Kdm7a

Summary

Gene Symbol: Kdm7a
Description: lysine (K)-specific demethylase 7A
Alias: A630082K20Rik, BB041802, Jhdm1d, mKIAA1718, lysine-specific demethylase 7A, jmjC domain-containing histone demethylation protein 1D, jumonji C domain-containing histone demethylase 1 homolog D, lysine-specific demethylase 7
Species: mouse
Products:     Kdm7a

Top Publications

  1. Tsukada Y, Ishitani T, Nakayama K. KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development. Genes Dev. 2010;24:432-7 pubmed publisher
    ..Our findings identify KDM7 as a dual demethylase for H3K9 and H3K27 that functions as an eraser of silencing marks on chromatin during brain development...
  2. Yokoyama A, Okuno Y, Chikanishi T, Hashiba W, Sekine H, Fujiki R, et al. KIAA1718 is a histone demethylase that erases repressive histone methyl marks. Genes Cells. 2010;15:867-73 pubmed publisher
    ..Thus, our study identifies KIAA1718 as a histone demethylase for repressive methyl marks and shows that it is involved in transcriptional activation. ..
  3. Huang C, Chen J, Zhang T, Zhu Q, Xiang Y, Chen C, et al. The dual histone demethylase KDM7A promotes neural induction in early chick embryos. Dev Dyn. 2010;239:3350-7 pubmed publisher
    ..Here, we show that an evolutionarily conserved dual histone demethylase KDM7A (KIAA1718) is predominantly expressed in epiblast cells of the primitive streak in early chick embryos...
  4. Osawa T, Muramatsu M, Wang F, Tsuchida R, Kodama T, Minami T, et al. Increased expression of histone demethylase JHDM1D under nutrient starvation suppresses tumor growth via down-regulating angiogenesis. Proc Natl Acad Sci U S A. 2011;108:20725-9 pubmed publisher
    Histone demethylase JHDM1D (also known as KDM7A) modifies the level of methylation in histone and participates in epigenetic gene regulation; however, the role of JHDM1D in tumor progression is unknown...
  5. Dahl J, Jung I, Aanes H, Greggains G, Manaf A, Lerdrup M, et al. Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition. Nature. 2016;537:548-552 pubmed publisher
    ..Our results provide insight into the onset of the developmental program in mouse embryos and demonstrate a role for broad H3K4me3 domains in MZT. ..