-RBP in a RNA-protein complex containing specific cAMP-responsive element modulator (..
  3. Kotaja N, Macho B, Sassone Corsi P. Microtubule-independent and protein kinase A-mediated function of kinesin KIF17b controls the intracellular transport of activator of CREM in testis (ACT). J Biol Chem. 2005;280:31739-45 pubmed
    ..The testis-specific kinesin KIF17b was shown to directly regulate cAMP-response element modulator (CREM)-dependent transcription by determining the ..
  4. Chu P, Rivera J, Arnold D. A role for Kif17 in transport of Kv4.2. J Biol Chem. 2006;281:365-73 pubmed
    ..2, which is a major regulator of dendritic excitability, is transported to dendrites by the kinesin isoform Kif17. We show that a dominant negative construct against Kif17 dramatically inhibits localization to dendrites of both ..
  5. Jenkins P, Hurd T, Zhang L, McEwen D, Brown R, Margolis B, et al. Ciliary targeting of olfactory CNG channels requires the CNGB1b subunit and the kinesin-2 motor protein, KIF17. Curr Biol. 2006;16:1211-6 pubmed
    ..the heterotrimeric KIF3a/KIF3b/KAP-3 complex plays a clear role in IFT; however, no role has been established for KIF17, the mammalian homolog of OSM-3 ...
  6. Kotaja N, Lin H, Parvinen M, Sassone Corsi P. Interplay of PIWI/Argonaute protein MIWI and kinesin KIF17b in chromatoid bodies of male germ cells. J Cell Sci. 2006;119:2819-25 pubmed
    ..In this study, we show that the kinesin motor protein KIF17b, which is involved in the nucleocytoplasmic transport of RNA and of a transcriptional coactivator, localizes in ..
  7. Macho B, Brancorsini S, Fimia G, Setou M, Hirokawa N, Sassone Corsi P. CREM-dependent transcription in male germ cells controlled by a kinesin. Science. 2002;298:2388-90 pubmed
    ..We found that ACT selectively associates with KIF17b, a kinesin highly expressed in male germ cells...
  8. Zhao C, Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, et al. Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta. Cell. 2001;105:587-97 pubmed
    ..We show that CMT2A patients contain a loss-of-function mutation in the motor domain of the KIF1B gene. This is clear indication that defects in axonal transport due to a mutated motor protein can underlie human peripheral neuropathy. ..
  9. Broekhuis J, Verhey K, Jansen G. Regulation of cilium length and intraflagellar transport by the RCK-kinases ICK and MOK in renal epithelial cells. PLoS ONE. 2014;9:e108470 pubmed publisher
    ..IFT motor, complex A protein IFT43, complex B protein IFT20, BBSome protein BBS8 and homodimeric kinesin KIF17, whose function in mammalian cilia is unclear. Interestingly, all five proteins moved at ∼0...

More Information

Publications31

  1. Tindi J, Chávez A, Cvejic S, Calvo Ochoa E, Castillo P, Jordan B. ANKS1B Gene Product AIDA-1 Controls Hippocampal Synaptic Transmission by Regulating GluN2B Subunit Localization. J Neurosci. 2015;35:8986-96 pubmed publisher
    ..associates with GluN2B and with the adaptor protein Ca(2+)/calmodulin-dependent serine protein kinase and kinesin KIF17, which regulate the transport of GluN2B-containing NMDARs from the endoplasmic reticulum (ER) to synapses...
  2. Howard P, Jue S, Maurer R. Interaction of mouse TTC30/DYF-1 with multiple intraflagellar transport complex B proteins and KIF17. Exp Cell Res. 2013;319:2275-81 pubmed publisher
    ..We also found that TTC30B can interact with mouse KIF17, a kinesin which participates in IFT...
  3. Zhao D, Liu D, Chen X, Wang K, Zhang A, Kang J, et al. Prenatal stress disturbs hippocampal KIF17 and NR2B in spatial cognition in male offspring. J Neurosci Res. 2013;91:535-44 pubmed publisher
    ..increasing numbers of studies have elucidated that hippocampal-mediated learning and memory are regulated by KIF17 (kinesin superfamily motor protein 17), which specifically transports and regulates the NMDA receptor subunit NR2B ..
  4. Wei Q, Zhang Y, Li Y, Zhang Q, Ling K, Hu J. The BBSome controls IFT assembly and turnaround in cilia. Nat Cell Biol. 2012;14:950-7 pubmed publisher
    ..Our results identify the BBSome as the key player regulating IFT assembly and turnaround in cilia...
  5. Lim Y, Tang B. A role for Rab23 in the trafficking of Kif17 to the primary cilium. J Cell Sci. 2015;128:2996-3008 pubmed publisher
    ..Rab23 in the ciliary targeting of known cargoes and found that ciliary localization of the kinesin-2 motor protein Kif17 was disrupted in Rab23-depleted cells...
  6. Yin X, Takei Y, Kido M, Hirokawa N. Molecular motor KIF17 is fundamental for memory and learning via differential support of synaptic NR2A/2B levels. Neuron. 2011;70:310-25 pubmed publisher
    Kinesin superfamily motor protein 17 (KIF17) is a candidate transporter of N-methyl-D-aspartate (NMDA) receptor subunit 2B (NR2B)...
  7. Dhar S, Wong Riley M. The kinesin superfamily protein KIF17 is regulated by the same transcription factor (NRF-1) as its cargo NR2B in neurons. Biochim Biophys Acta. 2011;1813:403-11 pubmed publisher
    ..In neurons, KIF17 is found to transport vesicles containing the N-methyl-D-aspartate receptor NR2B subunit from the cell body ..
  8. Saade M, Irla M, Govin J, Victorero G, Samson M, Nguyen C. Dynamic distribution of Spatial during mouse spermatogenesis and its interaction with the kinesin KIF17b. Exp Cell Res. 2007;313:614-26 pubmed
    ..Moreover, we found that Spatial colocalizes with KIF17b, a testis-specific isoform of the brain kinesin-2 motor KIF17...
  9. Kayadjanian N, Lee H, Piña Crespo J, Heinemann S. Localization of glutamate receptors to distal dendrites depends on subunit composition and the kinesin motor protein KIF17. Mol Cell Neurosci. 2007;34:219-30 pubmed
    ..The overlap between GluR5 distribution and the organization of microtubules in dendrites led us to examine whether KIF17, a microtubule motor protein expressed in distal dendrites, is involved in GluR5 localization to distal dendrites...
  10. Takano K, Miki T, Katahira J, Yoneda Y. NXF2 is involved in cytoplasmic mRNA dynamics through interactions with motor proteins. Nucleic Acids Res. 2007;35:2513-21 pubmed
    ..its binding partners by yeast two-hybrid screening and identified several cytoplasmic motor proteins, including KIF17. The interaction of NXF2 with KIF17, which was confirmed by GST pull-down and co-immunoprecipitation assays, is ..
  11. Leaf A, von Zastrow M. Dopamine receptors reveal an essential role of IFT-B, KIF17, and Rab23 in delivering specific receptors to primary cilia. elife. 2015;4: pubmed publisher
    ..requiring the receptor cytoplasmic tail, the intraflagellar transport complex-B (IFT-B), and ciliary kinesin KIF17. This targeting mechanism critically depends on Rab23, a small guanine nucleotide binding protein that has ..
  12. Insinna C, Humby M, Sedmak T, Wolfrum U, Besharse J. Different roles for KIF17 and kinesin II in photoreceptor development and maintenance. Dev Dyn. 2009;238:2211-22 pubmed publisher
    ..elegans channel cilia, and deficiency in either kinesin II or KIF17, the homologue of OSM-3, results in disruption of photoreceptor organization...
  13. Guillaud L, Wong R, Hirokawa N. Disruption of KIF17-Mint1 interaction by CaMKII-dependent phosphorylation: a molecular model of kinesin-cargo release. Nat Cell Biol. 2008;10:19-29 pubmed
    ..To address this specific question, we have investigated the mechanism behind the regulation of the KIF17-Mint1 interaction...
  14. McDermott J, Sanchez G, Chennathukuzhi V, Blanco G. Green fluorescence protein driven by the Na,K-ATPase ?4 isoform promoter is expressed only in male germ cells of mouse testis. J Assist Reprod Genet. 2012;29:1313-25 pubmed publisher
    ..These findings highlight the exquisite spatial and temporal control of expression exerted by the Atp1a4 promoter on Na,K-ATPase ?4, which is particularly well suited to fulfill the special functions of spermatozoa. ..
  15. Jiang L, Tam B, Ying G, Wu S, Hauswirth W, Frederick J, et al. Kinesin family 17 (osmotic avoidance abnormal-3) is dispensable for photoreceptor morphology and function. FASEB J. 2015;29:4866-80 pubmed publisher
    ..KIF3) kinesin-2 motors are required to establish sensory cilia by intraflagellar transport (IFT) where KIF3 and KIF17 cooperate to build the axoneme core and KIF17 builds the distal segments...
  16. Lewis T, Kundinger S, Pavlovich A, Bostrom J, Link B, Besharse J. Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms. Dev Biol. 2017;425:176-190 pubmed publisher
    Zebrafish morphants of osm-3/kif17, a kinesin-2 family member and intraflagellar transport motor, have photoreceptor outer segments that are dramatically reduced in number and size...
  17. Liu M, Liu Y, Hou B, Bu D, Shi L, Gu X, et al. Kinesin superfamily protein 17 contributes to the development of bone cancer pain by participating in NR2B transport in the spinal cord of mice. Oncol Rep. 2015;33:1365-71 pubmed publisher
    ..Kinesin superfamily protein 17 (KIF17), a recently characterized member of the kinesin superfamily proteins, has been demonstrated to transport and ..
  18. Liu Y, Liang Y, Hou B, Liu M, Yang X, Liu C, et al. The inhibitor of calcium/calmodulin-dependent protein kinase II KN93 attenuates bone cancer pain via inhibition of KIF17/NR2B trafficking in mice. Pharmacol Biochem Behav. 2014;124:19-26 pubmed publisher
    ..b>KIF17, a kinesin motor, plays a key role in the dendritic transport of NR2B...
  19. Yin X, Feng X, Takei Y, Hirokawa N. Regulation of NMDA receptor transport: a KIF17-cargo binding/releasing underlies synaptic plasticity and memory in vivo. J Neurosci. 2012;32:5486-99 pubmed publisher
    ..Ca(2+)/calmodulin-dependent protein kinase phosphorylates the tail domain of KIF17, a member of the kinesin superfamily, to control NMDA receptor subunit 2B (GluN2B) transport by changing the KIF17-..
  20. Cai D, McEwen D, Martens J, Meyhofer E, Verhey K. Single molecule imaging reveals differences in microtubule track selection between Kinesin motors. PLoS Biol. 2009;7:e1000216 pubmed publisher
    ..In contrast, individual Kinesin-2 (KIF17) and Kinesin-3 (KIF1A) motors do not select subsets of microtubules...
  21. Irla M, Saade M, Fernandez C, Chasson L, Victorero G, Dahmane N, et al. Neuronal distribution of spatial in the developing cerebellum and hippocampus and its somatodendritic association with the kinesin motor KIF17. Exp Cell Res. 2007;313:4107-19 pubmed
    ..cellular distribution of Spatial protein in dendrites is similar to that described for the kinesin motor protein KIF17. Immunofluorescence analyses show that Spatial colocalizes with KIF17 in dendrites of hippocampal neurons in ..
  22. Wong R, Setou M, Teng J, Takei Y, Hirokawa N. Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice. Proc Natl Acad Sci U S A. 2002;99:14500-5 pubmed
    The kinesin superfamily proteins (KIFs) play essential roles in receptor transportation along the microtubules. KIF17 transports the N-methyl-d-aspartate receptor NR2B subunit in vitro, but its role in vivo is unknown...