Gene Symbol: KEPI
Description: protein phosphatase 1, regulatory (inhibitor) subunit 14c
Alias: 6330514J04Rik, KEPI, protein phosphatase 1 regulatory subunit 14C, PKC-potentiated PP1 inhibitory protein, kinase-enhanced PP1 inhibitor
Liu Q, Zhang P, Zhen Q, Walther D, Wang X, Uhl G. KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine. J Biol Chem. 2002;277:13312-20 pubmed
cDNAs encoding KEPI, a novel protein kinase C (PKC)-potentiated inhibitory protein for type 1 Ser/Thr protein phosphatase (PP1), were identified...
Gong J, Liu Q, Zhang P, Wang Y, Uhl G. Mouse brain localization of the protein kinase C-enhanced phosphatase 1 inhibitor KEPI (kinase C-enhanced PP1 inhibitor). Neuroscience. 2005;132:713-27 pubmed
We recently identified the protein kinase C-enhanced protein phosphatase 1 (PP1) inhibitor KEPI based on its morphine-induced upregulation in striatum...
Terami H, Hidaka K, Shirai M, Narumiya H, Kuroyanagi T, Arai Y, et al
. Efficient capture of cardiogenesis-associated genes expressed in ES cells. Biochem Biophys Res Commun. 2007;355:47-53 pubmed
..5-10.5. Based on our results, we consider that the present profiling method may be useful to identify novel genes important for cardiac development. ..
Drgonova J, Zimonjic D, Hall F, Uhl G. Effect of KEPI (Ppp1r14c) deletion on morphine analgesia and tolerance in mice of different genetic backgrounds: when a knockout is near a relevant quantitative trait locus. Neuroscience. 2010;165:882-95 pubmed publisher
We previously identified KEPI as a morphine-regulated gene using subtractive hybridization and differential display PCR. Upon phosphorylation by protein kinase C, KEPI becomes a powerful inhibitor of protein phosphatase 1...
Xiong L, Xia W, Tang F, Pan J, Mei L, Xiong W. Retromer in Osteoblasts Interacts With Protein Phosphatase 1 Regulator Subunit 14C, Terminates Parathyroid Hormone's Signaling, and Promotes Its Catabolic Response. EBioMedicine. 2016;9:45-60 pubmed publisher
..Further mechanical studies revealed that VPS35 interacts with not only PTH1R, but also protein phosphatase 1 regulatory subunit 14C (PPP1R14C), an inhibitory subunit of PP1 phosphatase...