Gene Symbol: Kdm8
Description: lysine (K)-specific demethylase 8
Alias: 3110005O21Rik, Jmjd5, jmjC domain-containing protein 5, lysine-specific demethylase 8, jumonji domain containing 5, jumonji domain-containing protein 5
Species: mouse
Products:     Kdm8

Top Publications

  1. Sealock R, Zhang H, Lucitti J, Moore S, Faber J. Congenic fine-mapping identifies a major causal locus for variation in the native collateral circulation and ischemic injury in brain and lower extremity. Circ Res. 2014;114:660-71 pubmed publisher
  2. He Z, Wu J, Su X, Zhang Y, Pan L, Wei H, et al. JMJD5 (Jumonji Domain-containing 5) Associates with Spindle Microtubules and Is Required for Proper Mitosis. J Biol Chem. 2016;291:4684-97 pubmed publisher
    ..Chromosome instability caused by disturbed mitosis is one of the major features of various types of cancer. JMJD5 has been reported to be involved in epigenetic regulation of gene expression in the nucleus, but little is known ..
  3. Ishimura A, Minehata K, Terashima M, Kondoh G, Hara T, Suzuki T. Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression. Development. 2012;139:749-59 pubmed publisher
    ..The nuclear protein Jmjd5 (also called Kdm8) is a histone lysine demethylase that contains a JmjC domain in the C-terminal region...
  4. Oh S, Janknecht R. Histone demethylase JMJD5 is essential for embryonic development. Biochem Biophys Res Commun. 2012;420:61-5 pubmed publisher
    ..b>JMJD5 (jumonji C domain-containing 5) is a histone demethylase that specifically removes methyl moieties from ..
  5. Probert F, Rice P, Scudamore C, Wells S, Williams R, Hough T, et al. ¹H NMR metabolic profiling of plasma reveals additional phenotypes in knockout mouse models. J Proteome Res. 2015;14:2036-45 pubmed publisher
    ..In the remaining 16 lines, no ex vivo abnormal phenotypes were observed. Plasma (1)H NMR spectroscopy can therefore provide a novel perspective on the function of knocked-out genes. ..
  6. Ishimura A, Terashima M, Tange S, Suzuki T. Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis. Cell Tissue Res. 2016;363:723-33 pubmed publisher
    ..Previously, we have reported that Jmjd5, a member of the Jumonji C (JmjC) family, regulates embryonic cell proliferation through the control of Cdkn1a ..
  7. Dahl J, Jung I, Aanes H, Greggains G, Manaf A, Lerdrup M, et al. Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition. Nature. 2016;537:548-552 pubmed publisher
    ..Our results provide insight into the onset of the developmental program in mouse embryos and demonstrate a role for broad H3K4me3 domains in MZT. ..